Innate Immunity 1#pg.

57 - 72
R. A. Maghfirah

1. What is the term that refers to defense mechanisms that are always present,
ready to combat microbes and other offending agents
Innate immunity
2

2. What is the major components of the innate immune system which detect microbes
that have breached epithelia and initiate host responses
eosinophils
neutrophils
macrophages
natural killer cells
c
3

3. What is innate immunity component which combat microbes that have entered the
circulation
tissue sentinel cells
white blood cells
plasma proteins
APC
c
4

4. Mention 2 major type of innate immunity response

Inflammation and antiviral
5

5. This process involve circulating leukocytes and plasma proteins which are
brought into sites of infection in the tissues and are activated to destroy and
eliminate the offending agents#What is the process?
Inflammation
6

6. Which following statement that is CORRECT about innate immunity specificity

The receptor encoded by genes
There are only 2 types of receptors
may recognize nonmicrobial antigens
Nonclonal receptor
d
7

7. What is the term that refers to microbial substance that stimulate innate
immunity and shared by microbe?#(No abbreviation)
PAMP
8

8. Which mitochondrial components that act as DAMP?

ATP
HMGB1
HSP
Monosodium urate
a
9

9. Mention the Stress-induced proteins that act as DAMP (No abbreviation)

Heat Shock Protein
10

10. Mention 2 nuclear protein that act as DAMP (No abbreviation)

High Mobility Group Box 1 (HMGB1) protein, histone
11

11. Which carbohydrate that consider as PAMP in fungi and bacteria?

Glucan
Mannan
LPS
CpG
b
12

12. Which nucleic acid component that consider as PAMP in virus and bacteria?
dsDNA
ssRNA
dsRNA
CpG
d
13

13. Mention 2 proteins that is considered as PAMP in bacteria

Pili and flagellin
14

14. What is the PAMP on the cell wall of Gram negative bacteria?
Lipopolysaccharide
15

15. What is the PAMP on the cell wall of Gram positive bacteria?
Lipoteichoic acid
16

16. The statement that is correct about DAMP, EXCEPT

may indicate sterile injury to cells
released from cells dying by apoptosis
released from damaged and dying cells
released when the healthy cells are damaged
B
17

17. Name the subset of DAMP which its presence can alert the immune system
alarmins
18

18. The cellular receptor for DAMP and PAMP are called... (No abbreviation)
pattern recognition receptors
19

19. Where you can find Nod-Like Receptor?

Cytosol of phagocytes
Plasma membrane and endosomal membranes of DCs
Nuclear membrane of phagocyte
Nuclear membrane of B cell
a
20

20. Which of the following option below that belong to RIG Like Receptor?
MDA-2
Dectin-1 and Dectin-2
AIM2
MDA-5
AIM5

4
21

21. Which PRR that used bacterial and viral DNA as the ligands?
Rig-Like Receptor
Nod-Like Receptor
Cytosolic DNA Sensor
C-type Lectin Receptor
N-Formyl met-leu-phe receptors
3
22

22. Which PRR that used bacterial and fungal Glucans as the ligands?
Rig-Like Receptor
Nod-Like Receptor
Cytosolic DNA Sensor
C-type Lectin Receptor
N-Formyl met-leu-phe receptors

4
23

23. Mention one specific example of scavenger receptor

CD36
24

24. Mention the ligand of Rig-Like Receptor

Viral RNA
25

25. Mentionthe soluble PRR that you can find in alveoli

collectins
26

26. Which of the following example of pentraxin?

C-reactive protein
Mannose-binding lectin
Ficolin
Complement
Surfactant protein
1

27

27. Mention 2 ligands for ficolin

N-acetylglucosamine and lipoteichoic acid
28

28. What is the soluble PRR that used mannose and fructose as its ligand?
collectin
29

29. What is the ligand of C-reactive protein?

 phosphorylcholine
mannose
N-acetylglucosamine
Microbial surface

30. Why innate immune response dont attack normal cell

normal cells do not produce ligands
Because the receptor of immune cells are located in the cell
Normal cells do not express regulatory protein
normal cells do produce ligands
1
31

31. Which of the following TLR that is expressed on endoplasmic reticulum

TLR-1
TLR-2
TLR-5
TLR-6
TLR-7

5
32

32. Mention all type of TLR(s) that used bacterial lipopeptides as ligand
TLR1, TLR2, TLR 6
33

33. Which TLRs that used ssRNA as ligand?

TLR 3 and TLR 6
TLR 7 and TLR 8
TLR 8 and TLR 9
TLR 9 and TLR 3
2
34

34. Which TLR(s) that use dsRNA as it ligand

TLR 3
TLR 7
TLR 8
TLR 9
1
35

35. Which TLR(s) that use CpG DNA as it ligand

TLR 3
TLR 7
TLR 8
TLR 9
4
36

36. TIR are receptor for what kind of cytokines? (specific)

IL-1 and IL-18
37

37. Mention all type of TLRs that response to HMGB-1 and HSP
TLR 2 and TLR 4
38
38. There are between 16 and 28 leucine-rich repeats in TLRs. Each of these modules
is composed of 20 to 30 amino acids that include conserved LxxLxLxxN motifs. N
refers to ...
Asparagine
Nitrogen
Nitrit
Aspartat
Alanin
1
39

39. Name the extracellular protein that binds to the lipid A component of LPS,
forming a complex that then interacts with TLR4 and initiates signaling
MD2 (myeloid differentiation protein 2)
40

40. What are the proteins that associate with TLR to induce innate host response?
MD2 and CD14
41

41. Which of these