VITAMIN B9

FOLIC ACID

Hashmi amaan
 STRUCTURE Folic acid consists of three components .
1– pteridine ring
2 – p-amino benzoic acid
3 – L-glutamic acid

Folic acid (vitamin b9) 2

 ACTIVATION OF FOLIC ACID
NADHP +H Active form of folic acid is TETRAHYDROFOLATE
Folate
Reductase Folate is enzymatically reduced in tissue to yeild The
Vit-C DIHYDROFOLATE and then TETRAHYDRO FOLATE
NADP+
It is a two step process which requires VITAMIN C and
FOLATE REDUCTASE

FOLATE REDUCTASE is NADPH dependent enzyme

NADHP +H
Folate
Reductase
Vit-C
NADP+

PRESENTATION TITLE 3
SOURCE
Folic acid is found in

1-green leafy vegetables

2-liver
3-yeast
4-whole grains

5-eggs

The word folate is derived from latin word folium which

means leaf
FUNCTIONS
THF acts as a carrier of carbon units .The one carbon units are :

1- methyl CH3
2- methylene CH2
3- methenyl CH
4- formyl CHO

The one carbon units binds with THF at N⁵ or N¹⁰ or both N⁵,N¹⁰ position
of pteroyl structure

The coenzyme of folic acid (THF) serve as acceptor or donor of one carbon
units in variety of reaction

Folic acid (vitamin b9) 5

Folic acid (vitamin b9) 6
 Many important compounds are synthesized in one carbon metabolism

1-CONVERSION OF SERIES INTO GLYCINE

2- SYNTHESIS OF THYMIDYLATE

3- CATABOLISM OF HISTADINE

4-SYNTHESIS OF PURINES

5- SYNTHESIS OF METHIONINE FROM HOMOCYST 7

 Folic acid deficiency

DEFICIENCY MANIFESTATION Impaired DNA synthesis

Folic acid deficiency frequently occurs in PREGNENT WOMEN
and ALCOHOLIC PERSON
Impairs the maturation of erythrocytes
CLINICAL SYMPTOMS INCLUDE

1- MEGALOBLASTIC OR MACROCYTIC ANEMIA

Instead of NORMOBLAST,
• The deficiency of folic acid leads to impairement of synthesis of
MEGALOBLAST is formed
DNA. Impaired DNA synthesis, impairs the maturation of
erythrocytes. Consequently, megaloblasts are formed instead of
normoblast. These megaloblasts are accumulated in the bone
marrow and leads to megaloblastic anemia. Megaloblasts accumulate in
. bone marrow

Leads to macrosytic anemia

Folic acid (vitamin b9) 8
2- ACCUMULATION AND EXTRACTION OF FIGLU IN URINE

3- NEURAL TUBE DEFECT IN FETUS

4- HYPERHOMOCYSTEINEMIA

Folic acid (vitamin b9) 9

THANK YOU
Hashmi amaan

Folic acid (vitamin b9) 10