100 Questions that appear on every NBME

This information borrows heavily from a previous user, but reformatted for user friendliness.

Biochemistry

1 autosomal dominant or X-linked or mitochondrial

2 Patau vs. Edwards vs. Down Syndrome

3 Collagen/Elastin/insulin synthesis and corresponding diseases

4 amino acid derivatives, catecholamine synthesis

5 kartagener or cystic fibrosis [know CF real well]

6 pleiotropy or polygenic or heteroplasmy

7 Vitamin-E,B12,B3, Fataxia, Syphilis related neuropathy or parietal cell antibody

8 gluconeogenesis or HMP shunt

9 lysosome or mitochondria or proteasome or intron/exon

Immunology + Microbiology

1 30s, 50s, aminoacyl transferase, resistance, beta lactamase, penicillin binding protein

2 Celiac or whipple

3 sexual transmitted infection (gonorrhea, chlamydia, syphilis, HSV, Haemophilus, vaginosis,

Trichomonas)

4 antiviral medication

5 recurrent bacterial/fungus/viral patient

6 PLACES or SHiNE bacteria

7 malaria or mycoplasma

8 Type 1/2/3/4 hypersensitivity, transplant rejection

9 Which vaccines are toxoid vs. live vs. killed

10 lymph node drainage

11 albino or vitiligo or Leukocyte adhesion or Chronic granulomatous or tetrazolium blue test

12 asthma drug or cyclosporine or tacrolimus or other immunosuppressive

13 HIV: progression, associated diseases, treatments and side effects

 Public Health

1 false positive/negative, reliability, precision, accuracy

2 Cohort vs cross-sectional vs. case control vs. RCT

3 risk ratio vs. odds ratio

4 Smoking is number 1 cause for....

Ethics

1 NEVER refer or send to ethics committee, use patient-centered questions, respect patient
autonomy, never lie

Pharm

1 Km or Bioavailability or competitive/noncompetitive drug or maintenance dose or loading

dose or volume of distribution or Phase 1 to 4 or p450, Anesthetic principles: blood solubility
= induction & recovery; lipid solubility = potency = 1/MAC

2 atropine or stimigmine or muscarinic agonist or anti-muscarinic antagonist

Cardio

1 Brachial arch or pouch question/digeorge

2 lipid lowering drug

3 Shock

4 thermoregulation peripheral vasoconstriction in prolonged cold

5 HOCM S4 AS or Dilated S3 AR MR

6 polyarteritis nodosa or temporal arteritis or Kawasaki or Reye; all the vasculitis

7 post-ventricular MI complications

Endo

1 MEN 1/2

2 hyperthyroid or hypothyroid

3 myoma or rhabdomyoma

4 PTH vs Ca levels

5 endocrine drug metformin, sulfonylurea

6 Addisons or DI or adrenal cortical/medullary

7 signaling pathway of hormones, p53, HOX gene, motif, tumor suppressor genes, oncogenes

8 Islet cell tumors: insulinoma vs. gastrinoma vs. VIPoma, etc.

9 Type 1 vs. Type 2 diabeetus; DKA vs. HHM

GI

1 solid or liquid dysphagia

2 hernia or hemorrhoid

3 Causes and treatment of ulcers--gastric, peptic, etc.

4 Meckel diverticulum or appendicitis or ovarian tumor or Hirschsprung

5 esophageal varices or Mallory Weiss or Boerhave

6 vesicular steatosis or nodular cirrhosis or Hep A, B, C, D, E, Hep B markers

7 Crohn or UC or Th1 or Th2

8 Causes of upper quadrant pain

Heme/Onc

1 Coagulation cascade and associated defects

2 Causes of microcytic vs. macrocytic vs. normocytic anemia

3 Heme synthesis

4 CML or polycythemia vera or myelo

5 Blood smear - parvovirus B19 or Howell Jolly or Heinz or AML

6 Warfarin or heparin or von Willebrand or HUS or TTP

7 Blood group ABO classification or Thalassemia or Sickle cell

8 Multiple myeloma

9 cancer drugs and which categories for each / chemo man side effects

10 grade or TNM stage or brain to lung metastasis or colon to liver metastasis or prostate to
bone metastasis, pancreatic adenocarcinoma osteoBlastic (unlike other cancers)

MSK

1 succinylcholine or dantrolene

2 Neuromuscular junction
 3 bullous pemphigus or pemphigus vulgaris

4 basal cell or melanoma or squamous/acanthosis

5 neuroleptic malignant vs serotonin vs malignant hyperthermia

6 muscle conduction Ca2+ or troponin or tropomyosin

7 SLE antibody or CREST antibody or scleroderma or Sjogren

8 RA or osteoarthritis or PAIR or dermatomyositis/polymyositis

9 Causes of osteolytic vs. osteoblastic lesions

Neuro

1 optic nerve lesion or hemianopsia

2 hematoma epidural/subdural/subarachnoid

3 brain anatomy picture or dorsal column/spinothalamic tract/corticospinal

1 Know brain structures that correspond to pathology (be able to find substantia nigra and
subthalamic nucleus)

4 Sturge Weber or neurofibromatosis or Wilms or tuberous sclerosis

5 Horners (constricted pupil) or uncal herniation (blown pupil)

6 multiple sclerosis

7 Brain Tumors: Adults vs. Children

8 Stroke regions and post-stroke timeline

9 cranial nerve or corneal or pupillary reflex

Psychiatry

1 Time frame for conditions: schizophrenia, depression, bipolar 1+2, GAD, etc.

2 Drugs of abuse: overdose and withdrawal

Renal

1 diuretic places of action and side effects

2 nephritic or nephrotic or white casts or interstitial or kidney stones

3 Acute tubular necrosis vs. acute interstitial nephritis

Repro
1 PCOS or menopause

2 Disorders of sexual development: Kallman vs. Turner vs. Aromatase deficiency vs. Mullerian
agenesis vs. AIS vs. 5a reductase deficiency

3 developmental stage - roll, stand, walk, run, stairs

4 Endometriosis, Leiomyoma, Adenomyosis, Asherman

5 Causes of lower quadrant pain

Respiratory

1 A-a gradient

2 acidosis/alkalosis

3 hyperresonant or tactile fremitus

4 small cell lung carcinoma or carcinoid or serotonin syndrome

5 hydrostatic or colloid pressure

6 sarcoidosis, Vitamin D, 25-something, 1,25-something, 24,25-something

7 CO2 transport

8 Type 2 pneumocytes

Misc

1 random embryology from the heart or reproductive or a pudendal nerve

Anatomy: 100 Most Important General Anatomy Concepts