Absorción de Farmacos

"8HC8:E;DTJ@:8 89IEH:@WD ;@IJH@9K:@WDN<B@C@D8:@WD;<BEI=SHC8:EI 8FUJKBE
3>?I> $GBJMILPABQO>KPMLOQ>ALOBPAB JBJ?O>K>P
%>J FIF> ABQO>KPML OQ>AL OBP - L J BK@I>QRO> '4&. /OFK@FM>IBPPRPQO>QLPQO>KPML OQ>AL P
:5%7' 0/// !"
,#1 !"! 2SQRP?RMQBC J? EJSAMNPMRCaL? /A?RGMLCQ

MPE_LGAMQ QSQR?LAG?Q LCSRP?Q JaNGBMQ
A! 3!2$1 !"! zAGBMQ@GJG?PCQ
,1/ L !"" L LGMLCQMPE_LGAMQ AMLHSE?BMQBCEJSR?RGcL
A, 3,1/ !"" LGMLCQ
!"1/,71 !"& ,GRMV?LRPML? BMVMPPS@GAGL? B?SLMPPS@GAGL?
:5%7' 0///
/$/3 2+" .JGEMN`NRGBMQ?AMNJ?BMQ? NPMRMLCQ
"-3 2+" -SAJCcQGBMQ?AMNJ?BMQ? -?
-3"/ 2+" 3?SPMAcJGAM?AMNJ?BM? -?
. 3/ 2+" LGMLCQMPE_LGAMQNMJGCQNCAaDGAMQ
3 * 2+" ,CRMRPCV?RMCL CJ PGbcL
."3 2+" "?RGMLCQMPE_LGAMQ
1%" 2+" %cJGAM PCBSAGBM
1- <CH>CHA=;MM?NN? L <CF?;>>NL;HMJILN?L L <L?;MN=ZH=?LL?MCMN;H=?JLIN?CH L <CF?M;CN?RJILNJOGJ #K =;H;FC=OF;LGOFNCMJ?=C@C=ILA;HC=;HC^H
NL;HMJIH?LkJlL =IH=?HNL;NCP?HO>?INC>?NL;HMJILN?L L 7( 1*A #*41 $%/(%130 ):0 13K L GOFNC>LOAL?MCMN;H=? L G;DIL@;>FCN;NIL L GOFNC>LOA
L?MCMN;H=? L?F;N?>JLIN?CH L GCNIR;HNLIH? L?MCMN;H=?B;F@ NL;HMJILN?L L +; N;OLI=BIF;N?=INL;HMJILNCHAJLIN?CHjXk EC>H?SILA;HC=;HC^HNL;HMJILN?L
L ILA;HC=;HC^HNL;HMJILN?LJIFSJ?JNC>? ILA;HC==;NC^HNL;HMJILN?L L IFCAIJ?JNC>?NL;HMJILN?L L L?>O=?>@IF;N?=;LLC?LLMIFON?=;LLC?L
WPCBSACQS?AACQM?XML?QAPaRGA?Q AMKMCJ2-" CJDCRMM JMQRCQRaASJMQ NSCBCL ?JRCP?PJ? $JAMLMAGKGCLRM BC CQR?QA?P?ARCPbQRGA?QNCPKGRC

2C JMA?JGX? CL J? KCK@P?L? ?NGA?J BCJ CLBMRCJGM GLRCQRGL?J W BCTSCJTC CQR?@JCACPJ?COSGT?JCLAG?BCSL?DMPKSJ?AGdLD?PK?AaSRGA?WBCJ?Q
? J? JSX GLRCQRGL?J JMQD_PK?AMQ OSC QC F?L ?@QMP@GBM CL J? KCK@P?L? TCPQGMLCQECLaPGA?QBCJMQD`PK?AMQCVGQRCLRCQ BCK`Q CQeRGJN?P?
?NGA?JBCJ?QA`JSJ?QBCJRd@SJM NPMVGK?J PCL?J BCKMBM OSCCJD_PK?AM QCJCAAGML?PJ?Tb?BC?BKGLGQRP?AGdLWJ?DMPK?D?PK?AaSRGA?dNRGK?Q
NPMACBCLRC BC J? Q?LEPC QC CVNSJQ? ?J Rd@SJM PCL?J CL J? KCK@P?L?
N?P?A?B?A?QM WN?P?AMLMACPJ?QPCNCPASQGMLCQOSCNSCBCLRCLCP
A?L?JGASJ?P BC JMQ FCN?RMAGRMQ BMLBC ?WSB? ? OSC JMQ D_PK?AMQ QC
CVAPCRCL ? J? @GJGQ CL JMQ NGCQ ?QRPMAGR?PGMQ BC J? !'$ CL J? NJ?ACLR?
QM@PCJ?PCQNSCQR?J?CVGQRCLAG?BCD?ARMPCQOSC?JRCP?LJ?TCJMAGB?B
JMQRCQRaASJMQWMT?PGMQ DMPK?LBM N?PRCBC J?Q @?PPCP?Q OSCNPMRCECL ?J BC?@QMPAGdLMJ?A?LRGB?B?@QMP@GB?
DCRMWJ?QA`JSJ?Q ECPKGL?JCQWBGDGASJR?LBMCJ ?AACQM BC JMQ D_PK?AMQ ?
CQRMQcPE?LMQ TDGE WCLEJ_LBSJ?QQCAPCRMP?Q AMKMCJN_LAPC?Q +? ?@QMPAGcL BCSLD_PK?AM CLRCLBGB? CL CJQCLRGBMCQRPGARM BCJ N?QMBC
J?Q QSNP?PPCL?JCQ M CJ NJCVM AMPMGBCM +? EJSAMNPMRCaL? /R?K@G`L CQR_ SL? KCK@P?L?OSCQCN?P?CJ CVRCPGMPBCJ GLRCPGMPBCJMPE?LGQKM BCNCLBC
NPCQCLRC CL AGCPRMQRGNMQ ACJSJ?PCQ? JMQ OSC BMR? BC PCQGQRCLAG? DPCLRC BCJ?QQGESGCLRCQA?P?ARCPaQRGA?Q
? ?ECLRCQ ?LRGLCMNJ_QGAMQ NMPD?AGJGR?PQS CVNSJQGcL 2S QM@PCCVNPCQGcL
CL JGLDMAGRMQ NSCBC CVNJGA?P ?JESL?Q PCQGQRCLAG?Q ? ?LRGPPCRPMTGP?JCQ ? :K:<M>KWLMB<:L?BLB<HJNWFB<:L=>E?UKF:<H "MKNPCLBCL CJ NCQM KM
+? QM@PCCVNPCQGcL M J? NPCQCLAG? BCD_PK?AMQ GLBSARMPCQ BC J? EJSAM JCASJ?PAMLBGAGML?BMNMPCJR?K?bMBCJ? KMJÀSJ? J? JGNMQMJS@GJGB?BW
NPMRCaL? / ?SKCLR?L QS ?ARGTGB?B KGCLRP?Q OSC J? GLDP?CVNPCQGcL M J? QSA?P_ARCP_AGBMM?JA?JGLM OSC HSLRMAMLQSN*= AMLBGAGML?LCJEP?BM
NPCQCLAG? BC GLFG@GBMPCQ J? PCBSACL T A?N f e BC GMLGX?AGcL#CCQRMQD?ARMPCQBCNCLBCCJKCA?LGQKMNMPCJAS?JQC
NPMBSACJ? ?@QMPAGcLWJ?TCJMAGB?B? J? OSCQCPC?JGX?
@ :K:<M>KWLMB<:L=>E:IK>I:K:<BYG?:KF:<VNMB<: /?P?OSCCJD_PK?AMQC
?@QMP@? BC@CCQR?PBGQSCJRM +? NPCN?P?AGcLD?PK?A`SRGA? AMLBGAGML?
J? TCJMAGB?B AML OSC CJD_PK?AM QC JG@CP? QC BGQEPCE? WQC BGQSCJTC
K !2.1"(?- JESL?QA?P?ARCPaQRGA?QQMLJ?DMPKSJ?AGcL QMJSAGcL NMJTM A_NQSJ?QM
AMKNPGKGBMQ CJR?K?bM BC J?Q N?PRaASJ?Q J? NPCQCLAG? BC?BGRGTMQW
"LK@BMQL AB >?PLO@F`K CVAGNGCLRCQ WCJ NPMNGMNPMACQMBCD?@PGA?AGcL
A :K:<M>KWLMB<:L=>EEN@:K=>:;LHK<BYG #CNCLBCLBCJ?Ta?BC?BKGLGQ
+??@QMPAGdLAMKNPCLBCJMQNPMACQMQBCJG@CP?AGdLBCJD`PK?AMBC
RP?AGcL $L ECLCP?J J? ?@QMPAGcL QCP_ R?LRM K_Q P_NGB? AS?LRM K?WMP
QSDMPK?D?PK?AaSRGA? QSBGQMJSAGdL J? CLRP?B? BCJMQD`PK?AMQ WK_Q NPMJMLE?BM QC? CJ AMLR?ARM AML J? QSNCPDGAGC BC ?@QMPAGcL J
CLCJMPE?LGQKMBCQBCCJJSE?PBC?BKGLGQRP?AGdL JMQKCA?LGQKMQ ESL?Q A?P?ARCPaQRGA?QQML J? QSNCPDGAGCWCJ CQNCQMPBC J? KCK@P?L?
BCRP?LQNMPRCWJ?CJGKGL?AGdLNPCQGQRaKGA? ?QbAMKMJ?QA?P?ARCPbQ CJDJSHM Q?LESaLCM OSC K?LRGCLC CJ EP?BGCLRC BCAMLACLRP?AGcL CL J?
RGA?QBCA?B?Tb?BC?BKGLGQRP?AGdL J?TCJMAGB?BWJ?A?LRGB?BAML ?BKGLGQRP?AGcLMP?J CJN'BCJKCBGMWJ?KMRGJGB?BE?QRPMGLRCQRGL?J WCL
J?OSCCJD`PK?AM?AACBC?J?AGPASJ?AGdLQGQRaKGA?WJMQD?ARMPCQOSC J??BKGLGQRP?AGcLGLRP?KSQASJ?PMQS@ASR_LC? JMQCQN?AGMQGLRCPACJSJ?PCQ
|x
.<::@WD P J L C H = C J C I M A ? H ? L ; F ? M > ? ; = = C ^ H > ? F I M @ Z L G ; = I M
2GLCK@?PEM BCQBCCJNSLRMBCTGQR?BCJMQCDCARMQBCJMQD`PK?AMQ
3>?I> $GBJMILPABC\OJ>@LP@LK RK>CO>@@F`K AB
CQ K`Q GKNMPR?LRCJ? <CI>CMJIHC<CFC>;> CLRCLBGB?AMKM J?TCJMAG
>?PLO@F`K JBKLOAB MLOCBK`JBKL MOFJBOM>PL
B?BWA?LRGB?BBCJ D`PK?AMOSCJJCE??J?AGPASJ?AGdLQGQRaKGA? +?
?@QMPAGdL CLQCLRGBM CQRPGARM LM CQ K`QOSCSL CJCKCLRM BC CQ?
JNPCLMJMJ
@GMBGQNMLG@GJGB?B NCPM BC@CLRCLCPQCCL ASCLR? MRPMQ AMKM J?
KGRPGNRGJGL?
?FCGCH;=C^H JL?MCMN[GC=; OSCQCNPMBSACCL CJ JJ?K?BM DCLdKCLM
"GR?P?@GL?
NPGKCPN?QM2CCLRGCLBCJIL@?H^G?HIJLCG?LJ;MIJ?KCR?@MJGX?AGdL
"JMKCRG?XMJ
BCJD`PK?AM R?LRMCL J?N?PCBBCJ RP?ARM E?QRPMGLRCQRGL?J AMKMCL
"JMPNPMK?XGL?
CJ FbE?BM ? BMLBC JJCE? ?RP?TaQ BCJ?TCL?NMPR? BC KMBM OSC #CVRPMNPMNMVGDCLM
SL?DP?AAGdLBCD`PK?AM OSCB?KCR?@MJGX?B??LRCQ BC JJCE?P?J? #GFGBPMCPEMR?KGL?
AGPASJ?AGdLQGQRaKGA? +? CJGKGL?AGdLNPCQGQRaKGA?CVNJGA? J?@?H? #GJRG?XCK
@GMBGQNMLG@GJGB?BBC?JESLMQD`PK?AMQ ?NCQ?PBCOSCQS?@QMPAGdL #GLGRP?RMBCGQMQMP@GB?
E?QRPMGLRCQRGL?J QC?AMKNJCR? NMPCHCKNJM J?@GMBGQNMLG@GJGB?B #MVCNGL?
MP?J BCJ NPMNP?LMJMJWBCJTCP?N?KGJMNSCBCQCPBCJ fe ?NCQ?P #MVMPPS@GAGL?
BCOSCQS?@QMPAGdLGLRCQRGL?JCQQSNCPGMP?J 3?K@GaLCVNJGA? $LA?GLGB?
OSCJ?BMQGQBCCQRMQD`PK?AMQNMPTb?MP?J BC@?QCPLMR?@JCKCLRC $QAMNMJ?KGL?
K?WMPOSCJ??BKGLGQRP?B?NMPTb?GLRP?TCLMQ? $QRP?BGMJ
DJSMPMSP?XGJM
/MPAS?JOSGCPTa?OSCLMQC? J? GLRP?TCLMQ? NSCBCF?@CP?@QMPAGcL GLAMK 'GBP?J?XGL?
NJCR? NMPOSC N?PRC BCJD_PK?AM ?BKGLGQRP?BMQC? CJGKGL?BM M BCQRPSGBM (KGNP?KGL?
?LRCQBCJJCE?P? J?AGPASJ?AGcL QGQR`KGA?/MPTa?MP?J SLD_PK?AMNSCBC (QMNPCL?JGL?
*CR?KGL?
? $JGKGL?PQCNMPJ?QFCACQ?LRCQBCOSCQCAMKNJCRCQS?@QMPAGcL NSCBC +?@CR?JMJ
QCPOSCJ?BM BCEP?B?BMNMPJ??AAGcLBCJN'_AGBMBCJCQRcK?EMMBCJ?Q +GBMA?aL?
CLXGK?QBGECQRGT?Q WKCR?@MJGX?BMNMPJ?Q@?ARCPG?QBCJ?JSXGLRCQRGL?J
+MPA?GLGB?
> 4L?TCX?@QMP@GBMQ JMQD_PK?AMQNSCBCLQCPCVNSJQ?BMQBC LSCTM?
k KCPA?NRMNSPGL?
J? JSXGLRCQRGL?J NMPJ? EJSAMNPMRCaL? / M KCR?@MJGX?PQC CL CJ CNGRCJGM
,CRGJDCLGB?RM
GLRCQRGL?JD $JBCJKCR?@MJGQKMGLRCQRGL?JQCNPMBSACKCBG?LRCJ?
,CRMNPMJMJ
?AAGcLCLXGK_RGA?OSCSRGJGX?CJAGRMAPMKM/CLQSGQMDMPK?"8/
,MPDGL?
TA?N NMPJMOSCRGCLC SL? CQNCAG?J GKNMPR?LAG? CL JMQD_PK?AMQ
OSC QCKCR?@MJGX?L?RP?T`QBCCQR? CLXGK? BCK_Q J? ?@QMPAGcL BC -?J@SDGL?
JMQD_PK?AMQNSCBCQCPPCBSAGB?NMPJ?EJSAMNPMRCaL?/BCJ?KCK@P?L? -?JMVML?
JSKGL?JBCJCNGRCJGMGLRCQRGL?J OSC@MK@C?CJD_PK?AMDSCP?BCJ?A`JS -?JRPCVML?
J? CNGRCJG?JWJMPCCLTa?? J? JSXGLRCQRGL?J?LRCQBCOSCN?QC? J?Q?LEPC -CMQRGEKGL?
TDGE 4L?TCXOSCJJCE?L?J?TCL?NMPR? NSCBCLQCPBCQRPSGBMQCL -GA?PBGNGLM
CJ FaE?BM NPGKCPN?QM FCN_RGAM MCL JMQ NSJKMLCQ?LRCQBC JJCE?P? -GAMRGL?
J? AGPASJ?AGcL QGQR`KGA? +? DP?AAGcL BCCVRP?AAGcL FCN_RGA? DZ= CQ J? -GDCBGNGLM
DP?AAGcL BCD_PK?AM OSC F?WCL CJ ASCPNM OSC QC KCR?@MJGX? CL SL -GRPMEJGACPGL?
QMJMN?QMNMPCJFaE?BM /?N?TCPGL?
/CLR?XMXGL?
+?@GMBGQNMLG@GJGB?BBCJD_PK?AM CQBCAGP J?DP?AAGcLBCJD_PK?AM?BKGLGQRP? /CRGBGL?
BMOSCJJCE??J?AGPASJ?AGcLQGQR`KGA? QCP_CJNPMBSARMBCJ?QRPCQDP?AAGMLCQ /P?XMQGL?
JSKGL?J GLRCQRGL?JWFCN_RGA? /PMNP?LMJMJ
3CQRMQRCPML?
5CP?N?KGJM
/MPCHCKNJM QG J? KGR?BBCJD_PK?AMQCBCQRPSWCCLCJGLRCQRGLM J?KGR?BQC

KCR?@MJGX?CLCJCNGRCJGMGLRCQRGL?JWJ?KGR?BQCKCR?@MJGX?CLCJ FaE?BM J?
@GMBGQNMLG@GJGB?B QCP_ BCD i i CQBCAGP BCJ
BCJ?BMQGQ?BKGLGQRP?B? BC g ? fe F CQSLD?ARMPBCAGQGTMN?P?CJAMKGCLXMBCJ??@QMPAGdL
+MQD_PK?AMQ AML NPGKCPN?QM FCN_RGAM GKNMPR?LRC R?@J? QSCJCL BCJMQD`PK?AMQ WJ?BSP?AGdLBCJRP`LQGRMNMPCJGLRCQRGLMBCJE?BM
KCR?@MJGX?PQC KCBG?LRCCJ "8/ WCJ "8/# WNMQCCL SL? DP?AAGcL SL?Q F N?P? J? A?LRGB?B ?@QMP@GB? $L ?JESLMQ A?QMQ NSCBC
BCCVRP?AAGcLFCN_RGA?CJCT?B? K?WMPBC JMOSCQGELGDGA?OSCKCLMQBCJ F?@CPRP?LQNMPRC?ARGTMCGLAJSQMDGJRP?AGdL
BCJ?BMQGQ?@QMP@GB??JA?LX?P_ J? AGPASJ?AGcL QGQR`KGA? +?P\;IL;FCQAdKMB? @?P?R?WSLGNCPQML?J ?BCAS?B?N?P?CJRP?
R?KGCLRMAPdLGAM1COSGCPCTMJSLR?PGCB?BWA?N?AGB?BBCBCEJSAGdL
lM+ 8 $% $0*1*897 #*41 WLMBC@CSRGJGX?PQCAS?LBMCJD`PK?AMGPPGRCJ?KSAMQ?MCJN?AGCLRC
CQRaGLAMLQAGCLRC QCF?JJ?QMKCRGBM?SL?GLRCPTCLAGdL OSGPePEGA?
1W:L>GM>K:E>L M NPCQCLRCTdKGRMQ +MQNPCN?P?BMQAMLAS@GCPR?CLRaPGA?CTGR?LJ?
+??@QMPAGdLBCJD`PK?AMNMPP\;IL;FBCNCLBCBCDMPK?KSWGKNMP BGQMJSAGdLCLCJCQRdK?EMWPCRP?Q?LCJAMKGCLXMBCJ??@QMPAGdL
R?LRCBCJ?NPCN?P?AGdLD?PK?AaSRGA?OSCAMLBGAGML?JMQNPMACQMQBC NCPM LM QSTCJMAGB?B +MQ NPCN?P?BMQ BC JG@CP?AGdL K?LRCLGB?
BGQEPCE?AGdLWBGQMJSAGdL+??@QMPAGdLQCNPMBSACCLCJCQRdK?EM CLJCLRCACLJ??@QMPAGdLWNCPKGRCLPCBSAGPJ?QDJSARS?AGMLCQBCJ?Q
WCQNCAG?JKCLRCCLCJBSMBCLM NPGLAGN?JKCLRCNMPBGDSQGdLN?QGT? AMLACLRP?AGMLCQ NJ?QK`RGA?Q M PCBSAGPCJ LeKCPM BCRMK?Q?J Bb?
SLOSCRCdPGA?KCLRCBC@CL?@QMP@CPQCKCHMPJMQÀGBMQBa@GJCQCL N?P? KCHMP?PCJ ASKNJGKGCLRM RCP?NaSRGAM '?@GRS?JKCLRCCQR`L
CJ CQRdK?EMWJ?Q@?QCQ Ba@GJCQ CL CJ GLRCQRGLM BCJE?BM J?K?WMP DMPK?BMQNMPSL?K?RPGX?J?OSCQCSLCDSCPRCKCLRCCJD`PK?AMWBC
N?PRCBCJ??@QMPAGdLRGCLCJSE?PCL CJGLRCQRGLMBCJE?BM BC@GBM ? J?OSCQCT?JG@CP?LBMJCLR?KCLRCAMLDMPKCQCNPMBSACJ??@QMPAGdL
QSK?WMPQSNCPDGAGCBC?@QMPAGdL /MPJMR?LRM CJT?AG?BME`QRPGAM 3?K@GaLF?WA`NQSJ?QASW?N?PCBBCH?CLRP?PMQKdRGA?KCLRCCJ?ES?
|y
BCQBCJ?JSXGLRCQRGL?J CKNSH?LBM JCLR?KCLRCCJD`PK?AMF?B?CJ T A?N 3?K@GaLQCCKNJC?A?QGQGCKNPCCL DMPK?BCJ;L=B?M

CVRCPGMP?RP?TaQBCSLDGLMMPGDGAGM N?P?J??BKGLGQRP?AGdLQGQRaKGA?K?LRCLGB?BCD`PK?AMQBCDMPK?
$LJ?P\;MO<FCHAO;F CJD`PK?AMBCNMQGR?BMBC@?HMBCJ?JCLES?QC ?ESB? N CH CQAMNMJ?KGL? M APdLGA? N CH MNGÀCMQ LGRP?RMQ
?@QMP@CNMPJ?KSAMQ?QS@JGLES?J ?AACBGCLBMNMPJ?TCL?A?T??J? CQRPdECLMQWLGAMRGL? +? ?BKGLGQRP?BdL ASR`LC?CTGR?CJNPGKCP
?SLASJ?BCPCAF? JCTGR?PQSN?QMGLRCQRGL?JWFCN`RGAM QCAMLQGESC N?QMFCN`RGAMWJ?QDGSARS?BMLCQBCJ?QAMLACLRP?BMLCQNJ?QK`RGA?Q
SL CDCARMK`QP`NGBMCGLRCLQM OSCCQeRGJ CL QGRS?BMLCQ ?ESB?Q NCPKGRCRCPKGL?PP`NGB?KCLRCJ??@QMPBdLBCJD`PK?AM PCBSACJ?
AMKM CJRP?R?KGCLRM BCSL? APGQGQ?LEGLMQ?AML LGRPMEJGACPGL? +? T?PG?@GJGB?BGLRCPGLBGTGBS?J CLJ??@QMPBdL NPMJMLE?J?BSP?BdL
Tb? NL;HMGO=IM;SRGJGX?CJ KGQKM NPGLAGNGM CJ D`PK?AM NCPK?LCAC BCJ? ?ABdLWKCHMP?CJ ASKNJGKGCLRMRCP?NaSRGAM +? ?@QMPBdL
CL J?@MA?AMKMSLA?P?KCJMWQC?@QMP@C?RP?TaQBC J?KSAMQ? ASR`LC?CQKCLMPAS?LBM J?NGCJ CQEPSCQ?M CQR`CVNSCQR??J?GL
+?G;L?=N;FCQK`QGLAdKMB?OSCJ?Tb?MP?J WJ??@QMPBdLNSCBC RCKNCPGC /MPJ?NGCJ QC ?@QMP@CLR?K@GaL BGTCPQMQRdVGAMQ AMKM
QCPCPP`RGA? JCLR?CGLAMKNJCR? QMJTCLRCQMPE`LGAMQMNPCN?P?BMQMPE?LMDMQDMP?BMQ
+?P\;CHB;F;NILC;QCSRGJGX?NPGLAGN?JKCLRCN?P?J??BKGLGQRP?BdL
+? Ta? PCAR?J QC SRGJGX? N?P? ?BKGLGQRP?PD_PK?AMQOSC NPMBSACL GPPGR?AGcL BCD`PK?AMQOSCBC@?L ?ARS?PJMA?JKCLRCCLCJRP?ARMPCQNGP?RMPGM
E?QRPMGLRCQRGL?J QMLBCQRPSGBMQNMPCJN'_AGBMBCJCQRcK?EMMJ?QCLXGK?Q
AMKM /H ?BPCLaPEGAMQ APMKMEJGA?RMQdBGAM AMPRGAMGBCQM ?LRGAMJG
BGECQRGT?Q RGCLCLSLMJMPMQ?@MPBCQ?EP?B?@JCQ MN?P?CTGR?PN?PAG?JKCLRC
CJNPGKCPN?QMFCN_RGAM3?K@G`LQCSRGJGX?AMKMSL??JRCPL?RGT??J?Ta?MP?J
LaPEGAMQGLF?J?RMPGMQTA?N $J?AACQM?JJSE?PBC?ABdLBCNCL
CL N?AGCLRCQ AML TcKGRMQ GLAMLQAGCLRCQ MOSGPdPEGAMQ +? ?@QMPAGcL PCAR?J BCBCJ?RaALGA?SRGJGX?B?GLF?J?BMPCQMLC@SJGX?BMPCQ BCJR?K?cM
BC ?JESLMQD_PK?AMQ ?BKGLGQRP?BMQ AMKM QSNMQGRMPGMQ NSCBC QCPJCLR? BCJ?QN?PRbASJ?Q NMPCLBK?BC H H J QCBCNMQGR?CLJ?MPMD?PGLECW
C GPPCESJ?P KCHMP?LBM AS?LBM QC ?BKGLGQRP? AMKM QMJSAGcL PCAR?J N CH Tb?QPCQNGP?RMPG?Q?JR?Q WNMPBC@?HM BC f NLMQCBCNMQGR? WBCJ?
BG?XCN?K KGCLRP?QOSCJ??@QMPAGcLPCAR?JBCMRPMQD_PK?AMQCQKCHMPOSC CVGQRCLAG?BCM@QRPSAAGdL@PMLOSG?JOSCBGDGASJRCCJ?AACQMBCJ?CPM
J? MP?J NCH KCRMAJMNP?KGB?MNPMNP?LMJMJ QMJ JESLMQD`PK?AMQ?BKGLGQRP?BMQNMPCQR?Tb?NSCBCLNPMTMA?P
@PMLAMAMLQRPGAAGdL N CH CJ APMKMEJGA?RM M J?- ?ACRGJAGQRCbL? W
lMlM '413!-5!3+!4 CJSQMBCLC@SJGX?BMPCQAMLJJCT?PGCQEMBCGLDCABMLCQ +?Tb?GLF?
+?P\;CHNL;P?HIM;CQBCCJCAAGdLCLQGRS?BMLCQ?ESB?Q2SQTCLR?H?Q J?RMPG?QCSRGJGX?R?K@GaLN?P??BKGLGQRP?PE?QCQ N CH MVbECLM W
QML J?P?NGBCXBCJ? ?AAGdLWJ? NPCAGQGdL BCJ?Q AMLACLRP?AGMLCQ ?LCQRaQGAMQTMJ`RGJCQ/MPCQR?Tb??AACBCL?JMPE?LGQKMRdVGAMQAMKM
NJ?QK`RGA?QOSCQC ?JA?LX?L ?J LM BCNCLBCPBC JMQ NPMACQMQ BC CJR?@?AM JbOSGBMQTMJ`RGJCQ AMLR?KGL?LRCQW?JaPECLMQ
?@QMPBdLLGBCJMQD?ARMPCQOSCNSCBCL?JRCP?PJMQ3?K@GaLNCPKGRC
PCBSAGPJMQCDCARMQGPPGR?LRCQW?BKGLGQRP?PEP?LBCQTMJeKCLCQ 2SQ +?OW:G:L:ECQdRGJN?P?CJRP?R?KGCLRMJMA?JBCJ?PGLGRGQ?J`PEGA?WJ?AMLECQ
GLAMLTCLGCLRCQQML J?BCNCLBCLB? BCNCPQML?J CQNCB?JGX?BM J? RGcLL?Q?J NCPMR?K@G`LQCCKNJC?N?P?J??BKGLGQRP?BcLQGQR`KGA?BC?JES
NMQG@GJGB?B BCPC?ABMLCQEP?TCQ QM@PCRMBM AS?LBM J??BKGLGQ LMQD_PK?AMQ AMKMJ?QFMPKML?QNCNRaBGA?Q CJDCLR?LGJMMCJNPMNP?LMJMJ
+?QOW:L>IB=NK:E BGMK:M><:ECBGMK:O>GMKB<NE:KQCSRGJGX?L N?P?F?ACPJJCE?P
RP?AGdL CQ KSWP`NGB?WQC ?JA?LX?L ?JR?Q AMLACLRP?AGMLCQ W CJ
?J 2-"D_PK?AMQ OSC ?RP?TGCQ?L K?J J? !'$ N CH ?JESLMQ ?LRG@GcRGAMQ M
NCJGEPMBCCK@MJG?QCGLDCAAGMLCQ +?P\;CHNL;;LN?LC;FQCSRGJGX?N?P? ?LRGLCMNJ_QGAMQ WN?P?AMLQCESGPAMLACLRP?AGMLCQCJCT?B?QNCH BC?LCQ
PC?JGX?P?PRCPGMEP?Db?QWN?P??JA?LX?P?JR?QAMLACLRP?AGMLCQJMA?JCQ R`QGAMQJMA?JCQM?L?JE`QGAMQ CL_PC?QJMA?JGX?B?Q AMKMJ?QP?aACQCQNGL?JCQ
N CH BCSLDG@PGLMJbRGAM AMKMJ?CQRPCNRMAGL?Q? $L J??BKGLGQRP?AGcL CNGBSP?J QC GLWCAR? CJD_PK?AM CL CJCQN?AGMCNGBSP?J
+?P\;CHNL;GOM=OF;LM?CKNJC?N?P?J??BKGLGQRP?BdLBCD`PK?AMQ OSCOSCB?CLRPCCJJGE?KCLRM?K?PGJJMWJ?BSP?K?BPC BCBMLBCQCBGDSLBC
OSCNMPTb?MP?JQC?@QMP@CLK?JMQMLBCEP?B?BMQ3?K@GaLNSCBC ?J CQN?AGMQS@?P?ALMGBCM J?T?GL? BC J?Q P?aACQ LCPTGMQ?QW JMQT?QMQ $L
SRGJGX?PQCN?P? ?QCESP?PCJASKNJGKGCLRMRCP?NaSRGAM M AMKMSL? J? GLRP?RCA?J QC GLWCAR? CJD_PK?AM CL CJ CQN?AGM QS@?P?ALMGBCM BMLBCQC
MNBdL?J?Tb?MP?JWMPCAR?JCLN?BCLRCQOSGPePEGAMQMAMLTdKGRMQ CLASCLRP?CJ+"1WBCBMLBCQCBGDSLBC?J2-"M?JMQCQN?AGMQWJ?QT?GL?Q
?QbAMKMN?P?AMLQCESGPSLCDCARMK`QP`NGBM W?OSCJ?PGA?T?QASJ? BCJ?QP?aACQLCPTGMQ?Q/MPTa?GLRP?TCLRPGASJ?PQCAMLQGESCLK?WMPCQAMLACL
RP?AGMLCQ ACPC@P?JCQ OSC NMPTa? GLRP?RCA?J N?PRC BC J? K?WMPBGDGASJR?B
PGX?AGdL BCJ KeQASJMNCPKGRCSL?P`NGB??@QMPBdLCL KGL
RÀLGA? CQR?QTa?QRGCLCLPGCQEMBCLCSPMRMVGAGB?BCGLDCAAGMLCQ
+MQNPCN?P?BMQBC?@QMPBdL K?LRCLGB? >?JINIL?N;LZ JG@CP?L CJ
+?QTa?Q<HGCNGMBO:E NK>MK:E O>LB<:EWO:@BG:EQCSRGJGX?LN?P??ARS?PJMA?J
D`PK?AM JCLR?KCLRC AMLQGESGCLBMSLCDCARM K`QNPMJMLE?BM +? KCLRC QM@PC J?Q PCQNCARGT?Q KSAMQ?Q WJ? OW:BGMK:I>KBMHG>:EN?P? BG_JGQGQ
?@QMPBdLGLRP?KSQASJ?PNSCBCQCPBGQRGLR?CLJMQKeQASJMQEJeRCMQ CL A?QMQBCGLQSDGAGCLAG? PCL?JCGLRMVGA?AGMLCQ
WCLCJBCJRMGBCQ N CH J?JGBMA?bL?QC?@QMP@CAMLK?WMPP?NGBCX
BCJBCJRMGBCQ WNSCBCPCQSJR?PJCLR?CGLAMKNJCR?AS?LBMF?WFGNM
mM*1&9*# $% "837#*41
NCPDSQGdLNCH CQR?BMQBCQFMAI MCQR?QGQNCH CLCJCK@?P?XM
$LJ?P\;MO<=ONZH?; CJDJSHMQ?LESbLCMCQKCLMPOSCCLJ?Tb?GL +?BLaRGA?BC?@QMPAGdLAS?LRGDGA?J?CLRP?B?BCD`PK?AMCLJ?AGP
RP?KSQASJ?P NMPJMOSCJ??@QMPBdLCQK`QJCLR?#GQKGLSWCAS?LBM ASJ?AGdLQGQRaKGA?WCLEJM@?JMQNPMACQMQBCJG@CP?AGdLBCJD`PK?AM
F?WFGNMRCLQGdL T?QMAMLQRPGABdLNMPDLMM?BKGLGQRP?BdLQGKSJ BCQSDMPK?D?PK?AaSRGA? BGQMJSAGdL ?@QMPBdLNPMNG?KCLRCBGAF?
R`LC?BCT?QMAMLQRPGARMPCQ W?SKCLR?AS?LBM F?WT?QMBGJ?R?AGdL WCJGKGL?AGdL NPCQGQRaKGA? (LBSWCCJ CQRSBGM BC J?TCJMAGB?B BC
NPMBSAGB?NMPCJA?JMPM QC ?BKGLGQRP?LHSLRMAML FG?JSPMLGB?Q? ?@QMPAGdL BCJ?A?LRGB?B?@QMP@GB?WBCJMQD?ARMPCQOSCJ??JRCP?L
$QR`KSWPCBSAGB?AS?LBM F?WFGNMRCLQGdL AMKM QSACBCAML J?
KMPDGL?QS@ASR`LC?CLCJCBCK??ESBMBCNSJKdL $VGQRCLNPCN? UESE !+/& !4/3&0-; -5& 4/3&
P?BMQBC?@QMPAGdLJCLR? AMKMJ?Q@MK@?QMQKdRGA?Q OSCNSCBCL +? P?FI=C>;>>?;<MIL=C^H CQ BCBP CJ LeKCPM BC KMJaASJ?Q BCSL
GKNJ?LR?PQC@?HMJ?NGCJWNPMNMPBML?PLGTCJCQK?LRCLGBMQBSP?LRC D`PK?AMOSCQC?@QMP@CCLJ?SLGB?BBCRGCKNM BCNCLBCBCJ?AMLQ
RGCKNMQKSWNPMJMLE?BMQ N CH BC?LRGAMLACNRGTMQ 3?K@GaLQC R?LRCBC?@QMPBdLWBCJLeKCPMBCKMJaASJ?QOSCQCCLASCLRPCLCL
NSCBCLSRGJGX?P@MK@?QBCGLDSQGdL N CH BCGLQSJGL?M KMPDGL? QMJSAGdL CL CJJSE?PBC?@QMPBdL +?AMLQR?LRCBC?@QMPAGdL * )
ASW?TCJMBB?BQCNSCBC?B?NR?P?J?QLCACQGB?BCQBCJN?AGCLRC NSCBCCVNPCQ?PQCAMKMJ?NPM@?@GJGB?BOSCRGCLCSL?KMJaASJ?BC
?@QMP@CPQCCLJ?SLGB?BBCRGCKNM/MPCHCKNJM SL? BC Fw
TEUE 5348'4 GLBGA?OSCCL FQC?@QMP@CP`?NPMVGK?B?KCLRCCJBCJ?QKM
+? P\; >[LGC=; QC SRGJGX? CL DMPK? BC APCK?QWNMK?B?Q N?P? CJ JaASJ?QCLBGQMJSBdLOSCCQR`LBGQNMLG@JCQN?P??@QMP@CPQC +?QC
RP?R?KGCLRMJMA?J BC ?DCAAGMLCQ BCJ?NGCJ +MQD`PK?AMQJGNMQMJS KGTGB? BC ?@QMPAGdL R = H) CQ CJ RGCKNM OSCR?PB? CL PCBSAGPQC
@JCQQC BGDSLBCL@GCL NCPM QGCJD`PK?AM CQFGBPMQMJS@JCWCQR`L ? J? KGR?B CJ LeKCPM BC KMJaASJ?Q OSC OSCB?L NMP?@QMP@CPQC
?DCAR?B?QJ?QA?N?QNPMDSLB?QBCJ?NGCJ JJCE?P`KCHMPNMPMRP?QTb?Q WCQJ?GLTCPQ?BCJ?AMLQR?LRCBC?@QMPAGdL
|z
.<::@WD P J L C H = C J C I M A ? H ? L ; F ? M > ? ; = = C ^ H > ? F I M @ Z L G ; = I M
9MUl x j Jp s m U m 4"= # )N C Q M " ( )

D
4" #yNCQM "(y
/MPJMR?LRM AS?LRM K`Q P`NGB?QC? J??@QMPAGdL BCSLD`PK?AM
K?WMPQCP` QS AMLQR?LRC BC ?@QMPAGdLWKCLMPQS QCKGTGB? BC $J 4"BCNCLBC LM QMJMBC JMQ NPMACQMQ BC ?@QMPAGcL QGLMR?K@G`L BC
CJGKGL?AGcL FMP? @GCL AS?LBM J? CJGKGL?AGcL QC K?LRGCLC AMLQR?LRC
?@QMPAGdL
AMKN?P?AGcLBCJ?Q_PC?QCLCJKGQKMN?AGCLRC WJ?BMQGQNMPTa?CVRP?T?Q
ASJ?PCQGES?J?J?GLRP?TCLMQ? J?QT?PG?AGMLCQBC 4"PCDJCH?LJ?QBGDCPCLAG?Q
3GNMQ BC AGL`RGA? BC ?@QMPAGcL +? ?@QMPAGcL NSCBC QCP BC MPBCL
CL J?A?LRGB?B?@QMP@GB?
MBCNPGKCPMPBCL WBC MPBCL $L J? :;LHK<BYG=>HK=>G J?TCJM
AGB?B BC ?@QMPAGcL BGQKGLSWCAML J? A?LRGB?B BCD_PK?AM OSCOSCB? NMP
?@QMP@CPQCW NMPJMR?LRM CJ LdKCPMBC KMJÀSJ?Q OSCQC?@QMP@C CL J? 4"=
D
SLGB?B BCRGCKNM BGQKGLSWC AML CJ RGCKNM BCDMPK? CVNMLCLAG?J $QR? 4"
ASPT? CVNMLCLAG?J NSCBC PCNPCQCLR?PQC AMKM SL? PCAR? QG QC PCNPCQCLR?L
J?Q AMLACLRP?AGMLCQCL SL? CQA?J? QCKGJME?LRKGA? QGCLBM J? AMLQR?LRC
BC?@QMPAGcL J? NCLBGCLRC BC BGAF? PCAR? DGE $QA?P?ARCPaQRGA? BCJ?
K?WMPa?BCJ?QDMPK?QD?PK?A`SRGA?QCLJ?QOSCJ?RMR?JGB?BBCJ?QKMJÀSJ?Q
UETE /-!15/ !&/ &41/-&&+&
?BKGLGQRP?B?QCQR_LGLGAG?JKCLRCBGQNMLG@JCQN?P??@QMP@CPQC WBGQKGLSWCL +?<CI>CMJIHC<CFC>;>BCSLD`PK?AMGLBGA?J?TCJMAGB?BWJ?A?LRGB?B
?KCBGB? OSCQCT?L?@QMP@GCLBM BCJ?DMPK?GL?JRCP?B?BCSLD`PK?AMOSCJJCE??J?AGPASJ?AGdLQGQ
$LJ?:;LHK<BYG=>HK=>G* CJLdKCPMBCKMJÀSJ?QOSCQC?@QMP@CCL RaKGA?W NMPJMR?LRM CQR`BGQNMLG@JCN?P??AACBCP?JMQRCHGBMQW
J?SLGB?BBCRGCKNMNCPK?LCACAMLQR?LRCBSP?LRCRMB?MJ?K?WMPN?PRCBCJ NPMBSAGPSLCDCARM -MQMJMBCNCLBCBCJMQNPMACQMQBC?@QMPAGdL
NPMACQMBC?@QMPAGcL $QA?P?ARCPaQRGA? BCDMPK?QBC ?BKGLGQRP?AGcL AMKM
NPMNG?KCLRCBGAFMQ QGLMR?K@GaLBCJMQNPMACQMQBCJG@CP?AGdLBC
J? NCPDSQGcL GLRP?TCLMQ? AMLRGLS? J? ?BKGLGQRP?AGcL BC E?QCQ?LCQR`QGAMQ
J?DMPK?D?PK?AaSRGA?WBCJ?CJGKGL?AGdLNPCQGQRaKGA?DCLdKCLM
JMQ NPCN?P?BMQ BC?@QMPAGcL K?LRCLGB? GLRP?KSQASJ?PCQ QS@ASR_LCMQ M
B`PKGAMQ WJMQNPCN?P?BMQMP?JCQBCJG@CP?AGcL JCLR? CL J?QOSCCJLdKCPM
NPGKCPN?QM +? @GMBGQNMLG@GJGB?B RGCLC K?WMPGLRCPaQ AJbLGAM
BCKMJÀSJ?QBGQNMLG@JCQLMBGQKGLSWCAMLCJRGCKNM W?OSCJ?QKMJÀSJ?Q OSCJ??@QMPAGdLNPMNG?KCLRCBGAF? WCQF?@GRS?J OSCAS?LBMQC
?@QMP@GB?QQML PCNSCQR?QBCQBCCJBCNcQGRMTDGE F?@J? BCJ?q?@QMPAGdLr BCSLD`PK?AM QCBCQAPG@? PC?JKCLRC QS
@GMBGQNMLG@GJGB?B+?A?LRGB?B?@QMP@GB?QSCJCT?JMP?PQCKCBG?LRC
+?=;HNC>;>;<MIL<C>;CQGES?J?J?BMQGQ?BKGLGQRP?B?NMPJ?DG?A CJ 4"BCAMLACLRP?AGMLCQNJ?QK`RGA?QWCVNPCQ?PQCKCBG?LRCJ?D
AGdLBC?@QMPAGdL J?TCJMAGB?B BC ?@QMPAGdL QCT?JMP? NMPJ? DMPK? BCCQ?ASPT?CV
NPCQ?B?NMPJ?AMLACLRP?AGdLK`VGK? "== WCJRGCKNMCLOSCQC
"?LRGB?B?@QMP@GB?#D ?JA?LX?R=== DGE +?@GMBGQNMLG@GJGB?BBCNCLBCBCJ?Tb?BC
?BKGLGQRP?AGdLWBC J?DMPK?D?PK?AaSRGA?SRGJGX?B?Q NCPM NSCBC
);@L;==C^H>?;<MIL=C^H<CI>CMJIHC<F?D CQJ?DP?AAGdLBCJ?BMQGQ?B T?PG?PBCSLMQGLBGTGBSMQ?MRPMQAS?LBMF?W?D?ARMPCQOSC?JRCPCL
KGLGQRP?B?OSCJJCE??J?AGPASJ?AGdLQGQRaKGA?CLDMPK?GL?JRCP?B? J??@QMPAGdL +?<CI>CMJIHC<CFC>;>;<MIFON;QCA?JASJ?AMKN?P?LBMCJ
"S?LBMCJD`PK?AMQC?BKGLGQRP?NMPTb?GLRP?T?QASJ?P J?DP?AAGdLBC 4"BCSL?DMPKSJ?AGdLCVRP?T?QASJ?PAMLJ?BCJ?Tb?GLRP?TCLMQ?
?@QMPAGdLCQSLMWJ?A?LRGB?B?@QMP@GB?CQGES?J?J?BMQGQ?BKGLGQ +?<CI>CMJIHC<CFC>;>L?F;NCP;QCA?JASJ?AMKN?P`LBMJ?AMLJ?BCSL?
RP?B? /MPAS?JOSGCPMRP?Tb?CQNMQG@JCOSC J?A?LRGB?B?@QMP@GB? DMPKSJ?AGdLCVRP?T?QASJ?PBCPCDCPCLAG?WQC?NJGA?N?P?AMKN?P?P
QC?GLDCPGMP?J?BMQGQ?BKGLGQRP?B? BC@GBM?J?NPCN?P?AGdLD?PK? SL?Tb?BC?BKGLGQRP?AGdLCVRP?T?QASJ?PAMLSL?BCPCDCPCLAG? SL?
AaSRGA?W? J? CJGKGL?AGdLNPCQGQRaKGA? +?DP?AAGdLBC?@QMPAGdL NPCN?P?AGdLD?PK?AaSRGA?AMLMRP?BCPCDCPCLAG?MSLECLaPGAMAML
T?Pb?WCQCQNCAbDGA? BC A?B?DMPK?D?PK?AaSRGA?WBC A?B?Tb?BC CJD`PK?AMMPGEGL?J
?BKGLGQRP?AGdLSRGJGX?B?Q
+?A?LRGB?B?@QMP@GB?QSCJCCVNPCQ?PQCKCBG?LRCCJUK>:;:CHE:<NKO: 4"
BCAMLACLRP?AGMLCQNJ?QK_RGA?Q $QR? _PC? QSCJCA?JASJ?PQCNMPCJ K`RMBM
RP?NCXMGB?J?N?PRGPBCJ?QAMLACLRP?AGMLCQNJ?QK_RGA?QM@RCLGB?Q?BGDCPCLRCQ
RGCKNMQ BC J? ?BKGLGQRP?AGcL GLRP?TCLMQ? M CVRP?T?QASJ?PBCJD_PK?AM +?
DP?AAGcLBC?@QMPAGcLQCM@RGCLCBGTGBGCLBMCJ 4"M@RCLGB?RP?QJ??BKGLGQ
RP?AGcL CVRP?T?QASJ?P 4"= NMPJ? M@RCLGB? NMPTa? GLRP?TCLMQ? 4")
RCLGCLBM CL ASCLR? J? BMQGQ?BKGLGQRP?B? NMPA?B? Ta?WCJ ?AJ?P?KGCLRM
"J BCJGLBGTGBSM

($3-/.
%GESP? (LDJSCLAG? BC J?QT?PG?AGMLCQ CL J? @GMBGQNMLG@GJGB?B BC SL
D_PK?AM QM@PC J? GLRCLQGB?B W J? BSP?AGcL BC QSQ CDCARMQ $L ? gGWA
J? A?LRGB?B ?@QMP@GB? CQAMKNJCR? W J?Q _PC?Q @?HM J? ASPT? QML GES?JCQ
NCPM J?TCJMAGB?B BC ?@QMPAGcL CQBGQRGLR? GLDJSWCLBM CL CJ AMKGCLXM J?
-W486 GLRCLQGB?BWJ?BSP?AGcLBCJCDCARM $LA J??@QMPAGcLCQR?LJCLR? OSCLM
JJCE???JA?LX?PQCJ?AMLACLRP?AGcLKaLGK?CDGA?X"(5($ $L= J?TCJMAGB?B
%GESP? "GL`RGA?BC?@QMPAGcLBCMPBCL EBG>:KHC:WBCMPBCL.EWG>: BC?@QMPAGcLCQGES?JOSCJ?BC? NCPMJ??@QMPAGcLCQGLAMKNJCR?CJ_PC?
:SNECL PCNPCQCLR?AGcL?PGRK`RGA? WQCKGJME?PaRKGA?! @?HM J?ASPT?CQKCLMP AML PCQNSCQR? P_NGB? NCPMNMAM GLRCLQ?WDSE?X
|{
UEUE &/!26&8+!-&@ #/3,6+&0- !$!-"3&/4

+?@GMCOSGT?JCLAG? BCDGLC J? ?KOCP;F?H=C;@;LG ;=I>H [NC=; CLRPC
BMQNPCN?P?BMQD?PK?AaSRGAMQ CQBCAGP OSCRCLE?LSL?TCJMAGB?B
BC?@QMPAGdLWSL?DP?AAGdLBC?@QMPAGdLJMQSDGAGCLRCKCLRCQGKG
J?PCQAMKMN?P??QCESP?POSCRCLBP`LJ?KGQK?CDGA?AG?WQCESPGB?B
+MQCQRSBGMQBC@GMCOSGT?JCLAG?QMLSLRGNMCQNCAG?JBCCQRSBGMQBC
J?@GMBGQNMLG@GJGB?BCLJMQOSCCJM@HCRGTMLMCQBCKMQRP?POSCSL
D?ARMPKMBGDGA?BCDMPK?QGELGDGA?RGT?J??@QMPAGdLBCJD`PK?AM QGLM
OSCJ?@GMBGQNMLG@GJGB?BCQQSDGAGCLRCKCLRCQGKGJ?P2CSRGJGX?LN?P?
CTGR?PRCLCPOSCPCNCRGPJMQCLQ?WMQAJbLGAMQBCCDGA?AG?WQCESPGB?B
/MPCHCKNJM QG BGAFMQ CLQ?WMQ QC F?L FCAFM AML R?@JCR?QWQC ($,/.
OSGCPCLAMKCPAG?JGX?PA`NQSJ?Q QCTCPGDGA?OSCJ?QA`NQSJ?QRGCLCL %GESP? (LDJSCLAG? BC J? Ta? BC ?BKGLGQRP?AGcL W BC J? NPCN?P?AGcL
J? KGQK? @GMCOSGT?JCLAG? OSC J?Q R?@JCR?Q 3?K@GaL QC SRGJGX?L D?PK?A`SRGA?QM@PCJ?ASPT?BCAMLACLRP?AGMLCQNJ?QK_RGA?QBCSLD_PK?AM
N?P?T?JGB?PSLECLaPGAMW B?B?J??KNJG?SRGJGX?AGdL?ARS?JBCJMQ
ECLaPGAMQ CQGKNMPR?LRCAMLMACPQSQAMLBGAGMLCQWA?P?ARCPbQRGA?Q
?JRCP?AGMLCQBCJ??@QMPAGdL R?LRMNMPTb?MP?J BC@GBM
/?P? BCKMQRP?PJ? @GMCOSGT?JCLAG? QC ?BKGLGQRP?L JMQ BMQ NPCN?P?BMQ BC ??JRCP?AGMLCQCLCJN'WCLJ?KMRGJGB?BGLRCQRGL?J AMKM
DMPK? ?JC?RMPG?WAPSX?B? ? SLEPSNMBCQSHCRMQWQCAMKN?P?L CJ 4" J? NMPTb?GLRP?KSQASJ?PMQS@ASR`LC?NMP?JRCP?AGMLCQBCJDJSHM
WQGR== OSCBC@CLQCPoBCJNPCN?P?BMBCPCDCPCLAG?$LAMLAPCRM Q?LESbLCM T A?N m +??@QMPAGdLBCJMQD`PK?AMQNMPTb?
QCA?JASJ?LJMQGLRCPT?JMQBCAMLDG?LX??J OSCBC@CLCQR?PCLRPC W MP?JNSCBC?JRCP?PQCCLNPCQCLAG?BC?JGKCLRMQMBC?JEeL
BCJNPCN?P?BMBC PCDCPCLAG? +?QBGDCPCLAG?QCL J? A?LRGB?B?@QMP@GB? AMKNMLCLRCAMLAPCRMBCJMQ?JGKCLRMQ AMKM J?QEP?Q?Q
NPMBSACLBGDCPCLAG?QCLCJ 4"WJ? KGCLRP?QOSCJ?QBGDCPCLAG?QCL J?
+MQ;FCG?HNIMQdJGBMQPCRP?Q?LCJN?QMBCJMQKCBGA?KCLRMQ
TCJMAGB?BBC?@QMPAGcL NPMBSACL BGDCPCLAG?QCL J? WCJR==
BCJCQRdK?EM?JBSMBCLMW NMPJMR?LRM CJAMKGCLXMBC
"S?LBMQCAMKCPAG?JGX?SLLSCTMD`PK?AM QCPCNCPASRCLJMQE?QRMQ QS?@QMPAGdL BCK`Q NSCBCLPCBSAGPM ?SKCLR?PJ?A?LRGB?B
BCGLTCQRGE?AGdLBCJ BCQ?PPMJJM BCCQCD`PK?AMCLQSAMQRC /MPJM ?@QMP@GB? R?@J? R?K@GaLNSCBCLLM?JRCP?PJ? PCRP?Q?PJ?
R?LRM CJ AMQRCPC?JWCJNPCAGMBCTCLR?QMLLMR?@JCKCLRCK?WMPCQ MGLAJSQM?SKCLR?PJ? +?GKNMPR?LAG?BCCQR?GLDJSCLAG?CQ
OSCJMQBCD?@PGA?AGdL #SP?LRCSLRGCKNM J?N?RCLRCCTGR?OSCCQC KSWT?PG?@JCWAMLDPCASCLAG?AJbLGA?KCLRCGPPCJCT?LRC NMPJM
LSCTMKCBGA?KCLRMQC?D?@PGA?BMNMPMRP?QAMKN?cb?Q "S?LBMQC OSCQCNPCDGCPC?BKGLGQRP?PJMQKCBGA?KCLRMQAMLJ?QAMKGB?Q
?A?@?J?N?RCLRC MRP?QAMKN?cb?QNSCBCLD?@PGA?PCJKCBGA?KCLRM N?P?KCHMP?PCJASKNJGKGCLRMRCP?NaSRGAM AMLJ?CVACNAGdL
AMLJ?KGQK?NPCN?P?AGdLD?PK?AaSRGA?OSCCJMPGEGL?J $QRMQKCBG BC?JESLMQD`PK?AMQ AMKMJ?GQMLG?XGB? J?PGD?KNGAGL? J?
A?KCLRMQA?H[LC=IMQMLK`Q@?P?RMQ NMPOSCLMLCACQGR?LBCKMQRP?P NCLGAGJGL?M J?QRCRP?AGAJGL?Q OSCBC@CL?BKGLGQRP?PQC g F
OSCCJD`PK?AM CQ CDGA?XWQCESPM NCPM BC@CL BCKMQRP?POSC QML ?LRCQBCJ?QAMKGB?Q /MPCJAMLRP?PGM J?@GMBGQNMLG@GJGB?B
@GMCOSGT?JCLRCQ CQBCAGP OSCNPMBSACL 4" "===WR>===CQR?BbQRGA? BCJQ?OSGL?TGPWBCMRPMQD`PK?AMQOSCQMLNMAMQMJS@JCQMQC
KCLRCQGKGJ?PCQ g e PCQNCARM?JD`PK?AMMPGEGL?J M@GCLOSC CL ?BKGLGQRP?LCLDMPKSJ?AGMLCQNMAMQMJS@JCQKCHMP?AS?LBM
N?AGCLRCQCLRP?R?KGCLRMAPdLGAM NCPKGRCLA?K@G?PBCSLNPCN?P?BM QC?BKGLGQRP?AML?JGKCLRMQ W?OSC?SKCLR?CJRGCKNMCLCJ
?MRPMQGLOSCA?K@GCJ?AMLACLRP?AGdLNJ?QK`RGA?MCJLGTCJCQR?@JC OSCNSCBCLBGQMJTCPQC
@ #;=NIL?MJ;NIFÂC=IM +??@QMPAGdLMP?JNSCBC?JRCP?PQC
$L?JESL?QCLDCPKCB?BCQCQKSWGKNMPR?LRC?QCESP?POSCLMQCNPMBSXA?L AS?LBMF?WTdKGRMQ BG?PPC?WCLDCPKCB?BCQBGECQRGT?Q
A?K@GMQCL CQR?QAMLACLRP?AGMLCQNJ?QK_RGA?QCQR?@JCQ NMPOSCNPMBSAGPa?L OSC?JRCPCLCJT?AG?BME`QRPGAM CJRP`LQGRMGLRCQRGL?JMJ?
GLCDGA?AG?MRMVGAGB?B#C@CRCLCPQCCLASCLR?OSCQGQCA?K@G?BCSLECL`PGAM QSNCPDGAGCBC?@QMPAGdL $LECLCP?J BGQKGLSWCJ?TCJMAGB?B
?MRPM J?BGDCPCLAG?CLRPC?K@MQNSCBCQCPRCcPGA?KCLRCBCF?QR? SL MJ?A?LRGB?B?@QMP@GB? NCPMF?WCLDCPKCB?BCQBGECQRGT?Q
BCK_Q NSCBCF?@CPBGDCPCLAG?QCLRPCSLMQJMRCQBCKCBGA?KCLRMQWMRPMQ
OSCNSCBCL?SKCLR?PJ??@QMPAGdLBC?JESLMQD`PK?AMQ
$LCQRMQA?QMQNSCBCQCPLCACQ?PGMBCKMQRP?POSCJ?QBGDCPCLAG?QCLRPCJMRCQ
QML KaLGK?QM?QCESP?PSL?@GMCOSGT?JCLAG?RCP?N`SRGA? /MPTb?GLRP?KSQASJ?PWQS@ASR`LC?QMLGKNMPR?LRCQJ?Q
+? ;BH>JNBO:E>G<B: M>K:IVNMB<: GKNJGA? SL? T?JMP?AGcL BC J? CDGA?AG? W ?JRCP?AGMLCQOSCNPMBSACLJ?GLQSDGAGCLAG?A?PBb?A?WCJQFMAI
RMJCP?@GJGB?B/MPCHCKNJM QGN?P?SL??KGEB?JGRGQCQRPCNRMAcAGA?QC?BKGLGQ FCKMBGL`KGAMNMPPCBSAAGdLBCJDJSHMQ?LESbLCM T A?N
RP? F?@GRS?JKCLRCSL?BMQGQBCNCLGAGJGL? fe TCACQK?WMPBCJ? LCACQ?PG? A #;=NIL?MC;NLIA[HC=IM '?WLSKCPMQ?QGLRCP?AAGMLCQOSC
CQNMQG@JCOSCSL?DMPKSJ?AGcL LM@GMCOSGT?JCLRCAMLJ? KGR?B BC@GMBGQ NSCBCL?DCAR?P?J??@QMPAGdL BGPCAR?KCLRCNMPDMPK?AGdL
NMLG@GJGB?BQGE?QGCLBMCDGA?X /MPCJAMLRP?PGM CLCJA?QMBCD_PK?AMQAML BCNPCAGNGR?BMQOSCGKNGBCLJ??@QMPAGdL MGLBGPCAR?KCLRC
SL aLBGAC RCP?N`SRGAM NCOSCbM AMKM J? AGAJMQNMPGL? BGDCPCLAG?Q BC SL NMPNPMBSAGPA?K@GMQCLCJN' CJT?AG?BME`QRPGAM CJRP`LQGRM
NSCBCLQCPRCP?N`SRGA?KCLRCGKNMPR?LRCQ$LECLCP?J JMQECL`PGAMQ GLRCQRGL?JMCJDJSHMQ?LESbLCM T A?N +MK`QDPCASCLRC
QML K_Q ?BCAS?BMQ N?P? JMQD_PK?AMQAML aLBGACQRCP?N`SRGAMQEP?LBCQ
CQOSCCQRMQD?ARMPCQPCBSXA?LJ?TCJMAGB?BBC?@QMPAGdL
WKCLMQN?P?JMQD_PK?AMQAML aLBGACQRCP?N`SRGAMQNCOSCbMQAMKM?LRG?
PPaRKGAMQ ?LRGCNGJ`NRGAMQ GLKSLMQSNPCQMPCQ FCN?PGL?QSMNGMGBCQ$QRMLM
BGQKGLSWCLBMJ?AMLACLRP?AGdLK`VGK?W?J?PE?LBMCJ
QGELGDGA?OSCLMQCNSCB?SRGJGX?PSLECL`PGAM NCPMLMQCBC@CL?QSQRGRSGPSL RGCKNMCLOSCCQR?QC?JA?LX? JMOSCNSCBCPCBSAGPJMQCDCARMQ
ECL`PGAMNMPMRPMQGL?SRMPGX?AGcLCVNPCQ?BCJK`BGAMNPCQAPGNRMP W?OSCJ?Q BCBMQGQeLGA?QTDGE :@WA< 2GLCK@?PEM AS?LBMQC
BGDCPCLAG?QBCSLECL`PGAM?MRPMNSCBCLQCPGL?ACNR?@JCQN?P?CJN?AGCLRC ?BKGLGQRP?LBMQGQKeJRGNJCQ J?Q?JRCP?AGMLCQCLJ?TCJMAGB?BBC
?@QMPAGdLLMPCBSACLCJLGTCJCQR?@JC NMPJMOSCLMGLDJSWCL
UEVE 5/3!426!+5!3- + 4/3&0- CLJMQCDCARMQBCJMQD`PK?AMQAMLSL?QCKGTGB?J?PE? ?SLOSC
+?QBGDCPCLAG?QCLJ??@QMPAGdLBCJMQD`PK?AMQBCNCLBCL NPGLAGN?J NSCBCLPCBSAGPJMQCDCARMQBCJMQD`PK?AMQAMLSL?QCKGTGB?
KCLRC BCJ?NPCN?P?AGdLD?PK?AaSRGA?WBCJ?Tb?BC?BKGLGQRP?AGdL KSWAMPR?CLJMQOSCCJCDCARMBCNCLB?BCJK`VGKM?JA?LX?BM
DGE NCPMNSCBCQCP?JRCP?B?NMPMRPMQD?ARMPCQ +MQD?ARMPCQOSCPCBSACLJ?A?LRGB?B?@QMP@GB?R?K@GaL
PCBSACLJ?AMLACLRP?AGdLK`VGK?RP?QBMQGQeLGA?Q NCPMLMCJ
? #;=NIL?M@CMCIFÂC=IM $LCJPCAGaLL?AGBM CLCQNCAG?JCLCJ RGCKNMCLOSCQC?JA?LX?TDGE :B< RP?QBMQGQKeJRGNJCQ
NPCK?RSPM BSP?LRCCJCK@?P?XMWCLCJ?LAG?LMNSCBCF?@CP PCBSACLCJLGTCJCQR?@JCW NMPJMR?LRM JMQCDCARMQ T A?N k
||

Absorción de Farmacos

Uploaded by

Copyright:

Available Formats

You might also like

Absorción de Farmacos

Uploaded by

Document Information

Original Description:

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Absorción de Farmacos

Uploaded by

Copyright:

Available Formats

"8HC8:E;DTJ@:8 89IEH:@WD ;@IJH@9K:@WDN<B@C@D8:@WD;<BEI=SHC8:EI 8FUJKBE

3>?I>  $GBJMILPABQO>KPMLOQ>ALOBPAB JBJ?O>K>P

%>J FIF> ABQO>KPML OQ>AL OBP - L J BK@I>QRO> '4&. /OFK@FM>IBPPRPQO>QLPQO>KPML OQ>AL P

:5%7' 0/// !"

,#1   !"! 2SQRP?RMQBC J? EJSAMNPMRCaL? /A?RGMLCQ

A! 3!2$1 !"! zAGBMQ@GJG?PCQ

,1/   L !""  L LGMLCQMPE_LGAMQ AMLHSE?BMQBCEJSR?RGcL

A, 3,1/ !"" LGMLCQ

!"1/,71 !"& ,GRMV?LRPML? BMVMPPS@GAGL? B?SLMPPS@GAGL?

"-3 2+"   -SAJCcQGBMQ?AMNJ?BMQ? -?

-3"/ 2+"   3?SPMAcJGAM?AMNJ?BM? -?

 3 * 2+"  ,CRMRPCV?RMCL CJ PGbcL

."3 2+"   "?RGMLCQMPE_LGAMQ

1%" 2+"  %cJGAM PCBSAGBM

WPCBSACQS?AACQM?XML?QAPaRGA?Q AMKMCJ2-" CJDCRMM JMQRCQRaASJMQ NSCBCL ?JRCP?PJ? $JAMLMAGKGCLRM BC CQR?QA?P?ARCPbQRGA?QNCPKGRC

/MPCHCKNJM QG J? KGR?BBCJD_PK?AMQCBCQRPSWCCLCJGLRCQRGLM J?KGR?BQC

BCQBCJ?JSXGLRCQRGL?J CKNSH?LBM JCLR?KCLRCCJD`PK?AMF?B?CJ T A?N  3?K@GaLQCCKNJC?A?QGQGCKNPCCL DMPK?BCJ;L=B?M

9MUl x j Jp s m U m 4"= # )N C Q M " ( )

UEUE &/!26&8+!-&@ #/3,6+&0- !$!-"3&/4

You might also like

"8HC8:E;DTJ@:8 89IEH:@WD ;@IJH@9K:@WDN<B@C@D8:@WD;<BEI=SHC8:EI 8FUJKBE

3>?I> $GBJMILPABQO>KPMLOQ>ALOBPAB JBJ?O>K>P

:5%7' 0/// !"

,#1 !"! 2SQRP?RMQBC J? EJSAMNPMRCaL? /A?RGMLCQ

A! 3!2$1 !"! zAGBMQ@GJG?PCQ

,1/ L !"" L LGMLCQMPE_LGAMQ AMLHSE?BMQBCEJSR?RGcL

A, 3,1/ !"" LGMLCQ

!"1/,71 !"& ,GRMV?LRPML? BMVMPPS@GAGL? B?SLMPPS@GAGL?

"-3 2+" -SAJCcQGBMQ?AMNJ?BMQ? -?

-3"/ 2+" 3?SPMAcJGAM?AMNJ?BM? -?

3 * 2+" ,CRMRPCV?RMCL CJ PGbcL

."3 2+" "?RGMLCQMPE_LGAMQ

1%" 2+" %cJGAM PCBSAGBM

WPCBSACQS?AACQM?XML?QAPaRGA?Q AMKMCJ2-" CJDCRMM JMQRCQRaASJMQ NSCBCL ?JRCP?PJ? $JAMLMAGKGCLRM BC CQR?QA?P?ARCPbQRGA?QNCPKGRC

BCQBCJ?JSXGLRCQRGL?J CKNSH?LBM JCLR?KCLRCCJD`PK?AMF?B?CJ T A?N 3?K@GaLQCCKNJC?A?QGQGCKNPCCL DMPK?BCJ;L=B?M

9MUl x j Jp s m U m 4"= # )N C Q M " ( )

UEUE &/!26&8+!-&@ #/3,6+&0- !$!-"3&/4