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Chap3 Cells Anaphy Notes
Chap3 Cells Anaphy Notes
1. EPITHELIAL CELL
– Packs together in sheets
→ Intermediate fibers resist
– The human body houses over 200
tearing during rubbing or
different cell types
pulling
– Cells vary in size, shape, and
– hexagonal shape
function
– has abundant intermediate
Cells vary in length from
filaments and desmosomes
1/12,000 of an inch to over
that resist tearing when the
1 yard (nerve cells)
epithelium is rubbed or pulled.
Cell shape reflects its
specialized function
1. SKELETAL, CARDIAC, AND
SMOOTH MUSCLE CELLS 1. NERVE CELL (NEURON)
– Contractile filaments allow cells – Receives and transmits
to shorten forcefully messages to other body
move the bones structures
pump blood – The processes are covered with
change size of internal an extensive plasma
organs to move subs membrane, and a plentiful ER
around the body synthesizes membrane
components and signaling
molecules called
neurotransmitters.
1. FAT CELLS
– huge spherical shape of a fat
cell is produced by:
large lipid droplet in its
cytoplasm.
TYPES OF ENDOCYTOSIS
1. PHAGOCYTOSIS
– “Cell eating”
– Cell engulfs large particles such
as bacteria or dead body 3. RECEPTOR
cells – mediated endocytosis
– Pseudopods are cytoplasmic – Method for taking up specific
extensions that separate target molecules
substances (such as bacteria or – Receptor proteins on the
dead body cells) from external membrane surface bind only
environment certain substances
→ Phagocytosis is a protective – Highly selective process of
mechanism, not a means of taking in substances such as
getting nutrients enzymes, some hormones,
cholesterol, and iron
– Cell life cycle is a series of changes
the cell experiences from the time
it is formed until it divides
→ The function of cell division is to
produce more cells for growth and
repair processes.
→ All body cells must have the same
2. ACTIVE PROCESSES
genetic material; the DNA molecule
– the cell provides the metabolic
(genetic material) is duplicated
energy (ATP) to drive the
exactly in a process called DNA
transport process
replication.
– ATP is used to move substances
CELL LIFE CYCLE HAS TWO
across a membrane
MAJOR PERIODS
ACTIVE PROCESSES
1. INTERPHASE
ARE USED WHEN:
(METABOLIC PHASE)
– Substances are too large to travel
– Cell grows and carries on
through membrane
metabolic processes
– channels
– Longer phase of the cell cycle
– The membrane may lack special
2. CELL DIVISION
protein carriers for the transport of
– Cell reproduces itself
certain substances 1.1. PREPARATIONS:
– Substances may not be lipid- DNA REPLICATION
soluble – Genetic material is duplicated
– Substances may have to move and readies a cell for division
against a concentration gradient into two cells
ACTIVE TRANSPORT – Occurs toward the end of
– Sometimes called solute pumping interphase
– Is similar to facilitated diffusion in 1.2. PROCESS OF DNA
that both processes require protein REPLICATION
carriers that interact specifically – DNA uncoils into two
and reversibly with the substances nucleotide chains, and each
to be transported across the side serves as a template
membrane. – Nucleotides are
1. SODIUM-POTASSIUM PUMP complementary
(Na-K PUMP) Adenine (A) always bonds
– Alternately carries sodium (Na+) with thymine (T)
ions out of and potassium (K+) ions Guanine (G) always bonds
into the cell. with cytosine (C)
– More sodium ions outside the cells
than inside, and there are more
potassium (K+) ions inside the cells.
➢ For example, TACTGC bonds MITOSIS
with new nucleotides in the 1. PROPHASE
order ATGACG 1) As cell division begins, the
chromatin threads coil and
shorten so that the barlike
chromosomes become visible
under a microscope.
2) Because DNA has already been
replicated, each chromosome is
actually made up of two
identical strands called sister
chromatids, held together by a
small button-like body called a
centromere.
3) The centrioles separate from
each other and begin to move
toward opposite sides of the
cell, directing the assembly of a
mitotic spindle (composed of
microtubules) between them as
they move.
4) The spindle provides
EVENTS OF CELL DIVISION: scaffolding for the attachment
1. MITOSIS and movement of the
– division of the nucleus chromosomes during the later
→ Results in the formation of two mitotic stages. By the end of
daughter nuclei with exactly the prophase, the nuclear envelope
same genes as the “mother” and the nucleoli have broken
nucleus down and temporarily
→ each daughter nucleus ends up disappeared, and the
with exactly the same genetic chromosomes have attached
information as the original randomly to the spindle fibers
mother cell by their centromeres.
2. CYTOKINESIS – Chromatin coils into chromosomes;
– division of the cytoplasm identical strands called
– Begins when mitosis is near chromatids are held together by a
completion centromere
→ Results in the formation of two – Centrioles direct the assembly of a
daughter cells mitotic spindle
– Nuclear envelope and nucleoli have
broken down
2. METAPHASE 4. TELOPHASE
1) In this short stage, the 1) Telophase is essentially
chromosomes line up at the prophase in reverse. The
metaphase plate (the center of chromosomes at opposite ends
the spindle midway between of the cell uncoil to become
the centrioles) so that a straight threadlike chromatin again.
line of chromosomes is seen. 2) The spindle breaks down and
– Chromosomes are aligned in the disappears, a nuclear envelope
center of the cell on the forms around each chromatin
metaphase plate (center of the mass, and nucleoli appear in
spindle midway between the each of the daughter nuclei.
centrioles) – Reverse of prophase
– Straight line of chromosomes is – Chromosomes uncoil to become
now seen chromatin
3. ANAPHASE – Spindles break down and disappear
1) During anaphase, the – Nuclear envelope re-forms around
centromeres that have held the chromatin
chromatids together split. The – Nucleoli appear in each of the
chromatids (now called daughter nuclei
chromosomes again) begin to 5. CYTOKINESIS
move slowly apart, drawn – Division of the cytoplasm
toward opposite ends of the – Begins during late anaphase and
cell. completes during telophase
2) The chromosomes seem to be – A cleavage furrow (contractile ring
pulled by their half- of microfilaments) forms to
centromeres, with their “arms” pinch the cells into two parts
dangling behind them. – Two daughter cells exist
3) This careful division of sister
chromatids ensures that each ❖ In most cases, mitosis and
daughter cell gets one copy of cytokinesis occur together
every chromosome. Anaphase ❖ In some cases, the cytoplasm is not
is over when the chromosomes divided
stop moving. ❖ Binucleate or multinucleate cells
– Centromere splits result
– Chromatids move slowly apart and ➢ Common in the liver and
toward the opposite ends of skeletal muscle
the cell ❖ Mitosis is basically the same in all
– Anaphase is over when the animal cells. Depending on the type
chromosomes stop moving of tissue, it takes from 5 minutes to
several hours to complete, but
PHOTO REFERENCE: PAGE 102 typically it lasts about 2 hours.
Centriole replication is deferred ❑ The combination of sex
until late interphase of the next cell chromosomes determines the
cycle, when DNA replication begins individual’s sex, and the autosomes
before the onset of mitosis. determine most other
characteristics
– is the series of changes a cell goes
through from the time it is formed 1. GENE
until it divides – as a DNA segment that carries
– It is the formation of two daughter the information for building
cells from a single parent cell by one protein.
mitosis or meiosis – a DNA segment that carries a
Cell division that occurs by blueprint for building one
MITOSIS produces new cells for protein or polypeptide chain
growth and tissue repair → DNA
Cell division that occurs by – serves as the master
MEIOSIS produces gametes blueprint for protein
(sex cells). synthesis.
➢ Sperm cells – DNA information is coded
➢ Oocytes (egg cells) into a sequence of bases
→ A sequence of three bases
❑ During mitosis and meiosis, the (triplet) codes for an amino
DNA within the parent cell is acid
distributed to the daughter cells ➢ a DNA sequence of
– The DNA is found within AAA specifies the
chromosomes amino acid
The normal number of phenylalanine
chromosomes in a THE ROLE OF DNA
somatic cell is called the – Most ribosomes, the
diploid number manufacturing sites of proteins,
❑ In humans, the diploid number of located in the cytoplasm
chromosomes is 46 and the haploid – DNA never leaves the nucleus in
number is 23. interphase cells
Of the 23 pairs, one pair is the – DNA requires a decoder and a
sex chromosomes, which messenger to carry instructions to
consist of: build proteins to ribosomes
✓ XX chromosomes = female – Both the decoder and messenger
✓ X and Y chromosome = male functions are carried out by
❑ The remaining 22 pairs of RNA (ribonucleic acid)
chromosomes are called
autosomes PHOTO REFERENCE: PAGE 107
THE ROLE OF RNA PROTEIN SYNTHESIS
– By itself, DNA is rather like a coded INVOLVES 2 MAJOR PHASES:
message; its information is not 1. Transcription
useful until it is decoded. 2. Translation
– DN requires not only decoder but 1. TRANSCRIPTION
also a trusted messenger to carry – Transfer of information from
the instructions for building DNA’s base sequence to the
proteins to the ribosomes. complementary base sequence
– These messenger and decoder of mRNA
functions are carried out by a DNA is the template for
second type of nucleic acid, called transcription; mRNA is the
ribonucleic acid / RNA product
Each DNA triplet corresponds
→ RNA
to an mRNA codon
– differs from DNA in being
If DNA sequence is AAT-CGT-
single-stranded
TCG, then the mRNA
3 VARIETIES OF RNA PLAY corresponding codons are
ROLE IN PROTEIN SYNTHESIS: UUA-GCA-AGC
1. Ribosomal RNA (rRNA) 2. TRANSLATION
– helps forms the ribosomes, – Base sequence of nucleic acid is
where proteins are built. translated to an amino
2. Messenger RNA (mRNA) acid sequence; amino acids are
– carry the “message” containing the building blocks of proteins
instructions for protein – Occurs in the cytoplasm and
synthesis from the DNA (gene) involves three major varieties
in the nucleus to the ribosomes. of RNA
→ Carries the instructions for STEPS:
building a protein from the 1. Transcription
nucleus to the ribosome 2. mRNA leaves nucleus and attaches to
3. Transfer RNA (tRNA) ribosome, and translation begins
– are small, cloverleaf-shaped 3. incoming tRNA recognizes a
molecules that escort amino complementary mRNA codon calling
acids to ribosomes. for its amino acid by temporarily
→ Transfers appropriate amino binding its anticodon to the codon
acids to the ribosome for PROTEINS HAVE MANY
building the protein FUNCTIONS
A. FIBROUS (STRUCTURAL)
HOW DOES RNA DIFFER FROM
PROTEINS
DNA? – are the building materials for cells
✓ RNA is single-stranded B. GLOBULAR (FUNCTIONAL)
✓ RNA contains ribose sugar PROTEINS
instead of deoxyribose – can act as enzymes (biological
✓ RNA contains uracil (U) base catalysts)
instead of thymine (T)