Drug Na Classification Mechanism of Action Indication Contraindication Adverse Reaction Nursing Responsibilities

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Generic - Diclofenac Inflamma - Patients - Nause, Before:

Name: PHARMACOL primarily inhibits tory with diarrhea, -Check vital signs of the
DICLOFENA OGIC: Potent the enzyme disorders known bleeding, patient
C cyclo- cyclooxygenase like hypersen ulceratio - check for disorder
oxygenase (COX), osteoarth sitivity n, -check the patients’ medical
inhibition specifically both ritis, - Shouldn’t headache history
cyclooxygenase-1 rheumato be given ,
(COX-1) and id to dizziness, During:
Brand cyclooxygenase-2 arthritis, -check if it’s the right drug
patients vertigo,
Name: THERAPEUTIC: (COX-2). These and -check for the signs and
who have hypersen
ZIPSOR Reduce enzymes play a key ankylosin symptoms
role in the experienc sitivity
inflammation g - check for adverse effects
production of ed reactions
and pain. spondyliti
prostaglandins from asthma, e.g.
s are After:
arachidonic acid. uriticaria, bronchos
PREGNANCY among -check patient time-to-time
CATEGORY: C Prostaglandins are the or other pasm, -Inform the physician for
lipid compounds sources allergic- rashes, any adverse effect
that are involved in of pain type local -Educate patient for the
Actual various and reactions. discomfo adverse effect that might
Dosage: physiological inflamma - rt, occur.
25 mg processes, including tion that burning
inflammation, pain, diclofena or itching.
Route: Oral and fever. c is - Nephrotic
suggeste like
Frequency: Absorption: d to treat. syndrom
2-3 times a oxidative It is also e rarely
day metabolism to used to
hydroxy metabolites treat
as well as
injury-
conjugation to
related
glucuronic acid,
sulfate, and taurine.
 Absorbed from the inflamma
GI tract tion
Distribution: brought
Diclofenac has a on by
total volume of physical
distribution of 5-10 trauma
L or 0.1-0.2 L/kg. and
Metabolism:
surgical
Excretion:
procedur
Protein bound:
99.7% es.
Half-life:
approximately 2h

Reference: