Professional Documents
Culture Documents
RCR S 23 02486
RCR S 23 02486
RCR S 23 02486
Manuscript Number:
Section/Category: Oncology
Chakradhar Ravipati, MD
Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation
Declaration of Interest
Declaration of interests
☒ The authors declare that they have no known competing financial interests or personal relationships
that could have appeared to influence the work reported in this paper.
☐The authors declare the following financial interests/personal relationships which may be considered
as potential competing interests:
Patient Consent Statement
By signing this form, you agree to let us write about your health condition for educational purposes.
We assure you that your identity will remain confidential; your name or any personal identifiers will
not be used. If we include any pictures or medical information, we will ensure your anonymity is
maintained. Sharing your story is intended to help others learn about similar health issues. Remember,
your participation is completely voluntary, and you have the right to withdraw your consent at any
time before publication.
Cover Letter
Editor-In-Chief
Dear Dr.
Each of the authors confirms that this manuscript has not been previously published and is not
currently under consideration by any other journal. Additionally, all of the authors have approved
the contents of this paper and have agreed to the Radiology Case Reports (RCR) submission
policies.
Each named author has substantially contributed to conducting the underlying research and drafting
this manuscript. Additionally, to the best of our knowledge, the named authors have no conflict of
interest, financial or otherwise.
Sincerely,
Corresponding Author:
Dr. Chakradhar Ravipati
PG Resident
Department of Radio-Diagnosis
Saveetha Medical College and Hospital
Saveetha Nagar, Thandalam
Chennai, Tamil Nadu, India - 602105
Email: chakradharravipati5298@gmail.com
Mobile : +918438113827
Title Page
Contributing Authors:
Dr. VETTRIVIZHI.S.A1
MD
Associate Professor
Department of Radio-Diagnosis
Saveetha Medical College and Hospital
Saveetha Nagar, Thandalam
Chennai, Tamil Nadu, India – 602105
Email: arutperumselvi@gmail.com
Mobile: + 91 9944643867
Dr.VINOTH PANDIAN3
PG Resident
Department of Radio-Diagnosis
Saveetha Medical College and Hospital
Saveetha Nagar, Thandalam
Chennai, Tamil Nadu, India - 602105
Email: vinothpandian7@gmail.com
Mobile: +91 8754128850
Corresponding Author:
Dr. Chakradhar Ravipati
PG Resident
Department of Radio-Diagnosis
Saveetha Medical College and Hospital
Saveetha Nagar, Thandalam
Chennai, Tamil Nadu, India - 602105
Email: chakradharravipati5298@gmail.com
Mobile : +918438113827
Word count:
Declaration
Authors contributions: 1st author – Dr. Dr. Vettrivizhi.S.A, 2nd author - Dr. Karthik Krishna
Ramakrishnan, 3rd author – Dr. Vinoth Pandian, 4th author – Dr. Yuvaraj Muralidharan
Acknowledgement:
Nil.
Conflicts of interest:
Abstract:
Paratesticular myxoid liposarcoma is an exceedingly rare malignancy originating from the
spermatic cord or paratesticular tissues. We report a unique case of a 75-year-old male patient
who presented with a progressively enlarging painless scrotal swelling for four years.
Imaging investigations, including Ultrasonography (USG) and Contrast enhanced
Computerized tomography(CECT), revealed characteristics consistent with para-testicular
myxoid liposarcoma. Orchidectomy specimen confirmed a grade 2 right para-testicular
myxoid liposarcoma. Despite its rarity, clinicians must consider this tumour in the differential
diagnosis of painless scrotal swellings. Accurate diagnosis and comprehensive management,
encompassing surgical resection with wide margins and potential adjuvant therapies, are
pivotal. This case underlines the importance of collaborative research and long-term follow-
up in understanding and managing para-testicular myxoid liposarcomas better.
Keywords:
- Para-testicular myxoid liposarcoma
- Adipose tissue tumour
- Scrotal swelling
- Orchidectomy
INTRODUCTION
Para-testicular myxoid liposarcoma is a rare malignant soft tissue tumour originating from
adipose tissue in the para-testicular region. It is characterized by a myxoid matrix with
scattered lipoblasts, making it distinct from other liposarcoma subtypes. While myxoid
liposarcomas can occur in various anatomical sites, para-testicular involvement is particularly
unusual and presents diagnostic and therapeutic challenges due to its anatomical proximity to
vital structures.The peak incidence of para-testicular sarcomas is seen in men in their sixth
decade and usually presents with a painful or painless scrotal mass or swelling, occasionally
accompanied by a hydrocele. [1]
Para-testicular liposarcoma is an infrequent tumour characterized by a growing, painless,
inguinal or scrotal mass. Only about 250 cases have been reported as of yet in literature,
however there are a few cases regarding giant para-testicular liposarcoma measuring over 10
cm. Myxoid liposarcoma is the most common histological subtype and Giant liposarcomas
are those measuring over 10 cm. It is commonly misdiagnosed prior to histopathological
evaluation leading to local recurrence due to inaccurate diagnosis and treatment.
Liposarcoma can originate from the tissue of the cord, which can be an extension of
retroperitoneal fat, or it can result from the malignant transformation of a preexisting
lipoma.[2]
CASE REPORT
A 75- year-old male hailing from a modest social background, presented with a painless right
scrotal swelling that had gradually grown over four years. Denying any history of trauma, fever, or
weight loss, he expressed concern about the persistent enlargement. Clinical examination revealed a
firm, non-tender swelling in the right scrotum. The sole physical finding was a rigid mass, measuring
approximately 12 cm in maximum diameter, localized in the right scrotum.
This clinical observation highlighted the prominence and significance of the mass as the
primary focus of concern. The lack of additional positive findings underscored the discreet
nature of the manifestation, emphasizing the need for thorough diagnostic investigations to
unravel the nature and implications of the scrotal mass.
Financial constraints limited previous healthcare access, and the patient lacked a significant
medical history. Family history was unremarkable.
INVESTIGATIONS
The diagnostic journey incorporated a comprehensive assessment, including laboratory
examinations. Haemogram, urinalysis, stool routine, ESR, β-human chorionic gonadotropin,
α-fetoprotein, mycobacterium tuberculosis antibody Ig-G, liver and kidney function tests, and
chest X-ray were conducted. Notably, all these investigations yielded no specific
abnormalities, contributing to the challenge of diagnosing the scrotal mass. Despite the
absence of abnormalities in these baseline assessments, the imaging modalities, including
Ultrasonography (USG) and Contrast-enhanced Computerized Tomography (CECT) to
characterize the scrotal mass have been performed.
USG revealed a large heteroechoic solid mass (~9.9 x 9.4 x 8.7 cm), displaying hyperechoic
foci and faint internal vascularity, expanding the right hemi-scrotal sac (Fig.1A). However,
the testicular origin of the mass lesion remained unconfirmed, necessitating cross-sectional
imaging.
CECT of the abdomen and pelvis unveiled a large heterogeneously enhancing mixed
attenuating extra-testicular lesion (12.7 x 10.9 x 9.3 cm). Internal soft tissue/fat attenuating
areas and peripheral punctate & chalky calcifications were evident in the right hemi-scrotum,
along with lipomatous hypertrophy (white arrow in Figure-1C). The right gonadal vessels
likely supplied the lesion (white arrow in Figure-1D), causing inferior and peripheral
displacement of the right testis and significant compression and cranial displacement of the
left hemi-scrotum and testis (White Arrowhead in Figure-1C).
DISCUSSION:
Para-testicular myxoid liposarcoma (PTML) is an unusual clinical entity, hence presenting
challenges in diagnosis, management, and prediction of patient outcomes. This case-report
present a remarkable case of a 75-year-old male presenting with a giant PTML, expanding the
breadth of documented cases and enriching the available literature on the topic.
Para-testicular myxoid liposarcoma is an exceptionally uncommon form of liposarcoma,
representing only about 3% to 7% of sarcomas in the para-testicular region.[3]It arises from
the adipose tissue in the para-testicular region and is distinguished by the presence of a
myxoid matrix and scattered lipoblasts. This type of liposarcoma predominantly affects
adults, with the typical age of presentation falling between 50 and 60 years. [3]Clinically,
patients typically present with a painless, progressively enlarging mass in the para-testicular
area, as observed in this case. However, due to the non-specific symptoms, other benign and
malignant para-testicular masses, such as lipomas, fibrous pseudo-tumours, and
leiomyosarcomas, may be included in the differential diagnosis.
Imaging techniques in our case, identified a heteroechoic mass in the scrotum on USG,
suggesting a solid tumour component. CECT revealed further characteristics consistent with
para-testicular myxoid liposarcoma. orchidectomy followed by histopathological
examination was performed on the mass, and confirmed a grade 2 right para-testicular
myxoid liposarcoma.
The specimen's large size and involvement of the attached cord structure highlight the locally
advanced nature of the tumour. Histologically, myxoid liposarcomas are characterized by a
myxoid matrix with scattered lipoblasts, which were likely observed in the HPE. The grade
assigned to the tumour corresponds to its microscopic appearance and cellular atypia, which
aids in determining its aggressiveness and potential for local recurrence or distant metastasis
CONCLUSION:
Giant para-testicular liposarcomas remain an infrequent clinical finding. Given the absence of
a universally accepted diagnostic and treatment protocol for these tumours, it is pivotal to opt
for a high radical orchidectomy, ensuring comprehensive tumour removal, coupled with
consistent long-term monitoring due to the pronounced risk of recurrent tumour growth.
Diagnostic tools such as ultrasound, CT scans, and MRI provide initial insights, yet the
conclusive diagnosis stems from histological, immunohistochemical, and genetic evaluations.
In situations where such tumours are suspected, immediate high inguinal orchidectomy
combined with localized tumour resection is advised.
Acknowledgment:
None
Declaration of patient consent:
The authors certify that they have obtained all appropriate patient consent.
Financial support and sponsorship:
Nil
Conflicts of interest:
There are no conflicts of interest.
Declaration of generative AI and AI-assisted technologies in the writing process:
During the preparation of this work, OpenAI was used in order to improve language and
readability. After using this tool/service, the author(s) reviewed and edited the content as
needed and take full responsibility for the content of the publication.
REFERENCES:
[1] Coleman J, Brennan MF, Alektiar K, et al. Adult spermatic cord sarcomas: management
and results. Ann Surg Oncol. 2003; 10: 669–675. DOI: 10.1245/aso.2003.11.014
[2] Vukmirović F, Zejnilović N, Ivović J. Liposarkomparatestikularnogtkivaifunikulusa.
VojnosanitetskiPregled. 2013;70(7):693–6. https://doi.org/10.2298/VSP1307695V
[3] Fitzgerald S, MacLennan GT. Para-testicular Liposarcoma. J Urol. 2009;181(1):331–2.
https://doi.org/10.1016/j.juro.2008.10.080
[4] Noguchi T, Fukushima T, Hara H, Sekiguchi N, Kobayashi T, Ozawa T, Gomi D, Koizumi
T. Giant paratesticular liposarcoma with lung metastases: A case report and review of the
literature. Journal of Medical Case Reports. 2020;14(1). https://doi.org/10.1186/s13256-020-
02420-x
[5] Mouden K, Wakrim S, Semmar A. Paratesticular liposarcoma: A case report. Pan African
Medical Journal. 2019;33. https://doi.org/10.11604/pamj.2019.33.282.19545
[6] Montgomery E, Fisher C. Paratesticular Liposarcoma A Clinicopathologic Study. Am J
Surg Pathol. 2003;27(1). DOI: 10.1097/00000478-200301000-00005
Abbreviations:
1. USG - Ultrasonography
2. CECT - Contrast enhanced Computerized tomography
3. PTML - Para-testicular myxoid liposarcoma
4. HPE - Histopathological examination
5. CT - Computerized tomography
6. MRI - Magnetic Resonance Imaging
Figures Click here to access/download;Figure;FIGURE with
CAPTIONS.docx
Figure 1- (A) Scrotal ultrasound showing a large heteroechoic solid mass with
hyperechoic foci and faint internal vascularity seen expanding right hemi-scrotal
sac.(B - D) CT-abdomen and pelvis showing a large mild heterogeneously enhancing
mixed attenuating extra-testicular lesion with internal soft tissue / fat attenuating
areas and a few peripheral punctate & chalky calcifications seen involving and
expanding right hemi-scrotum (White arrow in 1B) with lipomatoushypertrophy
(White arrow in IC).Right gonadal vessels likely supply the lesion (white arrow in 1D).
The lesion is seen causing inferior and peripheral displacement of the right testis and
significant compression and cranial displacement of the left hemi-scrotum and testis
(White arrow head in C).
Figure 2 - (A) Gross Image of lesion: Solid lobulated para-testicular mass with
yellowish mucoid areas on right side. Normal uninvolved testis on left side (White
arrow). (B and C) Microscopic examination of the mass revealed a (B) Monomorphic,
stellate-shaped cells without atypia, chicken wire-type blood vessels (yellow square)
(Delicate thin-walled arborizing and curving capillaries), lipoblasts (red square)
& Myxoid matrix. (C) Testicular tissue composed of seminiferous tubule without
tumour involvement.