Download as pdf or txt
Download as pdf or txt
You are on page 1of 9

Journal of Mental Health

ISSN: 0963-8237 (Print) 1360-0567 (Online) Journal homepage: https://www.tandfonline.com/loi/ijmh20

Prevalence of mental distress and associated


factors among university students in Ethiopia: a
meta-analysis

Berihun Assefa Dachew, Brhanu Boru Bifftu, Bewket Tadesse Tiruneh,


Degefaye Zelalem Anlay & Meseret Adugna Wassie

To cite this article: Berihun Assefa Dachew, Brhanu Boru Bifftu, Bewket Tadesse Tiruneh,
Degefaye Zelalem Anlay & Meseret Adugna Wassie (2019): Prevalence of mental distress and
associated factors among university students in Ethiopia: a meta-analysis, Journal of Mental
Health, DOI: 10.1080/09638237.2019.1630717

To link to this article: https://doi.org/10.1080/09638237.2019.1630717

View supplementary material

Published online: 28 Jun 2019.

Submit your article to this journal

Article views: 21

View Crossmark data

Full Terms & Conditions of access and use can be found at


https://www.tandfonline.com/action/journalInformation?journalCode=ijmh20
JOURNAL OF MENTAL HEALTH
https://doi.org/10.1080/09638237.2019.1630717

REVIEW ARTICLE

Prevalence of mental distress and associated factors among university students


in Ethiopia: a meta-analysis
Berihun Assefa Dachewa, Brhanu Boru Bifftub, Bewket Tadesse Tirunehb, Degefaye Zelalem Anlayb and
Meseret Adugna Wassiec
a
Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar,
Gondar, Ethiopia; bSchool of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; cDepartment of
Health Informatics, Teda Health Science College, Gondar, Ethiopia

ABSTRACT ARTICLE HISTORY


Background: Mental distress is an important public health problem and is becoming common health Received 22 November 2017
problems among university students. Revised 8 March 2019
Aims: This study aimed to provide a pooled prevalence of mental distress and associated factors Accepted 18 April 2019
among university students in Ethiopia. Published online 24 June
2019
Method: We systematically searched PubMed, EMBASE and PsycINFO databases. A further search was
performed at Google Scholar search engine for additional studies. All observational studies reporting KEYWORDS
the prevalence of mental distress and/or associated factors among university students in Ethiopia Prevalence; mental distress;
were included. Pooled prevalence with 95% confidence interval (95% CI) were calculated using ran- university students; Ethiopia
dom effects and quality effects models. Subgroup and sensitivity analyses were performed.
Heterogeneity between studies and evidence of publication bias were assessed.
Results: The pooled prevalence of mental distress was 35% (95% CI; 28%–43%). Being female, partici-
pating in religious programmes, having close friends, experiencing financial distress, alcohol use, khat
use, conflict with friends, lack of interest in their field of study and a family history of mental illness
were factors associated with mental distress among students. We found significant heterogeneity, but
no evidence of publication bias.
Conclusions: More than one third of university students in Ethiopia have suffered with mental dis-
tress. The finding provides evidence that university students are at risk population for mental health
problems and suggests the need for early intervention to prevent severe mental illness.

Background new roommates and friends, exposure to new cultures and


environments, loss of or separation from traditional adult
Mental distress also known as common mental disorders
supervisors and low social support are some of these factors
(CDMs) is a mental health problem characterized by a range (Al-Busaidi et al., 2011; Mosley et al., 1994; Storrie, Ahern,
of depressive, anxiety or somatic symptoms including head- & Tuckett, 2010; Yussuf, Issa, Ajiboye, & Buhari, 2013). In
ache, backache and sleep problems (de Waal, Arnold, addition, academic stressors, peer pressure and financial dis-
Spinhoven, Eekhof, & van Hemert, 2005; Rocha, de tress have been recognized as risk factors for developing
Almeida, de Araujo, & Virtuoso, 2010). A person with men- mental distress amongst students (Dachew et al., 2015;
tal distress may also present with confused emotions and Sreeramareddy et al., 2007). However, many students do not
hallucinations (Giang, Dzung, Kullgren, & Allebeck, 2010; seek help for their problems and inability to manage these
Rocha et al., 2010). The term is used when it has not been conditions early will lead to adverse impact on their aca-
possible to obtain a specific diagnosis of mental disorder demic achievement (Kessler, Foster, Saunders, & Stang,
(Giang et al., 2010). Mental distress affects a substantial pro- 1995; Sijtsema, Verboom, Penninx, Verhulst, & Ormel,
portion of the world population and is prevalent in univer- 2014). More importantly, mental distress is associated with
sities worldwide (Dachew, Azale Bisetegn, & Berhe an increased risk of substance use (Kingston, Marel, &
Gebremariam, 2015; Lima, Domingues, & Cerqueira, 2006; Mills, 2017; Swendsen et al., 2010) and suicidal behaviours
Mosley et al., 1994; Patel & Kleinman, 2003; Rocha et al., (Dvorak, Lamis, & Malone, 2013; Garlow et al., 2008;
2010; Sidik, Rampal, & Kaneson, 2003; Stallman, 2008). Izadinia, Amiri, Jahromi, & Hamidi, 2010).
Various factors could contribute to mental distress In Ethiopia, mental and substance use disorders are com-
among university students. The experience of new lifestyles, mon public health problems responsible for about 1897

CONTACT Berihun Assefa Dachew berihunassefa21@gmail.com Department of Epidemiology and Biostatistics, Institute of Public Health, College of
Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
Institute for Social Science Research, The University of Queensland, Indooroopilly, QLD, Australia
Supplemental data for this article can be accessed here.
ß 2019 Informa UK Limited, trading as Taylor & Francis Group
2 B. A. DACHEW ET AL.

disability adjusted life years (DALYs) per 100,000 popula- published in English. Conference abstracts, letters to editors,
tion (Institute for Health Metrics & Evaluation [IHME], review and commentary articles were excluded. Two investi-
2016). Studies have shown that mental distress is prevalent gators (BAD and MAW) assessed the eligibility of each
among university students in Ethiopia, ranging from 21.6% study independently and disagreements were resolved
to 63.1% (Alem, Araya, Melaku, Wendimagegn, & Abdulahi, by discussion.
2005; Busi et al., 2016; Byrd et al., 2014; Dachew et al.,
2015; Dessie, Ebrahim, & Awoke, 2013; Getachew & Tekle,
2018; Haile, Alemu, & Habtewold, 2017; Kerebih, Ajaeb, & Data extraction
Hailesilassie, 2017; Melese et al., 2016; Tariku, Zerihun, A standardised pre-piloted form was used to extract data
Bisrat, Adissu, & Jini, 2017; Tesfaye, 2009). Although several from the included studies. Extracted information includes
individual studies have reported the prevalence of mental first author’s last name, year of publication, study location,
distress and associated factors among university students in sample size, prevalence of mental distress, estimates for risk
Ethiopia, to our knowledge, there is no published systematic or protective factors examined in each study, and ascertain-
review and meta-analysis that shows pooled estimates of ment of outcome.
mental distress and its associated factors. Having a pooled
prevalence of mental distress and identifying the associated
factors would help policy-makers and programme managers Quality assessment
in developing evidence-based mental health promotion and Two review authors (BAD and MAW) independently
disease prevention programmes. Therefore, the objective of assessed the quality of all included studies using Newcastle-
this systematic review and meta-analysis was to review the Ottawa quality assessment tool adapted for cross-sectional
existing literature, with the aim of quantifying the burden of studies (Anon, n.d.) and any disagreements were resolved
CMDs and identifying factors associated with CMDs among through discussion. The tool takes into account the selection
university students in Ethiopia. of participants, comparability and assessment of outcome. A
study can be given a maximum of one star for each num-
Methods bered item within the selection and exposure categories and
a maximum of two stars can be given for comparability.
This meta-analysis was conducted in accordance with the Finally, the results are summarised in three categories as
preferred reporting items for systematic review and meta- good quality (3 or 4 stars in selection domain and 1 or 2
analysis (PRISMA) (Moher et al., 2015). The study protocol stars in comparability domain and 2 or 3 stars in outcome/
was prospectively registered in an International Prospective exposure domain), fair quality (2 stars in selection domain
Register of Systematic Reviews (PROSPER) (Registration and 1 or 2 stars in comparability domain and 2 or 3 stars in
Number: CRD42017067223, http://www.crd.york.ac. outcome/exposure domain) and poor quality (0 or 1 star in
uk/PROSPERO. selection domain or 0 stars in comparability domain or 0 or
1 stars in outcome/exposure domain). Finally, the quality of
each study was categorized as good, fair or poor quality.
Data sources and search strategies
We have used quality scores for quantitative analysis
We searched PubMed, EMBASE and PsycINFO electronic (Supporting Information Table 1).
databases and Google Scholar search engine with no publi-
cation year restriction. The search comprises both Medical
Subject Headings (MeSH) and free text words (title and Data synthesis
abstract word searches). We used the following search We conducted random-effects meta-analyses with 95% con-
terms: “Mental distress” OR “Common mental disorders” fidence interval (95% CI) to obtain the pooled prevalence of
OR “Mental illness” OR “Psychological distress” OR “Stress” metal distress and the pooled odds ratios of identified fac-
AND “University students” OR “College students” AND tors associated with mental distress (Berkey, Hoaglin,
“Ethiopia.” In addition, the reference lists of included stud- Mosteller, & Colditz, 1995). Quality-effects meta-analysis
ies were manually searched for additional eligible articles. was also performed to examine how the quality of each
study changed the pooled estimate compared with the
results from random-effects meta-analysis (Doi & Thalib,
Study selection and eligibility criteria
2008). This analysis incorporates the quality score of each
All observational studies reporting the prevalence of mental study in the calculation of the study weight, which is a
distress and/or factors associated with mental distress robust and innovative technique to help minimize the esti-
among university students will be included. An article will mator variance and account for subjectivity in quality
be included if it meets the following criteria: (1) conducted assessment (Doi & Thalib, 2008). Heterogeneity between the
solely or partly among university and/or college students, studies was assessed using both Cochran’s Q statistic and
(2) reported the prevalence of mental distress using standar- the I2 statistics. I2 value greater than 50% were considered
dized instruments or questionnaires (such as the Beck’s as indicative of substantial heterogeneity (Higgins &
Depression Inventory, Patient Health Questionnaire -9, Self- Thompson, 2002). Evidence of publication bias was assessed
reporting Questionnaire-20 or clinical interviews) and (3) using Egger’s test (p < 0.05) (Egger, Davey Smith, Schneider,
JOURNAL OF MENTAL HEALTH 3

& Minder, 1997) and visual inspection of the symmetry in relevance and 11 papers were found to be eligible for meta-
funnel plots (Liu, 2011). analysis (Figure 1).
Subgroup analyses were undertaken by sample size, year
of publication, study quality and screening tool as possible
sources of heterogeneity between studies. Sensitivity analyses Study characteristics
were performed by excluding each study one by one and
Table 1 shows the characteristics of studies included in the
calculating a pooled estimate for the reminder of the studies.
meta-analysis. All of the included studies were cross-sec-
All statistical analyses were performed using MetaXL version
tional and published between 2005 and 2018. The partici-
5.3 and STATA14 Metaprop package (StataCorp, 2015).
pant ages ranged from 16 to 35 years. The sample sizes of
included studies ranged from 240 to 2817, with the response
rate of 80–100%. Most studies used stratified random sam-
pling techniques to recruit the study participants. Of the
Results
included studies, eight studies used the Self-Reporting
After duplicates removal, 246 articles were identified and of Questionnaire (SRQ-20) to assess mental distress. SRQ-20 is
them, 148 were excluded during initial assessment as their a screening tool having 20 item questions, originally devel-
titles were found to be irrelevant. We further screened the oped by World Health Organization (WHO) designed to
abstracts of the remaining 98 studies and excluded 64 of indicate mental distress (World Health Organization, 1994).
these as they did not fulfil the eligibility criteria. The The tool is adopted from WHO and was validated in low
remaining (n ¼ 34) full text papers were screened for and middle-income countries including Ethiopia; and found

Additional records defined


Total records identified trough cross-referencing
Idenficaon

(n=368) (n=1)

Records after duplication removed (n=246)

Records excluded (n=148)


Records screened by title for Not relevant, reviews,
relevance (n=246) conference papers, unrelated
Screening

outcome

Recodes excluded (n=64)


Not in Ethiopia (n=37)
Records screened by abstract (n=98) Different outcome (27)
Eligibility

Full text articles excluded


(n=23)
Full text articles assessed for Not in college/university
eligibility (34) students (n=6)
Not based in Ethiopia (n=11)
Different outcome (5)
Prevalence not reported (1)
Included

Studies included in the meta-


analysis (11)

Figure 1. Flow diagram of studies included in meta-analysis.


4 B. A. DACHEW ET AL.

to be highly sensitive and specific (Ali, Ryan, & De Silva,

diagnostic
Outcome

criteria

GHQ-R
2016; Lund et al., 2011; Youngmann, Zilber, Workneh, &

SRQ

SRQ
SRQ
SRQ

SRQ
SRQ
SRQ
SRQ
K10

NR
Giel, 2008). A cut-off point of eight and above was taken by
most of the studies (n ¼ 6). Seven of 11 studies were good

Prevalence
in quality studies. The average quality score of included

63.1%
35.2%
29.2%

24.4%
40.9%
26.6%
21.6%
49.1%
32.6%
38.3%
30%
Number of cases studies was 7 (Supplementray Table 1).

Prevalence of mental distress


The prevalence of mental distress ranged from 21.6% to
245
102
90
72
80
342
716
93
588
89
232
63.1%. The pooled prevalence of mental distress was 35%
(95% CI; 28%–43%) (Figure 2).
The quality effects model provides consistent finding
(pooled prevalence ¼ 35%; 95% CI, 25%–45%)
Response rate
91.9%

97.2%

95.4%
95.9%
93.9%
97.3%
95.4%

(Supplementary Figure 1). We found significant between


100%

100%
95%

80%

study heterogeneity (Q ¼ 381, p < 0.001 and I2 ¼ 97%).


Tests for publication bias demonstrated no asymmetry based
on funnel plot (Supplementary Figure 2). Egger’s test also
Sample size

confirmed non-significant bias coefficients (p ¼ 0.38) sug-


422
305
317
240
327
872
2817
442
1198
350
605

gesting absence of publication bias.


Subgroup analyses showed consistent prevalence estimate
among good quality studies (pooled prevalence ¼ 34%,
Stratified multistage sampling

95%CI, 26%–42%), studies using SRQ as a screening tool


Stratified random sampling
Stratified random sampling
Stratified random sampling
Stratified random sampling

(pooled prevalence ¼ 34%, 95%CI, 27%–41%), and studies


Entire student population

GHQ-R: General Health Questionnaire; K10: Kessler psychological distress; NR: Not reported; SRQ: Self-Reporting questionnaire (SRQ).
Simple random sampling

Simple random sampling


Simple random sampling

Simple random sampling


Sampling technique

published after 2010 (pooled prevalence ¼ 34%, 95%CI,


Multistage sampling

27%–42%) (Table 2 and Supplementary Figure 3–6)


Sensitivity analysis produced a pooled estimate ranging
from 33% (95% CI, 27%–39%) to 37% (95% CI; 30%–44%)
(Supplementary Table 2).

Factors associated with mental distress


Cross-sectional
Cross-sectional
Cross-sectional
Cross-sectional
Cross-sectional
Cross-sectional
Cross-sectional
Cross-sectional
Cross-sectional
Cross-sectional
Cross-sectional
Study design

In this study, we identified factors associated with


mental distress among students. Only those factors that
were assessed by at least two studies were considered for
meta-analysis. Being female, participating in religious pro-
Mizan Aman Health Science college, Southwest Ethiopia

grammes, having close friends, experiencing financial dis-


tress, alcohol use, khat use, conflict with friends, lack of
interest in their field of study and a family history of mental
Madda Walabu University, Southeast Ethiopia
Table 1. Characteristics of studies included in the meta-analysis (n ¼ 11).

illness were factors associated with mental distress among


Gondar and Haramaya University, Ethiopia
Debre Berhan University, Central Ethiopia

University of Gondar, Northwest Ethiopia

Addis Ababa University, Central Ethiopia

students (Table 3).


Hawassa University, Southern Ethiopia
Hawassa University, Southern Ethiopia

Hawassa University, Southern Ethiopia


Jimma University, Southwest Ethiopia
Study location

Adama University, Eastern Ethiopia

Discussion
This is the first meta-analysis that determined the pooled
prevalence of mental distress and associated factors among
university students in Ethiopia. Our finding suggests that
more than one third of university students have experienced
mental distress. The prevalence of mental distress found in
this study is much higher than that found in the general
population of Ethiopia (11.7%–17.7%) (Alem, Kebede,
Woldesemiat, Jacobsson, & Kullgren, 1999; Gelaye et al.,
Getachew & Tekle, 2018

2012; Kebede, Alem, & Rashid, 1999). The finding provides


Dachew et al., 2015
Kerebih et al., 2017

Melese et al., 2016

Dessie et al., 2013


Tariku et al., 2017

evidence that university students are at risk population for


Alem et al., 2005
Haile et al., 2017

Byrd et al., 2014


Busi et al., 2016

Tesfaye, 2009

mental health problems. This higher level of distress may


Author, year

have short and long-term influence on students’ achieve-


ment. Students are less likely to perform well at university
when suffering from mental illness (Kessler et al., 1995;
JOURNAL OF MENTAL HEALTH 5

Study Prev (95% CI) % Weight


Haile et al., 2017 0.63 ( 0.58, 0.68) 9.1
Kerebih et al., 2017 0.35 ( 0.30, 0.41) 8.9
Tariku eta1., 2017 0.29 ( 0.24, 0.34) 9.0
Melese et al., 2016 0.30 ( 0.24, 0.36) 8.8
Busi etal., 2016 0.24 ( 0.20, 0.29) 9.0
Dachew et al., 2015 0.41 ( 0.38, 0.44) 9.3
Byrd et al., 2014 0.27 ( 0.25, 0.29) 9.4
Dessie et al., 2013 0.22 ( 0.18, 0.26) 9.1
Tesfaye, 2009 0.49 ( 0.46, 0.52) 9.3
Alem et al., 2005 0.33 ( 0.27, 0.38) 8.9
Getachew et al.,2018 0.38 ( 0.35, 0.42) 9.2

Overall 0.35 ( 0.28, 0.43) 100.0


Q=380.89, p=0.00, I2=97%

0 0.2 0.4 0.6 0.8


Prevalence
Figure 2. Forest plot of studies assessing the prevalence of mental distress among university students in Ethiopia using random effects model (Pooled prevalence,
with 95% CI).

Table 2. Subgroup analysis.


Table 3. Factors associated with mental mistress among university students
Subgroups Number of studies Pooled prevalence 95% CI in Ethiopia (Pooled OR with 95% CI).
Publication year Factors Number of studies Pooled OR (95% CI)
2010þ 9 34% 27%–42%
Before 2010 2 41% 25%–58% Being female 7 1.70 (1.20–2.40)
Screening tool Relationship status (in relation) 4 1.03 (0.76–1.40)
SRQ 8 34% 27%–41% Year of study (first year) 4 1.31 (0.68–2.50)
Other 3 39% 18%–62% Religious practice (yes) 5 0.41 (0.31–0.67)
Study quality Not interested in their filed 2 2.20 (1.48–3.26)
Good 7 34% 26%–42% Family history of mental illness 4 2.20 (1.50–3.10)
Fair 4 38% 35%–42% Financial stress 3 1.6 (1.23–2.10)
Sample size Alcohol drinking 6 1.6 (1.10–2.40)
<500 7 33% 23%–45% Cigarette smoking 4 2.20 (0.98–1.84)
500þ 4 39% 28%–50% Khat chewing 4 1.7 (1.10–2.70)
Conflict with friends 3 2.0 (1.60–2.70)
Having close friends 2 0.43 (0.31–0.59)
Note. Only those factors that were assessed by at least two studies were con-
Sijtsema et al., 2014). Studies revealed that up to 5% of col- sidered for meta-analysis.
lege dropout has been associated with mental illness
(Kessler et al., 1995). Moreover, mental illness has been risk of mental distress compared with those who were not.
shown to be associated with higher risk of substance use Different studies have highlighted the protective role of spir-
(Swendsen et al., 2010) and suicidality (Dvorak et al., 2013; ituality in preventing depression, anxiety and substance use
Garlow et al., 2008; Izadinia et al., 2010). disorders and promoting well-being and quality of life
This finding is also higher compared to similar studies (Medlock et al., 2017; Tusa & Burgholzer, 2013;
conducted in East African countries, where a prevalence of Unterrainer, Lewis, & Fink, 2014). It is also important to
16.2%–19.8% of mental distress was reported (Hersi et al., note the possibility of reverse causation, as depressed stu-
2017; Ovuga, Boardman, & Wasserman, 2006). In Ethiopia, dents may stop going to worship. Similarly, students who
mental disorders are not considered as life-threatening prob- had close friends were less likely to have mental distress
lems, and mental health services are not given due priority than those who had not. As college life can be stressful,
and the needs of people for mental health care are not met experiencing strong, intimate friendships with a high degree
(Ayano et al., 2017). Although it is only partially imple- of attachment and support may help in promoting mental
mented, a National Mental Health Strategy has been avail- health during this period. A recent longitudinal study con-
able in Ethiopia since 2012 (World Health Organization, ducted in the United States of America found that close
2014). However, neither the National Mental Health friendships increase self-worth and decrease anxiety and
Strategy nor the Health Sector Transformation Plan men- depressive symptoms (Narr, Allen, Tan, & Loeb, 2019). On
tioned students as vulnerable groups for mental illness the other hand, our finding suggests that conflict with
(Federal Democratic Republic of Ethiopia Ministry of friends were found to increase the risk of mental distress by
Health, 2012, 2015). Our finding, therefore, highlights that two folds (Pooled OR ¼ 2.0, 95%CI: 1.6–2.7).
university students are a vulnerable group who require spe- We found that females reported higher levels of mental
cial consideration when developing mental health services. distress than male students, which is consistent with the
Our findings showed that students who participated in existing evidence that a greater proportion of females report
religious practice, regardless of which religion, had a lower common mental health problems than males (Tedstone
6 B. A. DACHEW ET AL.

Doherty & Kartalova-O’Doherty, 2010). This could be due is a possibility of reporting and response set bias as all
to the affective nature of their response to stressors, as data were self-reported. Finally, the cross-sectional nature of
women have lower self-esteem and sense of control than the study does not confirm definitive cause and effect
men, as well as gender-based violence and other biological relationships.
factors (Eaton et al., 2012; Tedstone Doherty & Kartalova-
O’Doherty, 2010). Our study also found that financial hard-
ship was another factor associated with mental distress in Conclusion
students. Students who reported financial stress had a The prevalence of mental distress among university students
greater risk of mental distress than those who did not. The in Ethiopia was found to be high. Being female, participat-
finding is consistent with the existing evidence where poor ing in religious programmes, having close friends, experi-
mental health has been consistently linked with the experi- encing financial distress, alcohol use, khat use, conflict with
ence of financial hardship (Cvetkovski, Reavley, & Jorm, friends, lack of interest in their field of study and a family
2012; Kiely, Leach, Olesen, & Butterworth, 2015). history of mental illness were factors associated with mental
Our review found that the risk of mental distress was distress among students. Prospective cohort studies would
70% higher in students who chewed khat as compared to be useful to confirm the observed associations. Qualitative
those did not. Khat is a flowering plant which is used as a studies are needed to further assess the contributory factors
stimulant in many parts of Africa and the Arabian leading to mental distress among university students. Our
Peninsula (Warfa et al., 2007). It is a commonly used psy- findings suggest the need for early intervention to prevent
choactive substance among students in Ethiopia, especially
severe mental illness in students. We encouraged students to
during examination periods (Gebrehanna, Berhane, &
seek formal as well as informal help, usually from friends,
Worku, 2014). Many studies in Ethiopia and abroad
family and religious leaders, and to implement self-care
reported a significant association between khat use and vari-
strategies to take care and control of their own wellbeing.
ous mental disorders (Damena, Mossie, & Tesfaye, 2011;
Gebrehanna et al., 2014; Odenwald et al., 2005; Warfa et al.,
2007). In line with other studies, alcohol use, lack of interest Acknowledgements
in their field of study and a family history of mental
The authors would like to acknowledge Ms Madonna Boman for edit-
illness were also other factors associated with mental ing the manuscript.
distress in students (Rohrer, Rohland, Denison, Pierce, &
Rasmussen, 2007).
The strengths of this meta-analysis are that we included Disclosure statement
all studies without time restrictions. Furthermore, we used No potential conflict of interest was reported by the authors.
standardized quality assessment tool with most (n ¼ 7) stud-
ies rated good in quality. In addition, almost all studies
(n ¼ 10) include in in the analyses used standardized screen- References
ing questionnaires to assess the prevalence of mental distress Ades, A. E., Lu, G., & Higgins, J. P. (2005). The interpretation of ran-
and eight of eleven studies used SRQ-20, the tool that has dom-effects meta-analysis in decision models. Medical Decision
been validated in Ethiopia (Youngmann et al., 2008). Making, 25(6), 646–654. doi:10.1177/0272989X05282643
However, this meta-analysis study had some important limi- Al-Busaidi, Z., Bhargava, K., Al-Ismaily, A., Al-Lawati, H., Al-Kindi,
tations. First, we found a high level of between study het- R., Al-Shafaee, M., & Al-Maniri, A. (2011). Prevalence of depressive
symptoms among University students in Oman. Oman Medical
erogeneity, but to address this we used a random effects
Journal, 26(4), 235–239. doi:10.5001/omj.2011.58
model as is recommended in situations with high level of Alem, A., Araya, M., Melaku, Z., Wendimagegn, D., & Abdulahi, A.
between study heterogeneity (Ades, Lu, & Higgins, 2005). In (2005). Mental distress in medical students of Addis Ababa
addition, we applied a quality effects model, which allowed University. Ethiopian Medical Journal, 43(3), 159–166.
us to overcome some problems with a traditional random Alem, A., Kebede, D., Woldesemiat, G., Jacobsson, L., & Kullgren, G.
effects model (Doi & Thalib, 2008). Second, although the (1999). The prevalence and socio-demographic correlates of mental
quality of all included studies was assessed using the distress in Butajira, Ethiopia. Acta Psychiatrica Scandinavica
Supplementum, 397, 48–55.
Newcastle-Ottawa quality assessment tool, methodological
Ali, G. C., Ryan, G., & De Silva, M. J. (2016). Validated screening tools
appraisal remains a subjective exercise. For this reason, to for common mental disorders in low and middle income countries:
minimize bias in the review process, two reviewers assessed A systematic review. PLoS One, 11(6), e0156939. doi:10.1371/jour-
the quality of all included studies independently any dis- nal.pone.0156939
agreements were resolved through discussion. Third, unlike Anon. (n.d.). The Newcastle-Ottawa scale adapted for cross-sectional
a fixed effects model which produce unbiased estimates, the studies. Retrieved from https://www.biomedcentral.com/content/sup-
random effects model introduce bias in the pooled estimates plementary/1471-2458-13-154-S3.doc
Ayano, G., Assefa, D., Haile, K., Chaka, A., Haile, K., Solomon, M., …
(Kinney & Dunson, 2007). Fourth, although the funnel plot
Jemal, K. (2017). Mental health training for primary health care
did not show asymmetry on visual inspection and Egger’s workers and implication for success of integration of mental health
test also showed no evidence of publication bias, we may into primary care: Evaluation of effect on knowledge, attitude and
not fully exclude the possibility of publication bias as this practices (KAP). International Journal of Mental Health Systems, 11,
meta-analysis considers only published studies. Fifth, there 63. doi:10.1186/s13033-017-0169-8
JOURNAL OF MENTAL HEALTH 7

Berkey, C. S., Hoaglin, D. C., Mosteller, F., & Colditz, G. A. (1995). A Getachew, A., & Tekle, T. (2018). Mental health disorder among
random-effects regression model for meta-analysis. Statistics in Madda Walabu University Students Southeast Ethiopia. Health
Medicine, 14(4), 395–411. Science Journal, 12(1), 546.
Busi, S., Oltaye, Z., Aklile, E., Ayenew, T., Yimam, B., Wubie, K., … Giang, K. B., Dzung, T. V., Kullgren, G., & Allebeck, P. (2010).
Tesfaye, S. (2016). Prevalence and determinants of mental distress Prevalence of mental distress and use of health services in a rural
among university students, College of Medicine and Health Sciences district in Vietnam. Global Health Action, 3. doi:10.3402/gha.v3i0.
in Hawassa University Ethiopia. Asian Journal of Nursing Education 2025
and Research, 6(3), 356–360. doi:10.5958/2349-2996.2016.00067.7 Haile, Y. G., Alemu, S. M., & Habtewold, T. D. (2017). Common men-
Byrd, K., Gelaye, B., Tadessea, M. G., Williams, M. A., Lemma, S., & tal disorder and its association with academic performance among
Berhanec, Y. (2014). Sleep disturbances and common mental disor- Debre Berhan University students, Ethiopia. International Journal of
ders in college students. Health Behavior and Policy Review, 1(3), Mental Health Systems, 11, 34. doi:10.1186/s13033-017-0142-6
229–237. doi:10.14485/HBPR.1.3.7 Hersi, L., Tesfay, K., Gesesew, H., Krahl, W., Ereg, D., & Tesfaye, M.
Cvetkovski, S., Reavley, N. J., & Jorm, A. F. (2012). The prevalence (2017). Mental distress and associated factors among undergraduate
and correlates of psychological distress in Australian tertiary stu- students at the University of Hargeisa, Somaliland: A cross-sectional
dents compared to their community peers. The Australian and New study. International Journal of Mental Health Systems, 11, 39. doi:
Zealand Journal of Psychiatry, 46(5), 457–467. doi:10.1177/ 10.1186/s13033-017-0146-2
0004867411435290 Higgins, J. P., & Thompson, S. G. (2002). Quantifying heterogeneity in
Dachew, B. A., Azale Bisetegn, T., & Berhe Gebremariam, R. (2015). a meta-analysis. Statistics in Medicine, 21(11), 1539–1558. doi:10.
Prevalence of mental distress and associated factors among under- 1002/sim.1186
graduate students of University of Gondar, Northwest Ethiopia: A Institute for Health Metrics and Evaluation (IHME). (2016). GBD com-
cross-sectional institutional based study. PLoS One, 10(3), e0119464. pare data visualization. Seattle, WA: IHME, University of
doi:10.1371/journal.pone.0119464 Washington. Retrieved from http://vizhub.healthdata.org/gbd-
Damena, T., Mossie, A., & Tesfaye, M. (2011). Khat chewing and men- compare
tal distress: A community based study, in Jimma City, Southwestern Izadinia, N., Amiri, M., Jahromi, R., & Hamidi, S. (2010). A study of
Ethiopia. Ethiopian Journal of Health Sciences, 21(1), 37–45. doi:10. relationship between suicidal ideas, depression, anxiety, resiliency,
4314/ejhs.v21i1.69042 daily stresses and mental health among Tehran university students.
de Waal, M. W., Arnold, I. A., Spinhoven, P., Eekhof, J. A., & van Procedia - Social and Behavioral Sciences, 5, 1615–1619. doi:10.1016/
Hemert, A. M. (2005). The reporting of specific physical symptoms j.sbspro.2010.07.335
Kebede, D., Alem, A., & Rashid, E. (1999). The prevalence and socio-
for mental distress in general practice. Journal of Psychosomatic
demographic correlates of mental distress in Addis Ababa, Ethiopia.
Research, 59(2), 89–95. doi:10.1016/j.jpsychores.2005.02.011
Acta Psychiatrica Scandinavica Supplementum, 397, 5–10. doi:10.
Dessie, Y., Ebrahim, J., & Awoke, T. (2013). Mental distress among
1111/j.1600-0447.1999.tb10687.x
university students in Ethiopia: A cross sectional survey. The Pan
Kerebih, H., Ajaeb, M., & Hailesilassie, H. (2017). Common mental
African Medical Journal, 15, 95. doi:10.11604/pamj.2013.15.95.2173
disorders among medical students in Jimma University, SouthWest
Doi, S. A. R., & Thalib, L. (2008). A quality-effects model for meta-
Ethiopia. African Health Sciences, 17(3), 844–851. doi:10.4314/ahs.
analysis. Epidemiology (Cambridge, Mass), 19(1), 94–100. doi:10.
v17i3.27
1097/EDE.0b013e31815c24e7
Kessler, R. C., Foster, C. L., Saunders, W. B., & Stang, P. E. (1995).
Dvorak, R. D., Lamis, D. A., & Malone, P. S. (2013). Alcohol use,
Social consequences of psychiatric disorders, I: Educational attain-
depressive symptoms, and impulsivity as risk factors for suicide
ment. American Journal of Psychiatry, 152(7), 1026–1032. doi:10.
proneness among college students. Journal of Affective Disorders,
1176/ajp.152.7.1026
149(1–3), 326–334. doi:10.1016/j.jad.2013.01.046
Kiely, K. M., Leach, L. S., Olesen, S. C., & Butterworth, P. (2015). How
Eaton, N. R., Keyes, K. M., Krueger, R. F., Balsis, S., Skodol, A. E.,
financial hardship is associated with the onset of mental health
Markon, K. E., … Hasin, D. S. (2012). An invariant dimensional problems over time. Social Psychiatry and Psychiatric Epidemiology,
liability model of gender differences in mental disorder prevalence: 50(6), 909–918. doi:10.1007/s00127-015-1027-0
Evidence from a national sample. Journal of Abnormal Psychology, Kingston, R. E., Marel, C., & Mills, K. L. (2017). A systematic review
121(1), 282–288. doi:10.1037/a0024780 of the prevalence of comorbid mental health disorders in people
Egger, M., Davey Smith, G., Schneider, M., & Minder, C. (1997). Bias presenting for substance use treatment in Australia. Drug and
in meta-analysis detected by a simple, graphical test. BMJ (Clinical Alcohol Review, 36(4), 527–539.
Research ed.), 315(7109), 629–634. doi:10.1136/bmj.315.7109.629 Kinney, S. K., & Dunson, D. B. (2007). Fixed and random effects selec-
Federal Democratic Republic of Ethiopia Ministry of Health. (2012). tion in linear and logistic models. Biometrics, 63(3), 690–698. doi:
National Mental Health Strategy 2012/13 - 2015/16. Addis Ababa: 10.1111/j.1541-0420.2007.00771.x
Federal Democratic Republic of Ethiopia Ministry of Health. Lima, M. C. P., Domingues, M. D S., & Cerqueira, A. T. D A. R.
Federal Democratic Republic of Ethiopia Ministry of Health. (2015). (2006). [Prevalence and risk factors of common mental disorders
HSTP: Health Sector Transformation Plan: 2015/16 - 2019/20 among medical students]. Revista de Saude Publica, 40(6),
(2008-2012 EFY). Addis Ababa: Federal Democratic Republic of 1035–1041. doi:10.1590/s0034-89102006000700011
Ethiopia Ministry of Health. Liu, J. L. (2011). The role of the funnel plot in detecting publication
Garlow, S. J., Rosenberg, J., Moore, J. D., Haas, A. P., Koestner, B., and related biases in meta-analysis. Evidence-Based Dentistry, 12(4),
Hendin, H., & Nemeroff, C. B. (2008). Depression, desperation, and 121–122. doi:10.1038/sj.ebd.6400831
suicidal ideation in college students: Results from the American Lund, C., De Silva, M., Plagerson, S., Cooper, S., Chisholm, D., Das, J.,
Foundation for Suicide Prevention College Screening Project … Patel, V. (2011). Poverty and mental disorders: Breaking the
at Emory University. Depression and Anxiety, 25(6), 482–488. cycle in low- income and middle- income countries. Lancet,
doi:10.1002/da.20321 378(9801), 1502–1514. doi:10.1016/S0140-6736(11)60754-X
Gebrehanna, E., Berhane, Y., & Worku, A. (2014). Khat chewing Medlock, M. M., Rosmarin, D. H., Connery, H. S., Griffin, M. L.,
among Ethiopian University Students - A growing concern. BMC Weiss, R. D., Karakula, S. L., & McHugh, R. K. (2017). Religious
Public Health, 14, 1198. coping in patients with severe substance use disorders receiving
Gelaye, B., Lemma, S., Deyassa, N., Bahretibeb, Y., Tesfaye, M., acute inpatient detoxification. The American Journal on Addictions,
Berhane, Y., & Williams, M. A. (2012). Prevalence and correlates of 26(7), 744–750. doi:10.1111/ajad.12606
mental distress among working adults in Ethiopia. Clinical Practice Melese, B., Bayu, B., Wondwossen, F., Tilahun, K., Lema, S., Ayehu,
and Epidemiology in Mental Health, 8, 126–133. doi:10.2174/ M., & Loha, E. (2016). Prevalence of mental distress and associated
1745017901208010126 factors among Hawassa University medical students, Southern
8 B. A. DACHEW ET AL.

Ethiopia: A cross-sectional study. BMC Research Notes, 9(1), 485. Stallman, H. M. (2008). Prevalence of psychological distress in univer-
doi:10.1186/s13104-016-2289-7 sity students-implications for service delivery. Australian Family
Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, Physician, 37(8), 673–677.
M., … Stewart, L. A. (2015). Preferred reporting items for system- StataCorp (2015). Stata Statistical Software: Release 14. College Station,
atic review and meta-analysis protocols (PRISMA-P) 2015 state- TX: StataCorp LP.
ment. Systematic Reviews, 4, 1. doi:10.1186/2046-4053-4-1 Storrie, K., Ahern, K., & Tuckett, A. (2010). A systematic review:
Mosley, T. H., Jr., Perrin, S. G., Neral, S. M., Dubbert, P. M., Students with mental health problems-a growing problem.
Grothues, C. A., & Pinto, B. M. (1994). Stress, coping, and International Journal of Nursing Practice, 16(1), 1–6. doi:10.1111/j.
well-being among third-year medical students. Academic 1440-172X.2009.01813.x
Medicine: Journal of the Association of American Medical Colleges, Swendsen, J., Conway, K. P., Degenhardt, L., Glantz, M., Jin, R.,
Merikangas, K. R., … Kessler, R. C. (2010). Mental disorders as
69(9), 765–767. doi:10.1097/00001888-199409000-00024
risk factors for substance use, abuse and dependence: Results from
Narr, R. K., Allen, J. P., Tan, J. S., & Loeb, E. L. (2019). Close friend-
the 10-year follow-up of the National Comorbidity Survey.
ship strength and broader peer group desirability as differential pre-
Addiction, 105(6), 1117–1128. doi:10.1111/j.1360-0443.2010.02902.x
dictors of adult mental health. Child Development, 90(1), 298–313.
Tariku, G. H., Zerihun, A. A., Bisrat, Z. S., Adissu, G. G., & Jini, D.
Odenwald, M., Neuner, F., Schauer, M., Elbert, T., Catani, C.,
(2017). Mental distress and its associated factors among students of
Lingenfelder, B., … Rockstroh, B. (2005). Khat use as risk factor Mizan Aman Health Science College, Ethiopia. Journal of Medical
for psychotic disorders: A cross-sectional and case-control study in Sciences, 17(2), 61–67. doi:10.3923/jms.2017.61.67
Somalia. BMC Medicine, 3(1), 5. doi:10.1186/1741-7015-3-5 Tedstone Doherty, D., & Kartalova-O’Doherty, Y. (2010). Gender and
Ovuga, E., Boardman, J., & Wasserman, D. (2006). Undergraduate stu- self-reported mental health problems: Predictors of help-seeking
dent mental health at Makerere University, Uganda. World from a general practitioner. British Journal of Health Psychology,
Psychiatry, 5(1), 51–52. 15(1), 213–228. doi:10.1348/135910709X457423
Patel, V., & Kleinman, A. (2003). Poverty and common mental disor- Tesfaye, A. (2009). Prevalence and correlates of mental distress among
ders in developing countries. Bulletin of the World Health regular undergraduate students of Hawassa University: A cross sec-
Organization, 81(8), 609–615. tional survey. East African Journal of Public Health, 6(1), 85–94.
Rocha, S. V., de Almeida, M. M., de Araujo, T. M., & Virtuoso, J. S. Tusa, A. L., & Burgholzer, J. A. (2013). Came to believe: Spirituality as
Jr. (2010). Prevalence of common mental disorders among the resi- a mechanism of change in alcoholics anonymous: A review of the
dents of urban areas in Feira de Santana, Bahia. Revista Brasileira literature from 1992 to 2012. Journal of Addictions Nursing, 24(4),
de Epidemiologia, 13(4), 630–640. doi:10.1590/S1415-790X2010000 237–246. doi:10.1097/JAN.0000000000000003
400008 Unterrainer, H. F., Lewis, A. J., & Fink, A. (2014). Religious/Spiritual
Rohrer, J., Rohland, B., Denison, A., Pierce, J. R., Jr., & Rasmussen, Well-being, personality and mental health: A review of results and
N. H. (2007). Family history of mental illness and frequent mental conceptual issues. Journal of Religion and Health, 53(2), 382–392.
distress in community clinic patients. Journal of Evaluation in doi:10.1007/s10943-012-9642-5
Clinical Practice, 13(3), 435–439. doi:10.1111/j.1365-2753.2006. Warfa, N., Klein, A., Bhui, K., Leavey, G., Craig, T., & Alfred
00737.x Stansfeld, S. (2007). Khat use and mental illness: A critical review.
Sidik, S. M., Rampal, L., & Kaneson, N. (2003). Prevalence of emo- Social Science and Medicine (1982), 65(2), 309–318. doi:10.1016/j.
socscimed.2007.04.038
tional disorders among medical students in a Malaysian university.
World Health Organization. (1994). A users guide to the Self Reporting
Asia Pacific Family Medicine, 2, 213–217. doi:10.1111/j.1444-1683.
Questionnaire (SRQ) Geneva: WHO.
2003.00089.x
World Health Organization. (2014). WHO: Mental Health Atlas-2014
Sijtsema, J. J., Verboom, C. E., Penninx, B. W., Verhulst, F. C., &
country profiles. Geneva: WHO. Retrieved from http://www.who.
Ormel, J. (2014). Psychopathology and academic performance, social int/mental_health/evidence/atlas/profiles-2014/en/
well-being, and social preference at school: The TRAILS study. Youngmann, R., Zilber, N., Workneh, F., & Giel, R. (2008). Adapting
Child Psychiatry and Human Development, 45(3), 273–284. doi:10. the SRQ for Ethiopian populations: A culturally-sensitive psychiatric
1007/s10578-013-0399-1 screening instrument. Transcultural Psychiatry, 45(4), 566–589. doi:
Sreeramareddy, C. T., Shankar, P. R., Binu, V. S., Mukhopadhyay, C., 10.1177/1363461508100783
Ray, B., & Menezes, R. G. (2007). Psychological morbidity, sources Yussuf, A. D., Issa, B. A., Ajiboye, P. O., & Buhari, O. I. (2013). The
of stress and coping strategies among undergraduate medical stu- correlates of stress, coping styles and psychiatric morbidity in the
dents of Nepal. BMC Medical Education, 7, 26. doi:10.1186/1472- first year of medical education at a Nigerian University. African
6920-7-26 Journal of Psychiatry, 16(3), 206–215.

You might also like