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Molecular Cell Biology Lodish 6th Edition Test Bank
Molecular Cell Biology Lodish 6th Edition Test Bank
Molecular Cell Biology Lodish 6th Edition Test Bank
4. All the following statements about molecular chaperones are true except
a. They play a role in the proper folding of proteins.
b. They are located in every cellular compartment.
c. They are found only in mammals.
d. They bind a wide range of proteins.
Ans: c
Ans: d
Ans: c
Ans: a
Ans: d
b. ubiquitinylation
c. acetylation
d. glycosylation
e. all of the above
Ans: b
Ans: a
11. Proteases that attack selected peptide bonds within a polypeptide chain are synthesized and secreted as inactive
forms called
a. carboxypeptidases.
b. aminopeptidases.
c. zymogens.
d. a and b.
e. none of the above
Ans: c
Ans: e
13. Protein kinase A is converted from an inactive state to an active state by binding
a. ATP.
b. calcium.
c. cAMP.
d. a and c.
e. all of the above
Ans: c
14. Kinases, which are responsible for the activation or inactivation of a number of proteins, serve to add phosphate
groups onto
a. tryptophan residues.
b. serine residues.
c. cysteine residues.
3-4
d. a and c.
e. none of the above
Ans: b
Ans: a
16. Which of the following methods can separate proteins based on their mass?
a. centrifugation
b. ion exchange chromatography
c. SDS polyacrylamide gel electrophoresis
d. a and c
e. all of the above
Ans: d
17. In two-dimensional gel electrophoresis proteins are first resolved by ______________________ and then by
____________________.
a. IEF; SDS-PAGE
b. SDS-PAGE; affinity chromatography
c. SDS-PAGE; ion exchange
d. IEF; gel filtration
e. SDS-PAGE; Western blot analysis
Ans: a
Ans: b
19. Starting with 1 mCi (milliCurie) of a phosphorus-32-labeled compound, how long would it take until only 0.125
mCi remains?
a. 14.3 days
b. 28.6 days
c. 42.9 days
d. 57.2 days
Ans: c
3-5
Ans: c
21. Describe the types of bonds/interactions that hold together or stabilize the primary, secondary, tertiary, and
quaternary structures of proteins.
Ans: The primary structure of a protein is linked by covalent peptide bonds. The secondary structure is stabilized by
hydrogen bonds between atoms of the peptide backbone. The tertiary structure is stabilized by hydrophobic
interactions between the nonpolar side groups and hydrogen bonds between polar side groups. The quaternary
structure is held together by noncovalent bonds between protein subunits.
22. Many proteins contain one or more motifs built from particular combinations of secondary structure. Describe
the three common structural motifs discussed in this chapter.
Ans: The three structural motifs described in this chapter include the coiled coil motif, the helix-loop-helix motif, and
the zinc finger motif. The coiled-coil motif consists of two or more helices wrapped around one another. The
helix-loop-helix motif consists of two helices connected by a loop that contains certain hydrophilic residues at
invariant positions in the loop. The zinc-finger motif consists of an helix and two strands held together by
a zinc ion in a fingerlike bundle.
23. Describe the mechanism by which the bacterial chaperonin GroEL promotes protein folding.
Ans: The bacterial chaperonin GroEL forms a barrel-shaped complex of 14 identical subunits. A partially folded or
misfolded polypeptide is inserted into the GroEL barrel, where it binds to the inner wall and folds into its native
conformation. In an ATP-dependent step, the GroEL barrel expands to a more open state, which results in
release of the folded protein.
24. What role does aberrant protein folding play in the development of a disease such as Alzheimer’s disease?
Ans: Misfolding of a protein marks it for degradation by proteolytic cleavage. In Alzheimer’s disease, misfolding
and subsequent proteolytic degradation of the amyloid precursor protein generates a short fragment called -
amyloid protein, which changes from an -helical to a -sheet conformation. This aberrant structure aggregates
into highly stable filaments called amyloid plaques that accumulate in the brains of Alzheimer’s patients.
LIBRO DECIMOSESTO
Capitolo
CLXXV. La rivoluzione francese Pag. 1
CLXXVI. Buonaparte in Italia. I Giacobini.
Fine di Venezia 24
CLXXVII. La Cisalpina. Conquista di
Roma, Napoli e Piemonte 63
CLXXVIII. Riazione. I Tredici mesi. Italia
riconquistata. Pace di
Luneville 97
CLXXIX. Buonaparte ordinatore. Rimpasto
di paesi. Concordati. Pace di
Presburgo. Regno d’Italia 130
CLXXX. I Napoleonidi a Napoli 194
CLXXXI. Ostilità col papa 213
CLXXXII. Campagne di Spagna e di
Russia. Caduta dei
Napoleonidi 237
LIBRO DECIMOSETTIMO
Capitolo
CLXXXIII. La restaurazione. Il liberalismo.
Rivoluzioni del 1820 e 21 299
CLXXXIV. La media Italia. Rivoluzioni del
1830. 371
CLXXXV. Letteratura. Classici e Romantici. 418
Storia. Giornalismo
CLXXXVI. Scienze morali e sociali 506
CLXXXVII. Scienze matematiche e naturali 534
CLXXXVIII. Belle arti 558
NOTE:
13. Il Gianni era fuggito da Roma dopo l’assassinio di Bassville col Salfi, che
su questo fatto compose un poemetto. A Firenze il Gianni improvvisava
colla Fantastici; e l’Alfieri ammirandolo diceva però che quello non era
improvvisare, ma un comporre in fretta, alludendo al suo lento
declamare.
17. Il pittore Gros ricusò le offerte de’ Perugini, pur promettendo levare sol
due o tre quadri.
18. Era console allora Antonio Onofrio, sul cui mausoleo nella pieve fu poi
scritto Patri patriæ.
19. Raccolta cronologica dei documenti veneti, tom. ii. part. ii.
Vascelli da 70 cannoni Nº 10
Vascelli da 66 » 11
Vascelli da 55 » 1
Fregate da 42 a 44 » 13
Fregate da 32 » 2
Galere » 23
Bombarde » 1
Cutter » 2
Barche cannoniere, armate di un cannone da 4, e »
quattro da 6 16
Brich da 16 a 18 cannoni » 3
Golette da 16 » 1
Galeotte da 30 a 40 remi » 7
Sciabecchi » 7
Feluche » 5
Barche obusiere armate con due obici da 40 o da »
50, e quattro cannoni da 6 31
Galleggianti sulle botti, armati con due cannoni da »
30 10
Passi, armati d’un cannone da 20 o quattro da 6 » 40
Batteria galleggiante di sette cannoni da 50 sul »
perno, detta Idra 1
22. Mutinelli ebbe la pazienza di notare che, negli otto giorni che i quaranta
elettori stettero in conclave per eleggere l’ultimo doge, si spese in pane,
vino, olio, aceto lire 129,421; in pesce 24,410; in carni, polli, selvaggina
23,360; in salami, salciciotti, prosciutti 3980; in confetti e candele di cera
47,660; in vini, caffè, zuccaro 63,845; in frutti, fiori, condimenti 6314; in
masserizie da cucina, legna, carbone 31,851; per guasto di mobili
noleggiati 41,624; per spese minute 108,910; stuzzicadenti 25: tabacco
4931; carte da giuoco 200; altri giuochi 606; berrette di notte 506; calze
e borse di seta nera per la coda 64; tabacchiere 3067; pettini 2150;
essenze 182.
25. Il maresciallo Marmont nel vol. i, p. 36 delle sue Memorie (Parigi 1857),
racconta che i Veneziani mandarono Dandolo ed altri al Direttorio per
lamentarsi del turpe mercato di Buonaparte, e che questo, prevedendo
come un tal passo sarebbe stato la sua ruina, spedì Duroc dietro alla
deputazione, e se la fece condurre a Milano. J’étais (soggiunse) dans le
cabinet du général en chef quand celui-ci les y reçut: on peut deviner la
violence de sa harangue. Ils l’ecoutèrent avec calme et dignité, et quand
il eut fini, Dandolo répondit. Dandolo, ordinairement dénué de courage,
en trouva ce jour-là dans la grandeur de sa cause. Il parlait facilement:
en ce moment il eut de l’éloquence. Il s’étendit sur le bien de
l’indépendance et de la liberté, sur les intérêts de son pays et le sort
misérable qui lui était réservé; sur les devoirs d’un bon citoyen envers
sa patrie. La force de ses raisonnements, sa conviction, sa profonde
émotion agirent sur l’esprit et sur le cœur de Buonaparte au point de
faire couler les larmes de ses yeux. Il ne répliqua pas un mot, renvoya
les députés avec douceur et bonté, et, depuis, a conservé pour Dandolo
une bienveillance, une prédilection qui jamais ne s’est démentie: il a
toujours cherché l’occasion de le grandir et de lui faire du bien: et
cependant Dandolo était un homme médiocre: mais cet homme avait fait
vibrer les cordes de son âme par l’élévation des sentiments, et
l’impression ressentie ne s’effaça jamais. Celui qui pouvait éprouver de
pareilles émotions, et garder de semblables souvenirs, n’était pas
assurément tel que tant de gens ont voulu le représenter.
Questo Dandolo non appartiene all’antica nobiltà: era un chimico, che
salì poi ad alti posti ed ebbe il titolo di conte come senatore del regno.