The document outlines the steps for manufacturing vessel processes which include pressurization, initial line draining, water for injection (WFI) filling, cooling, heating, media mixing, product transfer, cleaning, rinsing, air flushing, sterilization, drying, and nitrogen blanketing. Each process involves opening and closing specific valves and monitoring temperatures or pressures over set periods of time to complete the required steps.
The document outlines the steps for manufacturing vessel processes which include pressurization, initial line draining, water for injection (WFI) filling, cooling, heating, media mixing, product transfer, cleaning, rinsing, air flushing, sterilization, drying, and nitrogen blanketing. Each process involves opening and closing specific valves and monitoring temperatures or pressures over set periods of time to complete the required steps.
The document outlines the steps for manufacturing vessel processes which include pressurization, initial line draining, water for injection (WFI) filling, cooling, heating, media mixing, product transfer, cleaning, rinsing, air flushing, sterilization, drying, and nitrogen blanketing. Each process involves opening and closing specific valves and monitoring temperatures or pressures over set periods of time to complete the required steps.
Step-1 Open Air Inlet Valve Step-2 Fill Air inside the Vessel Step-3 Closed All Other Valves of Vessels Step-4 Fill Air Till Design Pressure of Testing Step-5 Wait For 15 Min Step-6 After 15 Min the Pressure Cycle Complete Step-7 Release the Air to Depressure the Vessel End
Manufacturing Vesse Initial Line Drain Start
Step-1 Open Vessel Jacket Valve Step-2 Water Drain Through Jacket Step-3 Jacket Volume Completely Drain Step-4 Close Vessel Jacket Valve End
Manufacturing Vesse WFI Filling Start
Step-1 Vessel Inlet Valve Open Step-2 Water Filling in Vessel Through Spray Ball Step-3 Vessel Volume Achieved End
Manufacturing Vessel Cooling Step Start
Step-1 Open Cooling water Valve Step-2 Cooling Vessel till Ambient Temperature Step-3 Temperature Achieved Step-4 Continue Till 5 Min Step-5 Close Cooling water Valve End
Manufacturing Vessel Heating Step Start
Step-1 Open Steam Valve Step-2 Heating the Vessel till Heat Setpoint Step-3 Temperature Achieved Step-4 Continue Till 5 Min Step-5 Close Steam Valve End
Manufacturing Vesse Media Mixing Process For
Batch Start Step-1 Start Mixer Step-2 Keep Running End
Product Transfer From Manufacturing Vessel to
Holding Vessel Start Step-1 Open Nitogen Valve Step-2 Purge Nitrogen inside Vessel Step-3 Open Vessel Bottom Valve Step-4 Pass Media Through MFG Vessel To Holding Vessel Step-5 Open Holding Vessel Inlet Valve Step-6 Media Transfer Completed Step-7 Nitrogen Flushing Continue Step-8 Close Vessel Bottom Valve Step-9 Close Holding Vessel Inlet Valve End
1of 2 Prepared By:Raviprakash
SHREE KIRSHNA KESHAV LABORATORIES
Manufacturing Vessel Process Step
Manufacturing Vessel Cleaning with WFI Water Start Step-1 Vessel Inlet Valve Open Step-2 WFI Water Filling in Vessel Through Spray Ball Step-3 Vessel Volume Achieved Step-4 Start Recirculation with Pump Step-5 Recirculation for 5 Min Step-6 Open Vessel Drain Valve Step-7 Drain Complete Water End
Manufacturing Vessel Rinsing with WFI Water Start
Step-1 Vessel Inlet Valve Open Step-2 WFI Water Filling in Vessel Through Spray Ball Step-3 Vessel Volume Achieved Step-4 Start Recirculation with Pump Step-5 Recirculation for 5 Min Step-6 Open Vessel Drain Valve Step-7 Drain Complete Water End
Manufacturing Vessel Air Flushing Start
Step-1 Air Inlet Valve Open Step-2 Pass Air Through Complete Pipeline and Vessel Step-3 Air will Dry the Pipeline and Vessel Step-4 Open All Drain Valve Step-5 Pass Air for 5 Min Step-6 Close All Drain Valve End
Manufacturing Vessel Sterilization Start
Step-1 Open Steam Valve Step-2 Sterilize the Vessel till 122 Deg.C Step-3 Temperature Achieved Step-4 Continue Till 15 Min Step-5 Close Steam Valve End
Manufacturing Vessel Drying Start
Step-1 Air Inlet Valve Open Step-2 Pass Air Through Complete Pipeline and Vessel Step-3 Air will Dry the Pipeline and Vessel Step-4 Open All Drain Valve Step-5 Pass Air for 5 Min Step-6 Close All Drain Valve End
Manufacturing Vessel Nitrogen Blanketing Start
Step-1 Nitrogen Inlet Valve Open Step-2 Fill Nitrogen inside the Vessel Step-3 Closed All Other Valves of Vessels Step-4 Fill Nitrogen Till Design Pressure of Testing Step-5 Waiting Time As per User Step-6 Release the Air to Depressure the Vessel End