Professional Documents
Culture Documents
Sun Effect and Number and Level of Emergency Medical Providers On Cardiac Arrest Outcomes
Sun Effect and Number and Level of Emergency Medical Providers On Cardiac Arrest Outcomes
Resuscitation
journal homepage: www.elsevier.com/locate/resuscitation
Clinical paper
a r t i c l e i n f o a b s t r a c t
Article history: Aim: The effect of the number and level of on-scene emergency medical technicians (EMTs) on the out-
Received 14 August 2017 comes of patients with out-of-hospital cardiac arrest (OHCA) remains unclear. We aimed to test the
Received in revised form 24 October 2017 association between the number and level of EMTs and the outcomes of patients with OHCA.
Accepted 19 November 2017
Methods: We analysed Utstein-based registry data on OHCA in Taipei from 2011 to 2015. The eligible
patients were adults, aged ≥20 years, with non-traumatic OHCA who underwent resuscitation attempts.
Keywords:
The exposures were the total number of EMTs or the EMT-Paramedic (EMT-P) ratio >50%. The outcome
Out of hospital cardiac arrest
of interest was survival to discharge.
Emergency medical services
Paramedic
Results: During study period, total 8262 OHCA cases were included, of which 1085 (13.1%) were
Emergency medical technician approached by crews with an EMT-P ratio >50%. While an increase in the number of EMTs on-scene
Advance life support was not associated with better chances of survival (adjusted odds ratio [aOR] 0.98, 95% confidence inter-
Teamwork val [CI] 0.89–1.08), an EMT-P ratio >50% was significantly associated with improved outcome (aOR 1.36,
95% CI 1.06–1.76). Subgroup analyses showed that EMT-P >50% significantly benefited survival in wit-
nessed OHCA cases with non-shockable rhythm (aOR 1.69, 95% CI 1.01–2.58). Survival was the highest
among cases seen by four EMTs with an EMT-P ratio >50% (aOR 2.54, 95% CI 1.43–4.50).
Conclusion: An on-scene EMT-P ratio >50% was associated with improved survival to discharge of OHCA
cases, especially in those with witnessed, non-shockable rhythm. The presence of four EMTs with an
EMT-P ratio >50% at the scene of OHCA was associated with the best outcome.
© 2017 Elsevier B.V. All rights reserved.
Introduction
https://doi.org/10.1016/j.resuscitation.2017.11.048
0300-9572/© 2017 Elsevier B.V. All rights reserved.
J.-T. Sun et al. / Resuscitation 122 (2018) 48–53 49
Therefore, the number and level of EMTs in the field are considered with two EMTs-I, although sometimes there is a third staff member
to influence the outcomes of patients with OHCA [4–7]. (usually a volunteer EMT) in the ambulance.
The number and level of EMTs on the scene for OHCA resus- The ALS team providers are authorised to perform endotracheal
citation is one of possible modifiable factors in OHCA treatment. tube intubation and intravenous injections of resuscitation medi-
However, their effects on outcomes of OHCA patients remain con- cations, like adrenaline, atropine, and amiodarone, as per protocol
troversial [4–6,8]. In a single-tiered system, Kajino et al. found [10]. The ALS providers conduct OHCA re-training for ALS treat-
that the presence of three paramedics (100% paramedic ratio) in ment every year. There are four ALS stations staffed by 120 EMT
resuscitation team was associated with improved favourable neu- paramedics who have completed 1280 h of training as per the
rologic outcomes in the witnessed OHCA group, although there was requirements of the Taiwanese Ministry of Health and Welfare. One
no difference in the 30-day survival [4]. However, Hagiwara et al. ALS station has three ALS ambulances. One ALS ambulance is usu-
showed the opposite, reporting no significant favourable neuro- ally teamed up with two paramedics, while one BLS ambulance is
logical outcomes in the resuscitation group with more than two teamed with two EMTs-I, although sometimes there is a third staff
paramedics (i.e. 66.7–100% paramedic ratio) [8] In a two-tiered member (usually a volunteer EMT) in the ambulance. Taipei has a
system, Eschmann et al. revealed no significant survival benefits single central dispatch centre to process all incoming EMS calls; all
in the group treated by the advanced life support (ALS) team with dispatchers are required to complete 40 h of training on priority dis-
an increasing number of paramedics, but the study did not inves- patch. BLS-D is the universal response for all dispatch calls. For cases
tigate the influence of the total number of EMTs [6]. Another study that meet the ALS dispatch criteria, additional ALS teams would be
conducted by Warren et al. showed a positive association between dispatched to the scene together with BLS-D teams. For an ALS case
the total number of EMTs and survival of OHCA patients, but they that occurs in an area close to an ALS squad, the nearby ALS team
did not consider the number of on-scene paramedics in the resus- would be the first response team to dispatch, and an additional ALS
citation team [5]. team, as opposed to the BLS-D, would be activated if available.
Taking both number and level of on-scene EMTs into considera-
tion is important in evaluating the effect of EMTs on the survival of Study population
OHCA patients because there might be interactions between them,
such as workload or leadership. A sufficient number of EMTs is From 1st January 2011, to 31st December 2015, non-traumatic
essential for the management of OHCA patients. For example, two adult (age ≥ 20) patients with OHCA that activated the EMS teams
EMTs may not be able to perform many treatments and simulta- were included in the study. We excluded patients if they were not
neously maintain a high quality of cardiopulmonary resuscitation transported to the hospital due to obvious death signs, such as rigor
(CPR). Paramedics are usually more skilful and confident in per- mortis, or if the family requested a do-not-resuscitate (DNR) or the
forming OHCA as they have more experience and training, and patient had given pre-existing consent for DNR.
theoretically could be team leaders for on-scene resuscitation.
However, too many paramedics might lead to ambiguous leader-
Definition of exposures
ship, thus threatening the team performance [9]. Proper paramedic
ratios could be an important component of EMS configuration.
The exposures in our study were defined as EMT configuration
Many EMS teams comprise different levels of EMTs, such as EMT-
including the total number of EMTs and a paramedic ratio >50%,
intermediate (EMT-I) and paramedics, but the best paramedic ratio
defined as paramedic proportion among all on-scene EMTs. For the
in prehospital resuscitation is still unknown in both single-tiered
paramedic ratio, we divided the ratio into two categories (>50% vs
and-two-tiered systems [4,8].
≤50%) because this was more practically applied by the dispatch
This study aimed to evaluate the effect of the number and level
centre.
of on-scene EMTs on the outcomes of OHCA patients. We hypoth-
esized that more than two EMTs and a paramedic ratio >50% for
the resuscitation team would be associated with improved survival Outcome measurements
among OHCA patients in Taipei City, Taiwan.
The primary outcome was defined as survival to hospital dis-
charge. The secondary outcome was favourable neurologic status
Materials and methods at discharge defined as cerebral performance category level 1 and
level 2 (CPC ≤2) [11].
Study design and setting Our data were extracted from the Utstein-based OHCA registry
system in the Taipei EMS. This registry system was initially devel-
We conducted a 5-year retrospective cohort study using oped for OHCA quality control [10]. The rates of missing data ranged
prospectively collected Utstein-based registry data from the Taipei from 0% (most data) to 2.6% (mainly “prehospital times”). The reg-
EMS to investigate the association between the number of EMTs istry system collected data on dispatch records, modes and timing
and the paramedic ratio with OHCA patient outcomes [10]. The of prehospital care, patient demographics (age, sex), arrest charac-
study protocol was approved by the Institutional Review Board of teristics (witness status, bystander CPR, initial rhythm on cardiac
the National Taiwan University Hospital. monitor), records on automated external defibrillator (AED) avail-
Taipei City is a metropolitan area with 2.65 million registered ability, prehospital ALS treatment including airway and medication
residents; this number fluctuates to 3.0 million during working used, patient records from the EMS-receiving hospitals, and patient
hours due to the inflow of workers within 272 km2 . Taiwanese peo- outcomes (survival to hospital discharge, and neurologic status at
ple comprise the majority of the population. Taipei city has a one discharge) [12,13].
fire-based EMS system with a two-tiered response consisting of a We conducted a subgroup analysis using the new Utstein
basic life support plus defibrillator (BLS-D) team and an ALS team. template, with methods suggested by the International Liaison
The BLS-D team is capable of performing defibrillation and placing Committee on Resuscitation (ILCOR) in 2014 to explore the effect
laryngeal mask airway (LMA). Taipei city has 45 prehospital BLS- of a paramedic ratio >50% among different subgroup patients with
D stations with 1020 EMT intermediate staff, who have finished at OHCA [11]. For this analysis, we stratified the data by shockable
least 264 h of training and constitute the fire base crews. One BLS-D bystander CPR groups, shockable bystander witness groups, and
station has two BLS-D ambulances. One BLS ambulance is teamed non-shockable witness groups.
50 J.-T. Sun et al. / Resuscitation 122 (2018) 48–53
Statistical analysis vival to discharge, and CPC ≤2 at discharge were 2289 (27.7%),
1973 (23.9%), 616 (7.5%), and 307 (3.7%), respectively. The aver-
We used Excel (Microsoft, Redmond, WA, USA) to record data age (±standard deviation) number of on-scene EMTs was 3.0 ± 1.0;
and SAS version 9.3 (SAS Institute, Cary, NC, USA) for analysis. 1085 (13.1%) OHCAs were treated by crews with a EMT-P ratio >50%.
The descriptive statistics for the population were presented as Table 1 shows the demographic data and outcomes of the enrolled
counts, percentages, or medians (interquartile range [IQR] Q1–Q3). patients categorized by paramedic ratio. Age, sex, and percent-
We conducted non-parametric Mann-Whitney rank sum tests to age of initial shockable rhythm were similar between two groups
analyse differences between continuous variables. We used Chi- (P > 0.05). More bystander-initiated CPR and longer response time
squared or Fisher’s exact tests to assess the associations between were noted in the group with a paramedic ratio >50% (P < 0.05). ALS
categorical variables and the outcomes. All variables revealing an treatments including endotracheal (ET) intubation, drug admin-
association with outcomes (P < 0.05) from the univariate analy- istration, and scene time were also significantly higher among
sis were included in the multivariate logistic regression analysis. patients in the paramedic ratio >50% group (P < 0.05). Those in the
Characteristics previously determined to be associated with the paramedic ratio >50% group had better ROSC (32.63%), sustained
outcomes were also included in the multivariable logistic regres- ROSC (28.20%), and survival to discharge (9.31%) (P < 0.05), how-
sion analysis to prevent overfitting. Odds ratios (ORs) and 95% ever there was no significant difference in those with favourable
confidence intervals (CIs) were calculated and two-tailed P-values neurological outcomes (3.96%, P > 0.05).
<0.05 were considered statistically significant.
Main result
Results
The adjusted ORs (aOR) for survival among OHCA cases based on
Study subject characteristics the number of on-scene EMTs and a paramedic ratio >50%, as well as
the subgroups suggested by the Utstein 2014 methods, are shown in
From 1st January 2011, to 31st December 2015, there were Table 2. The confounders of OHCA survival determined by statistical
16,062 cases of cardiac arrests activated by Taipei EMS, and 8262 significance and prior knowledge including age, sex, witnessed sta-
cases were enrolled in this study (Fig. 1). Of those enrolled, 1085 tus, bystander CPR, shockable rhythm, shorter response and scene
(13.1%) had a paramedic ratio >50%. Among these, patients with times, and location of arrest, ALS treatment including ET intubation
return of spontaneous circulation (ROSC), sustained ROSC, sur- and drug (atropine, amiodarone and other) administration were
J.-T. Sun et al. / Resuscitation 122 (2018) 48–53 51
Table 1
Demographic data and outcomes of enrolled out-of-hospital cardiac arrest patients stratified based on emergency medical technician paramedic ratio group.
OHCA All EMS treated arrest (n = 8262) EMTP ratio >50% (n = 1085) EMTP ratio ≤50% (n = 7177) P-value
Patient
Age, years(Median,[Q1-Q3]) 77 (62–86) 77 (63–85) 77 (62–86) 0.54
Male, number (percent) 5239 (63.4%) 707 (65.2%) 4532 (63.2%) 0.20
Witness, number (percent) 2762 (33.4%) 387 (35.7%) 2375 (33.1%) 0.09
Bystander CPR, number (percent) 2753 (33.3%) 402 (37.0%) 2351 (32.8%) 0.005
Shockable rhythm, number (percent) 1018 (12.3%) 129 (11.9%) 889 (12.4%) 0.64
Location of arrest, EMS time interval and treatment (median [Q1–Q3] or%)
Public number(percent) 1086 (13.1%) 130 (12.0%) 956 (13.3%) 0.22
Response time, minutes(Median,[Q1-Q3]) 4.98 (3.97–6.02) 5.13 (4.03–6.87) 4.9 (3.9–6) 0.0001
Scene time, minutes(Median,[Q1-Q3]) 13.99 (11.2–16.78) 15 (12.35–18.22) 13.68 (11–16.28) 0.0001
Medical center, number(percent) 4509 (54.6%) 564 (52.0%) 3945 (55.0%) 0.07
Adrenaline, number(percent) 1418 (17.2%) 420 (38.7%) 998 (13.9%) 0.0001
Atropine/amiodarane/others, number(percent) 63 (0.8%) 24 (2.2%) 39 (0.5%) 0.0001
Endotracheal tube, number(percent) 826 (10%) 302 (27.8%) 524 (7.3%) 0.0001
Survival status, number (percent)
Any ROSC 2289 (27.7%) 354 (32.6%) 1935 (27.0%) 0.00010
Sustained ROSC 1973 (23.9%) 306 (28.2%) 1667 (23.2%) 0.00034
Survival to discharge 616 (7.5%) 101 (9.3%) 515 (7.2%) 0.013
CPC ≤ 2 at discharge 307 (3.7%) 43 (4.0%) 264 (3.7%) 0.64
Abbreviations (in alphabetical order): CPC ≤ 2, cerebral performance category level 1 and level 2; EMS, emergency medical services; EMTP, emergency medical technician
paramedic; OHCA, out-of-hospital cardiac arrest; ROSC, return of spontaneous circulation.
Table 2
Subgroup analysis of adjusted odds ratios for the outcome of survival stratified by the number of emergency medical technicians and the different emergency medical
technician paramedic ratios.
Adjusted by age, sex, witness, bystander CPR, shockable rhythm, response time, scene time, public, medical center, endotracheal tube, adrenaline and
atropine/amiodarone/other drug.
Abbreviations(in alphabetical order): CPC1&2, cerebral performance category level 1 and level 2; CPR, cardiopulmonary resuscitation; EMS, emergency medical services;
EMT, emergency medical technician; EMTP, emergency medical technician paramedic; aOR (95% CI): adjusted odds ratios (95% confidence interval).
a
Statistically significant difference.
Fig. 2. The effect of emergency medical technician paramedic ratio on survival to discharge.
*Adjusted by age, gender, witness, bystander CPR, shockable rhythm, response time, scene time, public arrest, medical center, ETT, epinephrine and atropine/amiodarone/other
Abbreviations; (in alphabetical order): EMT, emergency medical technician; EMTP, emergency medical technician paramedic; OR, odds ratio; C.I., confidence interval.
on survival. Furthermore, we also found that four EMTs with a of the ALS team; consequently, the ALS team could not perform the
high paramedic ratio had the greatest survival to discharge when ALS treatment including ET intubation. This was likely the cause for
compared with two EMTs alone. low ALS treatment rate in the group with a paramedic ratio ≤50%,
There are two reasonable explanations for the improved out- thus influencing the survival to discharge.
comes among OHCA patients who received resuscitation by the Not only the number of EMTs but the configuration of team
crews with a higher ratio of paramedics in our study. We is also important to influence team performance when resuscitat-
believed that ALS treatment might enhance the outcome. In our ing patients [9,22]. The increase in the number of on-scene EMTs
study, patients with non-shockable witnessed OHCA benefited alone was not associated with an improvement in outcomes of
the most from teams with a paramedic ratio >50%. ALS treat- OHCA patients in our study. These findings were contradictory to
ment including the placement of an ET tube and administration those reported by Warren et al. [5] In another study conducted
of amiodarone/atropine were significantly associated with sur- by Eschmann et al., the number of paramedics was focused on,
vival to discharge in the univariate analysis. In Taipei, there are regardless of the EMT levels. These investigators concluded that
previous studies showing that ALS can enhance the outcomes in the total number of paramedics were not influenced by the out-
OHCA patients. In 2007, Matt Ma et al. found that an ALS team comes of OHCA patients [6]. In previous studies, most resuscitation
can improve ROSC and survival to admission, especially for non- teams were mixed with paramedics and various different levels
shockable rhythm [7]. Chiang et al. found that when American of EMTs were present on the scene [4,6]. Different configurations
Heart Association’s ALS-termination of resuscitation (TOR) rule was may affect team performance; paramedics are usually the leaders
applied to OHCA patients in Taipei, there were still 4.9% of OHCA of resuscitation teams in Taipei. Kajino et al. also considered that
patients with survival to discharge [13]. In another study, Chi- paramedics could offer good team-dynamics and improve survival
ang et al. found that adrenaline in traumatic OHCA can improve of OHCA patients [4]. In our studies, the total number of EMTs failed
short term survival in the traumatic OHCA cases [12]. Chiang et al. to improve survival to discharge for OHCA patients; however, we
also found that successful out-of-hospital intubation improved out- demonstrated that a paramedic ratio >50% could increase the OHCA
comes in OHCA cases [16]. patient’s outcome for groups treated by three or four EMTs. Com-
Another potential explanation for our findings is that pared to the study conducted by Warren et al., we decreased the
paramedics are usually more experienced and enthusiastic [7]. total number of EMTs in a specific configuration. In our study, we
According to the study conducted by Matt Ma et al., one paramedic also observed the same phenomenon as in the study by Warren et
treated almost all of the 10 OHCA patients in 1 year in Taipei [7]. al, i.e. when more than four EMTs were present and there was a high
There are many studies demonstrating that more experience can ratio of paramedics, the effect disappeared. These findings may be
improve the outcomes of OHCA patients [17,18]. caused by teamwork failure in an overstaffed situation, resulting in
The differences in ALS effects on OHCA patients could be partly no clear role assignment or communication problems [23,24].
explained by the local variations in study populations in previous
literature reviews [7]. However, in many OHCA studies from west-
ern countries, the study populations had a higher percentage of Limitations
shockable rhythm (approximately 30%) compared with our study
[19,20]. Theoretically, shockable rhythm can easily be converted This study was subject to several limitations. As this was a ret-
to survival by early defibrillation and high quality of CPR which rospective cohort study, it was associated with inherent problems.
may be achieved by enhanced training of prehospital BLS providers. Although we had information on the average number of OHCA
We believe this to be the reason why the study by Warren et al. patients treated, we did not have information on the individual
revealed the greatest benefit among the shockable rhythm group. experiences of OHCA patients. Additionally, although we had qual-
In a Japanese study, the relatively low ALS treatment rate (ET-tube ity control of CPR in Taipei fire department, it was mainly focused
6.5%), might have influenced the ALS effect [21]. In Taipei, the group on the verification of unnecessary hands-off time recorded in the
with a paramedic ratio ≤50% typically comprises of one BLS team AED records. The chest compression fractions were not accurately
and one ALS team. However, there is a time gap between the arrivals calculated for every OHCA case. Finally, although we observed
of the two ambulances. Thus, the BLS team might have inserted the better outcomes in the high paramedic ratio group, the different
supraglottic airway and prepared to leave scene before the arrival dispatcher systems or EMS teams may have different outcomes.
J.-T. Sun et al. / Resuscitation 122 (2018) 48–53 53
Conclusions [5]. Warren SA, Prince DK, Huszti E, Rea TD, Fitzpatrick AL, Andrusiek DL, et al.
Volume versus outcome: more emergency medical services personnel on-
scene and increased survival after out-of-hospital cardiac arrest. Resuscitation
In conclusion, an on-scene EMT-P ratio >50% was associated 2015;94:40–8.
with improved survival to discharge for OHCA cases, especially [6]. Eschmann NM, Pirrallo RG, Aufderheide TP, Lerner EB. The association between
for those with witnessed, non-shockable rhythm. The presence of emergency medical services staffing patterns and out-of-hospital cardiac arrest
survival. Prehosp Emerg Care 2010;14:71–7.
four EMTs with a paramedic ratio >50% at the scene of OHCA was [7]. Ma MH, Chiang WC, Ko PC, Huang JC, Lin CH, Wang HC, et al. Outcomes from out-
associated with the greatest survival. of-hospital cardiac arrest in Metropolitan Taipei: does an advanced life support
service make a difference? Resuscitation 2007;74:461–9.
[8]. Hagiwara S, Oshima K, Aoki M, Miyazaki D, Sakurai A, Tahara Y, et al. Does the
Conflicts of interest number of emergency medical technicians affect the neurological outcome of
patients with out-of-hospital cardiac arrest? Am J Emerg Med 2017;35:391–6.
None. [9]. Bayley R, Weinger M, Meador S, Slovis C. Impact of ambulance crew con-
figuration on simulated cardiac arrest resuscitation. Prehosp Emerg Care
2008;12:62–8.
Authors’ contributions [10]. Chiang WC, Ko PC, Wang HC, Yang CW, Shih FY, Hsiung KH, et al. EMS in Taiwan:
past, present, and future. Resuscitation 2009;80:9–13.
[11]. Perkins GD, Jacobs IG, Nadkarni VM, Berg RA, Bhanji F, Biarent D, et al. Car-
JTS drafted the manuscript. WCC, LWC, and MHMM provided
diac arrest and cardiopulmonary resuscitation outcome reports: update of the
conception and design of the study and final approval of the version Utstein Resuscitation Registry Templates for Out-of-Hospital Cardiac Arrest: a
to be submitted. WSY, YCC and YCW supervised the data collec- statement for healthcare professionals from a task force of the International
Liaison Committee on Resuscitation (American Heart Association, European
tion. BCL, MJH, SSS, and EPCH performed acquisition and analysis
Resuscitation Council, Australian and New Zealand Council on Resuscitation,
of data. KCT conceptualized and designed the study. All authors Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resus-
contributed substantially to its revision. WCC, MHMM, and LWC citation Council of Southern Africa, Resuscitation Council of Asia); and the
take responsibility for the manuscript as a whole. American Heart Association Emergency Cardiovascular Care Committee and
the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation.
Resuscitation 2015;96:328–40.
Grant support [12]. Chiang WC, Chen SY, Ko PC, Hsieh MJ, Wang HC, Huang EP, et al. Prehospital
intravenous epinephrine may boost survival of patients with traumatic car-
diac arrest: a retrospective cohort study. Scand J Trauma Resusc Emerg Med
This study was funded by the Taiwan Ministry of Science and 2015;23:102.
Technology (Grant numbers: MOST 105-2314-B-002-182, MOST [13]. Chiang WC, Huang YS, Hsu SH, Chang AM, KO PC, Wang HC, et al. Performance of a
105-2314-B-002-200-MY3 and 104-2314-B-002-032-MY2). simplified termination of resuscitation rule for adult traumatic cardiopulmonary
arrest in the prehospital setting. Emerg Med J 2017;34:39–45.
[14]. Tomio J, Nakahara S, Takahashi H, Ichikawa M, Nishida M, Morimura N, et al.
Acknowledgements Effectiveness of prehospital epinephrine administration in improving long-term
outcomes of witnessed out-of-hospital cardiac arrest patients with initial non-
shockable rhythms. Prehosp Emerg Care 2017;21:432–41.
We appreciate the excellent performance of EMTs and the [15]. Chiang WC, Hsieh MJ, Chu HL, Chen AY, Wen SY, Yang WS, et al. The effect of
quality assurance of the Ambulance Division of Taipei City. Their successful intubation on patient outcomes after out-of-hopsital cardiac arrest
commitment and accomplishments significantly improved prehos- in Taipei. Ann Emerg Med 2017. S0196-0644(17) 31445-2.
[16]. 2015 American Heart association guidelines for cardiopulmonary resuscitation
pital care. We are also grateful for the statistical assistance provided and emergency cardiovascular care. Circulation 2015;132:S397–413.
by the Taiwan Clinical Trial Bioinformatics and Statistical Centre, [17]. Gold LS, Eisenberg MS. The effect of paramedic experience on survival from
Training Centre, and Pharmacogenomics Laboratory (which was cardiac arrest. Prehosp Emerg Care 2009;13:341–4.
[18]. Wang HE, Balasubramani GK, Cook LJ, Lave JR, Yealy DM. Out-of-hospital
found by the National Research Program for Biopharmaceuticals
endotracheal intubation experience and patient outcomes. Ann Emerg Med
[NRPB] at the Ministry of Science and Technology of Taiwan; MOST 2010;55:527–37.
104-2325-B-002-032), and the Department of Medical Research of [19]. Morrison LJ, Laura M, Kiss A, Theriault R, Eby D, et al. Validation of a rule for
termination of resuscitation in out-of-hospital cardiac arrest. N Engl J Med
National Taiwan University Hospital.
2006;355:478–87.
[20]. Sasson C, Hegg AJ, Macy M, Park A, Kellermann A, Mcnally B, et al. Prehospital
References termination of resuscitation in cases of refractory out-of-hospital cardiac arrest.
JAMA 2008;300:1432–8.
[21]. Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, Miyazaki S. Prehospital
[1]. Chan PS, McNally B, Tang F, Kellermann A, CARES Surveillance Group. Recent
epinephrine use and survival among patients with out-of-hospital cardiac arrest.
trends in survival from out-of-hospital cardiac arrest in the United States. Cir-
JAMA 2012;307:1161–8.
culation 2014;130:1876–82.
[22]. Ford K, Menchine M, Burner E, Arora S, Inaba K, Demetriades D, et al.
[2]. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart
Leadership and teamwork in trauma and resuscitation. West J Emerg Med
disease and stroke statistics—2015 update: a report from the American Heart
2016;17(5):549–56.
Association. Circulation 2015;131:e29–322.
[23]. Cassera MA, Zheng B, Martinec DV, Dunst CM, Swanstrom LL. Surgical time
[3]. Wang CY, Wang JY, Teng NC, Tsai SL, Chen CL, Hsu JY, et al. The secular trends in
independently affected by surgical team size. Am J Surg 2009;198:216–22.
the incidence rate and outcomes of out-of-hospital cardiac arrest in Taiwan—a
[24]. Pendharkar PC, Rodger JA. An empirical study of the impact of team size on
nationwide population-based study. PLoS One 2015;10:e0122675.
software development effort. Inf Technol Manage 2007;8:253–62.
[4]. Kajino K, Kitamura T, Iwami T, Daya M, Ong ME, Nishitama C, et al. Impact of
the number of on-scene emergency life-saving technicians and outcomes from
out-of-hospital cardiac arrest in Osaka City. Resuscitation 2014;85:59–64.