Drug Mechanism of Action
Generic Name: histrelin
Brand Name: Supprelin LA, Vantas
Classification: GnRH Agonist
Dosage/Route/Frequency:
One implant (50 mg) implanted
subcutaneously every 12 mo
References:
https://www.supprelinla.com/
https://www.webmd.com/drugs/
2/drug-148444/supprelin-la
implant/details
It desensitizes responsiveness of
the pituitary gonadotropin which, in
turn, causes a reduction in ovarian
and testicular steroidogenesis..
Indications Side Effects/ Adverse Reaction/s
Palliative treatment of advanced
prostate cancer; treatment of
children with central precocious
puberty.
Contraindication/s
Nursing Responsibility
Irritation at the implant site (such
as bruising, pain, redness), mood
swings, or headache may occur. In
men using this medication for
prostate cancer, hot flashes
(flushing), increased sweating, night
sweats, tiredness, swelling of the
ankles/feet, or constipation may
occur. In girls using this medication
for early puberty, breast tenderness
or abnormal vaginal bleeding may
occur.
Examination and Evaluation:
Monitor signs of allergic reactions
and angioedema, including
pulmonary symptoms (tightness in
the throat and chest, wheezing,
cough, dyspnea) or skin reactions
(rash, raised patches of red or white
skin, burning/itching skin, swelling
in the face).
Assess heart rate, ECG, and heart
sounds, especially during exercise
Interventions
For patients who are medically able
to begin exercise, implement
appropriate resistive exercises and
aerobic training to maintain muscle
Patients who are hypersensitive to
gonadotropin releasing hormone
(GnRH) or GnRH agonist analogs
and in females who are or may
become pregnant while receiving
the drug.

strength and aerobic capacity

during cancer chemotherapy or to
help restore function after
chemotherapy.
Because of the risk of arrhythmias,
use caution during aerobic exercise
and other forms .