SYSTEMIC MYCOSIS

By: SONYA ESTI KHOLIFA

1. What is the temprature for Saprobic phase ?##1. 23 ° C #2. 25° C #3. 27 ° C #4.
29 ° C
2. 25 C
2

2. What is the temprature for Parasitic phase ?##1. 33 ° C #2. 35 ° C #3. 37° C #4.
39 ° C #
3. 37 ° C
3

3. Which fungi that the yeast cells are spherical, hyaline, multinucleated, and
have thick “double-contoured” walls ?##1. Blastomyces dermatitidis#2. Coccidioides
immitis#3. Emmonsia species#4. Paracoccidioides brasiliensis#5. Talaromyces
marneffei##
1
4

4. Which fungi that the infectious conidia are typically “barrel-shaped” and have
an annular frill at both ends ?##1. Blastomyces dermatitidis#2. Coccidioides
immitis#3. Emmonsia species#4. Paracoccidioides brasiliensis#5. Talaromyces
marneffei#
2
5

5. Which fungi that At 25° C colonies grew at a slow to moderate rate, taking on a
cerebriform appearance and becoming light brown with powdery segments over time ?
##1. Blastomyces dermatitidis#2. Coccidioides immitis#3. Emmonsia species#4.
Paracoccidioides brasiliensis#5. Talaromyces marneffei#
3
6

6. What species that has emerged as a prominent mycotic pathogen among HIV-infected
individuals in Southeast Asia ?##1. Blastomyces dermatitidis#2. Coccidioides
immitis#3. Emmonsia species#4. Paracoccidioides brasiliensis#5. Talaromyces
marneffei
5

7. What is the etiologic agent of Blastomycosis ?##1. Blastomyces dermatitidis#2.

Coccidioides immitis#3. Emmonsia species#4. Paracoccidioides brasiliensis#5.
Talaromyces marneffei#
1. Blastomyces dermatitidis
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8. What is the name of this stain ?

Giemsa stain
Blastomyces dermatitidis
9

9.
9. What is the name of this stain ?
Gomori methenamine silver-stain
Talaromyces marneffei
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10. What tissue stained can not visualize the yeast forms from Blastomyces derma-
titidis ?##1. hematoxylin and eosin (H&E)#2. Gomori methenamine silver (GMS)#3.
periodic acid–Schiff (PAS)#4. Gram stain
5
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11. Where is the ecologic niche of B. dermatitidis ?#

decaying organic matter#
12

12. What it the the usual route of B. dermatitidis infection in humans and animals
?#
inhalation of aerosolized conidia produced by the fungus growing in soil and leaf
litter#

13

13. Mention two form clinical illness caused by B. dermatitidis #

pulmonary disease or an extrapulmonary disseminated disease
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14. What is the other sites of B. dermatitidis hematogenous dissemination ,

except ?#1. prostate#2. liver#3. spleen#4. urinary bladder#5. kidney #6. central
nervous system (CNS)#
4
15

15. What disease can resemble subacute or chronic respiratory form of blastomycosis
?#
tuberculosis or lung cancer, with radiographic presentation of pulmonary mass
lesions or fibronodular infiltrates#

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16. What is the organ is the source of cutaneous form of blastomycosis?##1. lung#2.
liver#3. spleen#4. urinary bladder#5. kidney #6. central nervous system (CNS)#
1. lung, in most instances without evident pulmonary lesions or systemic
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17. What is not the stain for direct examination of Blastomycocsis infection
material ?##1. hematoxylin and eosin (H&E)#2. Gomori methenamine silver (GMS)#3.
periodic acid–Schiff (PAS)#4. Gram stain#5. Papanicolau stain##
4
GMS, PAS, Papanicolaou, or Giemsa stains
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18. Which is not the examination for diagnose blastomycosis ?#1. The mycelial form
conversion to the yeast form at 37° C#2. exoantigen testing #3. immunologic
detection of cell-free antigen A#4. nucleic acid probe hybridization.#
1
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19. What is the agent of choice for the treatment of life-threatening or meningeal
disease ?#1. Fluconazole#2. posaconazole#3. voriconazole#4. ketoconazole#5.
Amphotericin B#
Amphotericin B, preferably a lipid formulation

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20. What is not the treatment for those patients unable to tolerate itraconazole ?
#1. Fluconazole#2. posaconazole #3. voriconazole#4. ketoconazole
4
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21. Mention two species caused Coccidioidomycosis#

Coccidioides immitis and C. posadasii

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22. Mention 3 disease has been called Like “the great imitator.”#
syphilis and tuberculosis, coccidioidomycosis

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23. What are the synonyms for coccidioidomycosis ?##

coccidioidal granuloma and San Joaquin Valley fever
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24. What is the name of process of the spherules produce endospores in

Coccidiomycosis?#
by a process known as progressive cleavage

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25. What substance in the environment can enhanced the growth of the Coccidiodes
immitis ? ##
is by bat and rodent droppings.
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26. Where can we found C. immitis ?##1. Water #2. Soil#3. Air#4. Fomite##
2. Soil
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27. What is not the extrapulmonary sites of infection ?##1. include skin#2. soft
tissues#3. kidney#4. bones#5. joints#6. meninges#
3
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29. What is the name of disease caused by Inhalation of only a few Coccidiodes
arthroconidia ?##
produces primary coccidioidomycosis, which may include asymptomatic pulmonary
disease
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30. What temprature for cultured of Clinical specimens from Coccidiodes infection
on routine mycologic media ?#1. 23 ° C#2. 25° C#3. 27 ° C#4. 29 ° C#
2
30

31. What is the treatment for Primary coccidioidomycosis in the third trimester of
pregnancy or during the immediate postpartum period ?#1. Fluconazole#2.
posaconazole#3. voriconazole#4. ketoconazole#5. Amphotericin B##
5
lipid formulation of amphotericin B.
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32. What is the treatment for Chronic cavitary pneumonia ?##

should be treated with an oral azole for at least 1 year
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33. What is the Treatment of nonmeningeal extrapulmonary disseminated infections ?

##
fluconazole or itraconazole
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34. What is the route of transmission of Emmonsia ?#

The likely mode of infection with the “new” species of is by inhalation of fungal
conidia from the environment, similar to that seen with adiaspiromycosis

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35. What is the treatment for Emmonsiosis in the South African patients ?#
amphotericin B deoxycholate followed by itraconazole maintenance therapy

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36. What is the etiologic agent of pulmonary and disseminated infections in the
eastern half of the United States and most of Latin America?##
H. capsulatum var. capsulatum
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37. What is the etiologic agent of skin and bone lesions and is restricted to the
tropical areas of Africa ?#causes predominantly #
H. capsulatum var. duboisii
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38. Where is the natural habitat of the mycelial form of both varieties of H.
Capsulatum?#
is soil with a high nitrogen content, such as that found in areas contaminated with
bird or bat droppings

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39. What is the usual route of infection for both varieties of histoplasmosis ?##
via inhalation of microconidia #Aerosolization of microconidia and hyphal fragments
in the disturbed soil
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40. What is the name of another rare complication of histoplasmosis that result in
massive fibrosis and constriction of mediastinal structures?##
is a condition known as mediastinal fibrosis, in which persistent host response to
the organism may result in massive fibrosis and constriction of mediastinal
structures, including the heart and great vessels
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41. What form of histoplasmosis is marked by fever, weight loss, and malaise ?#
Subacute disseminated histoplasmosis

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42. Which disease that not produce because bone marrow involvement in
histoplasmosis ?##1. anemia#2. neutropenia#3. leukopenia #4. thrombocytopenia
2
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43. What form of histoplasmosis is is a fulminant process most commonly seen in

severely immunosuppressed individuals ?##
Acute disseminated histoplasmosis including those with AIDS, organ transplant
recipients, and those receiving steroids or other immunosuppressive chemotherapy
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44. Mention 2 Antibody detection assays for histoplasmosis#

CF assay and an ID test.#

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45. Mention 2 specimen for enzyme immunoassay to detect Histoplasma antigen ##

serum and urine
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46. What is the treatment for Disseminated histoplasmosis and severe obstructive
mediastinal histoplasmosis ?##1. amphotericin B#2. ketoconazole#3. voriconazole#4.
itraconazole#
1
lipid amphotericin B therapy
46

47. What is the other name of Paracoccidioidomycosis ?#

South American blastomycosis
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48. What is the etiologic agent of Paracoccidioidomycosis ?#1. Blastomyces derma-

titidis#2. Coccidioides immitis#3. Emmonsia species#4. Paracoccidioides
brasiliensis#5. Talaromyces marneffei
4
Paracoccidioides brasiliensis
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49. What animal that documented as natural infection of Paracoccidioidomycosis ?

##
has only been documented in armadillos
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50. What structure that can distinguishes P. brasiliensis from Cryptococcus

neoformans and B. Dermatitidis ?# #
The presence of multiple buds
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51. What is the treatment for Paracoccidioidomycosis ?#1. amphotericin B#2.

ketoconazole#3. voriconazole#4. itraconazole
4
Itraconazole is the treatment of choice for most forms of the disease and generally
must be given for at least 6 months.
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52. What is not the treatment for T. marneffei. Infection?##1. amphotericin B#2.
ketoconazole#3. voriconazole#4. itraconazole #
2
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53. What is the name of this fungi ?# #

Histoplasma capsulatum
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54. What is the name of this fungi ?# #

Blastomyces dermatitidis
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55. What is the name of this fungi ?# #

Paracoccidiodes brasiliensis
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