Kriteria diagnostic

Tabel 4. Gambaran Histologi dan molekular dari serrated polyps 6.

Type Histological features Molecular features

Crypt Proliferation Cytological Mucin BRAF KRAS CpG-island

architecture zone features type mutation mutation methylation

Serration
Goblet cell
MVHP Funnel- Located Small Mixed 70–80% 0% + limited 2/3
shaped uniformly in basally microve
crypts with the basal located sicular
serrations portion of nuclei; no and
limited to crypts dysplasia goblet
upper cell
two thirds

Elongated
GCHP Elongated Located Small Goblet 0% 50% − crypt
Goblet cell
crypts that uniformly in basally cell
resemble the basal located predomi
enlarged portion of nuclei; no nant
normal crypts dysplasia
crypts; little
to no
serration
SSL Horizontal Proliferation Small Mixed > 90% 0% ++
growth may be basally microve
along the abnormally located sicular
muscularis located away nuclei with and
mucosae, from the occasional goblet
dilation of crypt base, larger cell
the crypt variable from nuclei with
base (basal crypt to crypt inconspicuo
third of the us nucleoli;
crypt), no
and/or dysplasia
serrations
extending
into the
crypt base

Dysplastic component
SSLD Complex Like in SSL, Varied Varied > 90% 0% +++
architecture but with morphologi type
in the more cal
dysplastic proliferation appearance
component in the of
(crypt dysplastic dysplastic
crowding, component component
complex
branching,
cribriformi
ng, villous
architecture
)
 Ectopic crypt
TSA Slit-like Present Elongated Occasio 50–70% 20–40% +
serrations; within pencillate nal
often ectopic nuclei with scattere
ectopic crypts and nuclear d goblet
crypts crypt bases stratificatio cells;
n and rare
cytoplasmic goblet
eosinophili cell
a; may subtype
develop has
overt been
dysplasia describe
d