This review summarizes the history, the current use, the advantages and disadvantages and also

the future of the phage therapy for combating bacteria. The review is well written, but it is
required revised before published.
1. Detail figure legend should be provided except title. There is only figure title in figure 2. I can
not find the figure 1 in the manuscript only the figure 1 title.
2. I recommend to provide a flow chart to introduce the development and the history of phage
therapy. For example, the history of tumor vaccine development (Zhuting Hu, et al. Nature
Reviews Immunology. 2018)

3. Table 1 should be re-draw, for example

Phage Therapy Antibiotic Therapy

Phages have a high degree of Antibiotics often kill a broad

Specificity
species and strain
specificity as they only disrupt
target bacteria.
Therefore, ecologically
important bacteria (e.g.,
intestinal microflora) remain
safe [44].
spectrum of both Gram
positive and Gram-negative
bacteria, including benign
flora, which is increasingly
viewed as undesirable for
normal microflora [45].

Mechanism of Action

...

4. There are many unnecessary spelling mistakes for example: “injecttheir” and “cellmembrane”
in the abstract. Please check carefully.