Action Required

Dear BioMarin Contractor,

We are pleased to announce BioMarin Pharmaceutical, Inc. (BioMarin) has recently established a business
relationship with ISN (www.isn.com) to further enhance our contractor management program. Effective
immediately, ISNetworld will begin serving as BioMarin’s primary contractor information management system.
As a result of this action, contractors and their subcontractors performing services for BioMarin are required to
become subscribers to ISNetworld.

If your company is a current subscriber to ISNetworld, there is no additional fee; however, please ensure your
company has completed the requirements specific to BioMarin. If your company is new to ISNetworld, there is
an annual fee for this service. BioMarin believes the benefits to both parties will far exceed any associated costs.
A comprehensive list of contractor benefits and a subscription quick start guide are included from ISN.

BioMarin requires your company to complete/submit the following information in ISNetworld:

• Company Profile
• Environmental, Health, Safety and Sustainability (EHS&S) Questionnaire
• EHS&S Programs
• Document Submittal: Insurance, OSHA Forms, Experience Modifier and Job Hazard Analysis (JHA)

In order to be considered by BioMarin during the contractor selection process, your company’s subscription
must be in place and all required data must be posted. For further details about ISNetworld, please contact the
ISN Customer Service Team at (800) 976-1303 or visit their website at www.isn.com.

Your company’s cooperation and participation in bringing this cost effective technology solution to our business
relationship is appreciated.