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    Anti Depressent

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    Alaa Mohamed Naser
    This document discusses antidepressant and anti-dementia drugs. It notes that depression is a mood disorder and major cause of disability worldwide, and can lead to suicide. It describes how selective serotonin reuptake inhibitors (SSRIs) like Prozac and Zoloft work to treat depression by increasing serotonin levels in the brain. It also mentions tricyclic antidepressants from the 1970s and monoamine oxidase inhibitors (MAOIs) as older classes of antidepressants. The document provides references on antidepressant mechanisms of action, neuroinflammation, and treatment-resistant schizophrenia.

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    Anti Depressent

    Uploaded by

    Alaa Mohamed Naser
    5 views31 pages
    This document discusses antidepressant and anti-dementia drugs. It notes that depression is a mood disorder and major cause of disability worldwide, and can lead to suicide. It describes how selective serotonin reuptake inhibitors (SSRIs) like Prozac and Zoloft work to treat depression by increasing serotonin levels in the brain. It also mentions tricyclic antidepressants from the 1970s and monoamine oxidase inhibitors (MAOIs) as older classes of antidepressants. The document provides references on antidepressant mechanisms of action, neuroinflammation, and treatment-resistant schizophrenia.

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    This document discusses antidepressant and anti-dementia drugs. It notes that depression is a mood disorder and major cause of disability worldwide, and can lead to suicide. It describes how selective serotonin reuptake inhibitors (SSRIs) like Prozac and Zoloft work to treat depression by increasing serotonin levels in the brain. It also mentions tricyclic antidepressants from the 1970s and monoamine oxidase inhibitors (MAOIs) as older classes of antidepressants. The document provides references on antidepressant mechanisms of action, neuroinflammation, and treatment-resistant schizophrenia.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    Download as pdf or txt
    5 views31 pages

    Anti Depressent

    Uploaded by

    Alaa Mohamed Naser
    This document discusses antidepressant and anti-dementia drugs. It notes that depression is a mood disorder and major cause of disability worldwide, and can lead to suicide. It describes how selective serotonin reuptake inhibitors (SSRIs) like Prozac and Zoloft work to treat depression by increasing serotonin levels in the brain. It also mentions tricyclic antidepressants from the 1970s and monoamine oxidase inhibitors (MAOIs) as older classes of antidepressants. The document provides references on antidepressant mechanisms of action, neuroinflammation, and treatment-resistant schizophrenia.

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    © All Rights Reserved
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    of 31

    (Antidepressants and Anti-

    Dementia Drugs)
    Under supervision
    Prof. Dr. Amany Ali
    Prepared by
    Alaa Mohamed Nasr
    introduction

     Depression is disorder of mood


     Globally more than 350 million people of
    all ages suffer from depression
     Depression is a major cause of disability
    World wide
     Depression can lead to suicide
    MAOIS
     Mechanism of Action:
     SSRIs, such as fluoxetine (Prozac) and sertraline (Zoloft), work by
    increasing the levels of serotonin in the brain. They inhibit the reuptake
    of serotonin, allowing it to remain active in the synaptic cleft, thereby
    improving mood and reducing symptoms of depression.
    Tricyclic Antidepressants (TCAs): 1970
    References
     Effendi, W.I.; Nagano, T.; Kobayashi, K.; Nishimura, Y. Focusing on Adenosine Receptors
    as a Potential Targeted Therapy in Human Diseases. Cells 2020, 9, 785. [Google Scholar]
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     Vahid-Ansari, F.; Albert, P.R. Rewiring of the Serotonin System in Major Depression.
    Front. Psychiatry 2021, 12, 802581. [Google Scholar] [CrossRef] [PubMed]
     Lu, J.; Huang, C.; Lu, Q.; Lu, X. Therapeutic and Prophylactic Effects of Amphotericin B
    Liposomes on Chronic Social Defeat Stress-Induced Behavioral Abnormalities in Mice.
    Front. Pharmacol. 2022, 13, 918177. [Google Scholar] [CrossRef]
     Buckley, P.F. Neuroinflammation and Schizophrenia. Curr. Psychiatry Rep. 2019, 21, 72.
    [Google Scholar] [CrossRef]
     Howland, J.G.; Greenshaw, A.J.; Winship, I.R. Practical Aspects of Animal Models of
    Psychiatric Disorders. Can. J. Psychiatry 2019, 64, 3–4. [Google Scholar] [CrossRef]
     Nucifora, F.C., Jr.; Woznica, E.; Lee, B.J.; Cascella, N.; Sawa, A. Treatment resistant
    schizophrenia: Clinical, biological, and therapeutic perspectives. Neurobiol. Dis. 2018,
    131, 104257. [Google Scholar] [CrossRef] [PubMed]

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