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Understanding Insulin and Insulin Resistance Book • 2021

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 Understanding Insulin and Insulin Resistance

Book • 2021

Anil Gupta

About the book

Description
Understanding Insulin and Insulin Resistance is written in a simple
and clear language illustrated with diagrams that show the complex
interplay of various factors in the initiation of insulin resistance. The
design is systematic and meticulous, portraying topics in a flow from
simple to complex. This resource is intended for a broad audience
spanning across biochemistry, medicine, dentistry, academia,
physicians, and research scholars. It extends the approach to
biochemistry, physiology, metabolism of insulin along with the
coverage of pathophysiology of insulin resistance, its effects on the
body tissues, and its analysis on insulin resistance syndrome.

Key Features

∑ Provides exhaustive and latest knowledge related to the chronology of

diabetes mellitus, different phases in the discovery of insulin,
contribution of several workers in discovery of insulin, insulin structure,
types of insulin, and role of latest insulin delivery devices including
various transdermal insulin delivery devices and bionic pancreas in
the management of diabetes mellitus
∑ Delivers extensive and current information relevant to structure of
insulin gene, role of insulin gene-variable number of tandem repeats,
insulin two genes versus single gene system, role of wide array of
promoters, transcription factors, hormones and nutrients in the
regulation of transcription of insulin gene speckled with description of
dysregulation of insulin gene transcription by glucotoxicity, lipotoxicity,
unfolded-protein response, and activating transcription factor-6

∑ Provides knowledge about biogenesis of insulin granules, role of

SNARE proteins, SYNTAXIN, SNAP-25 and VAMP-2 in the
intracellular trafficking and exocytosis of insulin granules

∑ Important component of book is the description about models of

capillary blood flow in pancreatic islets, triggering pathway, amplifying
pathway, role of nutrients, hormones especially Malonyl-CoA/Long
chain-Acyl-CoA pathway, glucagon-like peptide-1, cholecystokinin
hormone, ghrelin hormone, insulinotropic and insulinostatic effects of
noradrenaline, Sirtuin 1, and mechanistic target of Rapamycin
(mTOR) in insulin secretion

∑ Book proves knowledge about insulin mediated signaling pathways,

role of glucose transporters, sodium–glucose linked transporters, and
coverage of several metabolic and physiological effects of insulin
including insulin mediated RANKL/RANK/OPG axis in
osteoclastogenesis and bone resorption

∑ Additional component of the book is the chapter on the

etiopathogenesis of insulin resistance covering wide range of topics
including role of genetic polymorphisms (gene FABP-1, gene FABP-2,
gene APOE, A–3826G polymorphism, A–1766G polymorphism, A–
112C polymorphism of UCP-1 gene, G–866A polymorphism of UCP-2
gene, Polymorphisms of the APM1 gene and other genetic
polymorphisms,) role of demographic factors, role of diseases
(hemochromatosis, obesity, hypertension, NAFLD, lipotoxicity,
 Cushing syndromes and others), role of pro-inflammatory molecules,
endoplasmic reticulum stress, and mitochondrial dysfunction in the
pathogenesis of insulin resistance

∑ Special emphasis is given to explain the implication of advanced

glycation end-products in the pathogenesis of insulin resistance
covering topics like pathogenesis of AGEs, dietary AGEs, their effects
on the pancreas, liver, adipose tissues, relation of AGEs-CD36-insulin
resistance, and special coverage of psychological stress—insulin
resistance—diabetes mellitus pathology

∑ Describes insulin resistance syndrome encompassing details

regarding its prevalence and components

∑ Book blends both theoretical and clinical knowledge related to insulin

and insulin resistance, and insulin resistance syndrome in a single
volume eliminating searches through hundreds of journal articles

∑ Present book shall certainly serve as "ONE STOP SHOP" on the

insulin, insulin resistance, and insulin resistance syndrome for the
benefit of students, research scholars, academicians, and clinicians
 Table of contents

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1. Select all Front Matter

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 Title page
Copyright
Dedication
Contents
Foreword by Prof. Anissa Atif Mirza
Foreword by Prof. Vimal K. Sikri
Foreword by Prof. Arpit Garg
Foreword by Prof. O.P. Jangid
Foreword by Prof. S.P.S. Sodhi
Foreword by Prof. Rakesh Arora
Foreword by Prof. Priyanka Garg
Foreword by Prof. Sanjay Bansal
Foreword by Prof. Rajwant Kaur Randhava
Preface
Acknowledgments

2. Select Chapter 1 - Discovery of insulin

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Chapter 1 - Discovery of insulin

Pages 1-27

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3. Select Chapter 2 - Structure and properties of insulin

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Chapter 2 - Structure and properties of insulin

Pages 29-70

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4. Select Chapter 3 - Biosynthesis of insulin

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Chapter 3 - Biosynthesis of insulin

Pages 71-133
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5. Select Chapter 4 - Biosynthesis, intracellular-trafficking, and exocytosis of insulin granules

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Chapter 4 - Biosynthesis, intracellular-trafficking, and exocytosis of insulin granules

Pages 135-158

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6. Select Chapter 5 - Regulation of insulin secretion

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Chapter 5 - Regulation of insulin secretion

Pages 159-178

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7. Select Chapter 6 - Direct and indirect actions of insulin: role of insulin receptor, glucose transporters
(GLUTs), and sodium-glucose linked transporters (SGLTs)

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Chapter 6 - Direct and indirect actions of insulin: role of insulin receptor, glucose transporters
(GLUTs), and sodium-glucose linked transporters (SGLTs)
Pages 179-201

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8. Select Chapter 7 - Metabolic and physiological effects of insulin

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 Chapter 7 - Metabolic and physiological effects of insulin
Pages 203-230

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9. Select Chapter 8 - Etiopathogenesis of insulin resistance

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Chapter 8 - Etiopathogenesis of insulin resistance

Pages 231-273

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10. Select Chapter 9 - Insulin resistance syndrome

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Chapter 9 - Insulin resistance syndrome

Pages 275-282

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11. Select Index

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Index
Pages 283-287

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resistance#book-info
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