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  • Práctica 9

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    Paula Flores
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    1. The document presents data on the lethal doses (mg/kg) of aprobarbital and fenobarbital in animals. It shows the dose-response relationship between increasing doses and mortality rates. 2. Regression analysis was used to calculate the linear equations that best fit the dose-response curves and determine the therapeutic index for each drug. 3. The lethal dose 50 (LD50) was calculated for aprobarbital (351.79 mg) and fenobarbital (340.63 mg) based on the regression equations.

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    1. The document presents data on the lethal doses (mg/kg) of aprobarbital and fenobarbital in animals. It shows the dose-response relationship between increasing doses and mortality rates. 2. Regression analysis was used to calculate the linear equations that best fit the dose-response curves and determine the therapeutic index for each drug. 3. The lethal dose 50 (LD50) was calculated for aprobarbital (351.79 mg) and fenobarbital (340.63 mg) based on the regression equations.

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    21 views4 pages

    Práctica 9

    Uploaded by

    Paula Flores
    1. The document presents data on the lethal doses (mg/kg) of aprobarbital and fenobarbital in animals. It shows the dose-response relationship between increasing doses and mortality rates. 2. Regression analysis was used to calculate the linear equations that best fit the dose-response curves and determine the therapeutic index for each drug. 3. The lethal dose 50 (LD50) was calculated for aprobarbital (351.79 mg) and fenobarbital (340.63 mg) based on the regression equations.

    Copyright:

    © All Rights Reserved
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    of 4

    % Hipnosis %Muerte

    Dosis (mg/kg) Aprobarbital Fenobarbital Dosis (mg/kg) Aprobarbital Fenobarbital


    20 5 0 280 0 7
    40 22 0 320 20 31
    60 52 0 360 54 66
    80 80 5 400 85 92
    100 95 42 420 96 98
    120 100 96 440 100 100
    140 100 100

    Dosis (mg/kg)
    1.301029995664
    Aprobarbital
    5
    Aprobarbital
    1.602059991328 22 120
    1.778151250384 52
    100 f(x) = 128.495612560593 x − 170.283229073066
    1.903089986992 80
    2 95 R² = 0.953224671260836
    80
    2.079181246048 100
    2.146128035678 100 60

    40

    20

    0
    1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2 2.1

    Dosis (mg/kg) Fenobarbital


    1.301029995664 0 Fenobarbital
    1.602059991328 0
    120
    1.778151250384 0
    1.903089986992 5 100
    2 42 80
    2.079181246048 96 60 f(x) = 118.803871573959 x − 18
    2.146128035678 100 40 R² = 0.59595688323416
    20
    0
    1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9

    Fenobarbital Linear (Fenobarbit


    Linear (Fenobarbital) Moving average (F
    Linear (Fenobarbital)

    Aprobarbital
    120

    100
    Dosis (mg/kg) Dosis Aprobarbital Aprobarbital
    280 2.44715803134 0 120
    320 2.50514997832 20
    360 2.55630250077 54 100
    f(x) = 550.923851638469 x − 1352.79354
    400 2.60205999133 85 80 R² = 0.986165695622785
    420 2.6232492904 96
    440 2.64345267649 100 60

    40

    20

    0
    2.4 2.45 2.5 2.55 2.6

    Aprobarbital Linear (Apro

    Fenobarbital
    120
    Dosis (mg/kg) Dosis Fenobarbital
    280 2.44715803134 7 100 f(x) = 511.203266177203 x − 1244.493838
    320 2.50514997832 31 R² = 0.982888505192877
    360 2.55630250077 66 80
    400 2.60205999133 92
    420 2.6232492904 98 60
    440 2.64345267649 100
    40

    20

    0
    2.4 2.45 2.5 2.55 2.6

    Fenobarbital Linear (Feno


    índice terapeutico
    Aprobarbital 6.79274
    Fenobarbital 3.746338

    VALORES
    a -170.28
    arbital b
    DE50=(50-A)/B
    128.5

    DE50 1.714241
    DE50 51.78944 mg
    − 170.283229073066

    7 1.8 1.9 2 2.1 2.2

    a -182.69
    Fenobarbital b 118.8
    DE50=(50-A)/B
    DE50 1.9586700337
    DE50 90.922220533 mg

    f(x) = 118.803871573959 x − 182.690697942071


    R² = 0.59595688323416

    5 1.6 1.7 1.8 1.9 2 2.1 2.2

    bital Linear (Fenobarbital)


    enobarbital) Moving average (Fenobarbital)
    enobarbital)

    Aprobarbital A -1352.8
    Aprobarbital B 550.92
    EL50=(50-A)/B
    EL50 2.5462862122
    = 550.923851638469 x − 1352.79354475055 EL50 351.79220501 mg
    0.986165695622785

    2.5 2.55 2.6 2.65 2.7

    Aprobarbital Linear (Aprobarbital)

    Fenobarbital
    A -1244.5
    B 511.2
    EL50=(50-A)/B
    EL50 2.5322769953
    EL50 340.62537309 mg
    11.203266177203 x − 1244.49383853215
    82888505192877

    2.5 2.55 2.6 2.65 2.7

    Fenobarbital Linear (Fenobarbital)

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