Anti Leprosy Drugs

used include
Drugs in
leprosy :
•

cis
Rifampicin iris
Minocycline
cii , Dapsone cviisclarithromyc.in
( iii ,
Clofazimine
(in Ethionamide

(v ) Ofloxacin

Dapso ne
Dapsone is le
prostatic drug related to
sulfonamides
•

with similar mechanism

of Action .

( Inhibition of Folic Acid Synthesis )

It active
remains the most
drug against Mr
leprae
•
.

Resistance should be
•
As is
increasing .
the
drug
used with combination with
Rifampin &
/ or

Clofazimine .
 the
•

Acedapsone is
repository form of Dapsone
whose
single intramuscular
injection maintains

inhibitory levels
of dapsone in tissues
for
months
upto 3 .

Adverse effects :

( is GI irritation

( Ii ,
Fever ,
Skin rashes

Liii , Methemoglobin emia

(in Hemolytic anemia in GGPD deficient patients .

•
Dapsone is alternative
drug for treatment
of
Pneumocystis jiroveci pneumonia in AIDS
patient .

Dapsone is DOC in Dermatitis herpetiformis .

Clofazimine
• A
phenazine dye with le prostatic and Anti -

inflammatory activity .

•
9T
interferes with the
template function of DNA .

Adverse effects :

ciiii Discoloration
"; GI irritation
ranging from
ciii Icthyosis of skin Red Brown to black .
 Treatment

• 2
types of leprosy :

Pauci
can
bacillary leprosy :

-
1- 5 skin lesions

Includes Tuberculin 'd

leprosy ( TT )
-

Boden line tuberculoid ( BT )

Indeterminate leprosy
Test Positive
lepromin
→
-

(b)
bacillary leprosy
:
Multi

- 55 skin lesions

Includes Boderline
leprosy ( )
- BB

Boden line lepromatous ( BL )

Lepnomatous leprosy ( LL )

lepromin Test
Negative
Ridley -

Jopling classification :

C
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