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    FA Synthesis Part Two Illustration Atf

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    nofov45585
    The document summarizes the process of fatty acid synthesis. It involves multiple enzymatic steps that add two-carbon units from acetyl-CoA to a growing fatty acid chain. These steps include: 1) condensation of acetyl-CoA with malonyl-ACP to form beta-ketoacyl-ACP, 2) reduction to beta-hydroxyacyl-ACP, and 3) dehydration and another condensation to elongate the fatty acid chain by two carbons. This cycle of reactions continues until the fatty acid is fully synthesized.

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    FA Synthesis Part Two Illustration Atf

    Uploaded by

    nofov45585
    3 views1 page
    The document summarizes the process of fatty acid synthesis. It involves multiple enzymatic steps that add two-carbon units from acetyl-CoA to a growing fatty acid chain. These steps include: 1) condensation of acetyl-CoA with malonyl-ACP to form beta-ketoacyl-ACP, 2) reduction to beta-hydroxyacyl-ACP, and 3) dehydration and another condensation to elongate the fatty acid chain by two carbons. This cycle of reactions continues until the fatty acid is fully synthesized.

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    FA Synthesis Part two Illustration atf

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    The document summarizes the process of fatty acid synthesis. It involves multiple enzymatic steps that add two-carbon units from acetyl-CoA to a growing fatty acid chain. These steps include: 1) condensation of acetyl-CoA with malonyl-ACP to form beta-ketoacyl-ACP, 2) reduction to beta-hydroxyacyl-ACP, and 3) dehydration and another condensation to elongate the fatty acid chain by two carbons. This cycle of reactions continues until the fatty acid is fully synthesized.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    3 views1 page

    FA Synthesis Part Two Illustration Atf

    Uploaded by

    nofov45585
    The document summarizes the process of fatty acid synthesis. It involves multiple enzymatic steps that add two-carbon units from acetyl-CoA to a growing fatty acid chain. These steps include: 1) condensation of acetyl-CoA with malonyl-ACP to form beta-ketoacyl-ACP, 2) reduction to beta-hydroxyacyl-ACP, and 3) dehydration and another condensation to elongate the fatty acid chain by two carbons. This cycle of reactions continues until the fatty acid is fully synthesized.

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    of 1

    METABOLISM: Fatty Acid Synthesis

    Pentose
    Glucose-6p Phosphate
    Pathway CoA NADPH • • •
    CoA

    ( ( ( ( ( (
    — Cyst —SH — Cyst — Cyst —SH NADP+ — Cyst —SH — Cyst • • • •
    — Cyst • • • •

    Glucose 1 5 9
    — ACP —SH — ACP • •
    — ACP • • • • — ACP • • • •
    Hydroxyl — ACP —SH — ACP • • •
    • •
    CoA CoA
    O O + O OH
    +
    Pyruvate Acetyl Transacylase ACP C C C CH 3 B-Ketoacyl ACP C C C CH 3
    (2c) Malonyl Transacylase
    + beta-ketone ACP Reductase H
    O2
    Malic
    Enzyme Malate CO2

    (
    •

    ( ( (
    • •

    ( (
    1 — Cyst — Cyst H 2O — Cyst
    "transfer" • •
    — Cyst —SH — Cyst —SH • • • •
    — Cyst —SH
    Acetyl NADPH
    CoA 2 6 10
    — ACP • •
    — ACP —SH — ACP • • • •
    — ACP • • • • — ACP • • •
    — ACP • • • • • •

    OAA O OH O H
    +
    4c 2c

    OAA Acyl Transacylase ACP C C C CH 3 3-Hydroxylacyl ACP C C C CH 3 Acyl Malonyl ACP


    H Dehyratase H Condensing Enzyme
    Citrate Citrate
    -
    +
    Citrate CoA • • •
    CoA NADPH

    ( ( ( ( ( (
    Lyase — Cyst • • — Cyst • •
    — Cyst —SH NADP+ — Cyst —SH — Cyst —SH — Cyst —SH
    3 7 11
    — ACP —SH — ACP • • •
    — ACP • • • • — ACP • • • • — ACP • • • • • •
    — ACP • • • • • •

    ATP CoA
    Citrate Acetyl O H O
    Insulin Enoyl ACP O OH H
    B-oxidation CoA Malonyl Transacylase ACP C C C CH 3 ACP C CH 2 CH 2 CH 3
    + + Reductase C C C C CH 2 CH 2 CH 3
    Enoyl H
    Acetyl H
    FA CoA
    CPT- 11 +
    Carboxylase (decarboxylation)
    - - CO2

    [ [
    +

    [ [ [
    2 — Cyst
    •
    — Cyst —SH — Cyst —SH — Cyst • • • • — Cyst Thioesterase O
    Malonyl
    • •
    Glucagon LCFA
    - Norepinephrine CoA (3c) 4 8 12
    O-
    ⑨
    CPT- 1
    Epinephrine
    (Building Block) — ACP • • •
    — ACP • • • •
    — ACP • • • •
    — ACP —SH — ACP • • • • • • • • • • • • • • •
    16c Fatty Acid
    O O O
    B

    1 +

    ,
    CoA — Cyst —SH
    Acyl Malonyl ACP C C Acyl Transacylase
    3
    2 Condensing Enzyme
    — ACP —SH

    FAS-1 Acyl Carrier


    Enzyme Protein

    Metabolism Fatty Acid Synthesis


    •
    ☒ I

    ¥-1

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