Professional Documents
Culture Documents
Other Drugs For Angina
Other Drugs For Angina
Other Drugs For Angina
Ivabradine
Trimetazidine
oxyphedrine
Ranolazine
Pharmacology
IVABRADINE - Ivabradine is a heart-rate-lowering agent that acts by selectively and specifically inhibiting the
cardiac pacemaker current (If), a mixed sodium-potassium inward current that controls the spontaneous
diastolic depolarization in the sinoatrial (SA) node and hence regulates the heart rate.
TRIMETAZIDINE - Trimetazidine increases cellular tolerance to ischemia by inhibiting fatty acid metabolism
and, secondarily, stimulating glucose metabolism.
OXYPHEDRINE - Oxyphedrine depresses the tonicity of coronary vessels, increase the coronary circulation
volume, the oxygen uptake by the heart and also to exert a positive inotropic and chronotropic action.
RANOLAZINE - Ranolazine inhibits rapid delayed rectifier potassium current, thus delaying action potential
and prolonging QT interval.
Adverse Effects
Side effects of Ranolazine are dizziness, weakness, constipation, postural hypotension, headache, dyspepsia.