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Funda Lec 1ST Week Oxygenation
Funda Lec 1ST Week Oxygenation
STRUCTURES OF RESPIRATORY
SYSTEM:
- Begins at nose and ends at terminal
bronchioles
Anatomy and Physiology of Respiration
- Divided into upper and lower airways
Three Functions: - Upper Airway:
o Nose (nasal cavity)
1. Ventilation – Breathing process
o Pharynx
which may occur naturally
o Larynx
(pulmonary ventilation) or with a
o Epiglottis
help an external device, such as a
ventilator (mechanical ventilation) o Tracheobronchial tree
2. Respiration – Act of breathing - Lower Airway:
3. Perfusion – Higher to lower o includes trachea, R and L
concentration mainstream bronchi, segmental
bronchi, and terminal
bronchioles.
o functions are conduction of air,
mucocilliary clearance, and
production of surfactant.
o Airways are lined with mucous
to trap cells, particles, and
infectious debris.
o Cilia propels trapped material
toward the upper airway to be
removed by coughing or
swallowing.
o adequate fluid intake in needed
for mucous to maintain watery
consistency to move particles.
o Lungs are the main organs of
respiration.
o Each lung is divided into lobes,
right has 3 Lobes, left has 2,
At the end of the terminal bronchioles are
clusters of alveoli.
- They are the site of gas exchange
- walls are made of single layer of simple
squamous epithelium
- allow for gas exchange with capillaries
covering alveoli
- adult has: 300 million alveoli
- surfactant reduces surface tension
between moist membranes of alveoli,
preventing collapse 1. Pulmonary Ventilation:
o Movement of air into and out of
*SURFACTANT – fluid in alveoli lungs
o 2 phases, inhalation and
* About 300 million alveoli are present in the
two lungs, 95% of which are added after exhalation
birth Inspiration- active
phase, Involves
Lungs and thoracic cavity lined with serous movement of muscles
membrane called pleura Expiration- passive
phase, movement of air
- Visceral pleura covers lungs, parietal
out of lungs
pleura lines thoracic cavity.
o Immediately before inspiration,
= two membranes are continuous with
air pressure in lungs is equal to
each other, and form fluid filled sac
that of surrounding atmospheric
- pleural space lies between the two
pressure.
layers, where excess fluid/mucus go
o The pressure in the lungs
- pleural fluid acts as adhesive and
lubricant decreases as the volume
= aids with ease of filling and emptying increases.
of lungs Other factors that contribute to air flöw into
- Pressure within pleural space (intra- and out of lungs:
pleural space) is always sub
atmospheric and keeps the lungs in an o musculature
expanded position. o compliance of lung tissue
o airway resistance
Physiology of Respiratory System:
Lung Compliance is ease with which lungs
Cells require oxygen and removal of carbon
can be inflated and affects lung volumes
dioxide with is a byproduct of oxidation.
Pulmonary ventilation is the movement of - ability of lungs to fill is aided by
air into and out of the lungs. elasticity and surfactant
- emphysema results in decreased
Respiration is the exchange of air.
elasticity and compliance
Perfusion is delivery to tissues.
- airway Resistance = is any obstruction
or impediment of air as it moves
through the airway
- bronchial constriction in asthma is a
form of airway resistance due to
decreased diameter of airways
2. Respiration:
Gas exchange occurs at terminal
alveolar capillary system Diffusion of gases in the lung is influenced
by four factors:
- via diffusion - high concentration to
lower concentration 1. change in surface area available
- the greater pressure of 02 in the alveoli 2. thickening of alveolar capillary
forces the 02 to diffuse into the membrane
unoxygenated venous blood; C02 from
blood to alveoli 3. partial pressure
4. solubility and molecular weight of gas