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    CBL Group 2: Pathogenesis & Clinical Manifestation Ofnsinsle

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    VARITPOL CHAROENYINGPAISAL
    1. Nephrotic syndrome in SLE can be caused by immune complex deposition in the glomeruli, which leads to inflammation and podocyte injury. 2. Clinical manifestations of nephrotic syndrome in SLE patients include massive proteinuria, edema, hyperlipidemia, hypoalbuminemia, and fatty casts in the urine. 3. In addition to nephrotic syndrome symptoms, SLE patients may also experience joint pain, rashes, oral ulcers, and fever.

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    CBL Group 2: Pathogenesis & Clinical Manifestation Ofnsinsle

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    VARITPOL CHAROENYINGPAISAL
    15 views27 pages
    1. Nephrotic syndrome in SLE can be caused by immune complex deposition in the glomeruli, which leads to inflammation and podocyte injury. 2. Clinical manifestations of nephrotic syndrome in SLE patients include massive proteinuria, edema, hyperlipidemia, hypoalbuminemia, and fatty casts in the urine. 3. In addition to nephrotic syndrome symptoms, SLE patients may also experience joint pain, rashes, oral ulcers, and fever.

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    1. Nephrotic syndrome in SLE can be caused by immune complex deposition in the glomeruli, which leads to inflammation and podocyte injury. 2. Clinical manifestations of nephrotic syndrome in SLE patients include massive proteinuria, edema, hyperlipidemia, hypoalbuminemia, and fatty casts in the urine. 3. In addition to nephrotic syndrome symptoms, SLE patients may also experience joint pain, rashes, oral ulcers, and fever.

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    15 views27 pages

    CBL Group 2: Pathogenesis & Clinical Manifestation Ofnsinsle

    Uploaded by

    VARITPOL CHAROENYINGPAISAL
    1. Nephrotic syndrome in SLE can be caused by immune complex deposition in the glomeruli, which leads to inflammation and podocyte injury. 2. Clinical manifestations of nephrotic syndrome in SLE patients include massive proteinuria, edema, hyperlipidemia, hypoalbuminemia, and fatty casts in the urine. 3. In addition to nephrotic syndrome symptoms, SLE patients may also experience joint pain, rashes, oral ulcers, and fever.

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    of 27

    CBL Group 2

    Pathogenesis &
    Clinical Manifestation
    of NS in SLE
    ADVISER
    AJ. CHAYUT TRIKITTIWONG, MD.
    AJ. SARANYA SIRIBAL, PH.D.
    AJ. AMONRUT YUENYONGWATTANAKUL
    AJ. SARAWUT LAPMANEE, PH.D.
    GROUP 2

    Group Members
    Pasakorn Soonthorntam 6406300001
    Supassara Koturapun 6406300007
    Chontipha Neeyakorn 6406300008
    Boonsita Kannika 6406300016
    Nattakan Treesaksrisakul 6406300025
    Suwanna Ruangthavornkul 6406300028
    Peerawit Engpongpan 6406300031
    Khumphong Trisaengrujira 6406300033
    Chayapa Uppapong 6406300039
    Patchara Polsongkhram 6406300044
    Warin Lerdthumterakul 6406300046
    Varitpol Charoenyingpaisal 6406300047

    2
    Our Contents
    Pathogenesis of Nephrotic Syndromes in SLE
    Clinical Manifestation of Nephrotic Syndromes and
    SLE with NS

    3
    Nephrotic syndrome
    A group of symdrome that defined by a triad of
    clinical features:

    Proteinuria > 3.5 g/24 hr.


    Hypoalbuminemia < 30 g/L
    Edema

    National institute of Diabetes and Digestive and Kidney Disease,2022 osmosis.org/learn/Nephrotic_syndromes:_Pathology_review


    4
    Primary causes
    An intrinsic renal disease such as:
    Membranous nephropathy
    Minimal-­change nephropathy
    Focal and segmental glomerulosclerosis (FSGS)

    Secondary causes
    Include systemic diseases such as:
    Lupus erythematosus
    Diabetes mellitus
    Amyloidosis
    Infection; HIV, HBV, HCV 5

    Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors. J Clin Med. 2018 Sep 9;7(9):265.
    Pathogenesis of
    Nephrotic Syndrome
    in SLE

    6
    7
    8
    Pathogenesis & Pathophysiology

    9
    Pathogenesis & Pathophysiology

    4
    5

    10
    11

    PROTECTING THE KIDNEY IN SYSTEMIC LUPUS ERYTHEMATOSUS: FROM DIAGNOSIS TO THERAPY. NAT REV RHEUMATOL 16, 255–267 (2020).
    12
    13
    14
    15
    Development of renal damage in SLE

    16

    PROTECTING THE KIDNEY IN SYSTEMIC LUPUS ERYTHEMATOSUS: FROM DIAGNOSIS TO THERAPY. NAT REV RHEUMATOL 16, 255–267 (2020).
    Clinical Manifestation of Nephrotic Syndromes

    17
    Symptoms Signs
    Puffy eyelids Massive proteinuria (> 3.5 g/day)

    Weight gain Edema

    Tiredness Hypercholesterolemia

    Loss of appetite Hypoalbuminemia

    Lipiduria

    18
    Clinical
    Manifestation of
    SLE with NS

    19
    Symptoms Signs
    Proteinuria, Lipiduria
    Abdominal pain
    Hypercholesterolemia
    Puffy eyelids
    Hypoalbuminemia
    Weight gain
    Foamy pee
    Loss of appetite
    Edema
    Oral ulcer
    Fever
    Joint pain
    Butterfly rash (Malar rash)
    Feeling unwell
    Low WBC, RBC, Hb
    20
    SLE criteria

    21

    https://www.mdedge.com/rheumatology
    Discoid rash
    Photosensitivity 22
    Malar rash
    Oral ulcers 23
    Nonscarring alopecia
    24
    REFERENCES
    1. Yu Y. Nephrotic syndrome: Pathogenesis and clinical findings: Calgary guide [Internet]. 2021 [cited 2023 Nov 7]. Available from:
    https://calgaryguide.ucalgary.ca/nephrotic-syndrome-pathogenesis-and-clinical-findings/

    2. Sakhi H, Moktefi A, Bouachi K, Audard V, Hénique C, Remy P, et al. Podocyte injury in lupus nephritis [Internet]. Multidisciplinary Digital Publishing
    Institute; 2019 [cited 2023 Nov 7]. Available from: https://www.mdpi.com/2077-0383/8/9/1340

    3. Tapia C, Bashir K. Nephrotic syndrome - statpearls - NCBI bookshelf [Internet]. StatPearls [Internet]; 2023 [cited 2023 Nov 7]. Available from:
    https://www.ncbi.nlm.nih.gov/books/NBK470444/

    4. professional NI of D and D and KD (NIDDK). Nephrotic syndrome in adults - NIDDK [Internet]. U.S. Department of Health and Human Services; 2020 [cited
    2023 Nov 7]. Available from: https://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults#common

    5. Nevares AM. Systemic lupus erythematosus (SLE) - musculoskeletal and connective tissue disorders [Internet]. MSD Manuals; 2023 [cited 2023 Nov 7].
    Available from: https://www.msdmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/autoimmune-rheumatic-disorders/systemic-
    lupus-erythematosus-sle

    6. professional CC medical. Nephrotic syndrome: Causes, symptoms & treatment [Internet]. 2022 [cited 2023 Nov 7]. Available from:
    https://my.clevelandclinic.org/health/diseases/5989-nephrotic-syndrome

    7. O’Brien F. Overview of nephrotic syndrome - genitourinary disorders [Internet]. MSD Manuals; 2023 [cited 2023 Nov 7]. Available from:
    https://www.msdmanuals.com/professional/genitourinary-disorders/glomerular-disorders/overview-of-nephrotic-syndrome

    8. Yu Y. Nephrotic syndrome: Pathogenesis and clinical findings: Calgary guide [Internet]. 2021 [cited 2023 Nov 7]. Available from:
    https://calgaryguide.ucalgary.ca/nephrotic-syndrome-pathogenesis-and-clinical-findings/

    9. Netter FH, Kelly CR, Landman J. Renal Disease. In: The Netter Collection of Medical Illustrations: Volume 5. Philadelphia, Pennsylvania: Elsevier Saunders;
    2012. p. 100–2. 25
    Q&A
    Biomimetic models of the glomerulus. Nat Rev Nephrol 18, 241–257 (2022).

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