This document provides a review of pharmacokinetics and drug distribution concepts, including:
- NN610, an investigational cholesterol-lowering agent, will have a low apparent volume of distribution (Vd) due to its high molecular weight and extensive binding to albumin.
- For a 40-year-old male patient given 2000 mg of Vancomycin, the apparent volume of distribution is calculated to be 1 L/kg by dividing the dose by the peak plasma concentration.
- For a drug to cross the blood-brain barrier (BBB), it should have a hydrophobic property.
- The formula to determine a drug's apparent volume of distribution is V
This document provides a review of pharmacokinetics and drug distribution concepts, including:
- NN610, an investigational cholesterol-lowering agent, will have a low apparent volume of distribution (Vd) due to its high molecular weight and extensive binding to albumin.
- For a 40-year-old male patient given 2000 mg of Vancomycin, the apparent volume of distribution is calculated to be 1 L/kg by dividing the dose by the peak plasma concentration.
- For a drug to cross the blood-brain barrier (BBB), it should have a hydrophobic property.
- The formula to determine a drug's apparent volume of distribution is V
This document provides a review of pharmacokinetics and drug distribution concepts, including:
- NN610, an investigational cholesterol-lowering agent, will have a low apparent volume of distribution (Vd) due to its high molecular weight and extensive binding to albumin.
- For a 40-year-old male patient given 2000 mg of Vancomycin, the apparent volume of distribution is calculated to be 1 L/kg by dividing the dose by the peak plasma concentration.
- For a drug to cross the blood-brain barrier (BBB), it should have a hydrophobic property.
- The formula to determine a drug's apparent volume of distribution is V
Pharmacokinetics | Drug Distribution Medical Editor: Dr. Ana Guerra
I) REVIEW QUESTIONS WITH ANSWERS
QUESTIONS ANSWERS
1) NN610 is an investigational cholesterol-lowering b) Low
agent. Has a high molecular weight and is extensively bound to albumin. NN will have a _____ apparent volume of distribution (Vd) a) High b) Low c) Extremely high d) Normal
2) A 40-year-old male patient (70 kg) was recently a) 1 L/kg
diagnosed with infection involving methicillin-resistant S. aureus. He received 2000 mg of Vancomycin dose. The apparent volume of distribution (Vd) for a drug is defined The peak plasma concentration of Vancomycin was as the hypothetical fluid volume through which the drug is 28.5 mg/L. dispersed. It is calculated by dividing the total amount of The apparent volume of distribution is: drug given by the concentration of drug in plasma a) 1 L/kg (2000 𝑚𝑔/ 70 𝑘𝑔) b) 7 L/kg 𝑉𝑑 = = 1 𝐿/𝑘𝑔 c) 10 L/kg 28.5 𝑚𝑔/𝐿 d) 14 L/kg e) 70 L/kg
3) Levodopa is a drug very commonly used to treat c) Hydrophobic
Parkinson’s disease that acts by being converted to dopamine in the brain. Which property should it have in order to being able to cross the BBB? a) Large and polar b) Large and nonpolar c) Hydrophobic d) Bound to proteins
4) What is the formula to determine Vd of a drug? a)Vd = F x dose / C
a)Vd = F x dose / C b)Vd = F / dose x C c)Vd = C x F / C d)Vd = F + dose / C