Innate Immunity 3#(50Q)#Abbas P.

82-93
By : GE_AWAEH

1. Which is not true about Principal Cellular Targets and Biologic Effects of TNF
cytokines ?##1. Eosinophils: activation#2. Hypothalamus: fever#3. Muscle, fat:
catabolism (cachexia)#4. Endothelial cells: activation (inflammation,#coagulation)#
1. Eosinophils: activation ------- NEUTROPHILS
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2. Name 2 cytokines that has Principal Cellular Targets and#Biologic Effects to

Hypothalamus and cause fever.
TNF, IL-1beta
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3. Which is not true about Principal Cellular Targets and Biologic Effects of IL-6
cytokines ?##1. Liver: synthesis of acute-phase proteins#2. B cells: proliferation
of antibody-producing#cells#3. T cells: TH17 differentiation#4. T cells: TH1
differentiation##
4. T cells: TH1 differentiation
4

4. Name 2 cytokines that has Principal Cellular Targets and#Biologic Effects to

Liver and cause synthesis of acute-phase proteins.
IL-1, IL-6
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5. Which is not true about Principal Cellular Targets and Biologic Effects of IL-1
cytokines ? ##1. Endothelial cells: activation (inflammation,#coagulation)#2.
Hypothalamus: fever#3. Liver: synthesis of acute-phase proteins#4. T cells: TH2
differentiation
4. T cells: TH2 differentiation (TH17)
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6. Name 2 cytokines that has Principal Cellular Targets and#Biologic Effects to NK

cells and T cells and cause IFN-γ synthesis.
IL-12, IL-18
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7. Which one is true below about cytokines that has Principal Cellular Targets
and#Biologic Effects to T cells and cause TH1 differentiation?#1.IL-1, IL-6#2.IL-6,
IL-23#3.IL-12, IL-27#4.IL-12, IL-18#
3. IL-12, IL-27
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8. 7. Which one is true below about cytokines that has Principal Cellular Targets
and#Biologic Effects to T cells and cause TH17 differentiation?#1.IL-1, IL-6#2.IL-
6, IL-23#3.IL-12, IL-27#4.IL-12, IL-18
1.IL-1, IL-6
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9. What cytokine that have Principal Cellular Targets and#Biologic Effects to All
cells and cause increased class I MHC expression?#
Type I interferons
(IFN-α, IFN-β)
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10. What cytokine that have Principal Cellular Targets and#Biologic Effects to T
cells and maintenance of IL-17–producing#T cells?
IL-23
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11. The name of this cytokine derives from its original identification as a serum
substance that cause necrosis of tumor. What cytokine?
TNF
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12. TNF is also called as?

TNF- Alfa
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13. TNF-beta is also called as?

Lymphotoxin
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14. TNF are produced mainly by what?

Macrophages and Dendritic cells
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15. Mention two of TNF receptor!

Type I ( TNF-RI) and Type II (TNF-RII)
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16. TNF production by macrophages is stimulated by what?

PAMPs ( pathogen-associated molecular pattern) and
DAMPs (damage-associated molecular pattern)
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17. What is cytokine that also a mediator of the acute inflammatory response and
has many similar actions as TNF?
IL-1
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18. There is another cytokine in acute inflammatory responses that has both local
and systemic effects. What?
IL-6

It induces the synthesis of acute phase reactants by

the liver, stimulates neutrophil production in the bone
marrow, and promotes the differentiation of IL-17–
producing helper T cells.
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19. The receptor for IL-6 consists of a cytokine-binding#polypeptide chain and a

signal-transducing subunit#that called as?#1. gp 130#2. gp 120#3. gp 41 #4. gp 350#
gp130
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20. IL-6 is a major contributor to#inflammation in several human inflammatory

diseases. Name disease that associated with IL-6.
rheumatoid arthritis
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21. What is cytokine that secreted by DCs and macrophages and stimulates#IFN-γ
production by ILC1s, NK cells, and T cells;#enhances NK cell and CTL-mediated
cytotoxicity; and#promotes differentiation of Th1 cells?#1. IL-10#2. IL- 12#3. IL-
15#4. IL-18
IL-12
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22. What cytokine are antibodies#specific for p40 block?
IL-12 and IL-23

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23. Patients with mutations in the IL-12 receptor#β1 subunit have been described,
and they are highly#susceptible to infections with intracellular bacteria. What
bacteria ?
Salmonella and atypical mycobacteria.
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24. What is cytokine that stimulates growth and functions of ILC1s, NK#cells, and T
cells?#1. IL-10#2. IL- 12#3. IL-15#4. IL-18#
IL-15
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25. What is cytokine that serves as a#survival factor for NK and memory CD8+ T
cells?#1. IL-10#2. IL- 12#3. IL-15#4. IL-18
IL-15
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26. IL-33 are structurally unrelated cytokines produced by#epithelial barrier

cells, as well as other cell types, which#stimulate ILC2s, Th2 cells, and mast
cells to produce what?
IL-4, IL-5, IL-13

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27. TNF and IL-1 also stimulate various cells to secrete#chemokines, such as what?
CXCL8 and CCL2

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28. What is process name that is an active, energy-dependent process of#engulfment

of large particles (>0.5 μm in diameter) into#vesicles?#
Phagocytosis
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29. Name Three classes of microbicidal molecules#are known to be the most

important.
Reactive oxygen species.
Nitric oxide.
Proteolytic enzymes.
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30. What is microbicidal molecules that enzymatically#dismutated into hydrogen

peroxide, which is used#by the enzyme myeloperoxidase to convert
normally#unreactive halide ions into reactive hypohalous acids#that are toxic for
bacteria?
Superoxide
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31. Because#it requires oxygen consumption (cellular respiration), the process by

Reactive oxygen species are produced is called as what?
respiratory burst
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32. What disease called that is caused by an inherited deficiency of one of

the#components of phagocyte oxidase?
chronic granulomatous disease#
33

33. What is the one of the important enzymes in neutrophils?

elastase
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34. Neutrophil extracellular traps (NET) formation#requires citrullination of

histones by an enzyme that called as?#
peptidylarginine deiminase (PAD4)

35

35. What are cytokines that act on the hypothalamus to induce an#increase in body
temperature (fever)?
TNF and IL-1
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36. Name all acute phase#reactants that IL-1 and IL-6 induce hepatocytes to
produced, which are secreted into the blood?
including CRP, SAP, and fibrinogen

37

37. A systemic complication of severe infection, usually#bacterial, clinically

characterized#by fever, fast heart and respiratory rates, metabolic#abnormalities,
and mental disturbances. This#is a syndrome called as what ?
sepsis
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38. IFN-α is in clinical use as an#antiviral agent in certain forms of what viral
infection?
viral hepatitis
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39. IFN-β is used as a therapy for what disease?

multiple sclerosis

40

40. The activation of lymphocytes#requires two distinct signals, the first being
antigen and the second being molecules that are produced during innate immune
responses to microbes or injured cells. This idea is called as what for lymphocyte
activation?
the two-signal hypothesis
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41. IL-1, IL-6, and IL-23 stimulate the differentiation of naive CD4+ T cells to
the T-helper subset of effector cells. What spesific Th?#1. Th1#2. Th2#3. Th17#
3. Th17
42

42. IL-25, IL-33, and TSLP stimulate the differentiation of naive CD4+ T cells to
the T-helper subset of effector cells. What spesific Th?#1. Th1#2. Th2#3. Th17
2. Th2
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43.What is cytokine that stimulates the differentiation of naive CD4+T cells to the
Th1 subset of effector cells?#1. IL-1#2. IL-6#3. IL-12#4. IL-15#5. IL-33
3. IL-12
44

44. What is cytokine that promotes the survival of memory CD8+ T cells?#1. IL-1#2.
IL-6#3. IL-12#4. IL-15#5. IL-33
4. IL-15
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45. What is cytokine that promotes the production of antibodies by activated#B

cells?#1. IL-1#2. IL-6#3. IL-12#4. IL-15#5. IL-33
2. IL-6#
46

46. What is substances that need to be administered#together with purified protein

antigens to elicit#maximal T cell–dependent immune responses?
Adjuvants
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47. What cytokine that is produced by and inhibits#activation of macrophages and

DCs?
IL-10
48

48. Mononuclear phagocytes produce a natural antagonist#of IL-1 that is

structurally homologous to the cytokine#and binds to the same receptors but is
biologically inactive,#so that it functions as a competitive inhibitor of IL-1.#It
is therefore called as what?
IL-1 receptor antagonist (IL-1RA).#

49

49. Secretion of inflammatory cytokines from a variety#of cell types appears to be

regulated by what?
the products of autophagy genes.

50

50. What name of proteins that inhibitors of JAK-STAT signaling pathways linked
to#cytokine receptors?
Suppressors of cytokine signaling (SOCS) proteins
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