MONOGRAPH

(ACETYL SALICYLIC ACID)

STEP 01: TO PREPARE 0.5N HCL, 0.5N Na2CO3 AND 0.5N NaOH SOLUTION.

WORKING PROTOCL
WORKING PROTOCL
To standardize 0.1N NaOH By 0.1N Oxalic Acid.

+ NaOH

Oxalic Acid Sodium Oxalate

INITIAL READING FINAL READING DIFFERENCE

Concordant Reading: __________

 Normality:
N1V1 = N2V2
N 2V 2
N1 =
V1

N1 = --------------------------------- =

STEP 02: ASSAY TITRATION OF API (SALICYLIC ACID).

 Weigh 0.5gm of salicylic acid accurately.

 Dissolve 0.5gm of salicylic acid in 25ml of ethanol.
 Add 2 to 3 drops of indicator (phenolphthalein).
 Titrate against 0.1N NaOH, a color change will indicate the end point of the reaction.
 Each ml of 0.1N NaOH is equivalent to 0.01381gm of C7H6O3

Observation:
INITIAL READING FINAL READING DIFFERENCE

 Burette Reading:___________

STEP 03: TITER FACTOR.

 1ml of 1N NaOH utilizes 13.81mg of salicylic acid.

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  1ml of 1 N NaOH utilizes 0.01381gm of salicylic acid.
 1ml of _________ NaOH utilizes __________________ gm of salicylic acid.

 1ml of _________ NaOH utilizes ____________ gm of salicylic acid.

OBTAINED AMOUNT = Titer factor × burette reading

STEP 04: % PURITY.

 The % purity range of Salicylic Acid is 99.5% - 101.0%.

OBTAINED AMOUNT
% Purity = × 100
ACTUAL AMOUNT

% Purity =

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