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Thyroid
∙ Pandred's syndrome: dyshormonogenesis due to TPO deficiency, characterized by goiter
+ sensorineural hearing losss
∙ Deep cervical lymphadenopathy along internal jugular vein is diagnostic of papillary
carcinoma.
∙ B-blockers inhibit peripheral conversion of T4 to T3, drug is given 7 days post operatively
∙ Potassium iodide reduces vascularity of the gland, given 10 days before operation
∙ Complications of thyroidectomy: bleeding/neck hematoma, laryngeal edema,
tracheomalacia, external/recurrent laryngeal nerve damage, thyroid storm,
hypothyroidism, hypocalcemia
∙ Papillary CA is spread via lymphatics, follicular via hematogenous to lungs and bone.
∙ Measurement of serum thyroglobulin is of value in followup and detection of metastatic
disease in pts w/thyroid surgery for cancer.
∙ Medullary CA tumors are not TSH dependant. Tumor markers are calcitonin and CEA.
∙ Chr lymphocytic thyroiditis presents as goitre mostly in women at menopause,
eventually causes hypothyroidism
∙ Sestamibi (radio-isotope) scanninng is used to localize abnormal parathyroid glands and
allows minimally invasive parathyroidectomy
∙ calciphylaxis: metastatic calcification of blood vessels, end stage of secondary
hyperparathyroidism
∙ Insulinoma is screened w/ hypoglycemia and inc plasma insulin after 72 h fast.
Suppresed w/ IV insulin and measure C-peptide. Tumor localized by endoscopic
ultrasound.
∙ MC site for sporadic gastrinoma is the head of the pancreas and for tumors ass w/ MEN
1 is 1st and 2nd part of duodenum.
∙ Non functional endocrine pancreatic tumors stain positively for chromogranin A and
synaptophysin. tx w/ chemo w/ streptozotocin, octreotide and interferon. Surgery toc.
partial pancreaticoduodenectomy.
∙ alpha blockade first then beta blockade should be done before surgery for
pheochromocytoma.
Breast
∙ Ligaments of cooper extend from dermis of skin to the pectoral fascia and provide
support for the breast. Its invasion by cancer causes dimpling of skin or inversion of
nipple.
∙ Slit like retraction of nipple may be caused by duct ectasia/ chronic periductal mastitis. A
circumferential retraction may be carcinoma.
∙ Poland's syndrome: amazia + absence of sternal portion of pectoralis major.
∙ Mondor's disease: Thrombophlebitis of superficial veins of the breast and anterior chest
wall.
∙ Fibroadenoma/ breast mouse: mc discrete mass in women <30 yrs
∙ Infiltrating ductal carcinoma is the mc variant of breast cancer.
∙ DCIS is treated as malignancy whereas LCIS is not (loss of E-cedherin)
∙ Peau d'orange suggests local lymph node invovement
∙ Cancer en cuirasse is carcinomatous infiltration of skin of chest, local recurrence after
mastectomy
∙ Modified radical mastectomy aka patey mastectomy: pectoralis major is left intact.
Breast, axillary LN, nipple areola complex and pectoralis minor is removed.
∙ Axillary LN levels are based on relationship to pectoralis minor muscle. level 1: lateral, 2:
posterior, 3:medial
∙ Silicon gel implant or latissimus dorsi muscle flap or transversus abdominis flap can be
used for breast reconstruction surgery
∙ Chemotherapy regimens-> traditional: 6 monthly cycle of cyclophosphamide,
methotrexate and 5-flurouracil
current: an anthracycline + taxane based regimen given in 5-6 cycles
∙ Trastuzumab is used in pts with her2/neu +ve tumors combined w/chemo.
∙ Tamoxifen is used for receptor +ve beast cancer in premenopausal women.
∙ Anastrozole is used for receptor +ve breast cancer in post menopausal women. Licensed
for tx of recurrent disease.
∙ LNRH agonists like goserelin causes reversible ovarian suppression decreasing estrogen
levels causing a reversible chemical menopause.
∙ If tumor size is >2 cm prognosis is poor
∙ Nottingham prognostic index is based on tumor size, grade + nodal score. <3.4 good
prognosis, >5.4 poor prognosis
∙ BRCA 1 mut is also ass w/ risk of ovarian and colorectal cancers, BRCA2: inc risk of male
breast cancer
∙ Pregnancy can mask breast cancer symptoms
Hernia
∙ Hernia is caused due to anatomical weakness or high intrabdominal pressure
∙ Irreducibility without othet symptoms is diagnostic of an omentocele
∙ Strangulated hernia is more common in femoral hernia
∙ Indirect inguinal hernia arises lateral to inferior epigastric artery or hesselbach triangle,
common on right side in childhood. Strangulation common
∙ Direct Inguinal hernia arises medial to inf epigastric artery and protudes thru posterior
wall of inguinal canal (transversalis fascia)
∙ Dual hernia: indirect and direct sacs stradle the epigastric artery
∙ Lichtenstein repair is superior method to repair hernia.
∙ Sliding hernia is a type of hernia in which posterior wall of sac is partially formed by wall
of viscera
∙ Strangulation is the initial presentation of 40% of femoral hernias. It is irreducible and no
cough impulse
∙ Inguinal hernia is above and medial to pubic tubercle, femoral hernia is below and
lateral to pubic tubercle
∙ Umbilical hernia surgery after 2 yrs of age
∙ Crescent shaped appearance of umbilicus in para-umbilical hernia
∙ Epigastric hernia commences as protusion of extra-peritoneal fat aka fatty hernia of linea
alba. Mimics pain of peptic ulcer disease..
∙ Spigelian hernia is almost always above arcuate line, below level of umbilicus near edge
of rectus sheath
∙ Howship-Romberg sign: Pain referred along the geniculate branch of obturator nerve to
the inner aspect of knee should raise suspicion of an obturator hernia.
The peritoneum
∙ Adhesional small bowel obstruction: Bowel sounds increased
∙ paralytic ileus: bowel sounds reduced
∙ Pelvic abscess: pelvis ismc site for intraperitoneal abscess. Rectal examination reveals
bulging of anterior rectal wall. Pelvic pain + diarrhea + passage of mucus in stool
∙ Pneumococcal peritonitis spread via resp tract infection, middle ear or vagina or
fallopian tube, nephrotic synd or cirrhosis
∙ Tuberculous peritonitis: abdominal pain, fever, night sweats, ascites, abdominal mass
∙ Pseudomyxoma peritonei is caused by mucinous cystic tumors of appendix(mc) and
ovary
∙ Mesenteric cyst: Chylolymphatic (most common type)lined by flat endothelium, n
mesentery of ileum
Enterogenous cyst: lined by ciliated mucus membrane, arises from diverticulum of
mesenteric border of intestine
∙ Tillaux's sign: swelling moves freely in a plane at right angles to attachement of
mesentery
Esophagus
∙ Dysphagia is the predominant symptom in advanced esophageal cancer
∙ malignant tracheoesophaegal fistula is a sign of incurable disease
∙ Resp complications of esophagectomy are most common
∙ Benign anastomotic stricture is mc late complication of esophagectomy
The stomach
∙ Post gastrectomy, it is a common practice to perform a water soluble contrast swallow at
5-7 days after the operation to determine whether anastomosis is intact
∙ The recurrence rates after truncal vagotomy and antrectomy are exceedingly low
∙ Criminal nerve of grassi is usually the first branch from posterior vagal trunk, it can lead
to recurrent ulcers if not ligated during vagotomy.
∙ Duodenojejunal flexure can be identified by the presence of suspensory ligament of
treitz
The pancreas
∙ In acute pancreatitis, on abdominal x-ray, sentinal loop sign, colon cut off sign and renal
halo sign are seen
∙ Antibiotics are given in severe pancreatitis, cefuroxime, imipenim, ciprofloxacin and
metronidazole
∙ Pseudocyst develops 4 weeks after acute pancreatitis, encapsulated collection of
amylase rich fluid
∙ Tropical pancreatitis is associated w cassava ingestion and SPINK-1 mutation
∙ Autoimmune pacreatitis ass w elevated IgG4
∙ Chr pancreatitis shows dilated chains of lakes on ERCP
∙ Dictal adenocarcinoma is mc, involves head of pancreas. Mets to liver and peritoneum
∙ Mucinous tumor -> peri menopausal women
∙ Elevated tumor marker CA 19.9 is seen in CA pancreas
∙ EUS more accurate than CT if tumor less than 3 cm, vascular invasion
Intestinal Obstruction
∙ Dynamic Obstruction: Peristalsis present and works against a mechanical obstruction.
Extramural adhesions mcc.
∙ Adynamic Obstruction: Peristalsis may be absent or present in a non propulsive form
without any mech obst.
∙ Absolute obstruction means neither feces nor flatus is passed. It is a cardinal feature of
complete intestinal obstruction
∙ Radiological dx of intestinal obstruction is based on supine abdominal x-ray
∙ Fluid levels appear later than gas shadows and are prominent on erect x-rays
∙ The development of severe colicky abdominal pain is indicative of strangulation
∙ Dehydration is seen most commonly in small bowel obstruction
∙ Coiled spring sign seen in jejunal obstruction
∙ If cecum is collapsed= small bowel obstruction
If cecum is dilated= large bowel obstruction
∙ Acute intestinal obstruction is managed firstly by nasogastric decompression and IV
rehydration w Hartmann's sol or normal saline and antibiotics
∙ MC type of intussusception in children is ileocolic (claw sign) and in adults is colocolic.
MC age group is 5-10 months.
∙ Sing of dance i.e feeling of emptiness in RIF, sausage shaped lump concavity towards
umbilicus, red currant jelly stool -> features of intussusception
∙ Cecal volvulus -twist is clockwise, common in females, bird beak deformity on barium
enema
∙ Sigmoid volvulus -twist is anticlockwise, most common type, coffee bean sign on AXR
∙ Conservative management for adhesions should not exceed 72 hours
∙ Ogilvie's syndrome: acute colonic pseudo-obstruction
∙ Embolisation of SMV(middle colic artery) is the mcc of acute mesenteric ischemia. c/f:
sudden onset of severe abdominal pain in pt w atrial fibrillation or atherosclerosis
∙ MC site of ischemic colitis is splenic flexure, may presnt in 3 forms: gangrenous, transient
and structuring (causes obstruction) forms.
∙ Intestinal pseudo-obstruction -> autoimmune destruction of myenteric plexus
∙ Distension in small bowel obst is greater, colonic obst is delayed and in mesenteric or
vascular occlusion is minimal or absent
∙ Billious vomiting is the dominant feature in jejunal atresia and distention in ileal atresia.
The rectum
∙ Puborectais muscle creates the anorectal angle
∙ Denonvillier's fascia: Separates the lower 3rd of rectum from prostate/vagina in front
∙ Waldeyer's fascia: Separates the lower 3rd of rectum from coccyx and lower two sacral
vertebra from behind
∙ Rectal mucosal prolapse is 1-4 cm, tx by submucosal inj of 5% phenol in almond oil,
rubber bands, excision or endoluminal stapling
∙ Full thickness prolapse aka procidentia, 10-15 cm, tx is suregry by perianal or abdominal
approach
∙ Strawberry lesion of rectosigmoid is caused by infection by Spirochaeta vincenti and
bacillus fusiformis.
∙ Rectal bilharziasis is caused by schistosoma mansoni, caused by stage 3 of the disease,
from deposition of ova in rectum
∙ Rectum is the most common site of colorectal carcinoma (adenocarcinoma)
∙ C/f of rectal CA include spurious diarrhea i.e the pt may endevour to empty rectum
several times a day often w passage of flatus and small amount of blood stained mucus.
∙ Pt w annular growth at rectosigmoid junction suffers w constipation
∙ Pt w growth in ampulla of rectum suffers from early morning bloody diarrhea
∙ Invasion of sacral plexus-> sciatica, liver met: weight loss
∙ Assesing local spread of rectal CA is by endoluminal US and MRI pelvis
∙ Anterior resection is an anal sphincter preserving resection of rectum, thru abdominal
approach. It is preferable for all the tumors whose lower margin is >2cm above the anal
canal. Upper 2/3rd of rectum
∙ Abdominoperineal resection: Does not preserve sphincter. When the lower margin of
tumor is <2cm below anal margin. Lower 1/3rd of rectum
∙ Hartmann's and brunschwig's procedure: In old frail pt. Removal of all pelvic organs +
end colostomy
∙ Mc drug used for chemo -> 6 fluorouracil + folinic acid
∙ Lower ant resection syndrome: frequency, urgency, altered bowel movements
∙ Complications of AR and APR-> impotence, anastomotic leak, pre-sacral venous bleed
The Prostate
∙ Skene's tubules on female urethra are homologous of the prostate
∙ BPH is mcc of bladder outflow obstruction in men >70 yrs of age
∙ Prostate enlarges because of increased estrogenic effects
∙ Persistence of median sulcus is a definite sign of BPH, it is obliterated in cancer
∙ TURP is gold standard for tx of BPH. Ass w water intoxication ->hyponatremia
∙ Ca of prostate spreads most commonly to pelvic bones and lumbar vertebra and
obturator nodes
∙ On DRE, median sulcus is obliterated and rectal mucosa tethered to gland in ca prostate.
Tissues lateral to gland may be infiltrated giving rise to winging of gland
∙ PSA levels more than 3 nmol/ml is dx of prostatic cancer
∙ Curative therapy is for stage 1 and 2 (radical prostatatectomy in young and TURP in
elderly) and palliative therapy for stage 3 and 4
∙ Medical castration for T3 and T4 can be achieved by 2 methods: LHRH agonists
(Goserelin) and Anti-androgen (flutamide)
∙ Acute prostatitis: fever + rigors, lower back + perineal pain, threads in initial voided
sample, tender prostate
∙ Chronic prostatitis: Persistent threads in voided urine, pus cells w or without bacteria in
absence of urinary infection. Dx by 3 glass test, DRE (soft boggy tender prostate),
prostatic fluid, urethroscopy
∙ Prostatic abscess should be suspected when there is no response after using antibiotics
for prostatitis
Hernia
∙ Reducible hernia has positive cough impulse
∙ Irreducibility without other symptoms is almost diagnostic of an omentocele
∙ Obstructed hernia is on which intestine is obstructed but has good blood supply
∙ strangulated hernia: blood supply of bowel is obstructed(more common in femoral
hernia)
∙ Superficial inguinal ring: Triagular aperture in the aponeurosis of external oblique
muscle, lies 1.25 cm above pubic tubercle
∙ Deep inguinal ring: U shaped condensation of transversalis fascia, 1.25 cm above
inguinal ligament
∙ Inferior epigastric vessels lie posteriorly and medially to deep inguinal ring
∙ Direct inguinal hernia: within hesselbach triangle
∙ Indirect Inguinal hernia: lateral to ", strangulation common
∙ Indirect inguinal hernia arises lateral to inferior epigastric artery and often protudes thru
deep inguinal ring, mc hernia of all, esp in children, more common on right side
∙ Direct inguinal hernia: Medial to inf epigastric artery + protudes thru psterior wall of
inguinal canal,mc in older men
∙ Dual hernia aka saddle bag or pantaloon hernia
∙ Sliding hernia: posterior wall of sac is partially formed by wall of viscera
∙ Femoral hernia: protusion of extra-peritoneal tissue, peritoneum/ abdominal contents
thru femoral canal