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  • Pathophysiology

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    Mary Kaye Silvestre
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    Decreased bile acid synthesis and increased cholesterol synthesis in the liver can lead to gallstone formation through supersaturation of bile with cholesterol, decreased bile flow, crystallization on the gallbladder surface, and enlargement into visible stones. Gallstones may cause inflammation of the gallbladder or bile ducts if they obstruct flow or move into bile ducts.

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    Decreased bile acid synthesis and increased cholesterol synthesis in the liver can lead to gallstone formation through supersaturation of bile with cholesterol, decreased bile flow, crystallization on the gallbladder surface, and enlargement into visible stones. Gallstones may cause inflammation of the gallbladder or bile ducts if they obstruct flow or move into bile ducts.

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    4 views3 pages

    Pathophysiology

    Uploaded by

    Mary Kaye Silvestre
    Decreased bile acid synthesis and increased cholesterol synthesis in the liver can lead to gallstone formation through supersaturation of bile with cholesterol, decreased bile flow, crystallization on the gallbladder surface, and enlargement into visible stones. Gallstones may cause inflammation of the gallbladder or bile ducts if they obstruct flow or move into bile ducts.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    of 3

    Predisposing Factors

    Precipitating Factors
    Previous pregnancies
    Female gender
    Fatty Meals

    Family History (Hereditary)

    Decreased bile acid synthesis


    and Increased cholesterol
    synthesis in the liver

    Super saturation of bile with


    cholesterol

    Decreased contractility of bile


    flow

    Formation of precipitates

    Forms solid crystals into


    gallbladder’s mucosal surface

    Enlarge to grossly visible stone


    (Gall stones)

    Cholelithiasis

    Inflammatory changes Stone may move in the bile duct

    Cholecystitis Obstruction in the common bile


    duct

    Inflammation of the bile duct


    (Cholangitis)
    Decreased bile acid synthesis and Increased cholesterol synthesis in the liver

    Super saturation of bile with cholesterol

    Decreased contractility of bile flow

    Formation of precipitates

    Forms solid crystals into gallbladder’s mucosal surface

    Enlarge to grossly visible stone (Gall stones)

    Cholelithiasis

    Inflammatory changes Stone may move in the bile ducts

    Cholecystitis Obstruction in the common bile duct

    Inflammation of the bile duct (Cholangitis)

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