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Biology The Essentials 1st Edition Hoefnagels Solutions Manual
Biology The Essentials 1st Edition Hoefnagels Solutions Manual
CHAPTER OUTLINE
10.00.01 Explain how genetic traits are passed from one generation to the next.
10.01.01 Describe the role of chromosomes in inheritance.
10.01.02 Differentiate between the terms gene, allele, locus and chromosome.
10.01.03 Explain how meiosis and the production of gametes are associated with inheritance.
10.02.01 Explain the relationship between dominant and recessive alleles of a gene.
10.02.02 Compare and contrast genotype and phenotype.
10.02.03 Differentiate between homozygous and heterozygous.
10.03.01 Use a Punnett square to diagram and explain a monohybrid cross.
10.03.02 Explain how meiosis contributes to Mendel’s law of segregation.
10.04.01 Use a Punnett square to diagram and explain independent assortment in a dihybrid
cross.
10.04.02 Explain how meiosis contributes to independent assortment of alleles.
10.04.03 Use the product rule to predict inheritance patterns for two or more genes.
10.05.01 Describe how linked genes produce inheritance patterns that do not appear to follow
Mendel’s laws.
10.05.02 Diagram how crossing over can separate linked genes.
Chapter 10 uses the information on meiosis covered in Chapter 9 to explain the principles of
classical or Mendelian inheritance. Students are likely to have many misconceptions about
inheritance and pedigree patterns. Students primarily do not associate meiosis to inheritance. It
is important to reinforce to students the goals and outcomes of meiosis before starting this chapter. A
brief review of meiosis is useful. Chapter 10 serves as an important reference for Chapter 11 which
discusses human inheritance.
SYNOPSIS
Mendel’s principles of trait inheritance paved the way for understanding the structure and
function of genetic information. Mendel performed cross-breeding studies on well-documented
varieties of peas. Most importantly, he quantified his experiments by carefully counting seeds of
hundreds of crosses and grouped them by apparent visible traits. Mendelian genetics is derived
from the mathematical ratios that describe the segregation and assortment of hereditary material.
However, Mendel’s work did not explain that traits were inherited on chromosomes. This
discovery was made later by Thomas Hunt Morgan’s work on fruit flies which led to the
chromosomal theory of inheritance.
Mendelian or classical genetics is based on the principle that parents each transmit a set of
information about its traits in its gametes. Each piece of information (trait) exhibits many
possible forms (alleles) that do not influence one another. According to Mendelian genetics, each
trait remains discrete within the cell. An individual may be homozygous and possess two
identical alleles, or heterozygous and have two different alleles. However, the presence of an
allele does not ensure its expression. Dominant traits are expressed, while recessive traits are
generally not expressed. The existence of the recessive allele in a heterozygote causes that factor
to be masked for a generation. Additionally, there is a difference between an individual’s
phenotype, or overall appearance, and its genotype, its precise genetic blueprint.
Mendel’s First Law of Heredity explains how alleles randomly segregate in the gametes. Each
gamete has an equal chance of receiving either allele. His second law explains that different
alleles assort into gametes independently of one another, the presence of an allele of one trait
does not preclude the presence or absence of any other allele of any other trait. Mendel was
unaware of the environmental influences on phenotype and was not familiar with gene
interactions such as polygenic traits.
Geneticists typically use pedigrees to trace inheritance patterns and genetic diseases in
agricultural animals and humans. Pedigrees help determine Mendelian inheritance patterns in
families. Genes are not the only explanation for phenotype expression and variation.
CONCEPT MAP
There is ample evidence in the educational literature that student misconceptions of information
will inhibit the learning of concepts related to the misinformation. The following concepts
covered in Chapter 10 are commonly the subject of student misconceptions. This information on
“bioliteracy” was collected from faculty and the science education literature.
The following articles provide strategies for increasing bioliteracy in the college classroom:
Baldwin JD, Ebert-May D, Burns, D. 1999. The development of a college biology self-efficacy
instrument for non-majors. Science Education 83(4): 397-408.
Ebert-May D. 2001. Research-based change: how one college professor approached the
challenge of changing teaching. In: Implementing the Science Standards in Higher Education,
eds. W. J. McIntosh and E. Siebert, pp. 36-39. Arlington, VA: National Science Teachers
Association.
Khodor J, Halme DG, Walker GC. 2004. A Hierarchical Biology Concept Framework: A Tool
for Course Design. Cell Biology Education, 3(2): 111-121.
Klymkowsky MW, Garvin-Doxas K, Zeilik M. 2003. Bioliteracy and teaching efficacy: what
biologists can learn from physicists. Cell Biol Educ, 2(3):155-61.
INSTRUCTIONAL STRATEGY PRESENTATION ASSISTANCE
Few students grasp the concept of segregation and independent assortment. Segregation of
alleles is difficult to visualize without a good understanding of meiosis. It would be valuable to
reinforce Mendelian genetic by using animations or tangible models of meiosis to reiterate the
mechanism behind Mendel’s principles.
Have the class use toys or objects to demonstrate Punnett square combinations. Have them place
the toys or objects into “gonads” drawn on a sheet of paper. Then have them produce gametes on
paper by modeling meiosis that assorts and segregates the objects. The students can use the paper
gametes to carry out fertilization. The students can be asked to place the fertilization results into
a Punnett square, and for monohybrid and dihybrid crosses.
It is encouraged to use some lecture or recitation time to discuss the “What’s the Point?,” “Why
We Care,” “Burning Questions” boxes, and the end-of-chapter reading titled “Investigating Life:
Heredity and the Hungry Hordes.” The information in these resources encourages students to use
the chapter information in critical thinking situations.
When assigning the chapter as a reading, encourage the students to stop and complete the
“Mastering Concepts” features as a way of assessing their knowledge of what they read. In
addition, the “Pull It Together” provides students with a visual summary of the important
concepts in the chapter.
HIGHER LEVEL ASSESSMENT
Higher level assessment measures a student’s ability to use terms and concepts learned from the
lecture and the textbook. A complete understanding of biology content provides students with the
tools to synthesize new hypotheses and knowledge using the facts they have learned. The
following table provides examples of assessing a student’s ability to apply, analyze, synthesize,
and evaluate information from Chapter 10.
Application • Have students explain what they would need to know to predict a
monohybrid cross Punnett square for a simple trait in their family.
• Ask students to explain the relationship between meiosis and the
assignment of alleles in a Punnett square.
• Have students explain why a family who had four female children in a
row had an equal chance of having a boy or a girl as the next child.
Synthesis • Ask students to come up with a reason why gender in many reptiles does
not follow the predicted 50:50 Mendelian pattern of inheritance.
• Have students hypothesize why a certain dominant characteristic only
appears in male offspring of an organism and does not show up in
females.
• Ask students to explain why the child of a father with type AB blood and
mother with type O blood was born with type O blood.
Evaluation • Ask students to evaluate the benefits and risks of drugs that block
dominant alleles that produce genetic disorders.
• Ask students to discuss the pros and cons of inbreeding crops that
express recessive traits for many characteristics.
• Ask students to evaluate the affects of crossing over during meiosis on
polygenic traits.
BIOETHICAL CONSIDERATION
Biological knowledge contributes to the betterment of human society in many ways. However,
there also are various ethical concerns that are raised by the applications of this knowledge.
Genetic testing has given the medical community the option to better council people about the
chances of passing genetic disorders to offspring. An ethical consideration provided by
ActionBioscience called “Genetic Testing to Predict Disease: Ethical, Legal, and Social
Implications” presents students with views about implications of genetic testing for human
disease. Ask students to come up with a way to balance the pros and cons of human disease
testing. The issue can be found at: http://www.actionbioscience.org/genomic/glenn2.html.
FUN FACTS
Trivial facts about biology are a fun way to spice up a lecture. They can be read in class or
placed at appropriate points into a lecture using the board or a projected presentation. The trivia
can be used as a jumping point for students to further investigate the fact.
This demonstration uses an on-line animated Punnett square to review the calculation of
offspring probabilities. It immediately draws the Punnett squares for monohybrid and dihybrid
crosses. In addition, it gives the offspring probability ratios. The animation is useful for in-class
formative evaluation of Mendelian inheritance.
Materials
1. Case studies are a wonderful way to reinforce complex concepts related to classical
genetics. A case study provided by the University of Buffalo uses skin color as a model
for understanding the outcomes of polygenetic traits. The website can be found at
http://www.sciencecases.org/skin_color/skin_color_notes.pdf.
2. Thomas Hunt Morgan’s fruit fly experiments and Mendel’s classical studies on pea traits
can be used to help students review the concepts covered in Chapter 10. The Biology
Project: Mendelian Genetics website, hosted by the University of Arizona, has an
interactive classical genetics tutorial that can be used as a projected class review exercise.
This website can be found at
http://www.biology.arizona.edu/mendelian_genetics/mendelian_genetics.html.
3. Cold Spring Harbor Laboratory provides a valuable website for teaching the basic
genetics needed to understand classical patterns of inheritance. It provides many
animated discussions and videostreams of Mendelian genetics. The website can be found
at http://www.dnaftb.org/dnaftb/.
4. Animations are a pedagogical tool known to reinforce the teaching of complex concepts
such as meiosis. This website hosted by PBS provides a useful narrated movie of
animated meiosis. This website is available at
http://www.pbs.org/wgbh/nova/baby/divi_flash.html.
QUICK LABORATORY IDEA
Mendel’s Mathematics
Materials
Provide a group of students with the following materials without tell them anything about the
genetic nature of the corn ears:
1. First ask the students to explain the differences between the three ears of corn.
2. Have students discuss which corn is typical of edible corn and whether that is the natural
characteristic that would be found in a large population of corn left to grow in the wild.
3. Instruct the students to use the Punnett square to calculate the offspring probabilities of
breeding two corn parents heterozygous for kernel color and shape. Provide students with
the following information:
a. Purple - P (dominant)
b. Yellow - p (recessive)
c. Smooth - S (dominant)
d. Wrinkly - s (recessive)
They should calculate a 9:3:3:1 ratio.
4. Ask the students if they believe the purple/yellow corn has a 9:3:3:1.
5. Ask them how they would determine this using the corn given to them.
6. Direct the students to count the different types of kernels on the purple/yellow corn. They
should be questioned to see if they recognize the four different types of kernels.
7. Have the students determine how close they came to a 9:3:3:1 ratio from counting kernels
on the purple/yellow ear of corn. They should record their information on a table such as
the one provided below:
8. Have the students hypothesize the genotypes of the yellow smooth and yellow wrinkly
corn. Ask them which corn will always produce pure lineages of offspring that resemble
the parents. Also ask the students how the corn sold in grocery stores is bred to have its
characteristics.
LEARNING THROUGH SERVICE
Service learning is a strategy of teaching, learning and reflective assessment that merges the
academic curriculum with meaningful community service. As a teaching methodology, it falls
under the category of experiential education. It is a way students can carry out volunteer projects
in the community for public agencies, nonprofit agencies, civic groups, charitable organizations,
and governmental organizations. It encourages critical thinking and reinforces many of the
concepts learned in a course.
Students who have successfully mastered the content of Chapter 10 can apply their knowledge
for service learning activities in the following ways:
1. Have students present a forum on the benefits and risks of monoculture to a civic group.
3. Have students tutor middle school or high school biology students studying classical
genetics.
4. Have students present a talk to a civic group about the significance of genetic testing and
the inheritance of genetic disorders.
CROSSWORD PUZZLE
Use copies and a projected image of the crossword puzzle as an entertaining way to review the
concepts in this chapter. Hand out the copies to the class and project an image of the crossword
using an overhead or LCD projector. Then use student input to complete the crossword puzzle
while quizzing them on other concepts and terms covered in the chapter.
Patterns of Inheritance
Across
Down
Across
Down