RED BLOOD CELL

EVALUATING
PARAMETERS
 Assessment Of RBC
Morphology
(Qualitative Changes)
Qualitative
Changes Of
RBCs
HEMATOCR
IT VS
PACKED
CELL
VOLUME
HCT = MCV × RBC
COUNT
 RBC SIZE • Determined By
Calculation Of The
Mean Cell Volume
(MCV)

MCV (fl) = (PCV / RBC) X 10

 MCV
CBC
Electrical impedance
According TO MCV Values

• Variations In
RBCs Size
(Anisocytosi
s)
Anisocytosis &
RDW
RDW (10 – 15 %)
 RBC Hb Content (Color)
Determination by calculation of
Mean corpuscular hemoglobin (MCH) and
Mean corpuscular Hb concentration (MCHC)
 According to MCH and MCHC values

(A) Normochromic (B) Hypochromic Sever

RBCs RBCs Hypochromic
Normal MCH value Lower MCH value RBCs
N.B: Hyperchromasia is not truly exist
 Spherocyte

(C) Hyperchromasia
(appear)
 (D)Polychromasia
What Are The Polychromatophilic RBCs?

Polychromatophilic
Polychromatophilic
RBCs
RBCs
(Routine stain)
(methelene blue stain)
RBCs RBCs rouleaux
agglutination

Change In Red Cell Distribution

(1) Elliptoocyte (Ovalocyte) (2) Stomatocyte

Hereditary
Hereditary Regenerative anemia
Megaloblast anemia Lead poisoning
Liver disease
 (3) Spherocyte (4) Acanthocyte

lipid abnormalities
Immune mediated hemolytic
anemia
Liver disease
Hereditary Splenic disorder
Electrolyte depletion
(5) Schistocyte (fragmented cell) (6) Target cell(Codocytes)

Regenerative anemia
Mechanical hemolytic anemia
Iron deficiency anemia
Inflammatory disease
Vasculitis thalassemia
Vascular tumor
 (7) Dacrocyte (tear drop cell)

Extramedullary
hematopoiesis
(Bone Marrow
disorder)

(9) Keratocyte (Bite cell)

Congenital due to
point mutation in Oxidative stress
the structure of ß-
globin chain of Hb

(8) Sickle shape RBC

RBCS INCLUSIONS
Metarubricyte (nRBCs)

Howl and jolly bodies

Basophilic
stippling

pappenheimer bodies
Heinz
bodies

Cabot
ring
hemoglobin C
crystals
THANK YOU!