PHINMA University of Pangasinan
College of Health Sciences
Name of Student Nurse: Rexie Carelle T. Macaraeg
Level/block/group : 2-BSN-14
NAME OF DRUG
GENERIC NAME
Fluoxetine
BRAND NAME
Prozac
CLASSIFICATION
Fluoxetine is in a class of
medications called
selective serotonin
reuptake inhibitors
(SSRIs). It works by
increasing the amount of
serotonin, a natural
substance in the brain
that helps maintain
mental balance.
INDICATION
Fluoxetine is FDA-
approved for major
depressive disorder,
obsessive-compulsive
disorder, panic disorder,
bulimia, binge eating
disorder, premenstrual
dysphoric disorder, and
bipolar depression, as
well as treatment-
Hospital/Area: N/A
MECHANISM OF ACTION
Fluoxetine is a selective serotonin
reuptake inhibitor (SSRI) and as the
name suggests, it exerts
it's therapeutic effect by inhibiting
the presynaptic reuptake of the
neurotransmitter serotonin.
Date: Oct. 1, 2021
Clinical Instructor: Sir Ken Vin Cerezo
CONTRAINDICATIONS SIDE EFFECTS ADVERSE EFFECTS NURSING RESPONSIBILITIES
Do not start PROZAC in a •unusual dreams •Suicidal Thoughts and •Watch for signs of neuroleptic
patient who is being •sexual problems Behaviors in Children, malignant syndrome, including
treated with linezolid or •loss of appetite, Adolescents, and Young hyperthermia, diaphoresis, generalized
intravenous methylene diarrhea, indigestion, Adults muscle rigidity, altered mental status,
blue because there is an nausea or vomiting, •Serotonin Syndrome tachycardia, changes in blood pressure
increased risk of weakness, or dry mouth •Allergic Reactions and (BP)
serotonin syndrome. In a •flu symptoms Rash •Monitor and report signs of serotonin
patient who requires •feeling tired or fatigued •Screening Patients for syndrome, including hyperthermia,
more urgent treatment •change in sleep habits Bipolar Disorder and rigidity, myoclonus, and autonomic
of a psychiatric •yawning Monitoring for instability with fluctuating vital signs.
condition, other •sinus infection or sore Mania/Hypomania •Monitor signs of allergic reactions,
interventions, including throat •Seizures including pulmonary symptoms
hospitalization, should be •tremor or shaking •Altered Appetite and (laryngeal edema, wheezing, dyspnea,
considered. •sweating Weight cough) or skin reactions (rash, pruritus,
•diabetes. •feeling anxious or •Abnormal Bleeding urticaria). Notify physician immediately
•a disorder with excess nervous •Angle-Closure Glaucoma if these reactions occur.
antidiuretic hormone •hot flashes •Hyponatremia •Assess pain levels periodically to help
called syndrome of •rash •Anxiety and Insomnia document drug efficacy
inappropriate •Assess any muscle, joint, or back pain.
antidiuretic hormone. •Assess dizziness
•low amount of sodium
in the blood.
•an increased risk of
bleeding.
•manic behavior.
•a form of mania that
has a lower severity of
symptoms.
resistant depression
when used in
combination with
olanzapine.

DOSAGE & FREQUENCY

Initiate PROZAC 20
mg/day orally in the
morning. Consider a dose
increase after several
weeks if insufficient
clinical improvement is
observed. Administer
doses above 20 mg/day
once daily in the morning
or twice daily (i.e.,
morning and noon).The
maximum fluoxetine
dose should not exceed
80 mg/day.