Mechanism of Indication/ Contraindications and

Drug Adverse Reactions Nursing Considerations

Action Purpose caution

Generic: Therapeutic effect: • Isosorbide • Contraindicated in CNS: headache, • Monitor vital signs and serum
isosorbide Relieves angina dinitrate is patients hypersensitive sometimes with electrolytes routinely.
dinitrate indicated to nitrates, in those throbbing; dizziness; • Notify physician if there are any
Chemical effect: ay for acute with idiosyncratic weakness rhythm disturbance (e.g tachycardia
Brand Names: reduce cardiac angina and reactions to nitrates, CV: orthostatic and bradycardia), symptoms of
Isordil oxygen demand by prophylaxis and in those with hypotension, increased arrhythmias, palpitations,
Apo-ISDN decreasing left in severe hypotension, tachycardia, chest discomfort, shortness of breath,
Coronex ventricular end situations shock, or acute MI palpitations, ankle fainting, and fatigue/weakness
Isotrate diastolic pressure likely to with low left edema, fainting, • Advise the patient to take an empty
Sorbitrate (preload) and, to a cause ventricular filling flushing stomach, 30 mins before meals or 1
lesser extent, angina. pressure. GI: nausea, vomiting hour after meal.
Dosage, Route, systemic vascular • It is also used as • Use cautiously in Skin: cutaneous • Advise patient to avoid concurrent use
and Frequency: resistance an patients with blood vasodilation of alcohol with this medication.
2.5 to 10 mg SL (afterload). May adjunctive volume depletion Other: hypersensitivity • Inform patient that headache is a
for prompt relief increase blood flow treatment (such as that resulting reaction, sulingual common side effect that should
of angina pain, through collateral of heart from diuretic therapy) burning decrease with continuing therapy.
repeated q2-3˚ coronary vessels. failure. or mild hypotension. Aspirin or acetaminophen may be
during acute • Other indication ordered to treat headache
phase, or q4-6˚ for if for • Swallow the extended release tablet
prophylaxis diffuse whole with a half glass of water. Do not
esophageal split, crush, or chew it.
Classification: spasm • Inform the patient that headache,
Pharmacologic without dizziness, lightheadedness, or faintness
class: nitrate gastroesoph may occur, especially when you get up
ageal quickly from a lying or sitting position.
Therapeutic class: reflux. • Instruct the patient to rest after taking
antianginal, the medicine to get up slowly.
vasodilator • Raise bedside rails to patient safety.