1. Thrombosis is the formation of a blood clot (thrombus) within a blood vessel. It occurs most commonly in the deep veins of the legs and can be distinguished from a postmortem clot by the presence of lines of Zahn and attachment to the vessel wall.
2. There are three main risk factors for thrombosis known as Virchow's triad: disruption of blood flow, endothelial cell damage, and a hypercoagulable state.
3. Embolism is when an intravascular mass or thrombus breaks off and travels through the bloodstream, blocking vessels downstream. Common types of emboli include thromboemboli, atherosclerotic embol
Herbotherapy and Ganotherapy Is Simply A Line of Thought Consists of Four Observation Theories Used To Explain How Ganoderma or Reishi Supports The Body Which in Turn Overcomes Its Health Prob
1. Thrombosis is the formation of a blood clot (thrombus) within a blood vessel. It occurs most commonly in the deep veins of the legs and can be distinguished from a postmortem clot by the presence of lines of Zahn and attachment to the vessel wall.
2. There are three main risk factors for thrombosis known as Virchow's triad: disruption of blood flow, endothelial cell damage, and a hypercoagulable state.
3. Embolism is when an intravascular mass or thrombus breaks off and travels through the bloodstream, blocking vessels downstream. Common types of emboli include thromboemboli, atherosclerotic embol
1. Thrombosis is the formation of a blood clot (thrombus) within a blood vessel. It occurs most commonly in the deep veins of the legs and can be distinguished from a postmortem clot by the presence of lines of Zahn and attachment to the vessel wall.
2. There are three main risk factors for thrombosis known as Virchow's triad: disruption of blood flow, endothelial cell damage, and a hypercoagulable state.
3. Embolism is when an intravascular mass or thrombus breaks off and travels through the bloodstream, blocking vessels downstream. Common types of emboli include thromboemboli, atherosclerotic embol
1. Thrombosis is the formation of a blood clot (thrombus) within a blood vessel. It occurs most commonly in the deep veins of the legs and can be distinguished from a postmortem clot by the presence of lines of Zahn and attachment to the vessel wall.
2. There are three main risk factors for thrombosis known as Virchow's triad: disruption of blood flow, endothelial cell damage, and a hypercoagulable state.
3. Embolism is when an intravascular mass or thrombus breaks off and travels through the bloodstream, blocking vessels downstream. Common types of emboli include thromboemboli, atherosclerotic embol
DEPARTMENT OF PATHOLOGY GENERAL PATHOLGY ASSIGNMENT
Name: MUGANZI JONATHAN
Reg no:2021/MBR/023 Qn; Discuss embolism, thrombosis and infarction Thrombosis is the pathologic formation of an intravascular clot called thrombus. It can occur in an artery or a vein but most commonly in the deep veins of the leg below the knee. Thrombus can be confused with a postmortem clot, however, to distinguish the two lines of Zahn (alternating layers of platelets/fibrin and RBCs) and attachment to the vessel wall are seen with thrombosis. There are three major risk factors for thrombosis and these make up the Virchow triad. These are; i) Disruption in blood flow; Normal blood flow is continuous and laminar, keeps the platelets and clotting factors dispersed and inactivated therefore when there is stasis and turbulence there is increased risk of thrombosis. This can be seen in immobilized patients where there is increased risk of deep vein thrombosis and in the case of aneurysms. ii) Endothelial cell damage; Endothelial cells protect the body against thrombosis by several mechanisms including blockage of exposure to subendothelial collagen and underlying tissue factor, production of prostacyclin and NO which facilitate vasodilation and inhibit platelet aggregation, secretion of heparin-like molecules that inactivate thrombin and coagulation factors, secretion of tissue plasminogen activator(tPA) which converts plasminogen to plasmin that cleaves fibrin and serum fibrinogen, destroys coagulation factors and blocks platelet aggregation. Endothelial cells also secrete thrombomodulin which redirects thrombin to activate protein C that inactivates factors V and VIII. When the endothelium is damaged due one or more of atherosclerosis, vasculitis and high levels of homocysteine, all the above mechanisms are disrupted and thrombosis risk increases. iii)Hypercoagulable state; This results from excessive procoagulant proteins or anticoagulant proteins and may be acquired or inherited. The common abnormalities that result in a hypercoagulable state include protein C and S deficiency (autosomal dominant) that decreases the negative feedback on the coagulation cascade due to reduced inactivation of factors V and VIII. A mutated form of factor V called factor V Leiden that lacks a cleavage site for deactivation by protein C and S is another abnormality that leads to hypercoagulable state and is the most common hereditary disorder leading to the same. Hypercoagulable state is also observed in a hereditary disorder involving a point mutation in prothrombin called prothrombin 20210A causes increased gene expression leading to elevated levels of prothrombin and as a result increased thrombin leading to thrombus formation. ATIII deficiency and oral contraceptives are other factors associated with hypercoagulable state. Embolism is the formation of an intravascular mass that travels and occludes downstream vessels. There are different forms of embolus that can form and these include; i) Thromboembolism which is due to a thrombus that dislodges and is the commonest type of embolus. It can lead to pulmonary embolism and systemic embolism. ii) Atherosclerotic embolus which is due to an atherosclerotic plaque that dislodges and is characterized presence of cholesterol clefts in the embolus. iii) Fat embolus which is associated with long bone fractures and soft tissue trauma.It develops while fracture is still present or shortly after repair and is characterized by dyspnea as fat often with bone elements is seen in the pulmonary vessels as well as petechiae on the skin overlying the chest. iv) Gas embolus which is seen classically in decompression sickness as seen with deep sea divers. Often presents with joint and muscle pain and respiratory symptoms. v) Amniotic fluid embolus which is seen when a amniotic fluid enters maternal circulation during labour or delivery. It presents with shortness of breath, neurological symptoms and DIC ( due to the thrombogenic nature of amniotic fluid). Upon examination of the embolus, squamous cells and keratin debris from fetal skin are observed. Infarction is the necrosis of tissue in an area of the body due to inadequate blood flow. It occurs when the blood flow to a particular organ or tissue is significantly reduced leading to oxygen and nutrient deprivation. The most common cause of infarct is the formation of blood clot or plaque that obstructs the blood vessels supplying the affected area. Infarcts can be classified as red infarcts or white infarcts. Red infarcts are those that affect veins that drain loosely packed or soft tissue such as lungs and gut and white infarcts are those that involve occlusions in arterial blood supply to organs especially those that have tough tissue like kidneys. Tissue area with an infarct are usually wedge shaped and the tip of the wedge is usually the site of occlusion.
Herbotherapy and Ganotherapy Is Simply A Line of Thought Consists of Four Observation Theories Used To Explain How Ganoderma or Reishi Supports The Body Which in Turn Overcomes Its Health Prob