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Cherng Et Al. (2007)
Cherng Et Al. (2007)
Cherng Et Al. (2007)
Affiliations:
From the Department of Physical RESEARCH ARTICLE
Therapy, College of Medicine,
National Cheng Kung University,
Tainan, Taiwan (R-JC, C-FL);
Institute of Allied Health Sciences,
College of Medicine, National Cheng Effect of Treadmill Training with
Kung University, Tainan, Taiwan
(R-JC); and Department of Physical
Medicine and Rehabilitation, Chi Mei
Body Weight Support on Gait and
Medical Center, Tainan, Taiwan
(T-WL, R-BH).
Gross Motor Function in Children
with Spastic Cerebral Palsy
Correspondence:
All correspondence and requests for
reprints should be addressed to Rong- ABSTRACT
Ju Cherng, Department of Physical
Therapy, College of Medicine, Cherng R-J, Liu C-F, Lau T-W, Hong R-B: Effect of treadmill training with body
National Cheng Kung University. No. weight support on gait and gross motor function in children with spastic cerebral
1 Ta-Hsueh Road, Tainan, Taiwan palsy. Am J Phys Med Rehabil 2007;86:548 –555.
701.
Objective: To examine the effect of treadmill training with body weight
Disclosures: support (TBWS) on gait and gross motor function in children with spastic
This study was supported by NSC cerebral palsy (CP).
92-2218-E-006-003 and through a
collaboration of National Cheng Kung Design: Eight children with spastic CP participated in the study. Their
University and Chi Mei Medical
Center. temporal-distance gait parameters, Gross Motor Function Measure, mus-
cle tone, and selective motor control were assessed three times: two times
0894-9115/07/8607-0548/0 under their regular therapeutic treatment (condition A), and one time after
American Journal of Physical
Medicine & Rehabilitation
receiving the TBWS treatment in addition to their regular therapeutic
Copyright © 2007 by Lippincott treatments (condition B). There were two treatment schedules, AAB and
Williams & Wilkins ABA. Except for the first one (taken at study entry), the assessments were
always taken after 12 wks of treatment. The children were equally divided
DOI: 10.1097/PHM.0b013e31806dc302
into two groups and randomly assigned to the two schedules. The two
groups were matched according to category of the Gross Motor Function
Classification System.
Results: The TBWS treatment significantly improved the children’s
gait (increases in stride length and decreases in double-limb support
percentage of gait cycle) and their Gross Motor Function Measure (di-
mension D and E scores as well as the total score). No significant
improvements on muscle tone or selective motor control were noted.
Conclusions: The TBWS treatment improved some gait parameters
and gross motor functions in children with spastic CP.
Key Words: Gait Training, Cerebral Palsy, Gross Motor Function, Total Body Weight
Support
sion criteria, but only eight children joined the amount of body weight of suspension was deter-
study program. All of the participants were diag- mined by clinical judgment. The weight was mon-
nosed with spastic diplegic CP, with ages ranging itored to be sufficient to avoid knee collapse during
from 3.5 to 6.3 yrs old. Two children were at level the single-limb support phase and to not hinder
II motor function according to the Gross Motor the swing leg from contacting the floor with the
Function Classification System, which indicated heel first.18 For the children with Gross Motor
that they were able to walk without devices. Six Function class II, the suspension weight needed was
children were at level III. They were moderately minimal, just for the purpose of safety. Treadmill
impaired and needed devices to ambulate (Table 1). speed was adjusted to a comfortable level for each
child and was gradually increased with the improve-
Equipment ment of child’s control. Children were encouraged
Treadmill and Suspension System not to hold the rail, and they freely moved their arms
A commercial treadmill (Trackmaster TM210AC) during gait training. One independent therapist
was used for gait training in this study. The tread- (T.H.) facilitated and corrected the gait pattern of the
mill started at 0.0 mph and gradually increased child while the child was walking on the treadmill.
speed in increments of 0.1 mph. Suspension was The treatment time was 20 min/session, 2–3 sessions/
achieved with LiteGait (LiteGait, Scottsdale, AZ). wk, for a total of 12 wks, in addition to their regular
This system consisted of several parts, including a therapeutic exercise program.
yoke, overhead straps, an adjustable harness, a
base, and an actuator. A harness was provided to Regular Therapeutic Treatment
subjects for weight suspension and safety during The regular therapeutic treatment was individ-
gait training. ually planned according to the child’s needs, ac-
cording to the philosophy of NDT. The treatment
GAITRite Electronic Walkway System program was set to meet each child’s motor func-
The system (GAITRite, CIR. Systems, Inc. tion status before entering the study program. The
Clifton, NJ)contains an electronic walkway, a net- goals of the program were to normalize muscle
work controller, and software. The walkway is a tone, maintain or increase the joint range of mo-
4.6-m-long, 0.9-m-wide, commercially available tion, increase muscle strength, and improve motor
electronic walkway; it contains 13,824 sensors dis- function. The program was 2–3 times/wk, 30 min/
tributed in a 3.6-m-long, 0.6-m-wide, active area. session, and comprised mat exercises of range of
The system outputs are temporal-distance gait pa- motion, stretching, strengthening, and motor
rameters, such as velocity, cadence, stride length, function activities. Gross motor activities included
and others. Excellent reliability of the quantification changing positions, lie to sit, sit to stand, and
of temporal-distance gait parameters (intraclass cor- standing. Movement patterns were of concern, and
relation coefficient between 0.82 and 0.92) was re- exercise was not to induce or exaggerate the ab-
ported.20,21 A high concurrent validity has also been normal movement pattern.
demonstrated in reference to a clinical stride analyzer
and the Vicon Motion Analysis System.20,22 Outcomes Measurement
The outcome measures included muscle tone,
Treatment Program selective motor control, gross motor function, and
TBWS temporal-distance parameters of gait. Muscle tone
TBWS was administered on a treadmill and was measured with the modified Ashworth scale.23
was supported in a LiteGait suspension system. The Selective motor control was measured with the
550 Cherng et al. Am. J. Phys. Med. Rehabil. ● Vol. 86, No. 7
subject sitting on the floor, with hips flexed and dependent variable was a percentage score, the
knees comfortably extended, and with the subject multivariate analysis of variance was not appropri-
able to see his or her feet. The subject was asked to ate. Therefore, we adopted the following analytic
dorsiflex each foot individually to a target. If the strategy, as reported in our previous paper on the
subject was able to dorsiflex his or her ankle with- effect of horse riding on children with CP.30 First,
out hip and knee flexion, a grade of 4 would be we decided that the primary analysis should be the
given; if ankle dorsiflexion was achieved mainly one that compared the children’s performances
using tibialis anterior, but accompanied by hip under the regular treatment and under the exper-
and/or knee flexion, a grade of 3 was scored; if imental treatment. To increase power, we needed
dorsiflexion was achieved using toe extensor mus- to pool the data from the group that received the
cles and some tibialis anterior, a grade of 2 was AAB schedule and the group that received the ABA
scored; if limited dorsiflexion was achieved mainly schedule. This means the second and the third
using toe extensor muscles, a grade of 1 was given; assessments of the AAB schedule and the first and
and a grade of 0 was given when there was no the second assessments of the ABA schedule. But,
movement of ankle dorsiflexion.24 Gross motor before we did that, we had to establish that there
function was measured with the Gross Motor Func- was no effect of simply taking a test twice. There-
tion Measure (GMFM).25 fore, the first analysis that we did was a comparison
The GMFM is a criterion-referenced evaluation of the performance between the first and second
tool designed specifically for children with CP. The assessments for the children who received the AAB
GMFM is composed of 88 test items, categorized schedule. Because the results of the first analysis
into five developmental dimensions: dimensions A showed no signs of a test-taking effect (see the
(lie/roll), B (sit), C (crawl/kneel), D (stand), and E Results section), we conducted the primary analy-
(walk/run/jump). Each item is scored on a four- sis by pooling the data as described above.
point rating scale. Item scores for each dimension We also added a third analysis that examined
are summed together and converted, yielding a the difference between the second and third assess-
percentage score for that dimension. The average ments in the ABA schedule. This analysis would
of the percentage scores for all five dimensions inform us whether a potential experimental treat-
yields a total score.25 Results of studies have pro- ment effect could be sustained after the treatment
vided support for the high internal reliability and had discontinued. The level of statistical signifi-
construct validity of measurement of changes in mo- cance was set at 0.05 for all the analyses.
tor function.26,27 The test–retest reliability and inter-
rater reliability of the GMFM was also established RESULTS
with intraclass correlation coefficients between 0.7
Effect on Temporal Distance of Gait
and 1.0.28,29 Therefore, GMFM was chosen as the
Parameters
outcome measure assessment tool for the study.
The temporal-distance gait parameters measured Table 2 presents the group means, standard
with the GAITRite electronic walkway included gait deviations, and ranges of gait velocity, stride
velocity, stride length, cadence, and double-limb sup- length, cadence, and double-limb support percent-
port time as a percentage of gait cycle. According to age of gait cycle for the two groups at three assess-
the GAITRite operating manual, the velocity was ob- ments. Our first step analysis revealed no signifi-
tained by dividing the distance by the ambulation cant difference in any of the gait parameters
time; it was expressed in centimeters per second. The between the first two assessments for children re-
stride length was defined and measured on the line ceiving the AAB schedule. These results allowed us
of progression between the heel points of two con- to proceed with our primary analysis. The results of
secutive footfalls of the same foot; it was expressed the primary analysis revealed a significant effect of
in centimeters. The cadence was the numbers of the experimental treatment (i.e., TBWS plus regu-
footfalls in a minute. One independent therapist lar therapy) on the stride length (F ⫽ 10.34, P ⫽
took all the measurements and was not involved in 0.0236) and a marginal, significant effect on dou-
therapy; this therapist was not aware of any child’s ble-limb support percentage of gait cycle (F ⫽ 6,
grouping or stage within the study. The study was P ⫽ 0.058) (Fig. 1). No significant change of veloc-
approved by and followed the guidelines of the ity or cadence was noted. Finally, our third analysis
institutional review board of National Cheng Kung revealed no significant difference in any of the gait
University Hospital. parameters between the second and the third as-
sessments for children receiving the ABA schedule.
Data Analysis
Statistical Analytic System (SAS) version 9.1 Effect on Dimension Score of GMFM
for Windows was used for data analysis. Because Table 3 displays the means, standard devia-
the sample size of the study was small, and the tions, and ranges of the dimension scores, and the
Velocity, cm/s
T1 23.49 ⫾ 26.31 3.80–61.10 24.79 ⫾ 34.75 3.37–76.73
T2 24.64 ⫾ 25.09 3.80–60.57 28.42 ⫾ 39.40 4.90–87.30
T3 38.51 ⫾ 47.10 9.77–92.87 29.39 ⫾ 31.67 10.73–76.60
Cadence, steps/min
T1 62.85 ⫾ 40.88 32.10–67.27 66.89 ⫾ 64.76 29.87–37.80
T2 63.63 ⫾ 44.65 30.33–55.93 63.56 ⫾ 60.36 28.77–40.17
T3 71.59 ⫾ 61.95 30.77–41.13 63.91 ⫾ 43.57 38.73–46.30
Stride length, cm
T1 36.21 ⫾ 19.14 18.46–61.59 34.27 ⫾ 16.79 16.27–56.85
T2 40.26 ⫾ 15.46 20.26–56.18 40.63 ⫾ 20.82 21.01–69.61
T3 51.48 ⫾ 23.04 37.70–78.08 47.05 ⫾ 17.49 33.97–71.28
DLS (%)
T1 58.82 ⫾ 26.09 31.77–94.18 60.84 ⫾ 31.39 15.42–87.65
T2 40.05 ⫾ 15.77 20.22–57.72 43.85 ⫾ 20.47 13.53–60.38
T3 26.38 ⫾ 6.47 20.35–33.22 43.95 ⫾ 23.08 13.95–70.22
DLS, double-limb-support time as a percentage of gait cycle.
total score of the GMFM measurement for the two the experimental treatment on the GMFM total score
groups at each assessment. At study entry, the (F ⫽ 52.74, P ⫽ 0.0008) as well as on dimension D
children had an average of score 86.8 or 90.5 on score (F ⫽ 8.4, P ⫽ 0.0338) and on dimension E
dimension A, and 84.8 or 86.3 on dimension B. The scores (F ⫽ 10.62, P ⫽ 0.0225) (Fig. 2). Our third
scores were nearly full scores. Therefore, a ceiling analysis found no significant differences in any of the
effect of dimensions A and B could be expected. GMFM scores between the second and the third as-
Our first step analysis revealed no significant sessments for children receiving the ABA schedule.
difference in any of the dimension scores or the
total score of GMFM between the first two assess- Effect on Muscle Tone, and Selective
ments for children receiving the AAB schedule. Motor Control
Therefore, we proceeded with our primary analysis. The results of the three-step analysis of muscle
The primary analysis revealed a significant effect of tone and selective motor control showed that there
FIGURE 1 Comparison of the treatment effect of TBWS and regular therapeutic treatment on the gait param-
eters. TBWS, treadmill training with body weight support; regular, regular therapeutic treatment;
DLS, double-limb support percentage of gait cycle. * P ⬍ 0.05; § P ⫽ 0.058.
552 Cherng et al. Am. J. Phys. Med. Rehabil. ● Vol. 86, No. 7
TABLE 3 The group means and SD of Gross Motor Function Measure dimension scores, and total
scores for both groups at three measurement times
Group AAB Group ABA
Dimension A
T1 86.8 ⫾ 16.11 62.8–96.1 90.5 ⫾ 4.84 84.3–96.1
T2 88.3 ⫾ 16.02 64.7–100.0 95.1 ⫾ 5.89 88.2–100.0
T3 89.6 ⫾ 11.97 76.5–100.0 97.1 ⫾ 3.73 92.2–100.0
Dimension B
T1 84.8 ⫾ 21.98 52.4–100.0 86.3 ⫾ 7.97 75.0–93.3
T2 86.1 ⫾ 19.11 59.5–100.0 90.4 ⫾ 4.36 86.7–95.0
T3 84.0 ⫾ 23.46 57.1–100.0 87.9 ⫾ 5.82 81.7–95.0
Dimension C
T1 70.3 ⫾ 27.14 33.3–92.9 80.4 ⫾ 9.00 71.4–88.1
T2 71.5 ⫾ 26.49 38.3–100.0 84.0 ⫾ 13.92 66.7–100.0
T3 74.1 ⫾ 23.75 53.3–100.0 77.4 ⫾ 15.60 54.8–90.5
Dimension D
T1 46.2 ⫾ 35.36 5.1–76.9 44.9 ⫾ 22.77 23.1–76.9
T2 43.6 ⫾ 41.98 5.1–87.2 47.4 ⫾ 25.86 25.6–84.6
T3 37.4 ⫾ 41.31 7.7–84.6 40.4 ⫾ 34.05 7.7–87.2
Dimension E
T1 19.5 ⫾ 25.71 0–54.2 26.1 ⫾ 27.01 0–63.9
T2 20.5 ⫾ 24.28 1.4–54.2 30.9 ⫾ 25.89 13.9–69.4
T3 34.3 ⫾ 37.80 9.7–77.8 32.6 ⫾ 27.60 13.9–73.6
Total
T1 61.5 ⫾ 23.78 30.7–83.6 65.6 ⫾ 12.54 54.4–83.1
T2 62.0 ⫾ 23.79 33.8–85.2 69.6 ⫾ 14.01 57.6–89.8
T3 63.9 ⫾ 26.24 40.9–92.5 67.1 ⫾ 16.26 50.7–89.3
FIGURE 2 Comparison of the treatment effect of TBWS and regular therapeutic treatment on the dimension
scores and total score of GMFM. TBWS, treadmill training with body weight support; regular, regular
therapeutic treatment. * P ⬍ 0.05.
554 Cherng et al. Am. J. Phys. Med. Rehabil. ● Vol. 86, No. 7
However, because of the small sample size of the with partial body weight support in nonambulatory patients
with cerebral palsy. Arch Phys Med Rehabil 2000;81:301–6
present study, and the limited number of studies of
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