Immune Support - The First 24 Hours Stopping

Colds in Their Tracks

Presented by: Dr. Sara Celik, ND

Retail Education Specialist

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 Complimentary Give Away Product
Thank you for attending this educational program!
We are pleased to send you the following complimentary product as a token of our appreciation for taking time out of
your busy schedule to attend this webinar lives (samples will be provided to clients attending the entire LIVE webinar).

SISU
ESTER C – 250MG ORANGE CHEWABLE

( each attendee, attending the LIVE webinar

will receive 2 bottles of these )

To place an order, register for an education event, or any additional questions,

please call your Atrium Innovations representative at 1 (800) 263-5861 or visit
www.atriumpro.ca or www.sisu.com

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Immune Support - The First 24 Hours Stopping
Colds in Their Tracks

Presented by: Dr. Sara Celik, ND

Retail Education Specialist

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Speaker Disclosure

Dr. Sara Celik, ND

I am a paid employee of Atrium Innovations. I have no other conflicts of interest to disclose.

The Company assumes no liability for presenter’s information, whether conveyed verbally or in these materials. All
presentations represent the opinions of the presenter and do not represent the position or the opinion of the Company.
Reference by the presenter to any specific product, process or service by trade name, trademark, or manufacturer does not
constitute or imply endorsement or recommendation by the Company.

Seminars and webinars such as this are for educational purposes only and are intended for licensed health care practitioners.

Practitioners are solely responsible for the care and treatment provided to their own patients. These therapies are not
substitutions for standard medical care. This presentation is intended for North American healthcare practitioners. U.S.
healthcare practitioners, please note, product claims and dosing are in accordance with Health Canada regulations and have
not been evaluated by the Food and Drug Administration (FDA). The information provided by speakers in this educational
program, together with any written material, do not necessarily represent the view of Atrium Innovations and are not intended
as medical advice.

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How Long Can Symptoms Linger with a Typical Cold?

CDC. Accessed November 2, 2023.

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Vitamin C Status in the Common Cold

One study found that leukocyte

vitamin C status was decreased
by 50% during the early stages of
common cold symptoms.

University of Otago, Christchurch Research. Nutrition in Medicine Research Group. Module 3.

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Vitamin C’s Influence on Immunity

Vitamin C influences various pathways of

immunity such as:

• promoting epithelial barrier activity

• migrating white blood cell (WBC) to infected
sites
• controlling growth and function of innate and
adaptive immune cells
• killing microbes via phagocytosis producing
antibodies

Uddin, M et al. Journal of the Egyptian Public Health Association. 96(33):2021.

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Vitamin C: Crucial to Everyday Health

Also plays an important role in numerous other body processes:

• Provides antioxidant support, protecting against free-radical damage associated with the pre-
mature aging of cells

• Promotes the development of healthy bones & connective tissue

• Helps metabolize nutrients

• Maintains normal blood sugar levels by facilitating healthy

glucose metabolism

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Vitamin C Declines Rapidly During Infection and Stress

Phagocytes consume extracellular vitamin C when activated during an immune challenge, causing the
level of vitamin C in plasma and white blood cells to decline rapidly during infection and/or stress 1
1. Stankova L, et al. (1975) Infect Immun 12(2):252–256
2. Mitmesser et al. SpringerPlus (2016) 5:1161

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Not All Vitamin C Is Created Equal

Ester-C® is better tolerated and more effectively absorbed.1, 2, 3

Ester-C® is a form of vitamin C that contains calcium ascorbate and

vitamin C metabolites, including:

• Threonate

• Dehydroascorbate

• 4-hydroxy-5-methyl-3(2H)-furanone

Gruenwald et al. 2006

Ye et al. 2015
Mitmesser et al. SpringerPlus (2016) 5:1161

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Ester-C® Clinical Research

Clinical study: Common cold prevention

Summary

In a placebo-controlled clinical trial, the group

taking 1000 mg of Ester-C® daily had fewer
colds when compared to the placebo group.
Symptom duration was also shorter for the
Ester-C® group (1.8 days) compared to the
placebo group (3.1 days)

Ester-C ® helps reduce the frequency and

# of colds reported Symptom duration reported duration of the common cold
Ester-C® Placebo

Van Straten M, Josling P. Adv Ther. 2002;19(3):151-159.

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Ester-C vs. Other Forms of Vitamin C

AVERAGE INCREASE IN MG PER

24 HRinURINE
Average increase mg per 24 hr urine
200

150

100

50

0
Citrate L-Ascorbate

Value obtained by comparison to baseline

Wright, JV and Suen, RM. Intl Clin Nutr Rev (1990) 10:1

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Gentle on the Stomach

Ester-C is non-acidic and gentle, making it gentle on

the digestive system unlike regular vitamin C.

In one study, 72% taking Ester-C rated very good

and tolerable compared to ascorbic acid
Ester-C® is the better vitamin C for acid-sensitive
people

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 Ester-C® vs. other Vitamin Cs: Clinical Research
Clinical study: Digestive tolerance
(Epigastric adverse effects)
60 Summary
In a randomized, double-blind crossover
50
clinical trial, subjects sensitive to acidic foods
# of adverse sx reported

40
took 1,000 mg of vitamin C (either as Ester-
C® or ascorbic acid). The group taking
30 ascorbic acid reported 66% more epigastric
adverse effects than those subjects in the
20 Ester-C® group.
10

0 Ester-C ® is the better vitamin C for acid-

Ester-C® Asbcorbic acid sensitive people

Gruenwald, Jet al. (2006). Adv Ther 23(1): 171-178.

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Quick Absorption

Better absorbed and more

bioavailable due to the active
vitamin C metabolites only
found in Ester-C.

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 Backed by Science

The patented Ester-C

has been studied for
decades and is better
researched than all
other buffered forms
of vitamin C.

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24 Hour Immune Support

Clinical studies show that

Ester-C increases vitamin C
levels in the body for up to 24
hours.

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Ester-C® vs. other Vitamin Cs: Clinical Research

Clinical study: Assessing concentration of

vitamin C in white blood cells (leukocytes) Summary

In a double-blind, placebo-controlled,
crossover trial, subjects received 1,000 mg of
vitamin C (either as Ester-C® or ascorbic
acid) or a placebo. The concentration change
of vitamin C in white blood cells (leukocytes)
was increased with Ester-C® compared to
ascorbic acid and placebo.

Ester-C ® is retained longer within white

blood cells (leukocytes), providing up to
24 hour immune support

Mitmesser et al. SpringerPlus (2016) 5:1161

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 Why Ester-C®?

1 2 3 4

Quick Absorption 24-Hour Immune Support Gentle on the Stomach Backed by Science

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There’s an Ester-C for Everyone … Even Kids!

Available in capsules, tablets, chewables, powders, and drink mixes

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Ester-C ® 600 - Capsules
Enhanced with antioxidant bioflavonoids from citrus fruits

Ideal for year-round daily use, ideally increasing dosage during cold
and flu season, times of stress or through allergy season.

Enhanced with 100 mg of citrus bioflavonoids, the Ester-C ® formula

supports immune health, and helps maintain strong bones, gums,
and teeth.

Gentle On The Stomach; Sisu Ester-C ® 600 mg is a less-acidic

vitamin C that is gentle on the digestive system.

Superior Absorption; Regular vitamin C is first buffered with

calcium, then a special process transforms it into trademarked Ester-
C that includes key metabolites.

Well Retained; Clinical studies show that Ester-C ® increases vitamin

C levels in the body for up to 24 hours.

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Ester-C ® SUPREME
Enhanced with antioxidant bioflavonoids from berry fruits

Ester-C with arabinogalactan for immune support.

• Citrus-free
• Provides 600mg of Ester-C
• Antioxidant properties from added bioflavonoids and quercetin

Gentle On The Stomach; Sisu Ester-C ® 600 mg is a less-acidic vitamin C that is gentle
on the digestive system.
Superior Absorption; Regular vitamin C is first buffered with calcium, then a special
process transforms it into trademarked Ester-C that includes key metabolites.
Well Retained; Clinical studies show that Ester-C ® increases vitamin C levels in the body
for up to 24 hours.

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 Case Study

Disclaimer - Reference by the presenter to any specific product, process, or service by trade name, trademark, or manufacturer does not constitute or imply
endorsement or recommendation by Atrium Innovations Inc. The information provided by speakers in this educational program together with any written
material does not necessarily represent the view of Atrium Innovations Inc. and is not intended as medical advice. These therapies are not substitutions for
standard medical care. Practitioners are solely responsible for the care and treatment provided to their own patients.

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 Case Study – Poor Sleep & Frequent Colds
Ayda 28 year-old lawyer

High stress levels & difficulty sleeping

Often gets a cold when she gets run down, especially in the Fall
and can be off work for 2 weeks. Congestion gets really bad
and she can’t work.
Doesn’t have time to be sick!

• Currently takes a probiotic with vitamin D that her ND

prescribed her a few years ago

Disclaimer - Reference by the presenter to any specific product, process, or service by trade name, trademark, or manufacturer does not constitute or imply
endorsement or recommendation by Atrium Innovations Inc. The information provided by speakers in this educational program together with any written
material does not necessarily represent the view of Atrium Innovations Inc. and is not intended as medical advice. These therapies are not substitutions for
standard medical care. Practitioners are solely responsible for the care and treatment provided to their own patients.

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Magnesium Relaxation Blend
Restorative combination of magnesium with GABA & L-theanine

*
133 g = 30 servings * all flavours except for honey grapefruit

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 Melatonin
A variety of options to meet every need and preference!

Isomalt is a
natural sugar
substitute – so no
effect on
glycemic index!

Dose ½ to 1 full dropper

1 full dropper = 1 ml = 10 mg
up to 118 servings per
container (5mg dose)

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Melatonin
Fast-dissolving sublingual mint flavored tablets

Improved Rest Aid

• Melatonin can help people with low
melatonin levels fall asleep more easily, sleep
longer and wake up less frequently by
resetting the internal clock disrupted by blue
light exposure, jet-lag or shift work

• Tiny, fast-acting, sublingual tablets flavored

with natural mint, work quickly to improve
sleep quality

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The Power of Melatonin
Produced by the pineal gland in the brain and its secretion is triggered by the onset of darkness

A Few Melatonin Facts:

• Decreased production is associated with chronically elevated stress

levels, as well as in individuals working the night shift, and frequent
travelers (ie. “jet lag”).

• Taken as a supplement, it has been clinically shown to improve

multiple aspects of sleep, from shortening the length of time it
takes to fall asleep to increasing total sleep duration.

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The Power of Melatonin
How does melatonin support healthy sleep?

Melatonin is a natural hormone, synthesized from

tryptophan.
Melatonin helps initiate the onset of sleep as well as the
transition from stage 3 to stage 4 sleep.

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Energy BoostTM with Ester-C ®

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Energy BoostTM with Ester-C ®

Daily vitamin drink mix with 1000 mg of immune-boosting Ester-C®,

energizing B vitamins, and electrolytes for hydration

Immunity Full-body support

Energy Convenience

Hydration 4 grams of sugar

per serving

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Ester-C ® 1000 - Tablets
Enhanced with antioxidant bioflavonoids from citrus fruits

High-dose ideal during cold & flu season, times of stress and
allergy season

Enhanced with vitamin C-rich acerola cherry extract and citrus

fruits as well as 200 mg of bioflavonoids and 25 mg of rutin for
superior immune system support in fewer doses.

Gentle On The Stomach; Sisu Ester-C ® 1000 mg is a less-

acidic vitamin C that is gentle on the digestive system.

Superior Absorption; Regular vitamin C is first buffered with

calcium, then a special process transforms it into trademarked
Ester-C that includes key metabolites.

Well Retained; Clinical studies show that Ester-C ® increases

vitamin C levels in the body for up to 24 hours.

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NAC 600mg

Benefits:

• Relieves symptoms of chronic bronchitis

• Supports the immune system

• Mucolytic activity

• May reduce the severity of tenacious mucus congestion

Target Consumer:

• Those looking to support immune function

• Consumers suffering from respiratory conditions

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Already Sick?
Ester-C Cold & Flu Rescue

• Featuring Ester-C, NAC, Andrographis, and

Echinacea
• Reduces the severity and duration of cold and
flu symptoms when taken within 72 hours of
onset of symptoms

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Case Study #1
Ayda 28-year-old lawyer

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Which One Is Most Cost Effective?

Product Name Average Cost / Product Average Cost / 1000mg

SISU Ester-C 1000mg
$46.99 for 120 tablets $0.39 per tablet

SISU Ester-C 500mg Orange $27.99 for 90 chewable

$0.62 per 2 tablets
Chewable tablets

SISU energy BOOST $17.99 for 30 packets $0.60 per packet

Liposomal Vitamin C $52.99 for 120ml $2.20 per tsp

Liposomal Vitamin C $44.99 for 450ml $1.50 per tbsp

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Who Should Be Supplementing with Vitamin C?

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“I believe vitamin C can fix everything.”
Shawn Mendes

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Upcoming Atrium Innovations Retail Webinar

Join Dr. Phil Rouchotas at 8 pm – 9 pm EST/5 pm-6:00 pm PST on Thursday

Nov 30th – Healthy Liver Healthy Hormones

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Upcoming Atrium Innovations Retail
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Join Dr. Katie Schiavon at

10:30pm – 11:30pm EST/7:30pm -8:30pm PST on Tuesday

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Perimenopause Transition

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9- 9 30pm EST/ 6- 6 30pm PST

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 Thank you for your participation!

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