SacrscOma: Sors coma

co mabegins
Ahe SSUe hat &uppoot nc
ConneCt the bocy.
deelop in boney, jont
Fat , mucle, biood iusels. lymph
resr.

(8 leukomi ar:Tt is
Tt bcCUcohen healthy Bl0od o
Change (becore aonosmu and
Uncolloty.

Subtyre Aeute lyophocyhc leutog

Actte myyetot
myelor oukomç¡, Chronc
.
myeloid

G lymphoma: TE is cöncers' ob 1ymphat

subtyrw: Hdgin (ymphcima
Jon- Hdgn jmphona.

bon nd
Sna Hssue
nlineoplastic Anti concoMoUs Agents
Antineo plasie Og Aoti cancor aqenk
He Substances wed to
CCnc.

Mechansim Of Acton
0 Ceu cyele qisrupin: Some agente
intexpeO
cancontow ca fsom diriding.
Ex. Vinna blcrsire.

eDNA clorma ge Some dhug damage

ONA OF cancog. col disoupBng
the aoi lity ef to eplicatt.
Ex. Cisptehn
Ap0pto81S incu cti on. Ani cancog du
can auO: ind ce cpotont y poo
-dre eall olecath.
Er Etopo side f bieomyc1n.
(t Tnhibition of ONA (NA &yheysi BlocG
the yntheis 0f DANA & NA in concos
EX 5- lucroUaci

Torqeed thesapied
HOSmol theopy
ImmunotteSAPy
 Clas&iicatn&
+Toinine Mechbve th
E.
aobrNe ATkaitinat
COomuwHre Thiotepa:
Chioambuil
EHUlerNme et NihOen
-amine.
Busulphan

S-FUTomoaal-OeTopto
ARtadauit Antcams
PyimdnAntocthMethoa
xate ntimelablie

’campto
Ephylletoxn
TOpOteCan pacitarel
inca AntineOplasttc
alkalCidJ
etöpösicLe vinbloR
EpipodoToxanej NJotusgit
biotici
Arti
dium
osphat
iu
adioetire

e "mitorycime ActHnomyEx.
mthoamyco

etsplastin
catboplahn
MiSCCtlareouJ

ginase

Futannc
Antande sfesfso\ Fo
Pcetate Finotet
ekcAniPeadnisolo
analo
GneH esrogn -cid
 oAaty ting
This agents fosms UkylPea acdicl
FOOm
A*ylote ONA et poiteo
orolet loon
N-# uantne,
MOA
o Alkglytion oF DNA CaUuse,. inhii o
4 RNA toansceoipto
oF ONUA Sunheis
Feom aFfe fed ONA.
formed that
int!
ÒNA r seporay
Hatclio Stop

Sulo classi&e

ANisogen Mugtaoel. oeveroped foog

uitagd gases.
N-CHs frSt chêrcals
used
mechlo ethamne

óyntheic.
Cl-ctacha
\cH,-cHa-0M

Cycdo phosphamide, cy chlorombucl

Ohes E,
so
To theot Hodkin's dweose 4tympharg
-’ EX Thiotepa ,, Casbo cquone,
etc. TnQun
Thiotepa.
CN
- N

’ Ex? Busutphan , TeeosupRon,

usulphn,

’ t . Cas muwte, lomwt, sermyhhe ek

CaTmwhe.
A obamylot
This
duqs pogducey
poaduce) is0ynot nd
Pionyeooxids on doconpooten.
 Ex! Dacobmie, Temo z010mide

-iN-N

ntimeta boliHe'
"They ae fios t erfecti chemo tHera
-petic gent
They hae molecuteg caeigled
onalogue t FoInc aeid, pumnei
fo
ond pyaiaidne
Thers Shouctu oe imilcato those
of natusly occaìng. molecle9
inrolred n ONA eA 8yes.
MOA
" They
heg ett by in hitbittno thee e

Alsoniolck Nuclooide (Puo 4eyoiely

NA RNA syntteis
 Cau tten to
incopoTot mole Ceele
ito 'qenlhe motem tt leads to
DNA totécahon.
Folatt nta goumi They inhib
yme e0qued foT Fo l e
metabolism Cahch eoqulok
t puone
-e.
1eadng to Tmpront 1n
PNA E RNA Sytes.
Classifrcoton
) folateAneoit
Ex Methotofxat

cOOH

rmethoroe

Pugirt
Tnhibit
Ankcigonst,
pusine metabolrsn
ER meTCO pto pue

6- MeTCaptopu
Syntheis:
SH
N

7H-puin-6-o\
6-mescoplopure

slock
Uaclire to
hymiciei
Ex: 5- FluoOUga cil Deci tobie.
oUTaci,
HN

Fluogouxai|
) Natrral pooducy;
A Plante pooduct e e wedy nt
Canc

O pisouphon in cQl siqnc ory

E*: Etoposide, vinb(othne &ulphet cht

(h Antibichcg
’Tmpt Clasr t arireoplosno
MOA
Anti bioic! act by bnding to DNS
Ating into Lelical \ati cQ
betoeoo Ssecikic bau es,thw
btoceing the toonscoophon d re
RNA NA

Ex! bCHnO mycin, Douno subicin,

OOxOTubicne

Dauno3ubcin

(6) HoomGnes
Tt invrole) maniput attom of
endocire sygke ' huqh
eroqenous alcdmintshrahon c
Seatic hormny.. potulor
Sesoid hoomnenes
 ecress1 in Comcor colls
Ex P d n i a l o e , Fosfoslerool Actatt ee,
tamoifem

AcctaH

Eynt
EK, Aspra gin.

HaN-H--0

Raciachw i9dBoe
Sodium phunhett , s0di (odida
Ex
Nar
Ngt

Golium phosphot
Nat
Sodium fodiole
Ex: Crpt esh , coboHoom
NHO

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