NTRODUCTION

Proto 30an
. am oibe (ánek) change shabe] Habitat lanqe htesHne
Causes amoebiasts.

FPIDEMIOLOGY

MOre seun in topicaksibthopfcal countrles

MoRPHOLOuY

unicellulak 4 pentoms all tunction.

’ 3 Stages :
Thophozoite Pre cyst stage Cyst stage
Ound| Nal wtth blunt sphext cal
shae Trregulan pAudo pdtum
I0-1S M
si3e L0-20 M
eanly cyst has 1
nuc leuS spheuali
Contal Small dlot ike
Stuetue hat s cenha
stage. mPtotc matne
aNsn yst
Kanyoome whleh is (quaduthulate)
Swwoundd by clat
halo
altyeencaked
clas, ecko blurt peudopadhn
thn, clw
cytoplasrm " ectoplagn hgeskd tod
thanyluwnt outn layN dubnis " contalnd chtmateid
qranulat ihgested ted
" endo plam laar glycogen
innen layn(nuluws
mars .
Rbc, Jbe
tood vacuole,
LIFE C4CLE

deintire Aurnan leing

irturmdiat het not quined, pauees theyce in ne het- he man
Cyst pan
Stomaeh enter
s Conwalcant)a cont pol | dánk Srnall nteune

Cconie) food duint

contaminatn
eneyrtatn o h caun

nuce ytopam metayt o ium ay to plam qett

lawen pant
wll , then cauing
dutachd from yst tetnuellate
cyst wal, a
a t t fo (metayst)
ttK
lodge n subutan anaba comes ut

mulHpy by
tney qhow ?
bfray finion condit fer tophoyofbe
Dwthg coekd hbo
Ome get
tonm ) AOR
tinaly hto
phodue chanact utos pheeyste 2 stage
yste tage
ameebafs

ysts a e bared n

PATHOUHENE SIS
food b0Ne fomites fle
tansmiion futd bohe Beual
finges
intestine bnain, akin
sTte: latge Qung
* tytinal - ire, plen
extha
: vaable
Inub petod gwey ysdays
 metayshc tophooites iwad muuA memb o, lang htesttn e

Ohganiarn qet nowihud eu abe abondng tuun jut (Albugh)

feanllet nnodlan elun, Openna hcentu hiypareno 4 ma

SUough fall doun . lartng ehtnd an anmoee wen

hautophogats

Coot

Then

(ron tnvastre) Smetastatt

°/rtesthal
2°/ tha intestinal

CLINICAL
OIntestiha amoebiast ooeLiasts)
lted to latge hteytine amoebft dyrenty
cf: bld]muus tn atool ) koul snll G browwnish hlalk colon atool
patnt - wually afebile non to xie ,abd Cays
slt - only dí awhoea y vague abd. sympns

Exta frtejttnal (2°| metastat)

> 4pain &tenanen h right hyp0 chondriua

shoulden ph (dus to ihitaty bwene he

Jaun alee
" þuln uaneous cvubhal amobiauis, Splente abacs, aginhs , oeni
 Contosr
ANCHOvy SAUCE U3

niton+

LAB DIAa

+ stool ex orninotr.: ayst| tr ophogoTe

torogotes
(us (onchovy ou. pu) motile
(Livn)

Ax enie -nesont medium

- Noroaenic - hilps sdi
tuyarenic

serolog4
. bdcth : CFT, Inaireet heneagg. elra, ropia mauno chuo matogaphy ifa
epoter torrefurne (tyod mor) test
1htodmal aken test.

puythla tol2o- 24 hny)

 Mc'ctiag

Animal ho

dogt cat, hate, gutnea, monkoy

PHeat

TRTNENT:

methóni dasse ( Doc)

. Luminol agent Todoquinst

PROPHYLA X1S:

boiling dun king waten

wasd neggies

4 dettetn management
 leishmaniasis
JNTRODUCTN
puotogoan) dlrcovuk by!
* psotogooh (flagelate
dothelial cell pathogen
* Refiuloen Darare
Causes Kala hset eeton
mammal,

MORPH afagellan stag )

lelshnanial. foum ,
Amastigoke forn (LDbody ,
O hotophil, hdotholia
host (human dog )
venteb rate

Cells
Rong
oval; 2-4M
ghae: rOund |
mDruA)
kinetoplast ( speial ed colowud
’ at b to nule ,
found
Fod) dot lce body
(od)
’fuabasal lody
blepharofplast (aot)
blphaoplast to mangi
Oot e Bageluan onitingf u
Axoneme : a
body
blue (Romano ws ky tatn)
aytolasm: pale
Leptohmonad Blagelan stagr)
homostigote joh (

pean = ong slhon

shae: shont, oral
45-20
ahte°Øn end
thanneuy ean
letoplast : ees
EPDEMI0
utna

LIFE CyLE

Dekniirt hest humon

vecto A fenal andHy (hteum dfote, hest)
eseroin mammal (dog, wtly dox. rodent )

oews ly kandby
Human ngectn
ny nanophoges
homaigote fom enguyed
odulrg lange
change to omatigote kom 4 mulHpy
daugte celll

o intuted has+cL elasng So-200

Endagenent uptu
nacophags y
daughta wlu
cçulatn,agan engultd sy
hittoy tes

Cylu epeated,
enti &E Rytnm atfeeted

fnsí neito mono ute

Some bpdles kound & bld

that dutp into

sandly feede , taku amatigote fom
homast&got foams

by binay tnn7no dagher

promathgote fos
cells , tran Poted fom nud gut to ohayns
, bueal caty

hen ingeeted andty brtes, elass goastt

hto gun chue awand y cyel Mpeat
PATHOaENESIS

mode ef ban : Rk o4 kandhy, somal vontical

hyiete sfoge Promagtgote
Inab petod : 3-6month gny

fmatgotea tpeolikonate Sdothllot

QLonlonakoua bonafte induuk 4 lay mauophaa

ulberoted dlamag

CLINICAL
(sceral letyhmaniasts)
kuypako Cinh magaly
ch Ruer (ontin, ae tHert |ihegulan), glen
lymphadlnop atng
emalatn y anemio n

foundla

dy, rough ,dak omnted ( hene kalo arau nam)

ean :
otua eyte
Compl>e: baull amoebfc dyerty pneumonia , lmTb,

otd
ogat desna lelmani
Pott kala non uluah'e
cutanoA
tueovd fn kalaasan .dw
* obt l0-0). case
tuatnnt

* 3type lyns ex tiemties)

dpfgrented mauw (tunt
joathes (nose chut chin photoengitire)
erthenetous
h phk odules
eyendonmatos nsduly (painlen yeowú eet tonge eyes)
- Yen,
LAB DIA

Specdmen bld, spleun apiat . bon mavow , Aopky tu eplent puls hK

Omco: aasiaote fo demo by Romansuky gtain, Lof armann atan

Nory matNeal Nicolle (NNN)haedam

) sealogg : CFT, THA,ELISA ,

Latex asyqthatn tst
Countea cutHt fmunoletDphouit ,

4) Molec
pNA obe )6eR nulic aid, detn

) Atmol ino c
Entapetonealahtadml sieen impenton

(b) kin test:

Monttneg o

denmal th (+ e)
(4ne)
fho coneedhm kala ay
altre kata aga -)ne
OHemat Panytopenio
TRTMENT :
Amphotouiin B (Do)
* L'pid fomuatr

Fentavalent antimony compound

(megluine anhmoni ake)

Sftomauihe
Pentaidtn
nabegostne (oral)
 laediu
|NTRO

FPIDEMIO

vtroM topial , aubspical

malana s Case top (al fio

+ ovale o') car, not potd in lndia

MORPH

malaou
Spono3oftes nabow,alqht Cumwd ulohvdy tutck 2tye
2t4pe Tachy-balt ho hyproorme
(dvptn PES) no hypnot PES
Brady eow
(hyprozolteá)
ne eythmocyhe
nchigont
42M In dia
60x30 M not obed. 10-20MX
40-Sou
\0000 n000 20000~ SOD 1s000 (apph) |5000

mhOoes
4oung Rbs Reteulos
old ibe
young 9 matw otd 4oung nbu

euythoyte
schigogon
4e hs 12hu

hvaun ohabe eath aG by 1 pahasite moe thon

By

bpto so'. Losten 1, |-2'/.

Thophoyite sf3e- 5 -3 longe 1.2 S-1-SM Amall

aing atahe to be
2SM 2-25 M
mangen
6Thul ate rengromnonhi none
Stane d
amocbet
lange , iagulat band te belobed
LIFE CYCLE:

Juftnihire hot- fem ahopheles mor, (unalghave)

temedlate - humon ( olual)

hs ycle in hun an (achi yog ony lastvual)

bfe t Runaneph motqito

Hulease a aponoou fn bd

Heach captlloes

euythoytta sehisogony n nbe

[méonomeogotu - eany toaphogotk amoeootd stage (laktuaghagot)7

late achgont
moono'tes

ae hlbeated erythmoy tro shi g0gony ayeles oma of muogottes

fhiRake qamtto gony foamirg mala ey Behlu qanatoyy
Checyle tn mes quitosporogony | Aevual)
Sucktng %ganmetoe byy mmorgutto dwing bld meal

Comen mitho mawe tametoeyku mlu maro qamete

mtd gut o mosqutoe)

Mluo y maco gamet seut% to fo dgote

foumatn ooklnete

Con to ooy t

Sporogoike Aeke heat altry glands

fnfectn SOnogoites to ftate wunan

cyee tn nw h t
PATHOMENESIS
mod o taantmên . ectn, vertlcal, ert rector bahne

malaniot ( lon) a 29-30 day

nfeeted abe
coat Drei

Rulea

al tortn
Rlean Aoxec waste oducts 4 malal
fmmuno uysh
(Rbe mernb poduct, Amo totn pigmnt4
tautofmnisat

Tyaes HS
atrat mauophagu y endotnellun

mediatos

hiadacu sue, go , hauoy a onox> a

congulopatiy
fatgue, myalgio tomboytopent a
fmngppasn

CLINICAL
Ch:Ofeb ntle paOxy Srns : Ahow 3 ueenive etage
’a)told stage - Rast to is-60 min
fnterse co d, wneontohable hrering
6 hot stage - last hr 2-6 hs
hgh gad fren
Senee headau

naeea, vomt abd dscohmngot

<) Sueattng stage -ghs

Oanenia mivolnomo aytie , hypo coront type,tonowned t, Pfolip.

sylnamgaly hyfic aig , plon ualy yalbable by wak a
 qett ovel, but aasitee au not comply
eln they pestt th Gome rbe

These
malaía wfthin a y hwo.
th
B) Ralap4e (n P. rirax |p. oale) Aome sp0AO Zoika on entoing
hepotoytes an totrtto
m
Cyptotofohc phase callad hy no 2ofles (Heupirg Apono
anu. atHrated on time to me. bo fom
Thuse toam hethne
meoortea, which. fleet abes 4 ca
malaa . tts hon as lapse

- Cobral
Comp keahns ponlios
- olqid
sephiiaumtc
blatk uwate

LAB DIAa

&omple bld (by antmal agent)

aspfhates (sarsy) ’++ (I1- lbo )/ n

tdnt})
tesiphesl tmear : Thin (Bpeeies
Thtck (dahect panatte pesenu)
as,Feld etan
Stolning: kershman, b°em
centuge e obe
Putty white coat !

Bnan Jones techniqu

Tragor

Jaology
foceu latn (Hertyn tet) hon spauit
Malanin

4 Tmaenotfluowine aoato qaphc

 DNA,NA PAebe
pCR

S) Anim d inoc

keon key etc

Hematologial:

anemia ) neltoenta, monouytuss

t
thoombocytopenta
TRTMENT:

’ Chloroquine (Do)
Prim ogu'ne

Malaulal acelne
-5 Spß 66 vacune
candldate moleulu valhe