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Pyelonephritis - Case Study
Pyelonephritis - Case Study
In Partial Fulfillment
Care for Clients with Problems in Oxygenation, Fluid and Electrolyte, Infectious, Inflammatory, and
Submitted By:
Table of Contents
2
Introduction................................................................................................................................................3
Objectives of the Study...........................................................................................................................3
Overview of Medical Diagnosis..............................................................................................................3
Prevalence and Incidence.......................................................................................................................4
Overview of Care....................................................................................................................................4
Patient’s Database......................................................................................................................................5
Health History.........................................................................................................................................5
Review of Systems..................................................................................................................................2
Physical Assessment...............................................................................................................................3
Diagnostic Test........................................................................................................................................3
Final Medical Diagnosis..........................................................................................................................2
Developmental Tasks..............................................................................................................................2
Underlying Concepts...................................................................................................................................4
Anatomy..................................................................................................................................................4
Physiology...............................................................................................................................................4
Pathophysiology (Narrative)...................................................................................................................5
Pathophysiology (Diagram)....................................................................................................................7
Standard of Care.....................................................................................................................................9
Nursing Process.........................................................................................................................................10
Prioritized Nursing Problems List.........................................................................................................10
Problem No. 1: Back pain and dysuria..................................................................................................10
Problem No. 2: Fever and Chills............................................................................................................13
Problem No. 3: Urinary urgency with unsuccessful urination.............................................................15
Recommendations....................................................................................................................................19
Bibliography..............................................................................................................................................21
3
Introduction
Objectives of the Study
This case study aims to aid in:
fever, regardless of the presence or absence of tenderness and flank pain, acute prostatitis, nausea and
vomiting, dysuria, urinary frequency, and urinary-source bacteremia. This denotes inflammation of
kidneys and the renal pelvis (Johnson & Russo, 2018). This arises as a complication of an ascending
urinary tract infection (UTI), which progresses from the bladder to the kidneys and their respective
collecting systems. In most patients, the infecting organisms, such as Escherichia coli, Proteus, Klebsiella,
and Enterobacteria, will be contracted from their fecal flora. E. coli is the most common etiology of
pyelonephritis due to its unique ability to adhere to and colonize the urinary tract and kidneys.
Furthermore, inadequate emptying and urine stasis brought on by urinary tract obstruction—which may
be brought on by kidney stones—can result in acute pyelonephritis by providing conditions for the
bacteria to flourish in the body. Pyelonephritis classically presents as a triad of fever, flank pain, and
nausea or vomiting. Costovertebral and suprapubic tenderness during abdominal examination may be
present. While some may appear weak and ill, some patients appear healthy and asymptomatic,
therefore laboratory works and imaging studies should be done to confirm diagnosis (Belyayeva &
Jeong, 2022).
4
Buttolph, & Hammer, 2020), with lifetime incidence of 50-60% in adult women. Women are more at risk
to Pyelonephritis due anatomical factors. A population-based study in the United States found overall
annual rates of 15-17 cases per 10,000 females and 3-4 cases per 10,000 males (Fulop, 2023). This is due
to that women have shorter urethra than men. The proximity of the urethral opening makes it easier for
the bacteria to reach the urethra and bladder, thus posing a great risk for progressing to kidneys, thus
leading to pyelonephritis (Pruthi et. Al, 2023). The prevalence of UTI increases with age, and in women
aged over 65 years of age is approximately double the rate seen among overall female population.
Etiology in this age group varies by health status with factors such as catheterization, changes in the
vaginal flora, urethral changes, urinary retention, incomplete bladder emptying, decline in immune
function due to medications and overall physical status, affecting the risk for infection and the
microorganisms most likely to be responsible, such as E. coli. Increased sexual activity is a significant risk
factor for UTIs in younger women, and recurrence within six months is common. Approximately 20% of
women over 65 years of age experience this condition, compared to 11% of the general population.
Furthermore, groups with extremes of age, such as elderly and infants, impose high risk for this
complication due to abnormalities in anatomy and hormonal changes (Medina & Pina, 2019).
Overview of Care
A 58-year-old patient was presented to the emergency department with complaints of fever,
chills, dysuria, urgency, and back pain, as verbalized and assessed. Upon physical exam, CVA tenderness
is noted, no other significant physical findings. She has a fever of 101.2F; however, she is
hemodynamically stable in ED. Patient was admitted with chief complaint of having severe back pain and
5
dysuria. Upon admission, vital signs and review of systems were assessed. Laboratory works were done.
Patient’s Database
Health History
Client Information and Source
dysuria
fever, chills, dysuria, urgency, and back pain. Upon physical exam CVA tenderness is noted; no
other significant findings. She has a fever of 101.2F; however, she is hemodynamically stable in
ED.
a. Hospitalizations/Surgeries
None
d. Medications
● Home Medications
○ Lisinopril 40 mg PO daily
○ Furosemide 20 mg PO daily
○ Atorvastatin 40 mg PO daily
e. Allergies
f. Transfusions
Family History
Parents:
Personal/Social History
Patient KJ is married, lives at home with husband, and has 2 adult children who do not
live at home.
Review of Systems
General
HEENT
Atraumatic, pupils equal round and reactive to light and accommodation, moist mucosa, normal
Pulmonary
Cardiovascular
Genitourinary
Muscolo-skeletal
CVA tenderness noted, normal ROM in upper and lower extremities, no swelling, no joint
Neurological
Physical Assessment
Subjective
Patient complains of back pain, dysuria, and urinary urgency. Patient reports pain scale of 9/10.
Inspection
Palpation
Skin is warm to touch. Abdomen is soft and non-tender. CVA tenderness is noted.
Percussion
N/A
Auscultation
Heart at regular rate and rhythm. No murmurs and gallops. Normal S1 and S2. Normal bowel
Diagnostic Test
A. Laboratory Findings
B. Urinalysis
Color Yellow
Transparency Cloudy
pH 5.0 5.0-8.0
Developmental Tasks
Developmental Task Theory Status
Underlying Concepts
Anatomy
The renal system consists of the kidneys, ureters, bladder, and urethra. The system's general
function is to filter about 200 liters of fluid each day from renal blood flow, allowing excess ions, toxins,
and metabolic waste products to be expelled while maintaining blood levels of vital nutrients. The
kidneys are paired retroperitoneal organs located anterolateral to the spinal cord, near the posterior
wall of the body. The lower rib cage and a layer of perirenal fat provide protection for the bean-shaped
kidneys. The renal vein and renal artery are the two main blood arteries that enter and leave the
kidneys. Located on each kidney's superior pole are the adrenal glands. The inner renal medulla and the
highly vascularized outer renal cortex make up the two layers that make up the kidney's interior.
Millions of nephrons, the functional units of the kidneys, are distributed across these two layers. Urine is
temporarily stored in the muscle bladder during urination. It is situated immediately behind the pubic
symphysis in the pelvis. Because the smooth muscle in its walls is what gives the bladder stretch, it may
hold more urine in store. Urine is transported from the bladder to the outside of the body via the
urethra, a single, thin-walled tube. It's linked to two urethral sphincters: the voluntary external skeletal
muscle urethral sphincter and the involuntary internal smooth muscle urethral sphincter (Netter, 2019;
Physiology
Blood is filtered by kidneys in three stages. Blood that passes through the glomerulus's capillary
network is first filtered by the nephrons. A procedure known as glomerular filtration is used to filter out
almost all solutes—aside from proteins—into the glomerulus. Second, the renal tubules are where the
filtrate is gathered. Tubular reabsorption is the process by which most of the solutes in the PCT are
reabsorbed. The filtrate keeps exchanging water and solutes with the renal medulla and the peritubular
capillary network inside the loop of Henle. In this step, water is also reabsorbed. Then, during tubular
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secretion—basically, the reverse of tubular reabsorption—more solutes and waste products are
secreted into the kidney tubules. Filtrate from the nephrons is collected by the collecting ducts, which
then merge in the medullary papillae. The filtrate, which is now known as urine, is then transported by
the papillae into the minor calyces, which subsequently connect to the ureters via the renal pelvis.
Pathophysiology (Narrative)
Pyelonephritis can be caused by various risk factors. First is immunosuppression. The immune
system plays a huge role in recognizing and clearing infections. A compromised immune system may
struggle to detect and eliminate bacteria efficiently, allowing them to adhere and proliferate in the
urethra and may then ascend to kidneys. Secondly, instrumentation such as the use of foley catheters
put the patient at risk for Pyelonephritis as E. coli can have direct and quick access to the bladder, which
may ascend to kidneys. Moreover, renal calculi cause urine stasis due to the obstruction present that
disturbs the flow of urine through the urinary tract. This creates a suitable environment for bacterial
growth. The stagnation of urine increases the risk for urinary tract infections (UTI) that may further
progress to pyelonephritis as the infection ascends due to reflux of urine (Belyayeva & Jeong, 2022). In
addition to this, patients with Type-2 Diabetes Mellitus are at higher risk for Pyelonephritis. Antibiotic-
resistant urinary pathogens may emerge more frequently in these patients due to the high rates of
antibiotic prescriptions, particularly broad-spectrum antibiotics, for UTIs. Furthermore, increased urine
glucose concentrations could facilitate the development of pathogens. In addition to this case, diabetic
patients may experience autonomic neuropathy. When autonomic neuropathy affects the genitourinary
tract, it causes dysfunctional voiding and retention of urine. This reduces the physical elimination of
bacteria through micturition, which promotes the growth of bacteria (Nitzan et. al, 2015).
For non-modifiable factors, women are more at risk for UTIs because of a short urethra that is
close to the vulvar, perianal, and warm, moist areas where enteric bacteria are present (Nitzan et. al,
13
2015). The prevalence of UTI increases with age, and in women aged over 65 years of age is
approximately double the rate seen among overall female population. Etiology in this age group varies
by health status with factors such as catheterization, changes in the vaginal flora, urethral changes,
urinary retention, incomplete bladder emptying, decline in immune function due to medications and
overall physical status, affecting the risk for infection and the microorganisms most likely to be
responsible, such as E. coli. Lastly, sexual intercourse can be a risk factor for acquiring UTI, although it is
not sexually transmitted. It can result to poor sexual practice and hygiene after sex (Medina & Pina,
2019). Moreover, thrusting during sexual intercourse can introduce bacteria into the urethra, which may
Escherichia coli is the most common bacteria to cause acute pyelonephritis due to its ability to
adhere to and colonize the urinary tract and kidneys. Once the bacteria are introduced to the system
due to the presence of risk factors, it will adhere to the mucosal lining of the urethra, initiating an
infection, therefore leading to urethritis. This will then cause urethrovesical reflux or the backing up of
urine, which is supposed to be expelled, into the bladder, therefore causing infection into the bladder,
called cystitis. Due to the inflammation, the flow of urine is disrupted, therefore causing the urine to
reflux once again into the ureter, causing ureteritis. The stagnation of urine in the ureter will cause the
urine to back up once again to the kidneys, leading to a severe upper urinary tract infection, called
Pyelonephritis. Pyelonephritis causes the activation of immune response that activates the pyrogens or
the fever-inducing hormone, and the release of prostaglandin E2. This signals the hypothalamus to
increase body’s thermostat, causing the vasoconstriction to reduce heat loss through the skin, therefore
manifested as fever and chills. The patient will also experience malaise due to the action of infection.
Moreover, since the kidneys are responsible for the production of erythropoietin, it cannot take its
course due to inflammation and infection, therefore causing decrease of RBC production, leading to
14
anemia. Moreover, the most symptoms that the patient will experience are dysuria, back pain, and
Pathophysiology (Diagram)
Cystitis
Uterovesical reflux
Ureteritis
Infection ascends to
kidneys
15
PYELONEPHRITIS
Decreased
Release of pyrogens
Malaise stimulation of bone
from bacteria Dysuria
marrows
Release of Decreased
prostaglandin E2 erythropoiesis Back pain
Elevation of the
Decreased RBC
body thermostat by
production Urinary urgency
the hypothalamus
Vasocontriction Anemia
Standard of Care
Diagnostics
Imaging (MRI), or Ultrasound can be done to assess the condition of the kidneys
Treatment
NSAIDs, or nonsteroidal anti-inflammatory drugs, are effective in treating the fever and pain that
accompany acute pyelonephritis. Based on the level of antibiotic resistance in the area, an
empirical selection of antibiotics should be made initially. The outcomes of the urine culture
should then be used to modify the antibiotic treatment. E. coli will be the cause of most simple
cases of acute pyelonephritis. E. coli, for which patients may receive a 14-day course of
treatment with TMP-SMX or oral cephalosporins. Intravenous (IV) antibiotic therapy is necessary
for complex cases of acute pyelonephritis until clinical improvements occur. Fluoroquinolones,
Vancomycin can be used for patients with penicillin allergies. Follow-up for non-admitted
patients should occur within a day or two in order to assess symptom resolution.
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Nursing Process
pain as 9/10.”
Nursing Diagnosis: Acute pain related to inflammation and infection in the urinary tract as evidenced by
complaints of back pain and dysuria, and grimace, with pain scale of 9/10.
Rationale:
The patient’s chief complaint includes back pain and dysuria. This has to be addressed first because this
is what made the patient bring herself under the care of healthcare providers. Pain interferes with many
daily activities and the goal of prioritizing it is to reduce the effect of pain on patient’s function, quality
of life, and even emotional well-being (Wells, Pasero, & McCaffery, n.d.).
Goal
Short Term: After 1 hour of nursing intervention, patient will report pain relief, having a pain scale lower
Long Term:
After 3 days of NI, the patient will be able to perform at least 3 preventive measures and treatment
Planning
Independent
discomfort of the back, abdomen, or flank area with or without radiation to the groin. Assess for
2. Use alternative therapies like positioning, heat, relaxation, and guided imagery to promote
comfort.
Rationale: Development of specific images helps remove the perception of pain and offers
distraction. These measures assist in relaxation of perineal muscles which can further healp
Rationale: Adequate fluid intake at 2 liters per day will help with urine dilution, promote renal
blood flow, reduce bladder irritation, and flush bacteria from the urinary tract (Wagner, 2023).
4. Provide comfortable environment by dimming the lights and adjusting room temperature based
on client’s preference.
Rationale: Comfortable environment promotes relaxation and patients tend to recover quickly
and have better health outcomes. A negative and uncomfortable environment delays healing
and induces anxiety and stress, which may trigger pain (Clark, 2021).
Rationale: To reduce risk for urinary retention that may worsen bladder irritation that
6. Instruct to avoid urinary irritants such as food and drinks containing caffeine and spicy foods.
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Rationale: Bladder irritants such as caffeine and spicy foods irritate the lining of the bladder and
triggers the nervous system that controls the bladder. These then results to further discomfort
that the patient might be experiencing (Bradley, Kowalski, & Kenne, 2020).
7. Promote rest.
Rationale: Fatigue worsens pain sensations and induces stress to the patient (Wagner, 2023).
Dependent
Rationale: Antibiotics are prescribed to treat the infection. Pain medications are given to
alleviate pain.
Collaborative
Evaluation
Short Term Goal: Goal met. After 1 hour of nursing intervention, the patient reported pain relief, having
Long Term Goal: Goal met. After 3 days of nursing intervention, patient was able to perform at least 3
preventive measures and treatment modalities, such as wiping and cleaning the vagina front to back,
avoided bladder irritant food and drinks, and voided on regular basis instead of refusing to go to the
toilet, and recovered from severe pain with no signs of further complications.
20
Objective Data:
Temperature of 38.4 C
verbalization of feeling extremely cold, temperature of 38.4C, and presence of WBC in urine as shown in
urinalysis.
Rationale: When a body generates or absorbs more heat than it can release, a malfunction in
high can range from moderate to severe; body temperatures over 40 °C (104 °F) can be fatal. This has to
be addressed because uncontrolled fever may lead to further complications such as dehydration, and
Goal
Short Term: After 1 hour of nursing intervention, the patient will be able to reduce body temperature to
at least 37.5 C.
Long Term:
After 3 days of nursing intervention, the patient will be able to maintain or restore defenses and
demonstrate at least 3 ways to prevent infection and early detection to allow for prompt treatment.
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Planning
Independent
Rationale: Unreduced fever is a sign of progressive infection that has to be treated as soon as
Do not use alcohol as it can cool the skin rapidly and may cause shivering (Vera, 2023).
Rationale: Dehydration can coincide with hyperthermia. Dehydration manifests as a weak and
rapid pulse, dry mouth, poor skin turgor, thirst, decreased urine output, and elevated urine
Dependent
Collaborative
Rationale: Severe plasma leakage patients will have hematocrit levels that are at least 20%
higher than baseline. Hypovolemia shock can be brought on by severe plasma leakage.
22
Moreover, during a fever, the body may lose more fluids through sweating and increased
Rationale: Encourage high-calorie diet due to increased metabolic demands when a patient has
fever. Acid-ash diet is also necessary for patients with pyelonephritis to increase the acidity of
urine to fight off bacteria. Bacteria survive poorly in an acidic environment. Urine pH should be
maintained at around 5. Cranberry or prune juice and Vitamin C can help acidify urine and
Evaluation
Short Term Goal: Goal met. After 1 hour of nursing intervention, the patient was able to reduce body
temperature to 37.5 C.
Long Term Goal: Goal met. After 3 days of nursing intervention, the patient was able to maintain and
restore defenses as her fever was significantly reduce and was able demonstrate at least 3 ways to
prevent infection and early detection to allow for prompt treatment, such as by practicing proper
hygiene, learning how to monitor her own vital signs especially her body temperature, and having
“I experience this constant feeling of having the urge to go to the toilet and it’s painful to urinate.”
Objective Data:
Output of 5 mL/hour
23
Nursing Diagnosis: Impaired urinary elimination related to irritated and weakened bladder muscles as
Rationale: Patients with pyelonephritis may experience this as a result of the illness symptoms and
complications, which include frequent urination, a strong, ongoing urge to urinate, and urinary
hesitancy. This has to be addressed because further stasis of urine in the body will lead to further fatal
Goal
Short Term: After 1 hour of nursing intervention, the patient will be able to increase urinary output to
30 mL/hour, absence of dysuria with pain scale of at least 3/10 and improved bladder control to be
Long Term:
After 3 days of nursing intervention, the patient will be able to demonstrate at least 3 behaviors and
Planning
Independent
Rationale: The documentation of the patient’s intake and output can help monitor changes in
urine characteristics, such as amount and concentration, which can suggest the progression of
pyelonephritis.
2. Provide patient with routine voiding measures such as by providing privacy, effective voiding
positions, and non-pharmacologic methods that may stimulate urination like the sound of
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running water.
Rationale: Development of specific images helps remove the perception of pain and offer
distraction. These measures assist in relaxation of perineal muscles which can further healp
Rationale: This indicates incomplete emptying after urination or urinary retention (Wagner,
2023).
4. Facilitate a comfortable voiding position and making use of urinals or bed pans as needed.
Rationale: Discomfort can affect the patient’s elimination patterns. Offer urinary devices
frequently for the patient who cannot communicate to support urination (Wagner, 2023).
Rationale: Bladder irritants such as caffeine and spicy foods irritate the lining of the bladder and
triggers the nervous system that controls the bladder. These then results to further discomfort
that the patient might be experiencing (Bradley, Kowalski, & Kenne, 2020).
Rationale: This strengthens the pelvic floor muscles to promote urethral support to prevent
Dependent
Rationale: Medication can help with overactive bladder and retention if prescribed by a doctor.
Flomax relieves blockage by relaxing the bladder muscles. Ditropan is an anticholinergic that
Rationale: To facilitate urine elimination to prevent urinary retention that may worsen infection
25
Collaborative
1. Collaborate with patient with regards to the time and habit preferences for routine/timed
urination.
Rationale: This allows patients to be involved in the plan of care and express their preferences.
Rationale: Chronic urinary elimination problems need further monitoring and evaluation. A
urologist can perform testing and provide treatments to ease pain, incontinence, and retention.
Evaluation
Short Term Goal: Goal met. After 1 hour of nursing intervention, the patient was able to increase
urinary output to 30 mL/hour, absence of dysuria with pain scale of 0/10 and improved bladder control
Long Term Goal: Goal met. After 3 days of nursing intervention, the patient was able to demonstrate at
least 3 behaviors and techniques to improve urinary elimination and prevent urinary infection such as
cleaning vagina from front to back, performing pelvic floor exercises, and avoiding bladder irritants in
her diet.
26
Recommendations
The study of Johnson and Russo (2018) investigated the case of an otherwise healthy 35-year-
old patient that presents herself with urinary urgency, dysuria, fever, malaise, nausea, and flank pain.
She recently took a fluoroquinolone for diarrhea while visiting India. Upon examination, the patient's
temperature is 38.6°C, her blood pressure is 105/50 mm Hg, and her pulse and suprapubic areas are
tender, but her abdomen is not tender. The serum creatinine concentration is 1.4 mg per deciliter (124
μmol per liter) (most recent measurement prior to presentation was 0.8 mg per deciliter [71 μmol per
liter]). The white-cell count is 16,500 per cubic millimeter. A positive urine analysis for leukocyte
The recommendations of this study suggest that in the emergency room, fluid resuscitation
would most likely be beneficial for her. If she makes quick progress, her condition might be cleared to be
sent home with instructions to start an empirical oral therapy (such as an extended-spectrum
cephalosporin or fluoroquinolone). However, due to her recent use of antibiotics and her recent visit to
a region where endemic extensively resistant bacteria exist, prior to being released from the emergency
room, she ought to start receiving additional treatment that more reliably addresses multiresistant E.
coli (such as amikacin or ertapenem). However, before being released from the emergency room, she
should receive additional therapy that more reliably covers multiresistant E. coli because of her recent
use of antibiotics and her recent visit to a region where extensively resistant bacteria are endemic. coli
(such as amikacin or ertapenem). A more consistently effective antibiotic regimen and hospital
admission would be necessary if symptoms of sepsis emerged during her visit to the ER. Prudence
dictates that, in this case as well as others that may involve highly resistant pathogens, a combination
regimen that maximizes the chance that at least one agent will be effective against the pathogen should
be used initially, pending the availability of susceptibility data. A consultation on infectious diseases
could be beneficial. Following the discovery of susceptibility results, therapy should be suitably
27
constricted. If an appropriate medication is on hand, the patient can receive oral treatment once her
condition is clinically stable. If the clinical course proceeds as planned, there is no need for additional
testing; however, if the condition worsens or does not improve within a day or two, repeat cultures and
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