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Chapter 2, Unit 1, Human Anatomy and Physiology 1, B Pharmacy 1st Sem, Carewell Pharma
Chapter 2, Unit 1, Human Anatomy and Physiology 1, B Pharmacy 1st Sem, Carewell Pharma
Chapter 2, Unit 1, Human Anatomy and Physiology 1, B Pharmacy 1st Sem, Carewell Pharma
C
Thi 4) dependext of by lutracdlula
4eneyal
Trans Syllabus
CELLULAR
division
which tndoino
AR
intracolular
port
extacellular Stuchuk
is
principea -
corjaina aoss
b) sionalling
Cell
LEVEL
HAPTeR-2
cellulay paracrine nd
E
siqnalling
funcions
(celly signal
TUnchions.
of col OF
W
pathway
ceLl
lerel menbva, ORGANSATMON
y : moleeule,
of
a)
Communlahion,
EL
Syhapie
(Tissuc of ochivaion
Cell
body oitact
forms
Cel
L
i) i) -
Cells
t
PH
Eükaryotic
-huy Prokanyohc
about
and human
human
functional
which
which have nanoqam
organlls. and
lo4y
ely bod.
AR
ells Uni
of
ae ->
less
Thee (tuo)
stvuctural,
Con
L00
folly deelopd
ndt
e).
espechvey.
sisf of
ae typui tillions
M
duveloped,
fully of of oUr
tuose
Bacher those basic
about
body
nUcluus
ia
dvcdoped.
calu al
A
iving ond
cellu cel
thy
ee lo
and with
m .
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Nucleolus
trdoplsni
Rehiculum
C Apponatus
(e) Gtosol
aolgi houe
CELL
bo oqanllu
dy plauts,
AR
struchural
ysosoms endosed l
t (animals)
pieset
dveloped
cel
E
and
evtosomQs within
is
in nucwS
W
funchional
tungi
the cell.
ete. and
EL
mimbranu.
basic
of Sructu peroxisoma
mumbvanL
- Unut
Cel
Mitochondia
Nuclauç
RibosomL Gytoplasm
Plasma
living
ot
of
L
u) ii) i) proein
(Movement)
Thue
PH
Srudue funchion
Cell
PlaAMa ranlation.
Nucdeus Monbrane
divicion.
Of
toplasm qrouth
Synthis
at
colls
munbran
It of oF
of of
AR
about
aud tu aud
cell
is
all by OUr (200)
dividd matabolism
tranaciption
M
aroSs
fPibosoLy diferent
+ Organdlls bo
Golgi nitochandria
dy.
into
by th
A
tpparotus
tyKoson th typs
fPeasison
Cetrotor ee and col ce
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C Manbra
It
-
Chumicad Struture
Tt
alloulgsubgancas
enivONmwt Plauma
and
Phospholipid
cell Membrae.
AR
is The
ompo
is
phasphat
Made Membran
G.L wlich
nada was
tud selectively
thi
sihin
Gpéds
- of
up
Nicholson.
Mosaje
qven
qiven Hso
E
(Sepasal) oUternmost
ell
with
to (2urmeabl
known
W
to
by Model
pass the out meblane
hilaycr
ST:
a
EL
phsphati exteoroal
through
ipid (hajdnaplilic)
of nhich
the
singu Cel
of
of plasm
(ndra phospho- intonal
phopho
lipid
4t.
envion,
of
phalic)
L
pop
phespholipid
funchions
biluyo
IF
PH
proteind,
"t I arhohudatel,
proejna
tequlaes
provida Tntcga,
qive proeia
protein
pevipharol
(Ahapa
of
tu
AR
tha (protectin)
(extiic) (glycopvotein)
the
Transmunbran ipid
VaroUs
tow to molecule
blayr
prokin
from
tu
M
Channl
of Ahapt
and
au
naterial
col
external
lipidu
4
s
protein Tnkegval attachad
Peviphaal ad embddd
A
ento
(qyolipid
envirnm (qlobva)
q'yclipd prtins
sizu.
"piskin
qlyo
wtth
and
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MSsiy
-
C 2) 1)
ytoplaanj
with ou
Orqanllus
woae viscoUs ytosol
t
specific
AR
t
other
also to
c the
pe whjch
TE 2) It plasma
It tu
foncton sent proteins
Organ play
furthr
cels.
Is is cell.
E
in , Contain
ts mombrans
the
or a
fcor toplaAm
upids
It fluid
dividad
kayrdle
ceyrole
W
is a) total exernal
and oMmUnÜGtia
to pats
907.
L
Nucdus(
flattentd O
ibosoms rdoplosmjc
EndoplasmNie
PH
in Cenvosoml
ysocoms
nitochondvia 2ibosoM
Golgi
proxsoma.
network
the
System pparavs
sacs
form
that Reticulum
It
AR
Reticulum
aud encbsed
consists ef is /
banchud
Body
ustenae. thee aa (Ee)
(Ee)
onl
M
SMooth
-Rough within comply
of dimnsional
ubulus
veaicdes,
the
A
Erdaplasmc Channl
Reticul
(ER) menbran
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.t
C fko -furcion,
i) )
in riboso
SERY exhang
Atct Smoth Rovgh
. cutplasm is
AR
kndwn
ma
Thee
cholustrol a ER Mubran EK
ot
hetþ
materials atjachd,
RNA
as tuo
factory
aae in sfvctural
PabosorA
those
E
t and suynthuis
sayntei. typus
sureral
Hiy a ER
finy hulbed ohich
W
triglycwidus.
s off
framuork
ae
sphses
have
-
takes ribosomal oF not in
protcins,
EL
(rotein)
phosphslipidi,
vibosomus
atachd.
that
placad
blcaust
proeina.
of aud
onfin
L
Spoca i.e.
membrane subunit
Mitochondria
The
PH
attahd
Outer
of is
SMallu
memb
cel, (6os).
pleAeKt
raL
It with
subunts
Made
AR
bacause
s
DN E-R.
oistau
kuouUn in
A up
fee (40s)
Libosons
it and
M
aA foum.
withto
qnrae and
the
thu
(Pouwer
A
atochorcria
1fTP|
sbunts
(natrly) laqer
Jfotida
-Head House
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Midjal
C Ti
•
tegin Le.
eqim,
is upon
-Hattentd Golgi
alco
t
with cellular innay
is
AR
puform
0ch Made
mada
fippavehs
expanded proliferationspeod-
and
funchion
othy, Sacs
It up
collulr outer
E
Consists /Body
Lika with
allid
bulgs
is
to
W
siqnalling
as to
of qonrate
Lsosome at pila cisfen
four -
mnbrans
EL
(
sacetovy
Gsterna
their
vesclu ancd
grnule)
of to enrgy
plaad
plates egulaka
ends.
six
L
.Moleules,
of tuy -thogh
huydvolyic
ot Also
PH
thuy
dafencaug
Vaay proteina
aud
AR
wok huy
againt a ortain as Compy.
in protein
kangeng ipids.
ae ganules
to
the ekcr
and
RNt Seoefory k-
ehing
th
M
digestve)
digustie ting nodiky)
trom holyst ,
wken
aud plasma
exces
formad
0.l thn
A
L2 lag -enzyn
membra
from and
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- Cetiosornd
C
orqauje
t
subspncas
tonic
t
auds,
It
CLl. that
-the (onsists
Cotain
cel and
cel
E
UriC
etfeatr
Can
eNym SUch
division)
play
ad d
W
OXidjza many Cevriw
Tranipot as an a
ete.
Catala, oxidases
pair
EL
imporfat
fatty Vaujous
protein
-Gqsthllin
ipid acid, of
"bilayr
aud
L
the
"contol
- allad sphical soparale
It Tt If F
PH
Pasent lasgst
and aggregahöns
ontan
col. is and
dicty also
tranfer caote| nucleolus.
Consis
The
cey shuctue nNclus
in ovoal
AR
tha
to involveA
f the of of shaped
nucleus
all Nuded
from
cel.
daugho double
protein
9anhi) plasm
qonhc
in • isis
suctue the struce
M
the menbra,
Usually
cols
informatin DNA malerial
kprodvction, Gytoplasm.
Of .
-Nucleay which
A
NucUeus
enuelope
NucleoluS
induding
RNA. Nuclear
-chromahn
which sphical
-frm
Is
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Y
C iY Made • TRANSPoRT
cell
)
Endocytosi Active
Pascive Substonus
It allo
Mambran
to
parmable,
Plasma
vbrou
is up
AR
CoSs
tanspotinnytttonspot Bubstanca
knoun
tapot Mubran
wth
is which
through
ae pkosphalipáda) a
t. AcROSS
E
to
biological
tranipoted allow
Secondany
Mnbyone
NOve
of
W
call
faciilated fassive ony MEMBRANES
nebans,
acsOSs (traupon
though bilayur
som e
EL
difusion
hat sekectively
difusion (Bubs}anu
Munbran
which allae
the ad
ond
is
L
i)
•(Concantration
amoUnt
from High
q passive
rmove
PH
Conen Passive
aOSS
dffusjon (acosc)
ac0ss
th difusion
3eE• from
wi tansport
thout
the conch
eqion
eqion
oF Giadient
t the (high)
AR
ipd Coneh
conch
> In qradyen
o}amount
whn
is jConch
soluble
of th, Concudration
qrodjent
th any
of hghar
tranuport
qrodien
subsfant
M
molbculus
enug4 dug/
conCONch (aqains}
i.e. te kubstana
concsilyatt
A
grodicn (lower
High
aka
to of ranporf
ie. supsfaxs
O,
loueY
to
f
leu
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- Aoluble
CO
C
Injeshinal
Carrier
Tt hlp faaltated
dovgs aossthe
across
Eit s
AR
of
absorption of
Used Suitabu
also
any diffusion
f
qlucoSe he Poe
caUad
such
arrier
(any cou
for conc Tn
E
channal)
into thu,
of poovly Caier
qradient,
"Hiqh menbranL
W
(RRAI. bodjes|
SLC substanca
that's
but
transpont
B. thanipente)
arrier
tanypot)
chann!.
substauL with
aq-
why
pietein
th
L
- Tn
ii)Active
membrne.(from
It particle
PH
Primavy
Seconda
hgh louw
help
is thii (againut
Conc"
conc)
-trangort
tasport
typus
te los high th
thi
moe
ud
-
Conch olue) Senipumble
, to Munt
,ATP Avbstonca Conc (sole)
M
qrodient
to
hydrolysa
Solvent
arier
with trans
A
(
peort wato)
the bodu
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C Artiportl(
.Primavy
Secanday
both
AR
Molecule grodiet
Subitanu
achve
H* Na*- active
coUnjer Smport ATP
Na
pump.
in
qlucosa
a Tvanspot
enuqy-
tansport
-traupor in Lou
E
used
oposte co-trowpovt)
Sarmd High
sumpoter
In In
thiu,
W
H' instad
t) ire
Absorption
thiu,
Naic*
>
dr movemnt
chion
elechochujcol
TP)
EL
cthon
(Lc)
moremnt of Arfase
. enrqy of is
Nat qlucose
Used
punp.
of qlucoe
Na
of
L
o |OUTSIDE
i)
q
PH
Phaqocujosus
procAs NacOMalecues
Pinocu,tosis
lags Endocutosis
enqulfing
fat, enquifmunt
Cellular
sauch, sizL
of
(ell In
(call ad
AR
molecules
uptaka
this
drinkivg]
oil-
by
eating]
dng ttanport,
solublu
call
Of( of
Slid
like qt
M
Mavomaleubr
uifamnu
menbrans.
uptake
) ad lnsulin.
ttonpoed
quqs
Bdlute pasti scyptic
ot
A
cul
of aes.
(fiud) like very
ptake MaO INSIDE
via
Wk.
A,
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ii) i) O
C Coll
It
((ncHeasa)
Mejosis The
Of
itothe
Nitosis
el cel
(th.ply colls is CELL
is
AR
dvision
the eKoctty
qenehc divjdes
chromosond
cCUYS
kiponsi no. esponsiblu i.
amoUn
no
procass
cUrs
of is qrouwth
DIVIsiON
sSame into
ontent
in bta chvomosOme
in of
E
epvoduchive of
for
tuo by
decaLed
Somatic
for tuo) cells
formation to (CNA)
W
(grouwth)
which
typs
Sama
the davghter
CReduchonal
cels
cell
of of - tuo
parent
a
EL
(equatiaal
identicol
f
{qamats
parent
and cols. nuwly parent
cells.
divislon
no.
divisio]
daugkey el.
cell. all
of oymad
L
calls
I) i)
PH
evertually
Cell
M-phase Interpas-
It
Cyde
utaphaAhaphan has call
,
TelophasL
(peparation
Prophas ytakiuu Phoss
for (second
The
- tuo dupiates
phaseJ AhsResting
Cfint dividu
Cell papanatin.
AR
mitosis
Phase Collphasr soqvenca)
divitga
phae phasU
qrouwth
(ka qrowh a,
G,
divicin
Onstiuendts)
ONA
(Grouwth
Ce uo of
events
daugher
Ceutridu
Cromosoma
Phase
S
Phasa
(9 RNA
AD) tu
Replicahian
A
Syntkuis
wi) Nucleaticu,
cel synthis
b
/duplicothian,
pepasohin
CNA
protejn
dupliatio
DNA
colls which
eplictia
and
of for
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i)
i) 1)
C •
huclei.
kayolinesus i) Cl oleady .It
Gytokinis kayokinsis IH pakent In Mitosu
phaAe
cell is
AR
is is
thi,
(SaM)
(nudeus idential
exiching AHso
cell. CUrs
the
fquational
into
as lonoun
no. daughter
in
E
dividas parent
to
Telophase
(Somatic
coll)
by of divids
EL
tuo which (a) Chvomosonm oind
in in
daugney daughe which
or
into Mitotic
th (2n)
L
in
cwomaidi
O - Nucdear
•
ase Spindlu inatochores chomosomal Ntaphase
opposit
Prophase
PH
Cevtrioles
Sutey Organea
Malerial
Äntochoe
cetonue
moved disinteqation
fiblu
chomatds
ervelopa
oF
poles This
to (smal (cortrosom]
ie.l CondeNsationof
atach
condensation
This ike
AR
chyomatin
spindle
disc
phace
disapptor
qolgi
of phase
ae of the
to shaped)
move
equaor holds cleat bqins
kinatochores
Complus
baqin cell.
conpued
at
M
at toguther
towards
with
thu
and th envelopa. with
-riatic
Ek, hvomosa
surfae
and
end Nuclelus,
get and -Nudw
inihtion
A
tentrosom
by Comle
spindl th
allignad. of
chomosor
of cortonre two
propkase
coston
fibacs
aud
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Cytplaum
ti) - •Telophase
- •naphae
C
othu -foumd
Nucluay and wonosOmLA
Separatin
-form
qtokinAs
kappiat.. a opposik
cOMain
last
AR
ca oqaull
to chomosoMLs.
Memorn
two
utoplasm
polA
atin
ag of Bgins
olus.
It material
maferial
looe
choatids
dawahter
is af
E
the eaPplat with
individalit
aflr
is
W
divisin osis
ces. splthing
nvcuus
aud
collected
nd
and
two Move
EL
of
(delondunsatia)
en
division
porent
nudar as owardA
of
ths,
a
och
daug Ma
ker to
L
Peplcate
DNA
Diplsd
2)
()n femals
Mal by
PH
Meiosis
call).
(XX
(au) (au) male the
X) ) It
paent Tn
qarmate. fucin
n OCCUrS
AR
this,
e! haplaid
ors
Spemm
ef offspring in
(u) qomte
M
MEIOS|S
femal
(ud
colla
Davguler Zygati
orent tuman
-DNA
A
qamek (eproduhie
prodwead
eplictu
Mitocis
colla meiosis
cal
(eu)
Niosis (an) and
-T
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-Prophast
i) in)
C a) i)
Meiosis Meiosis Mejosis
uptotehd
AR
-
-I
phases
-I L -I
phase in
t "t
t
Telophau Anaphase Nataphase Prophase
Condnsaion
Telophase Anaphase-I Naaphast-T
twoskagus
Aauts. erophase-
is
E
furthur
dinidd
-I
longer
-II -T -I -I
I.
W
of sub- 3
info
chomosoM and Diploe achuyfen Zygotend Laptoen
did Diakins
EL
(for
moR
phaA. w
ino Complw,
five
L
aud is
e) ) -formud b)
tuo
aud
PH
coss Synaptonunol
choNOsom
is
eveloP nq phase Comp
Herminalsohionof
phase phasa
Nucduolus
ouduniation md X-Chapd
noun
-
AR
discljn over
exchange
ad pauring
a
chroroom
asdhiasmata
efered
Spanoton
of ot
onplted.
ef
of
a
M
uyhaptonumal chromO
qenhie
chias tHomologous
SOmUS,
mirothic mata,
matrial dromatids
A
Tefiad
Biyaleut
Complu
fomatin
chuOMO
and
spindl Somes
by / th
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C this Duplsid
nudoulus
Telophase (Anaphase
Seen allign
|Muaphase-I
a -formd
9
Meiotic
spated.
plate.
shot tlophase
Nucua
atachng
AR
Homal0uS
at
divisjons
to 2n (2n
teappeo
-I -I mjootubu
te
cwomoSOMU
pjd
Tt follaused
munbran
to equatorial
haplsid
cwomoonMS
the
E
is
of and + pai. ae
th
tims (qamhes)
by
W
stage daghte
usual
USually
cutoEinuis
hoplakd
EL
baucN
call.
lasts
and
for tuo
L
•|Metaphae-L -|Prophasa-I
•|Telophas
Nvdeor
and
(fnaphaA-I|
spindlu ii)
s ond
PH
of
t
ChromosOm.
nqonelus Melosu
polu.
ma chomain sepanatn
equotonal
move
wOMtSOMU nucus.
munbranl
aho
of and
-|
Condensatim
uauds
TI
tuo
ytoplasm
Sepavahen
materl
aligunt
disapporarA
Compoisu
It
AR
eappas
pols loose of
cronhidy is
opposte
4
s indiogualy
of
simlar
of
M
four as
fvT
/ ()
normal
daughter
formain stags
A
matoil.
alls.
of
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C •
complex.
•These
the •Tt
Thy
their
cels nd
|CELL
AR
neiqhboring
ae is
Dunbu the
prrçut
te
Made
extracelular
onact
E
cells JUNCTION
in up
mok Tjercolulas
W
\Various
spoco oith t onnNchon)
in matvix
beween
epithlial
Cel
mutfipvolin
odlusion
EL
colls, extraeula
(ung). Tunchon
batueen
a
-Itacdlulo
tissu
but Tissue
L
) iv) im)
ii) i)
•Typs
ves
- .fUnction
Solutes preven
thy thuy
PH
helps
tten also ponsibla cells.
DeA
Gap Adhwens
ight thy
MOSOML
moajntajn
ctaes
Tunchi
-dmosome provid
in and
Juncion ae -for attochumu
the
AR
Tundhon
oth
dwidd
steqnt)
transfof
MoVemiKt
ths
th
substanCs.
CoMmUni
COmofon pasacellulas
seal
into
prevent to of
M
/prerent
t of Cahion
five cels
cel substanes
unwauted
sepaatin
and
of : also
wate
- and
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vorioUs
•Thuy aud • i)
C
orqons
i2o preven
lw
try
ftulds. (MacO each Tn Tignt_
and
ae ot
cellA.
suDsfvs
blw
this,
AR
q
(ie
skin),
mostly
MOluuw) matrials
t Iujercellula
othr
othur too occlding onchion
cell
Urinary
toUnd
Junction Tiqht spac
adjoat tigt,
If
plasma
Mmbioe
by
blood
ae is
E
|Col-A Tunctions.
proteina
(seal) also
bladdr.
vesss in (held)
W
epethulial
cells.
knOun
pocked
and
cell-&]
ie. tightly)
claudjs
EL
tissud
auihes.
junchon
as
cgalh 2Onla
inchvdus 4
jwnchian
Tight oclodin
L
iii) during
j)
- fnocula
cols -they
thy of acuens
g sepaahion
thuy ytoplasmjc bla
PH
adhaeyu
DesmOsOMA
dens
l these
of pesant procs.
covtvatile prevent th proUjda
prouidt
Sate
iee pRsnt
epithial
adjacant bluw
or
juntin.
junthin, in of junctin
y faco These
AR
haant
muscde
of an woning
sftoMg
Sam
cortinuOUS,
tissuw. the atachemt
te the Tntercollua
A
adsion
(kerotin) as litag
Spac
typ (actin) Picofib
of
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C
AR
jonA,
- the
ar •In ) -spot
iv) -funchn,
E
bfuw
(onduction
Small
T formd
Gap
epithial
this,
temjdearmosom
cel allous
ftoplasm
thiu
W
-liku
AHso
Smooth
Tünchion
to moleul
col location
siqnals of filaments
adhuing
PH
MUsUa
(subitanc)
adjacant
from
th
cels. Rase basu
( junctian.
ConnEoh Call
ona maiy]
AR
Cardiac
channd
thyough 4 of
honnly
Cell
Poce
infer
epital
of
cellulcar
blo Tn
M
A
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•
- •
C *
Tn
potential
thy for I†
T to CeLL
to
To in anothy
and this,
qrowth is
AR
Chang ofMmunjae
ransport inportantto
proass
all-A
tu Also CoMMUNICATiON
orcuvivg cel
and call
substancas,
Cel
cel
Respons
o the
known
E
with developntnt
ransmiFsend)),
with
in memb mmintain
suqnal
as
W
ingernal Cal-B
20ch
ran qnai tself.
"el
oth (honuosaciu) from
of
EL
extonal
nd elkchical -Biclcqico Signalling
Siqnalling'.
espontd
to cella.
Ttiacatlwla
envivonnt. hls
ctfc
Natkulus cell
L
i) i) Intaclluia
thvough
by Genayal
PH
Send
within
Taocalular
Tntecelluar
dl exva tecapbr
the
communNCahionis
cellulor
pathwa cals.
efers Secondoy (recoptor it In principlu
signalijng
ativates signals)
the
AR
signa calU
o
siqnaltinq
Signalliu
ce )of
which côm
(pothuay) mesengr (
the
(expacalular]
Molecul
ahd (anGthe ie. mUnj
lisondy)
Imvolves
ommunicahion
of
M
e qive atin
eg.
It t0
tuO
octivaon
etfes
Inside tefers cme, espon cel ,
typus which
vaioUs
],
ong
tun
A
cell
butween 1P3].
tha
to 3
by
chain
the t - To9
cel
rceived
call
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-
procucingj
C cell Stqnal
signalling cells' Intacllular
BloLOGICAL
these these
signal
aud
AR
cells oth
siqnals siqnal
(sungu
Choin.
in
vecogni iqnalling
CAMP,DAG,
Seconday
IP3-. chunjcoy
th
thn
proein
Kecaptor
sed form
E
tranducd producad
by primaily
of
W
ayqt
mAenger
Ligavd.
into
el'(eceptor).
by Uss
EL
signal-
an
tronduchan
Signling
Tntracell TARGET
othe.
signalng
intraeyukr
or
(homoNS
exfenal
cely
ula
L
a) e) d) b) a) o Response
|Trasduchion
Reaption
fom
H
PH
membrone-
in Contact
fiutoorinu
EhdoCHins Paracin (onact- -these
ontact
s
signadling
depanclent
ar of conpluted
with
depardert
of
Inracdllulay
AR
mambran calllo
indaaellulan
ignalling
gaud)+
follaoing
another
Th
thid, rsponcs. nsuue (Pacapto in
ontat. Sianallig
thre
cel
M
signolting
onS typs
thyouah - steps
cell_ wh
:
A
binds
is
thu
irctty
lqand
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body
C b) Siqnalling.
siqnalling
Parooina
cell
OcUed
Of Close
AR
juxtacina
ond
mmu
.
arqet sqnalig
b
siqnalling
In
Mambrone-bound
celll
(elecbical)'
norb
this,
-
E
cell,
(MUScle
cell
- initiation
SUnOpe.
.Neurotrana
W
Synap tavgat
cells)
which cell and
and segval
Tarout
poancria
baueen
of
CommUnjahim
cel
EL
imU
molecules
milter is
ons nurons is
(churie eaponse
very
typ
L
tndocrin
e) d)
from
of
PH
tdocina
fhtpoina, through
Le.
ancu ached
cells
twhich horMonus
on
AR
segnaling
H
In
the re0
iqnuda<, thiis, this,
ep chd
ecaptot
spogn
mole into siqnalling
M
Sanallingq
culu
ecapor of 4-Bloocd
ek-.
ts
was targt
A
cel caUA
with
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