Slim-Excess ®

by Beauty Creations
The face and body designer
Slim-Excess ®

Demonstrated reshaping efficacy on face

and body
Weight changes have visible effects on the shape of the face and body. Whether
due to hormonal imbalances or unhealthy lifestyles, these changes contribute Cosmetic use
to the formation and storage of fat not only in our body but also in our face.
This fat is stored in the forehead, temples, cheeks and around the mouth. Daily treatment that helps
A harmonious face is perfectly balanced with smooth, round contours and a redesign and reshape the face
well-defined jaw line. Excess fat, however, leads to slackness in the oval of the and body.
face and the development of a double chin.
V-shape contouring.
This oval also changes with age:
the bone structure loses density and
muscle fibers weaken, letting fat
pockets migrate to the lower half of Cosmetic properties
the face 1. This effect is accentuated
by skin sagging and gravity. The most
Lipogenesis inhibitor.
obvious sign is the development of
jowls, which break the lines of the face Lipolysis activator.
and affect facial harmony. Inhibitor of preadipocytes
Women often wish for a firm, flawless proliferation (increased fat-
body. Reshaping the face and body
storing potential).
has become a major part of the search
for wellbeing.
Ageing of the face with the development of jowls
and a double chin.

Beauty Creations has developed a reshaping active ingredient with proven Origin
efficacy on both the face and body. Inspired by studies conducted in the field
of obesity 2, we have targeted two compounds that are found in abnormally high Slim-Excess ® is a red algae
concentrations in obese subjects: spermine and spermidine. hydrolyzate
These two compounds take a part in many mechanisms in fat metabolism:
activation of lipogenesis, inhibition of lipolysis and activation of preadipocyte
differentiation (increased fat-storing potential).

Slim‑Excess ®, the slimming solution

Beauty Creations has developed a unique active ingredient blocking these two
polyamines for a revolutionary slimming effect. Acting as a molecular trap,
the sulfo-carabioses of Slim-Excess ® have a high affinity with spermine and
spermidine for optimal inhibitor effect.

1
C. Kron Nouv. Dermatol. 2006
2
Jamdar S, Cao FW, Samaniego E.Enzyme and protein 1996 ; 49 : 222-230
In vitro studies
Slim-Excess®, three slimming actions combi-
ned for an optimal efficacy

Our aim Slim-Excess ® enables a 87% stimulation of lipolysis

Assess the efficacy of
% free fatty acids / negative control
Slim-Excess ® at 3% to positively (**)
200
activate the lipidic metabolism
on a culture of adipocytes
obtained by abdominal biopsy. + 87 % Statistics :
Measurements were done vs. (**) p<0.01
100
untreated control.

0
Negative control Slim-Excess® 3%

Conclusion Fig. 1 – Effects of Slim-Excess ® on the release of free fatty acids by human adipocytes as compared
Slim-Excess ®
optimizes the to an untreated control group.

lipidic metabolism acting Slim-Excess ® enables a 79% inhibition of lipogenesis

simultaneously, in vitro , on
% acetate incorporation / negative control
the 3 associated biological
mechanisms: lipolysis, lipo- 100

genesis and preadipocytes 80

proliferation.
-79%
60 Statistics:
(**) p<0.01

40
(**)

20

0
Negative control Slim-Excess® 3%

Fig. 2 – Effects of Slim-Excess ® on the incorporation of acetate by human adipocytes as compared to

an untreated control group.

Slim-Excess ® inhibits the preadipocytes proliferation with a higher

efficacy than caffeine

Number of preadipocytes (in millions)

3.5
3
-35%
2.5
(***) Statistics:
2 (***) p<0.001
1.5
1
0.5
0
Negative Caffeine Slim-Excess®
control 0.02% 0.2%

Fig. 3 – Number of preadipocytes after 7 days in a culture medium.

In vivo studies on the
Our aim Instrumental
The clinical study of Slim-Excess ®

applied at 2%* on the face aimed

to demonstrate its reshaping Measurement the angle of inflexion
effect (reduced double chin and between the chin and the cheek: with the
redesigned oval of the face). development of jowls, the outline of the
face is less clearly defined and an angle
forms. The more this angle increases
The efficacy of Slim-Excess®, toward 180°, the more the lines of the
when used twice daily on the face face are corrected and the contours
and neck by a panel of 49 Asian smoothed.
volunteers for three months,
was evaluated. An instrument
evaluation of the «chin/cheek»
inflexion angle and of the double
chin area was performed as
well as an assesment of the
biomechanical properties of the
skin (elasticity). Fig. 4 – Measurement of the cheek/chin angle of inflexion.

Results
The statistically significant
Cheek/chin angle
increase of the cheek/chin angle
Cheek/chin angle (% modification/D0)
after Slim-Excess ® treatment 2.5 (***)

by +1.5% (4 weeks), +1.3% 2 (*) +2.2% Placebo emulsion

(*)
(§) (*) Emulsion containing
(8 weeks) and +2.2% (12 weeks) 1.5
+1.5%
(§°)
2% Slim-Excess®
+1.3% +1.4%
corresponds to a decrease of 1
Statistics:
the low-face sagging. 0.5 Percentage calculated from
the mean of 23 (Slim-Excess®)
0 and 26 (placebo) volunteers
Wilcoxon or Student’s paired test (Dx/D0):
The number of volunteers with -0.5
-0.5%
(NS)
-0.5%
(NS)
(NS) not significant
(*) p<0.05
positive effect represents 82.6% -1 (***) p<0.001
Unpaired test Slim-Excess®/placebo:
4 weeks 8 weeks 12 weeks (§°) p<0.1
after 12 weeks of treatment. (§) p<0.05

Fig. 5 – Effect of Slim-Excess ® at 2% vs placebo on cheek/chin inflexion angle. Macrophotographs

analysis. Percentage of modification comparatively to D0.

Conclusion
Slim-Excess® redesigns the
contours of the face for a reshaped
oval in four weeks.

*Tested product has the same concentration of active matter as the commercial product
Results Clinical evaluation
Slim-Excess ® visibly helps to
reduce the double chin area: Area of the double chin
the average reduction is 10.2%
Area of double chin (% modification)
after eight weeks of treatment,
0
and may reach -40% in some Placebo emulsion
-2 -3.4%
volunteers after twelve weeks. Emulsion containing
-4 -4.8% (NS) 2% Slim-Excess®
-5.6%
-6 (NS)
These results, which were (NS) -8% Statistics:
-8 -9.1% -10.2% Percentage calculated from
obtained by instrumental (*) the mean of 23 (Slim-Excess™)
and 24 (placebo) volunteers
-10 (**) (**)
measurements, can clearly be Wilcoxon or Student’s paired test (Dx/D0):
(NS) not significant
-12 (*) p<0.05
observed on the pictures of 4 weeks 8 weeks 12 weeks
(**) p<0.01
-14
volunteers taken before and
after twelve weeks of treatment.
Fig. 6 – Effect of Slim-Excess ® at 2% vs placebo on the area of double chin. Macrophotographs analy-
sis. Percentage of modification comparatively to D0.

Conclusion Volunteer 1 Volunteer 1

Visible reduction of double
chin area in 4 weeks using Baseline 12 weeks Baseline 12 weeks

Slim-Excess ®.

Cheek/chin angle -23% double

improved by +8.7% chin area

Volunteer 2 Volunteer 2
Baseline 12 weeks Baseline 12 weeks

Cheek/chin angle -40% double

improved by +12.2% chin area
For a complementary action, Slim-Excess®
contributes to improve skin elasticity
Our aim
The biomechanical parameters
of the skin were monitored by a
contactless evaluation method:
Tonoderm TM. The Tonoderm TM
instrument directs an air flow
with given force onto the skin,
causing local deformation of the
skin tissue. This deformation is
recorded and analyzed with a
laser sensor.

The Cr/Yf ratio expresses the

elastic/viscous behavior of the
skin. A reduction in the value of
this ratio indicates a reduction
in the viscosity of the skin and Fig. 7 – Example of the skin deformation curve obtained with Tono-
derm™.
an improvement in elasticity.

Cr/Yf (force 4 g)

Results Cr/Yf (Force 4 g) (% modification/D0)

2
Placebo emulsion
Significant reduction in the Cr/ (NS) (NS) Emulsion containing
2% Slim-Excess®
0
Yf ratio in twelve weeks. Slim- 0.4% -1.1% 0.6%
-1.3%
-0.6%
(NS)
Excess ® improves skin elasticity -2 (NS) (NS) Statistics:
Percentage calculated from
the mean of 23 (Slim-Excess®)
for combined action with the -4 and 26 (placebo) volunteers
Wilcoxon or Student’s paired test (Dx/D0):
loss of fat volume. -5.2%
(NS) not significant
-6 (*) (*) p<0.05
(§°) (**) p<0.01
Unpaired test Slim-Excess®/placebo:
-8 4 weeks 8 weeks 12 weeks (§°) p<0.1

Conclusion
After twelve weeks, Slim- Fig. 8 – Effect of Slim-Excess ® at 2% vs placebo on skin biomechanical properties (Cr/Yf ) ratio.
Excess ® visibly improves Percentage of modification comparatively to D0.
skin elasticity with greater
effectiveness than placebo.

Slim-Excess®:
- helps to reshape the oval of the face in four
weeks,
- helps to decrease the double chin area,
- contributes to improve skin elasticity,
- shows a significantly greater efficacy than
placebo.
In vivo studies on the
Our aim Clinical scoring on cellulite
The clinical study on Slim-
Excess ® applied to the body
Differences of clinical score (Tn-T0)/10
aimed to demonstrate its
0.1 Placebo
anti-cellulite and slimming Slim-Excess® 3%
0
effectiveness and its synergy
-0.1
with caffeine. A 3% formulation Statistics:
-0.2 Difference of clinical score calculated from the mean of 25
of Slim-Excess ® was applied (Slim-excess®) and 24 (placebo) volunteers.
-0.3 -9% Wilcoxon or Student’s paired test
twice daily on the thighs of up to (*) significant difference as compared
to T0 (p<0.05)
-0.4 -32% (*) -11%
(°) significant difference as compared
a panel of volunteers for two -0.5 (°) up to
(*) to the placebo (p<0.05)
-40%
months. (°)
2 weeks 4 weeks

Results Fig. 9 – Decrease in clinical scores for cellulite on thighs treated either with Slim-Excess ® 3% or with
the placebo.
A decrease in the scores given
by the expert clinician showed
an improvement in cellulite over
Volunteer Volunteer after
time. After 2 and 4 weeks of before treatment 8 weeks of treatment
application, the clinical expert
noted a significant decrease
in cellulite on those thighs
treated by Slim-Excess ® 3%,
respectively -9% and -11%.

At 2 and 4 weeks, respectively

68% and 75% of the subjects
showed an improvement in the
quality of their skin.

Conclusion
Slim-Excess ® contributes to
reduce cellulite in 2 weeks.
Our aim Measurements of the volume of the skin over
Measurements of the volume
of a section of the thigh, which
the thighs using fringe projection
was reconstructed in 3D, were
carried out prior to product Volume in section of thigh (cm3)
application and after 4 weeks of +1.6 cm3
4 weeks
product application. Placebo
Slim-Excess® 3%

Statistics:
Volume difference calculated from the mean of 22
Results -16 cm3
(Slim-Excess®) and 21 (placebo) volunteers.
Wilcoxon or Student’s paired test
(**) significant difference as compared to T0 (p<0.01)
The comparison of the volume up to
(**) (°°) significant difference as compared to the placebo (p<0.01)
- 67 cm3
(°°)
of the thighs over time showed
a significant decrease of
-16 cm 3 in the thighs treated with
Fig. 10 – Decrease in volume of the section of thighs treated either with Slim-Excess ® 3% or with
Slim-Excess ® 3% (and up to
‑67 cm 3).

Measurements in centimeters of the thighs

Our aim circumference
The slimming effect of
Decrease in centimeters vs D0
Slim-Excess ®
was evaluated
through the loss in centimeters of 0 -0.1 Caffeine 3%
thighs circumference. The effect -0.2
-0.6
Slim-Excess® 3%
of Slim-Excess ® combined with -0.4
95% of the subjects
caffeine was also evaluated. -0.6
up to
-1.3 cm
showed a measurable
decrease
Statistics:
Difference calculated from the mean of 25 (Slim-Excess® 3%)
(***) and 24 (cafeine 3%) volunteers.
-0.8 Man Whitney or Student’s unpaired test.
(***) p<0.001 vs caffeine 3%
Results used alone 4 weeks
The average loss in cm around
the thighs of the volunteers who Fig. 11 – Differences in centimetric measurements taken from around the volunteers’s thighs treated
applied Slim-Excess ® 3% alone either with Slim-Excess ® 3% or with cafeine 3%.
was -0.6 cm after 4 weeks of
treatment (fig. 11).
Differences in centimetric measurements (Tn-T0)
2 weeks 4 weeks 8 weeks
0

Results combined with caffeine -0.1

up to (*)
After 4 weeks of treatment, the -0.2
-0.5 cm (*) Caffeine

results on thighs circumference -0.3

Slim-Excess® 3%
+ caffeine 3%

were multiplied by 4, when com- -0.4

(***)
Statistics:
bined with caffeine compared to up to
-1 cm
(***) Difference calculated from the mean of 25 (Slim-Excess® 3% +
cafeine 3%) and 24 (cafeine 3%) volunteers.
-0.5 (°°°)
caffeine alone (fig. 12). Man Whitney or Student’s unpaired test
(*) significant difference as compared to T0 (p<0.05)
-0.6 (***) significant difference as compared to T0 (p<0.001)
(°°) significant difference as compared to caffeine 3% (p<0.01)
-0.7 (°°°) significant difference as compared to caffeine 3% (p<0.001)
up to (***)
-1.2 cm
-0.8 (°°)
Time (weeks)

Fig. 12 – Efficacy of Slim-Excess ® when combined with caffeine on thigh circumference.

Conclusion
Slim-Excess ® contributes to
slim down the thighs in 4 weeks.
Slim-Excess®:
- contributes to reduced cellulite in 2 weeks,
- contributes to slim the thighs in 4 weeks,
- shows a greater efficacy than caffeine.
Slim-Excess ®

Origin / Description
Slim-Excess ® is a red seaweed hydrolyzate based on sulfo-carrabioses

Summary file
Slim-Excess® Reference A00073
Regulatory data INCI: Water, Butylene Glycol, Pentylene Glycol, Sodium Chloride,
Hydrolyzed Rhodophycea Extract, Xanthan Gum
China: Each component listed in
- «International Cosmetic Ingredient Standard Chinese name» (2007 and 2010 versions)
- «Inventory of Existing Cosmetic Ingredient in China» (IECIC 2014)
CAS# 7732-18-5, 107-88-0, 5343-92-0, 7647-14-5, 9000-07-1, 11138-66-2
EINECS/ELINCS# 231-791-2, 203-529-7, 226-285-3, 231-598-3, 232-524-2,
234-394-2

Appearance Clear liquid to opalescent

Formulation data Concentration of use: 2 to 3%
Solubility: dispersible in water
Incorporation method: Slim-Excess™ can be incorporated into formula
at room temperature, not affected by normal cosmetic processing.
Optimal pH: 4 - 8
Storage In its original packaging and protected from moisture, at 10 - 30°C.
Shelf life 12 months
Patent family FR2917971B1, US8153611B2, US8604001B2
Under examination in EP, BR, JP, KR and CN
Credits
Publisher
BASF Beauty Care Solutions France SAS
3 rue de Seichamps - 54425 Pulnoy France
Email: bcs-europe@basf.com

Editorial team
Beauty Creations, France.

Pictures
© BASF Beauty Care Solutions France SAS. All rights reserved.
®/™ = registered trademark/trademark of BASF in several countries

Global Edition, March 2014

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