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_Porinciples _of i 7 4
on dap cleline aa dhe
teeench of Science dhich —olecls _coith Study
of — effects ot cltugie_orndl thet tans
of poise “S % also Jo Sdudy advlence eHect
y of leu g - i _
AdNense effecd= 9+ ip Ihe umdeniable amd :
: umndtended elect of a: Q
—terlegorieS mio 9 Ska beet -
uy) predeclable_ et Seaction.) — bane —_—__—_—
aa 94 ferestidule
80s ae of — ddvesrce akxuq 1q__eae aged
—Arnamnly _4he __Com8i (uem Ce psi Pa
» eHlecd of fhe dug 0% aid tanvetpn de
p—_eHecd am _@_imdex ofthe ug
5 Now prcelecki ble Cty pe B_ a
> Sector These acre
~ cli 9 syn estedlic (a8 PT TT. oX_MoNad sceiponn Se
zs Conn not be _preclicled chrom the k/nn | e cology)
rs the abut weg $f tops eh 5
Side edted — :
Sol cere the. Jan Wanders) 8
adhe nal at Sherapeule clase
7 Toric eHecl may rest gi ge —to be oes,
ee of the dx. ao py ein“Texicify etl _-
= 3 Acule toxicity Corn be olalected
within 4 days - } ia
he 2 alay
Sub pale — pric id clealecdeal the _2& ;
er deseiciiy deolec|ecl dhe 6 month
a ~Specieel MW Getcinagen
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i
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ee edRewle derrcrty test —
E Po li'gove new tral
Umnaspected eHecl of olxuy - |!
D> To determine Lis deco « ——
~S— Requlatty —authdy need okila om acute
—— Aexcicky fore th “study ef 4ho . ob rugy om humans
r
a Rede torre! fy — ‘
tos 3 Toxicity produce. ye tha Single — 7
an rnuliple dose" Woithin 24 |
Acute Aowicity Nest “This deat ato Pesichrnny
im those amine? jn Which
tre gimgle_clore 2} the _olxuy 2% ol Hesrerd_
Oléadion Carepy—2_ etre) Syom torn Inne ude nn
Cagney _famtlonn Wor Amusele Spagna, :
Convers S10
> Suh actute_ . Joxicity ap ay adver, Hey
OCCUStiny ak ee 7 1 vepen pfs
Cos-e of, et cheans ak OVeo4 Pedy oz
aA Seok Week 4s iy olegy
ign to
— @kdyote aren — of men -
Lae the | of any "chant, ao Jo—_chswernie_hoxicity. — — st ip oleae cas the help.
— hich _clenelop _affeo, the
~epeatecl 0¥ comtineous aolmnimishesed of Jeb
—koenaple fox dhe oe cone of ame fe
eH: (tie A) 7
— Obyechive _ _the exit ciy= shad —
3 —cledesmmine the —dowicity of _ dheo bseor viarey
— changing — tne onchinn Shape — of er hurley
ONGANIEN » ia pects H haw ts
> EHect of Pesthiculus, chuy on _$ Gone due
__ Reproduction crn fst _and__ ow net
= deleormime dhe cbrrage take
— fedut
—=>"To cleleommme — the— Giinege cy 04d —
— beugy _Sususre Lanatan ce nt
sien ~ Genodo%ici dy -
—
> oge toxicity a wootd_— “genodicc udhich ve?
delime cA oll isheutive elec fon celle_gene hie
_ enol _geno Ao ence Cougeg on
con they ——trnclude__ FR loo th _aCeadhy ton S
_ chemical % — they Aste ee ae
__genotoricihy - eee aan 4
=< stain of “Gat Gino JOY) _- es —— es 7
—————————— |Vervogenact sy ~ I TC Geni dic a Gay ‘
Beforelive ‘
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1
1
olegoviet. 7 hcg
ecegowiet= 2 = $4 shoo am Cute _Camces im
See arr ee es Foner _
Categorie k~2 = Cauhe Cupar jammed &
“wees ——_prohesdy to human _alaso
——Coeqoviet . = — = They — Asie tastmagem bid.
—————atkeolence Bugort tm rar crmagencity yp
——Wurmonn _do mot eset s
——_Bgent _C CaQable — of eee DNA shomage
—_3s_Uv Sadialion \
ive — Oxygen Spied down fermen, ‘
—trliilite 7 prodalen eed
> clachoghiic — Sperulic a lien tend 1
1D i dn HAD py AB eters - ate
_ _ Gear fy! 1 ee ae,
as IE eg the —albitidy ov dendenty of he
chermmiaely to _Imeluce _Sumous ov _@nces,
—_dasucinngenn _—sangy—be_ “chemitr? Subeamce
Physi ce — Agent ox ee
Cammy Sirus)
enaci4 co ees
—Teso.toy 8 wD ie Rpwelvoline tie
aay rea ne dp _Ocusvence lo biologic
: ee? _weproduchve syoten
ad vere effect —“_wweweey
Gene toxicid
- Geno oxic Subsiance Can be dacibed ag all,
a
Chermi(a0s thad _pNoduce DNA obrmage leading —
smutation eX __Ganfex:
Gyemelic_rmnoteria2 trnelud rng pnt & RNP ubich —
thereby alec ssewla.
Thus _geroloving _Can_be clelimed af omulagen’
Yat “Carus —_ gernoloxtecdy —efetulding in darnage. of
sna
___Sdxmahie cell —€ = Germ cet
: a £ ee seh = mm Authrod
casidinyastulad Disease __
DR aeage Genie pee -
aa Lange Gene)
- —tyshe ek 1s —
: Arms Sie¥le i) Paawophilia
— — Proves’
_ — techn’ of _Lewol xcicily - eras
The “goxno fori _Sulastern (ep provoke —dhemage Jo the
__germelic —venak@otia) im the (ells: thou
—volkh dre DNA S€quence_ cilia” Bet ex
re beungdion ome dad chro ani um —interacd coc\ — XV) ba E : : 3
natn Sie. aia —