Feature

Patents https://doi.org/10.1038/s41587-023-02010-4

Antibody engineering
Check for updates

Recent patents relating to the manufacture and design of engineered immunoglobulin

polypeptides.
Patent number Description Assignee Inventor Date

US11643437B2 An isolated cancer-targeting peptide that includes at least two copies of Chang Gung Yu J, Yu, A, 6/9/2023
the amino acid sequence PFLP or PFLF, a bispecific anti-cancer antibody Memorial Hospital Wang S-H
that includes the isolated cancer-targeting peptide and an antigen-binding (Taoyuan City,
peptide that stimulates T cell activity, and methods for diagnosing and Taiwan)
treating cancer by administering the pharmaceutical composition or the
bispecific anti-cancer antibody.
US11545238B2 Methods for designing engineered polypeptides that recapitulate molecular iBio (Newark, Greving MP, 1/3/2023
structure features of a predetermined portion of a reference protein structure, DE, USA) Taguchi AT,
for example, an antibody epitope or a protein binding site. The methods Hauser KE
include training a machine learning model based on a first set of blueprint
records, or representations thereof, and a first set of scores, each blueprint
record from the first set of blueprint records being associated with each
score from the first set of scores.
US11377485B2 Methods for making modified Fc regions of antibodies and antibody Academia Sinica Wong C-H, Wu C-Y 7/5/2022
fragments, both human and humanized, and having enhanced stability (Taipei, Taiwan)
and efficacy; antibodies comprising Fc regions with core fucose residues
removed, and attached to oligosaccharides comprising terminal sialyl
residues; antibodies comprising homogeneous glycosylation of Fc regions
with specific oligosaccharides; Fc regions conjugated with homogeneous
glycoforms of monosaccharides and trisaccharides; and methods of
preparing human antibodies with modified Fc using glycan engineering.
US11332540B2 A method for treating a tumor by administering Circ-CDH1, a circular RNA The First Affiliated Zhang N 5/17/2022
Circ-CDH1 nucleic acid molecule or the protein Circ-CDH1-28 KD expressed Hospital, Sun
by the circular RNA Circ-CDH1 nucleic acid molecule. A monoclonal antibody Yat-sen University
anti-Circ-CDH1 is designed against Circ-CDH1-28 KD, which can specifically (Guangzhou, China)
detect the content of a protein encoded by endogenous circular RNA
Circ-CDH1, can inhibit invasion and metastasis of cells from tumors such
as glioma and breast cancer, and has wide application prospects in clinical
detection of tumors and invasion and metastasis treatment.
US11203645B2 Novel glycosynthase enzymes for glycoprotein engineering and/or OBI Pharma Yu C-DT, Hsieh YH, 12/21/2021
homogeneous antibody remodeling. The enzyme variants, termed (Taipei, Taiwan) Hsieh Y-C,
EndoSd-D232M and EndoSz-D234M, contain the glycan conjugation and/or Huang T-Y,
modification activity at the conserved N297 glycosylation site of the Fc region Tsai Y-C, Wang N-H,
of an exemplary antibody. Hu P-L
US11192951B2 Methods of engineering surface charge for bispecific antibody production, Janssen Biotech Nesspor T 12/7/2021
including providing an antibody comprising a first polypeptide comprising (Horsham Township,
a heavy chain variable region and a second polypeptide comprising heavy PA, USA)
chain variable region and substituting, in at least one of the first and second
polypeptides of the antibody, one or more amino acid residues of the heavy
chain variable region.
US11077144B2 A chimeric antigen receptor (CAR) in which extracellular ligand binding Cellectis Galetto R, Smith J, 8/3/2021
is a scFV derived from a CD19 monoclonal antibody, preferably 4G7. Also, Scharenberg A,
polynucleotides, vectors encoding said CAR and isolated cells expressing Schiffer-Mannioui C
said CAR at their surface, and methods for engineering immune cells
expressing 4G7-CAR at their surface, which confers a prolonged ‘activated’
state on the transduced cell.
Source: Espacenet, United States Patent and Trademark Office.

Published online: 10 November 2023

nature biotechnology Volume 41 | November 2023 | 1520 | 1520