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    Additional Slides For L05

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    bebble bopple
    This document discusses several topics related to biochemistry: 1. A table showing how yield per step and overall yield over 10 steps changes at different percentage yields per step. Overall yield drops dramatically as percentage yield per step decreases below 90%. 2. Asian glow, a reaction some people have to alcohol due to a deficiency in the aldehyde dehydrogenase 2 enzyme. This causes toxic acetaldehyde to accumulate after drinking. 3. A list of 20 amino acids and their ability to participate in acid-base catalysis, with glycine, threonine, serine, aspartic acid, and glutamic acid highlighted as amino acids whose side chains can donate or accept protons.

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    Additional Slides For L05

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    bebble bopple
    19 views6 pages
    This document discusses several topics related to biochemistry: 1. A table showing how yield per step and overall yield over 10 steps changes at different percentage yields per step. Overall yield drops dramatically as percentage yield per step decreases below 90%. 2. Asian glow, a reaction some people have to alcohol due to a deficiency in the aldehyde dehydrogenase 2 enzyme. This causes toxic acetaldehyde to accumulate after drinking. 3. A list of 20 amino acids and their ability to participate in acid-base catalysis, with glycine, threonine, serine, aspartic acid, and glutamic acid highlighted as amino acids whose side chains can donate or accept protons.

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    L05 additional slides

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    Additional slides for L05

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    This document discusses several topics related to biochemistry: 1. A table showing how yield per step and overall yield over 10 steps changes at different percentage yields per step. Overall yield drops dramatically as percentage yield per step decreases below 90%. 2. Asian glow, a reaction some people have to alcohol due to a deficiency in the aldehyde dehydrogenase 2 enzyme. This causes toxic acetaldehyde to accumulate after drinking. 3. A list of 20 amino acids and their ability to participate in acid-base catalysis, with glycine, threonine, serine, aspartic acid, and glutamic acid highlighted as amino acids whose side chains can donate or accept protons.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    19 views6 pages

    Additional Slides For L05

    Uploaded by

    bebble bopple
    This document discusses several topics related to biochemistry: 1. A table showing how yield per step and overall yield over 10 steps changes at different percentage yields per step. Overall yield drops dramatically as percentage yield per step decreases below 90%. 2. Asian glow, a reaction some people have to alcohol due to a deficiency in the aldehyde dehydrogenase 2 enzyme. This causes toxic acetaldehyde to accumulate after drinking. 3. A list of 20 amino acids and their ability to participate in acid-base catalysis, with glycine, threonine, serine, aspartic acid, and glutamic acid highlighted as amino acids whose side chains can donate or accept protons.

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    of 6

    Additional slides for L05

    Yield per Overall yield over


    step 10 steps

    50% 0.098%
    90% 34.9%

    97% 73.7%
    Asian Glow Alcohol dehydrogenase (ADH)
    Aldehyde dehydrogenase 2 (ALDH2)

    Acetaldehyde accumulates in ALDH2-deficient individuals. Ethanol is


    first converted to a toxic intermediate, acetaldehyde, by ADH, then
    converted to acetate by wild type ALDH2*1. The mutant form,
    ALDH2*2, cannot fully convert acetaldehyde into acetate, and toxic
    acetaldehyde accumulates as a result.

    https://collectionsblog.plos.org/say-no-to-glow-reducing-the-
    https://www.niaaa.nih.gov/publications/alcohol-flush-reaction carcinogenic-effects-of-aldh2-deficiency/
    Amino acids in acid-base catalysis
    1. Glycine Enzyme can make some atoms or functional group
    2. Threonine
    3. Alanine in their substrate more reactive by adding or
    4. Asparagine
    5. Valine
    removing a proton from them.
    6. Glutamine
    7. Leucine
    8. Tyrosine
    9. Isoleucine ➢ Which of these amino acid side changes can participate
    10. Cysteine in acid-base catalysis?
    11. Methionine
    12. Lysine
    13. Proline
    14. Arginine
    15. Phenylalanine
    16. Histidine
    17. Tryptophan
    18. Aspartic acid
    19. Serine /Thr
    20. Glutamic acid

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