To spruce this is an important cause of acute kidney injury in animals and who he

and. This is a systemic bacterial disease of humans invest again among such as dogs
and were seized and swine and many faces of well this is also one of the most
common diseases transmitted from animals to humans that is this is a zoo or not
it's Since I don't think we've covered spiral kids before let's spend a moment with
the structure of our kids so left to spur is one of your major general it's arity
Taylor leaves of the orders leg Tilly's There's also a parolee have broken spiral
trap of the m r a kids are. Bacteria uniquely spiral model red negative and left a
spider has and the flagellum both heated in the. Area between the outer membrane
and cell that these paraplegic gentle are important for motility support. As I said
they're highly mobile there he'll point you can see the evidence here totally Poil
with shake hands motility which is related to those and the flagellum is associated
with variable it's not a mobile display or are greatly ridges it's their grand I
get here but L.P.'s to look disparate is less toxic Then why it's so they still
have L.P.'s as part of their subsurface but it isn't as sheeple triggering their
play the charger spots as L.P.'s. Let despair are found in aquatic environments
will particularly in warm climates and trouble. So it warm climates with high
rainfall this is a Demick in your ground in most of those countries in temperate
climates this is war season rather than Iraq left despite their systemic infection
many species of mammals they are shed of the urine are affected species and they
are obligate parasites can't replicate outside hopes legislator and have multiple
different sirrah far's I think the last count was 250 syrup. And the syrup doors
are based on an answer to the differences in the O.P.'s that's on her cell surface.
Trying to keep track of those sirrah fours will drive the price so he often hears
the term wet despair in Tara good sense of logic which describes Levy spurs that
can cause disease and. There are many sirrah VARs that are not just there are also
share of ores that are distributed differently in different countries these 6 are
the important ones. Critical to understanding what conspiracists is understanding
of the Easter of our has one or more maintenance as well as incidental it's
maintenance house is the reservoir of. These are animals that are the performer
hosts for a given Ciro of are but once are infected obvious illnesses this point
where they don't generate a quote of anybody to the left is there and that maybe 2
genetic regulation of which antigen are expressed in different. So anybody support
for clearing the seeds without an Avanti ordinance or cysts in the kidneys and
there is a long term shedding of blood just fires in your. Reservoir hosts don't
get very. Often 30 percent or more of the animals in an area are baby infected and
they are the very infectious while term rest. Incidental hosts are the animals that
get sick or miss. So in these and it's basically all mammals except night that's
Host There are certain species that are much more susceptible to certain.
Incidental posts appear disease is incidental host anybody titers generally
increase within the 1st 2 or 3 weeks after exposure and if there's a high enough
and a body tighter before their significant damage the organism can be cleared from
one strain and eventually also from Kit there's little setting in these organisms
and they're not highly infectious transmission to other animals is quite rare you
should know the difference between Nathan's house and incidental hosts this for us
this table outlines maintenance hosts and dental hosts for her 6 Syrah horrors that
are common in the us this is gemma and straight not to. But notice that for example
r.v.o. has a maintenance dose of at home. And humans are incidental. Actually
humans and dogs are incidental hosts for just about every one of these humans are
highly susceptible to let us proceed and so also our will see different words show
up more in horses or in cattle or in school so for elections for us this Yamba
reservoir is a nonsense and the medication is renal tubules the kidneys sometimes
in the genital. Another reservoir is a political environments into which
intimidated urine has been said this could be ponds and rivers it could be one
puddles. More the soil it is but content didn't move you're into getting let
aspires to let just perish Well they can't replicate their can survive for long
periods. Not what just fires are generally killed by Friesan So what are time
you're going to kill them gee hydration or mother that dries up those bottles
you're going to kill them direct sunlight one puddles in bright sun you're going to
kill her just that said ons and rivers are the white margin reservoirs for the
athletes again remember they have to be inside of those animals replicate so
they're being shared into the wet across the floor but not multiplying in.
Transmission the bacteria are shed in urine from those maintenance hosts which
contaminates water and aquatic permits and then the bacteria can enter through skin
breaks or ration in the only down or exposed surfaces on eyes or only if most of
the genital tract or by ingestion Europeans have a good one or so that again that
could be spread through the posts. Bocelli is critical for the organism to ensure
images of us we don't know very well whether this organism and enter through its
half skin it goes through skin breaks or branches or. Water so to tissue which can
kind of damage the skin some studies have said that it can penetrate between host
cells others have said that it can't penetrate through. That's not entirely clear
you're going to find out about we're just corrosive it's not entirely clear but we
do know that if 10 is where it is can penetrate through breaks in the skin or give
us a surface. Transmission it's more common or warm weather and wet weather and. If
you have transmission it now so and acutely affected how can transmit this
organism. Which can infect her calf and infect humans if the asteroid answers they
should doubts. Despite humans have been known to have a register osis from a mother
in breast well to 4 and so once the bacteria penetrate that Morrison skin or a
great skin or mucous membranes children's critical then they are going to spread
through the body via the foot strips you have actually via or not just Harvey and
from there penetrate into a variety of different. We know again the volatility
supports both who are moving into the bloodstream but also who are perceiving taxes
towards things like iron in which the organism so there's human Texas to it in a
book for example and that requires motility and actually for just. Eventually the
bacteria can and let her kidneys genital track and the c.n.c. of the us. Many
surface proteins and lipoproteins have been proposed as he's And she would hear 2
different tissues again then that's his that's in a state. We don't really know
enough we know that there are many redundant. We know that some of them binds to
exercise proteins or fiber Nexen or just certain cell types but the classic study
shows that a particular protein is wired is to genetically knock out that protein
ensure rejection. And that's been a problem up to scrutiny because the genetic
tools are difficult and there are many redundant you may have 5 different surfaces
he's an early into the same extracellular matrix protein so knocking out one isn't
going to greatly reduce virulence that strain there's a lot more to learn about how
up just a little suspenseful. The incubation period once the origin is that gets
into the bloodstream it's roughly $4020.00 days and during this time the bacteria
are going to work and in Tish's this is the acute but disproofs phase and clinical
signs of acute disease occur. In time you can anybody be regions to talk about
that. So during this period the bacteria begin to damage the rescuer in the form
which is going to push off that hemorrhage is damaged the renal tubules resulting
fragments and damage the liver resulted in John. Well just virus tend to have a lot
of different probably is a spectrum I want to have his whole life cases all of
which are likely to contribute to damaged. But dispersed also have surface
molecules that are in 5 religion which blocks white English and cascade which could
lead to excessive bleeding which is one of the big during that or 20 days as in
most incidental post you will start to have an antibody response to the left
despair of the respective antibody response is take $10.00 to $14.00 days to
develop but once that has developed in most incidental posts you're going to see
clearance of the venture once straight up so figures toasts they decide are binding
to anybody which is why I didn't inject the whole surface they're just in the order
ingested the organism and killing it for checks in advance but disposes is not so
you are. However some mortgages are going to have made that anybody responsible for
shifts one location is approximately 2 fields but you can also find factory
persisted long term. In the Army the Marine engineers and other fish. To fields are
a site where there is very minimal antibody or complement presence and that
contributes to long term survival in the kidneys even the presence of animal. In
the bloodstream usually get clearance persistence of the kidneys results of the
carrier state and shedding of Europe for months to years if they can use the length
of time that you get shedding it's a gentle hose is going to vary with the spaces
and the strain. Here's a silver stay. Looking at Forsyth kitty and that silver is
staining the. Barricades like. Them in the. Rocks arguably the unpolluted. Here
this isn't it here it's a chemical stain but disperse for stating bright red and
again this is
showing that our in the renal to feels home in the middle who orders of tubular
and. So the immune response to what disparity is critical to the disease
progression so you've got the organism and the environment and the traits they need
close in some way and it's now in the systemic circulation what happens next
depends. On a body in that new post and if the animals but let's start with the
animals but vaccinated and you have a high or adequate everybody tighter the
organism is going to be named in the blood stream not spread into the tissues and
you don't get credit. If you've got a moderate antibody type or you have mild or
shortened what despite Rabia. The spread into the various fishes but usually mild
or in appearance put it in science and eventually you will eliminate the order to
support his knee and there's really very little shedding here once that gets. In
the systemic circulation in the absence of an ability to get increasing numbers of
organisms they are going to start to cause mass killer damage and thrombosis India
and clinical disease where you could have were no failure to us who had to modify
and potentially death. As the ever body tighter increases then Rod and tissues are
cleared of 1st purchase hours over you can get our Nic to see it's like product
hepatitis but you still have remote And station fetuses very little in the air and
shutting up left to suppliers in Europe that's just carrier state this could be
eliminated with usually go there by Alex so that you could a lemonade the
participant kitty or this could lead to chronic shedding and a body tighter is
critical to what happens it's high tide or could protect low titer does not protect
and it takes time to develop protective and upon me during that time get very very
severe. So in John's Desboro says is usually a cure for Sepic you have had it or
read about 50 or. So in acute disease you'll see either and share friend muscle
tenderness or what. Anorexia. There's often an acute and a zillion damage leading
to vasculitis and throw aside that. Which is going to get manifested as fresh blood
in urine and feces and then. And also in your memberships you're likely to see
kidney damage with acute there for itis with a zip T.V.'s where they did the un
elevated Riyad your ear and acute renal failure this is likely to be something but
probably you're near all Egypt Syria and dehydration and if you disease you may
also see the panic damage elevated liver enzymes severe jock. Your analysis is
likely to show. Area immaterial proteinuria even Tunji is likely to salute the
psychosis of robo centipede media you may see him jump to find this movie out of
this whole area have marriage as well here are just some pictures to illustrate
here you see if you research on the brands here you see thier faces with fresh
blood and while we're in we're in it and you the ictus which is particularly common
in horses as well as. In cattle you can see if you can see is primarily in cans and
see in the near John just and human. Running diseases what problem is over have all
these baby carriers. Ardea abortion and still birth can occur after infection
usually late just station and this is due to feel that. It had to give her also
have mastitis the production of young blood tinge part of it now and you had can't
have transmission of the organism in milk to caps and other current still have a
significant amount of fertility in horses as you can see if you don't feel you're
an infection of the reproductive organs needed to abortion and still her usually
lives late just Station. But one of the most important signs or clinical problems
is furthest orses is if I refer to the I think it's also called lights it's a
leading cause of blindness of course tends to occur months 2 years after infection
it is believed to be mediated by this even 5 into parties so let despair and it's
chins in the eyes but not very prominent you actually find put the square in the
eyes or after infection so the thought is that there's a cross reactivity in
response produced we have an ability to get sleep disperse the rest reacts with
injections of the. Antibiotics don't usually work here because you're looking at a
long term here and speculate rather than. Diagnosis approaches for us it's going to
be down to either via take to tension or kids such as geographic detection in
Europe or. Darkfield microscopy here in Cedars were right if you know sustaining
specific for esoteric specific antibodies. Or by p.c.r. where you're looking for
the presence of some specific antigen of that Sparky culture responsible it's not
how many germs This is a highly infectious organism and one of the groups most
frequently infected our lab techs a more common test is detection of in a body
against a leftist. All standard is a microscopic Naish tests this is widely
available although it needs to be delivered by well trained tax relatively
specific. You need a parent Stuart to show our horizon tighter for Holder more
increase and tighter over one or 2 nice problem is that it requires you to live
much aspire an antigen which is a hazard to the people. And another is that thanks
in a Chicago who hates the interpretation because vaccination is going to church or
a high titer of. That this is the gold standard and every other test that develops
this is a solid case of my success are always compared to the yet. So this is what
at test looks like what you have here is examples of multiple different reactions
this is negative this is a 4 post positive you have lots of pats your presence in
there and they will mate in the presence of them so negative us minus one plus
you're starting to sensible that nation 2 plus 3 plus or. And this is where serial
to full delusions serum were and a body to be able to then come up with that
anybody. Can be prevented by vaccination correct that scenes are primarily back to
in fact seen for the kill. It don't tend to give turn immunity and usually earth
ministry is evidently dumb to receive 2 initial post is 0 point anymore or maybe 70
anymore if you're in on parts of the country where this disease is common on here.
Immunity is 0 for specific need to be sure that the vaccine against Syrian forces
that are prevalent in that area at present in a specific it's solar jobs there's
both are 2 way thanks again Connect 4 and drove home rationality and a 4 way event
if you will have already posted. And which one book is depends on her part of the
country and which sort of large part common in those areas there's a $5.00 and
$6.00 what it will available for can a home that is given before printing trying to
prevent. Acquisition of disease an abortion or still at this point there's no next
100 spices of course you can treatment just for emphasis renal failure and liver
disease are treated with their He answers or death measures as well as into biopics
so in Don's you normal. And some remarks asylum were not Cyclon never. Veterinarian
who is like sugar on this tells you you need to use those are common to a lemonade
celeb to spy Revia That's followed by usually 3 weeks of something like ducks a
cyclon to try to clear the organisms for the kidneys to a limb of a mental carriage
and shut. There are public health concerns with this sort of this this is a major
cause of tsunami disease. In her to killer laboratory workers who like this or
handle what contaminated with us that are Marianne said agricultural workers people
who work in sewage treatment and drainage systems all or attention leave exposed
due to their occupation. Recreationally there's been obstacle operates in the past
few years due to exposure to contaminated freshwater there was an iron man
triathlon we're apparently the water. Temperatures had to swim through was
contaminated and many of the competitors were dispersed lots of different
recreational exposures in water and handlers are also at increased. Incidence of
what this virus is if they have a companion animal that has a disease and is
intentionally shedding the organism or will talk about what distresses or joining
the class tomorrow and it moved here with other causes of the q.b. 50 inch.