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Last edited: 9/2/2022

PHARMACODYNAMICS
Pharmacodynamics Medical Editors: Aldrich, Jona & Jude

I) REVIEW QUESTIONS WITH ANSWERS

QUESTIONS ANSWERS

1) Which of the following is TRUE about pharmacodynamics? a) What drug does to the body
a) What drug does to the body
b) What body does to the drug
c) Involves ADME
d) Concerned in first pass effect

2) GABA-A receptors are examples of a) Ligand-gated ion channel receptors

a) Ligand-gated ion channel receptors
b) Intracellular receptors
c) GPCR
d) None of the above

3) Which G-protein is responsible for the breaking down of PIP2 when a) Gq

activated?
a) Gq
b) Gi
c) Gs
d) Gd

4) Ligand-gated ion channel receptors are classified as extracellular a) True

receptors that are related to influx and efflux of ions
a) True Extracellular receptor
b) False o Via second messenger systems work
to be able to stimulate second
messages to produce the cellular
response
Intracellular receptor
o The drug has to be able to move into
the cell and bind onto a intracellular
receptor
o Where it produce a cellular response
via specific cascade of events

5) G-stimulatory proteins work by activating adenylate cyclase in

a) True
order to activate protein kinase A
a) True Once Adenylate cyclase is activated, it
b) False takes ATP and converts it into cAMP
(cyclic AMP)
o cAMP will activate protein kinase A
o Protein kinase A phosphorylates
things

6) Which of the following ligands will not be able to utilize the b) Polar
extracellular receptor pathway
a) Large
b) Polar
c) Hydrophilic
d) Uncharged

7) Which of the following is TRUE about tolerance? d) All the choices are correct
a) Due to chronic exposure to a drug
b) Due to successive stimulation of the receptors
c) Employs the same mechanisms as tachyphylaxis except that it does
not involve inactivation by arrestin
d) All the choices are correct

8) Which of the following is NOT true about tyrosine kinase receptors d) Tyrosine kinase receptors start out as
inactive dimers
a) Its cytosolic domain has tyrosine kinase activity
b) Its extracellular domain is for ligand-binding
c) Tyrosines cross-phosphorylate each other
d) Tyrosine kinase receptors start out as inactive dimers
9) Which of the following is TRUE about drug potency? c) Potency can be measured with EC50
and this is inversely proportional to each
a) The stronger the interaction, the higher the affinity, the less potent
other
the drug is
b) Higher potency usually produces higher efficacy
c) Potency can be measured with EC50 and this is inversely Potency and efficacy are different
proportional to each other concepts. A higher potency does not
d) All of the above necessarily mean a higher efficacy.

10) Which of the following is FALSE about drug efficacy? b) A higher efficacious drug shifts the curve
to the right
a) Efficacy can be measured through Emax
b) A higher efficacious drug shifts the curve to the right
c) Efficacy is dependent upon the drug-receptor interaction and It increases Emax shifting the curve upwards
intrinsic activity of the drug (taller curve)
d) All of the above

11) Which of these drugs should be monitored CLOSELY? c) Digoxin

a) Amoxicillin
b) Bumetanide
c) Digoxin
d) All of the above

12) Partial agonists may act as antagonist a) True

a) True
b) False

13) Competitive agonist decreases Emax b) False

a) True
b) False

14) Which type of drugs that may cause the receptor activity to be c) Inverse agonist
lower than basal activity?
a) Full agonist
b) Partial agonist
c) Inverse agonist
d) Competitive antagonist
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e) Uncompetitive antagonist