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The discovery of DNA….

Use the model of the DNA research in the 1st column to come up with a reasonable conclusion (in the second column)
that can be derived from each discovery. Limit your conclusion to addressing only what this particular discovery
added to the overall understanding DNA structure and function

Smooth-strain is a lethal form of Streptococcus pneumonia. Rough (1928)


strain is non-lethal The mouse would not die if a nonvirulent
strain of bacteria was injected. Injecting a
pathogenic bacteria into a mouse results in
death when the animal gets pneumonia.
Even if there is a mix of virulent and non-
virulent mice, the mouse will die as the
disease progresses. The nonvirulent
bacterium must have been infected by the
virulent bacteria, making it dangerous to
mice.

Extraction of the DNA, proteins and lipids from smooth strain (1944)
Streptococcus pneumoniae, then exposed rough-strain The understanding was separation of lipids,
Streptococcus pneumoniae to each molecule separately. polysaccharides, proteins, and nucleic acids
from the lethal bacteria. The nucleic acids
were the ones responsible for the harmless
bacteria becoming harmful. The presence
of high amounts of DNA in the nucleic acids
supports the theory that DNA was a trigger
for the transformation.
(1950)
All four bases, adenine, thymine, guanine
and cytosine are found in all organisms.
Adenine and thymine were detected in
identical amounts in a DNA molecule, as
were guanine and cytosine. However, each
base has a distinct concentration in the
different organisms.

(1952)
A bacteriophage is a virus which causes viral replication within The bacteriophage injects its DNA into
bacterial cells bacterial cells, causing an infection. They
can inject their materials into the cell,
where they will reside. Based on this
conclusion, it helps us better understand
the experiment conducted in 1928. The
virulent bacteria must have injected their
DNA into the nonvirulent bacterium,
infecting it.

(1951-1953)
This provides further validity to the 1950
experiment. The nucleotides in DNA were
linked together using the pairs: Adenine +
Thymine and Cytosine + Guanine. This
explains why the purine and pyrimidine
concentrations. If they are not the same
the DNA will either be too thick or too thin
and this is also supported by x ray data.

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