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4753-Article Text-31653-2-10-20221130
4753-Article Text-31653-2-10-20221130
RESEARCH ARTICLE
WMJ (Warmadewa Medical Journal), Vol. 7 No. November 2, 2022, Pg. 60-69
Antibiotic resistance is closely related to the inappropriate use of antibiotics, namely the indication, dose, frequency,
and duration of use. Permenkes No. 5 of 2014 states that acute pharyngitis is given antibiotic therapy if it meets the
diagnostic criteria using the center criteria, but this criterion is difficult to apply because doctors take longer to diagnose.
Previous research at the Klungkung I Primary Health Center used diagnosis utilizing a swab test. It was found that 100% of
bacterial pharyngitis patients were negative. The strategy of delaying antibiotics for 3 days can prevent antibiotic resistance, but
in therapy, without antibiotics, it is im -portant to increase the effectiveness of therapy, it is deemed necessary by the
researchers to conduct a study to analyze the factors that affect the recovery of patients with acute pharyngitis, which are
mainly caused by vi-ruses. Analyzing the factors that affect the recovery of viral pharyngitis patients. The design of the cross-
sectional study was through observation of the medical record data of patients who came to the Klungkung Primary Health
Center I for 3 months and got diagnostic facilities using the swab test. Patients who got a nega-tive swab test were analyzed
for the factors that influenced their recovery. Anti-inflammatory variables, rest, and paracetamol significantly affected the
recovery of acute pharyngitis patients (p <0.05), and the importance index in CART analysis found that paracetamol was
the most influential, followed by rest, administration of vitamins, and anti-inflammatory. Antibiotics, anti-allergies, and cough
medicines do not affect the recovery of patients with acute pharyngitis viral. Paracetamol has the most effect on patient recovery,
followed by rest and administration of vitamins, anti - inflammatory has very little effect on the recovery in patients of acute
pharyn-gitis viral.
INTRODUCTION
junctivitis. It is not recommended that anti-biotics be
Pharyngitis is inflammation of the pharyngeal
given as therapy for viral pharyn-gitis, but in fact,
wall which can be caused by viruses (40-60%), bacteria
pharyngitis accompanied by cough (a characteristic
(5-40%), aller-gies, trauma, toxins, and others. Viruses
feature of viral pharyngitis) is treated with antibiotics,
and bacteria invade the pharynx and cause a local
that empirical diagnosis is no longer visible to use
inflammatory reaction. Group A he-molytic streptococcal
considering that history by looking at signs and symptoms
bacterial infection can cause severe tissue damage
is very difficult to use for distinguishing viral pharyngitis
because these
and bac-teria (Sutema, 2018). For medical manage-ment,
bacteria release extracellular toxins that can cause
in addition to self-management by patients who can help
rheumatism, heart valve damage, acute
reduce or treat phar-yngitis symptoms, therapy is also
glomerulonephritis due to impaired glomerular function
needed to eradicate the main cause, one
due to the formation of antigen-antibody complexes
of which is the administration of antibiotics. Antibiot- ics
(1) are only given in cases of proven phar-yngitis due to
bacterial infection, for exam-ple in Group A
.
WMJ (W armadewa Medical Journal), Vol.7, No.2, November 2022, p-ISSN 2527-4627
DOI: https://doi.org/10.22225/wmj.7.2.4753.60-69
Machine Translated by Google
WMJ (W armadewa Medical Journal), Vol.7, No.2, November 2022, p-ISSN 2527-4627
DOI: https://doi.org/10.22225/wmj.7.2.4753.60-69
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40 66.66
Male the bivariate analysis. The method used for bivariate
analysis is the chi-square method.
Female 20 34.34
In line with the research Rasmala Dewi Table 2. Results of the effect of independent varia-bles on Pharyngitis.
Reco Not
and viruses that cause respiratory tract infections (4) No ery
Factor Giving Spend-
-
Re-
. Square
very covery
Therefore, elderly people are more suscep-tible or
susceptible to various kinds of in-fectious diseases. This Anti- Yes 22 7
1.
vulnerability occurs because of reduced production of biotic
No 27 4
0,261
6. 0,655
results of the study, from 85 patients, the male sex Cough
Yes 37 9
Drug No 12 2
was more dominant, namely 49 people 57.64%, while
7. Anti- Yes 24 6 0,739
the female sex was 36 patients 42.36%. This is in line
histism No 25 5
WMJ (Warmadewa Medical Journal), Vol.7, No.2, November 2022, p-ISSN 2527-4627
DOI: https://doi.org/10.22225/wmj.7.2.4753.60-69
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WMJ (W armadewa Medical Journal), Vol.7, No.2, November 2022, p-ISSN 2527-4627
Machine Translated by Google
DOI: https://doi.org/10.22225/wmj.7.2.4753.60-69
Machine Translated by Google
microorganism. Acute pharyngitis is caused by had a significant effect on the recovery of viral
bacteria severe headache, fever or, ma-laise, pharyngitis patients were giving para-cetamol,
painful swallowing, vomiting, and possibly rest, and vitamins. Paracetamol, which is a
coughing but rarely occurs. Phar-yngitis due to symptomatic drug, is very likely to give CART, it
bacterial infection group A streptococci can be does not represent the op-portunity for rest
estimated by using the Centor criteria, namely to improve recovery, but in theory and research, rest
fever, anterior cer-vical lymphadenopathy, tonsillar can increase the immune system through stimulation
exudate, and no cough. Pharyngitis caused by of pro-inflammatory hormones wherein this con-
virus-es usually dition the adaptive immune
has symptoms of a sore throat severe and may be response is stimulated and increases so that the
accompanied by cough-ing, hoarseness, and inflam-matory response as a marker
substernal pain. Fever, chills, malaise, myalgia, and increases. So the researchers can conclude that
headache may also occur. Then, symptoms of the pro-cess of viral eradication is increased, and
fungal phar-yngitis are sore more foreign bodies are attacked and para-lyzed
throat and swallowing pain. in the first immunity
On examination, white plaque appears hy- (initial) which correlates with an increase in the
peremic oropharynx and another pharynge-al inflam-matory response in the beginning. The
mucosa (6)
.
WMJ (W armadewa Medical Journal), Vol.7, No.2, November 2022, p-ISSN 2527-4627
DOI: https://doi.org/10.22225/wmj.7.2.4753.60-69
Machine Translated by Google
WMJ (W armadewa Medical Journal), Vol.7, No.2, November 2022, p-ISSN 2527-4627
DOI: https://doi.org/10.22225/wmj.7.2.4753.60-69
Machine Translated by Google
ilar, but the antibody levels in the HDBR plus amin C accumulates in phagocytic cells, such as
exercise group remained higher than in the HDBR neutrophils, and can increase chemotaxis,
group (P = .03). The HDBR (P = .001) phagocytosis, the formation of reactive oxygen
and HDBR plus diet (P = .02) groups had time- species, and ultimately kill microbes. It is also
related progressive in-creases in TNF- alpha, but necessary for apoptosis and clearance of
the HDBR plus exercise group remained at neutrophils that are ex- pelled from the site of
baseline. The HDBR plus exercise group had an infection by macro- phages, thereby reducing
acute increase in IL-1 receptor antagonist levels potential tissue damage. The role of vitamin C
compared to the HDBR (P = .02) and HDBR in lympho-
plus diet (P = cytes is less clear, but it has been shown to increase
.02) groups. B and T cell differentiation and
Sleep rest during the day and nor- mal proliferation, possibly due to its gene- regulatory
sleep at night can boost the immune system effects. Vitamin C deficiency leads to
through the initiation of an adaptive immune compromised immunity and a higher
response, where sleep rest can in- susceptibility to infections. In turn, infection
crease growth hormone and prolactin re- lease significantly impacts vitamin C levels due to
and decrease levels of the anti- increased inflammation and metabolic
inflammatory stress hormone cortisol sup- porting requirements. Furthermore, sup-plementation with
the initial steps in producing an adaptive immune vitamin C appears to be able to prevent and treat
response in the lymph gland. systemic infec-tions. Vitamin C prophylaxis is
required to prevent infection which provides insuffi-
c) Effect of Vitamins C and B on the Cure of cient, if unsaturated
Viral Acute Pharyngitis Pa-tients (ie 100-200 mg/day) plasma levels, which optimizes
cell and tissue levels. Conversely, good infection
Vitamin C is known as an antioxi-
treatment requires a higher vitamin dose (gram) to
dant that helps neutralize free radicals. Vit- amin compensate for the increased in-flammatory
C is an antioxidant because of its abil-
response and metabolic de-mand (9)
ity to reduce several chemical reactions, one of .
WMJ (W armadewa Medical Journal), Vol.7, No.2, November 2022, p-ISSN 2527-4627
DOI: https://doi.org/10.22225/wmj.7.2.4753.60-69
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vitamins are essential nutrients, including thiamine, occurs when an in-fection causes various changes in the state of
riboflavin, niacin, vita-min B6, folic acid, vitamin B12, biotin, and health. The presence of several types of microorganisms in a
tamarind pantothenate. Vitamin B12 is in-volved in part of the body that is not a proper place for these microorgan-
carbon-1 metabolism and there are interactions with folate isms can also be referred to as
metabolism. In the vitamin B12-containing state, the irre- infection and can cause disease. The period of SBHGA
versible reaction to form 5-methyl tetrahy-drofolate (THF) infection occurs in the season cold and early spring in
produces an inactive form of folate if it is not declined with temperate climates, in tropical climates like Indonesia, the highest
methio-nine synthase. THF 5-methyl can cause fo-late incidence occurs in the rainy season, so patients
deficiency secondary to decreased thy-midine and purine synthesis with pharyngitis can warm them-selves in winter and avoid consuming
and then DNA and RNA synthesis, leading to cold water (ice water).
changes in immunoglobulin secretion. A human study of vitamin
B12 deficient patients evaluated changes in immunological
indicators after vitamin B12 administration. In these pa-tients,
significant decreases were found in the number of lymphocytes
and CD8 cells and the number of CD4 cells. In addition, the Inflammation is a condition in re-sponse to tissue injury or
findings indicated a very high CD4 / CD8 ratio and suppressed infection, which can occur in the oral cavity.
NK cell activity. Inflammation that occurs will go through the body's de-fense
mechanism caused by a response to the influence of local tissue
damage, the influence of tissue damage can occur in the presence
of bacteria. In particular, I think it is important to properly define
the terms 'inflammation' and 'infection'.
Just by read-ing the definition of inflammation on Wik-ipedia, we
learn that 'inflammation is part of the complex biological
Supplementation with vitamin B12 reverses this effect response of vas-cular tissue to noxious stimuli, such as
suggesting that it can act as a modulating agent for cellular pathogens, damaged cells, or irritants (11)
immunity, especially concerning CD8þ and NK 73 cells. In
elderly subjects (aged 70 years) who received more than 4
months in addi-tion to a regular diet, formula Specific nu-
trients, including nutrients, vitamin E, 8 mg of vitamin B12, .
and 400 mg of folic acid, showed increased NK cell cytotoxic This Result of two randomized con-
activi-ty in research subjects Vitamins support immune function trol trials has shown that corticosteroid use can reduce the
so that they can increase innate immunity in the elderly. A incidence of treatment fail-ure and shorten the time to
defenseless adult (aged 65 years) with low serum vitamin B12 clinical stability in patients with community-acquired pneu- monia.
(10)
concen- .
This does not apply to patients with severe influenza
trations has an antibody response to the pneumococcal virus infection. Our results revealed that steroid treatment
polysaccharide vaccine. prolonged the duration of MV and ICU stay. The ef-fect of
steroid use on oxygenation could not be subjected to meta-
analysis, owing to the diversity of data. Several studies report-
ed that systemic corticosteroid treatment
WMJ (W armadewa Medical Journal), Vol.7, No.2, November 2022, p-ISSN 2527-4627
DOI: https://doi.org/10.22225/wmj.7.2.4753.60-69
Machine Translated by Google
WMJ (W armadewa Medical Journal), Vol.7, No.2, November 2022, p-ISSN 2527-4627
DOI: https://doi.org/10.22225/wmj.7.2.4753.60-69