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2023 10 24 - IMNN MC ValuationReport - Draft03C
2023 10 24 - IMNN MC ValuationReport - Draft03C
licensing revenue peaked at only $500k per annum. After a reverse stock split Y-o-Y Growth 47.88% 29.59% -33.47%
(2006: 1-for-15), Celsion restructured in the 2010s, retiring the first generation 23-Yr Chart: (2000/01/03 2023/08/28) IMNN | IXIC
of managers. New leadership aggressively pursued CRISPR research and new
DNA plasmid-based therapeutics targeting under-served cancer specialties
(breast, ovarian and liver cancers, in particular). Finally in 2022, Celsion
completed its transition to a leading-edge R&D and marketing biotech/pharma
entity, hiring Corinne LeGoff as CEO and changed its name to Imunon. The firm
currently boasts an excellent pipeline of anti-viral and cancer therapeutics
managed by talented, seasoned medical and pharmacological experts.
Key Financials 2016 2017 2018 2019 2020 2021 2022
‘000 $USD (Except Per Share Values)
Net Sales 2016 2017 2018 2019 2020 2021 2022
% Change 500 500 500 500 500 500 500
Net profit 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%
% Change -22,054 -20,402 -11,883 -16,852 -21,484 -20,769 -35,898
Depreciation / Amortization -1.81% -7.49% -41.75% 41.81% 27.49% -3.32% 72.84%
EBIT Margin 1,023 553 357 722 742 703 732
EBIT Margin % Revenue -21,331 -20,310 -21,590 -17,275 -22,037 -21,583 -32,437
EBITDA Margin -4266.15% -4062.08% -4318.09% -3454.92% -4407.41% -4316.56% -6487.33%
EBITDA Margin % Revenue -20,308 -19,757 -21,234 -16,553 -21,296 -20,880 -31,705
interest Expense -4061.58% -3951.48% -4246.72% -3310.59% -4259.10% -4175.98% -6341.00%
Celsion announced other studies testing HIFU with 2014 June Acquisition of EGEN
ThermoDox in U.S. and U.K. research hospitals. On June 20, 2014, the Company completed the
acquisition of substantially all of the assets of EGEN,
2013 January Inc. (EGEN) pursuant to an Asset Purchase Agreement
Extensive review of the HEAT study in patients with (EGEN Asset Purchase Agreement)... In the acquisition,
hepatocellular carcinoma (HCC) confirmed that the HEAT (the Company) purchased GEN-1, a DNA-based
study DID NOT MEET THE GOAL of demonstrating persuasive immunotherapy for the localized treatment of ovarian
evidence of clinical effectiveness (i.e., 33% improvement and brain cancers, and three platform technologies for
in Progression Free Survival PFS at p=0.05) that could form the development of treatments for those suffering
the basis for regulatory approval. x (In 2013, this was a with difficult-to-treat forms of cancer, novel nucleic
major let-down for Celsion followers, including this analyst. acid-based immunotherapies and other anti-cancer
Nevertheless, the analyst recalls that Celsion was DNA or RNA therapies, including TheraPlas™ and
faultlessly transparent and promptly published the TheraSilence™. xii
ambivalent results disclosing reduced prospects for
2014 July
commercial exploitation of ThermoDox-RFA for liver
“The Company announced interim data from the
cancer.)
DIGNITY Study of ThermoDox in RCW Breast Cancer. Of
the 14 patients enrolled and treated, ten were eligible
Hisun paid Celsion a non-refundable R&D fee of $5 million
for evaluation of efficacy. Based on data available to
sponsoring Celsion for continued ThermoDox research, in date, approximately 60% of patients experienced a
exchange for technical expertise and a transfer of research stabilization of their highly refractory disease with a
results to Hisun to satisfy China regulatory requirements. local response rate of 50% observed in the ten
For the promise of an additional $5 million due within a evaluable patients, notably three complete responses,
specified option period, Hisun also incepted an option two partial responses and one patient with stable
agreement to enter into exclusive China license for disease. These data are consistent with the combined
manufacture and commercialization of ThermoDox in clinical data from the two Phase I trials.” xiii
(cont.)
IMUNON INC. OVERVIEW: TIMELINE (CONT.) 2015 September
(The Company) announced enrollment of the first patient in the
OVATION Study. The OVATION Study will seek to identify a safe,
2015 January Early Access Program for ThermoDox for the tolerable and potentially therapeutically active dose of GEN-1 by
Treatment of Patients with RCW Breast Cancer recruiting and maximizing an immune response and is designed to enroll
three to six patients per dose level...to define an optimal dose for a
“The Company entered into an Early Access Agreement
follow-on Phase I/II study combining GEN-1 with Avastin® and Doxil®. In
with Impatients N.V., a Netherlands company addition, the OVATION Study establishes a unique opportunity to assess
(Impatients), pursuant to which Impatients will develop how cytokine-based compounds such as GEN-1, directly affect ovarian
cancer cells and the tumor microenvironment in newly diagnosed
and execute through its brand myTomorrows an early patients. The study is designed to characterize the nature of the immune
access program for ThermoDox in all countries of the response triggered by GEN-1 at various levels of the patients’ immune
European Union territory, Iceland, Liechtenstein, Norway system, including:
• infiltration of cancer fighting T-cell lymphocytes into primary tumor
and Switzerland (the Territory) for the treatment of and tumor microenvironment including peritoneal cavity, which is
patients with RCW breast cancer. Under the early access the primary site of metastasis of ovarian cancer;
program, Impatients will engage in activities to secure • changes in local and systemic levels of immuno-stimulatory and
immunosuppressive cytokines associated with tumor suppression
authorization, exemption or waiver from regulatory and growth, respectively; and expression profile of a
authorities for patient use of ThermoDox that may comprehensive panel of immune related genes in pre-treatment
and GEN-1-treated tumor tissue.
otherwise be subject to approvals from such regulatory
authorities before the sale and distribution of (The Company) initiated the OVATION Study at four clinical sites at the
ThermoDoxin the relevant territories. (The Company University of Alabama at Birmingham, Oklahoma University Medical
Center, Washington University in St. Louis and the Medical College of
would) be responsible for the manufacture and supply of Wisconsin. During 2016 and 2017, (the Company) announced data from
quantities of ThermoDox to Impatients for use in the Early the first four cohorts of patients in the OVATION Study, respectively. The
Access Program and Impatients will distribute and sell first four cohorts each enrolled three patients. Enrollment of three
additional patients in the fourth cohort is ongoing, and Celsion expects
ThermoDox pursuant to such authorization, exemptions or to complete the OVATION Study in the first half of 2017. Future studies
waivers.” xiv of GEN-1 may include a Phase I/II study combining GEN-1 with Avastin®
and Doxil®. The results of the OVATION Study to date are as follows:
Totality of Results in the First Four Cohorts
2015 January • Of the first twelve patients dosed, one (1) patient demonstrated a
“(The Company) announced that (it) submitted to the FDA complete response (“CR”), eight (8) patients demonstrated partial
response (“PR”) and three patients demonstrated stable disease
a Phase I clinical trial protocol for GEN-1 for the treatment (“SD”), as measured by RECIST criteria. This translates to a 100%
of ovarian cancer. The protocol, developed with guidance disease control rate (“DCR”) and 75% objective response rate
from the Company’s Medical Advisory Board, is designed (“ORR”).
• Eleven patients had successful resections of their tumors, with six
to establish a safe dose and biological activity of GEN-1 in (6) patients having an R0 resection, which indicates a
newly diagnosed ovarian cancer patients who will be microscopically margin-negative resection in which no gross or
undergoing neoadjuvant chemotherapy. The clinical trial microscopic tumor remains in the tumor bed, and four (4) patients
with a R1 resection, indicating microscopic residual tumor. One
will identify a safe, tolerable and potentially patient had an R2, indicating macroscopic residual tumor. One
therapeutically active dose of GEN-1 while maximizing an patient in the second cohort was ineligible for debulking surgery
due to a medical complication unrelated to the study or the study
immune response with the potential to identify an drug.
enhanced population for definitive study. • Of the eleven surgically treated and evaluable patients, one patient
demonstrated a complete pathological response (“cPR”), five (5)
patients demonstrated a micro pathological response (“microPR”),
2015 February and five (5) patients demonstrated a macroPR. These data compare
(The Company) announced that the FDA ha(d) accepted, favorably to historical data, which indicate that cPRs are typically
without comment, the Phase I dose-escalation clinical trial seen in less than 7% of patients receiving neoadjuvant
chemotherapy followed by surgical resection. cPRs have been
of GEN-1 in combination with the standard of care in neo- associated with a median overall survival of 72 months, which is
adjuvant ovarian cancer. The trial is designed to enroll more than three years longer than those who do not experience a
cPR. In addition, microPRs are seen in approximately 30% of
three to six patients per dose level and will evaluate safety patients, and are associated with a median overall survival of 38
and efficacy and attempt to define an optimal dose to months.
carry forward into a Phase II trial. (The Company) • All eleven patients who completed treatment follow-up
experienced a dramatic (greater than 90%) drop in their CA-125
expect(ed) to initiate enrollment for the trial in the second protein levels as of their most recent study visit. CA-125 is used to
half of 2015 at five to six U.S. clinical centers.” xv monitor certain cancers during and after treatment. CA-125 is
present in greater concentrations in ovarian cancer cells than in
other cells. A 50% reduction in CA-125 levels is considered
meaningful.
NCT
STUDY TITLE STUDY STATUS CONDITIONS INTERVENTIONS STUDY TYPE
NUMBER
3 This list is not comprehensive. Imunon conducts studies with research hospitals, governments, and international agencies such as WHO in other jurisdictions outside of the USA.
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PESTLE: CHARACTERISTICS
Derived principally from IMNN FY 2022 10-K; and IH 2023 10Q Legal
Economic Resolved:
2023 - 1H2024: The analyst expects annual revenue of $500k per 29 October 2020, a putative securities class action was
annum for ongoing royalties for ThermoDox® licensing; filed against the Company and certain of its officers and
4Q2024 - FY2025: The analyst projects the appearance of directors (the “Spar Individual Defendants”) in the U.S.
revenue of $7,000k ($7 Million) emerging from Pipeline research: District Court for the District of New Jersey, captioned
1) PlaCCine modality system for Covid-19, influenza and other Spar v. Celsion Corporation, et al., Case No. 1:20-cv-
novel viruses; and also 2) OVATION 2. This $7M figure is a low- 15228. The plaintiff alleged that the Company and
ball assessment to affirmatively arrive at $10M revenue during Individual Defendants made false and misleading
FY 2026, assuming a low/moderate 20% revenue growth rate. statements regarding one of the Company’s drug
Other analysts will impute different parameters. candidates, ThermoDox®, and brought claims for
damages under Section 10(b) of the Exchange Act and
Peer Group Research and ‘000s 2021 2022
Rule 10b-5 promulgated thereunder against all
Development Expenditure: IMNN 703 732
Defendants, and under Section 20(a) of the Exchange Act
o This notation is solely for illustrative HILS 1,843 2,278
ERNA 12,705 10,392 of 1934 against the Individual Defendants. The Company
purposes. The analyst has not
PCSA 6,878 11,494 believes that the case is without merit and defended it
conducted exhaustive review of the LSTA 17,576 13,067
peer group’s pipeline of research
vigorously. On 06 February 2023, the U.S. District Court
FRTX 28,231 14,043
endeavors. These figures only MBRX 14,418 18,968 granted a Motion to Dismiss filed by the Company and
illustrate the range of R&D QNCX 60,795 25,178 Spar Individual Defendants and granted Plaintiff leave to
ATXS 15,552 34,264 file an amended complaint within 30 days. “Plaintiff did
expenditure among start-up biotech GNFT 35,166 35,818
firms within IMMN’s peer group. not file an amended complaint within the 30-day
Vaccine Market: Due to the Covid-19 pandemic, the global trade deadline.”
in vaccines surged 26% Y-o-Y (2020-2021) to $USD 41B during In August 2021, a complaint regarding a corporate books
2021 from $USD 32.6B in 2020. Belgium, China, Germany, Spain, and records demand was filed against the Company in the
and the U.S. accounted for nearly 75% of total 1H 2021 exports. xvi Court of Chancery of the State of Delaware, captioned
Our globally interconnected world offers novel opportunities for Pacheco v. Celsion Corporation, Case No. 2021-0705. The
nefarious pathogens to emerge into the human ecosystem, plaintiff alleged he was entitled to inspect the Company’s
bringing dangers to health and safety, interrupting trade, and books and records concerning the OPTIMA Study and
wreaking havoc upon our fine-tuned civilization. This becomes other materials. On May 31, 2023, the Court of Chancery
more problematic as heretofore inaccessible territories in Africa entered the parties’ stipulation dismissing the case
and Asia, and parts of Central and South America open up to without prejudice.
global economic intercourse. In October 2021, an arbitration was commenced against
o “Anthony Fauci, who retired as head of the National the Company before the CPR Institute for Conflict
Institute of Allergy and Infectious Diseases, National Prevention & Resolution, captioned Curia New Mexico,
Institutes of Health, at the end of 2022, wrote that “The LLC v. Celsion Corp., Case No. G-22-85-S. The claimant
emergence of new infections and the reemergence of old alleged that the Company failed to pay invoices for the
ones are largely the result of human interactions with and manufacture of two batches of ThermoDox®. On April 19,
encroachment on nature. As human societies expand in a 2023, the arbitral tribunal issued an interim award,
progressively interconnected world and the human– upholding claimant’s claim with respect to one of the two
animal interface is perturbed, opportunities are created, batches of ThermoDox® for an aggregate amount of
often aided by climate changes, for unstable infectious approximately $583,500 including interest and legal fees
agents to emerge, jump species, and in some cases adapt
which was paid in second quarter 2023 and the
to spread among humans.” “ xvii
arbitrators denied their claim with respect to the other
Imunon has grown a core competency in cutting edge vaccine
technology. Consequently, the company may experience high and
batch of ThermoDox®.
rapid Revenue Growth multiples once it commences commercial
licensing transactions for its PlaCCine immunization platform among Unresolved: Breach of fiduciary duty/other allegations for ThermoDox®:
the major vaccine producers worldwide. The analyst posits that this In February 2021, a derivative shareholder lawsuit was filed
transition will occur within the immediate 15 months to 2 years. against the Company, as the nominal defendant, and certain
of its directors and officers as defendants in the U.S. District
Court for the District of New Jersey, captioned Fidler v.
Environmental
Michael H. Tardugno, et al., Case No. 3:21-cv-02662. The
The company is subject to a number of laws and regulations plaintiff alleges breach of fiduciary duty and other claims
forcing compliance with federal, state, and local regulations for arising out of alleged statements made by certain of the
the protection of the environment. The regulatory landscape Company’s directors and/or officers regarding ThermoDox®.
continues to evolve, and additional regulations will emerge in the The Company believes it has meritorious defenses to these
future. National governments and international agencies claims and intends to vigorously contest this suit. At this
implement laws and regulations to mitigate the effects of climate stage of the case neither the likelihood that a loss, if any, will
change mainly caused by greenhouse gas emissions. Imunon’s be realized, nor an estimate of possible loss or range of loss,
business is not energy intensive. The analyst does not anticipate if any, can be determined. On 10 March 2023, the U.S.
that the Company will fall subject to a cap-and-trade system or District Court for the District of New Jersey issued an order
that the action is administratively terminated pending the
other mitigation measures that would materially impact capital
submission, by 17 March 2023, of a joint letter advising as to
expenditures, operations or competitive position.
how the parties wish to proceed in the matter.
Sociological
Aging and longer-lived Western populations generate
opportunities for pharmaceutical firms to extend brand
loyalties and grow legacy revenue for longer durations;
Americans have cultivated a perception that
pharmaceutical companies charge exorbitant/unfair
rates for medications. This may work in IMNN’s favor as
it evolves to produce revenue in a lower-price
environment. Unlike existing biotech companies facing
downward pricing pressure, startup: IMNN is initiating
from baseline prices and would only see an upside;
Post-Covid-19 worldwide appeal for vaccines as a must-
have therapeutic measure may increase interest in
IMNN PlaCCine modality;
Public interest groups and radical factions assail
pharmaceutical companies for needlessly testing
products on animals (the testing of which often
involves the dissection of the subject to review
pharmacological effects on the organs).
Technological
Next generation computer programming and AI
algorithms enhance R&D and offer alternatives to
quickly image pathogen biochemical structure and
virus infection pathways. These endeavors may
enhance or circumvent animal and human testing;
New biochemistry technologies continue to gain
greater efficacy in medication, more efficient
production methods, and non-invasive disease
detection.
CRITERIA (UNITS: ‘000S) BV0 Multiple: P0/BV0 = PBV = “(RoE-gn)/(ke-gn)” 0.486 xxi
CoGS: F(Rev) 13.989% Forecast Share Price from Multiple5.80 X BV0 15.28
Depreciation/Amortization (CoGS): F(Rev) 5.085%
SGA (Only): F(Rev) 15.787% KB Long-Term Debt 10K:2022
R&D: F(Rev) 21.476% MatDate Coupon Value Annual
Depreciation/Amortization (SGA): F(Rev) 0.000% 2022-03-31 6.330% % 0.001 0
2022-09-30 N/A % 0.000 0
Other Expense (Income)/Overhead: F(Rev) 0.000% 2023-09-30 N/A % 0.000 0
Interest Expense (Income): F(Rev) 2.940% 2023-09-30 N/A % 0.000 0
2024-04-30 N/A % 0.000 0
Tax Rate xviii: F(EBT) 21.000% 2025-02-28 N/A % 0.000 0
Capital Expenditures: F(Rev) 6.751% 2026-03-31 N/A % 0.000 0
Working Capital: F(Rev) 15.000% 2027-03-31 N/A % 0.000 0
2027-10-31 N/A % 0.000 0
2030-10-31 N/A % 0.000 0
βeta 2.09 2035-09-30 N/A % 0.000 0
2036-09-30 N/A % 0.000 0
Shares Outstanding (Thousand) 9,100.000 2040-10-31 N/A % 0.000 0
Inflation Rate (Long-term Historical Est.) 2.500% 2041-12-31 N/A % 0.000 0
2044-04-30 N/A % 0.000 0
RF (T-bill annual) Rate 5.250%
2045-02-28 N/A % 0.000 0
CAPM KE Calculation 15.178% 2046-03-31 N/A % 0.000 0
GORDON DIVIDEND GROWTH KE Calculation 15.343% 2047-03-31 N/A % 0.000 0
2050-10-31 N/A % 0.000 0
KB Result 6.330% N/A % 0.000 0
KB Result with Tax Shield 5.0007% N/A % 0.000 0
WACC 11.1323% Totals 0.000 0.00
Market Historical Returns (Est.) 10.000% With Tax xxii Shield (21%) 5.0007%
Revenue Growth Rate (Proj. Est. 10-Yr) 20.000% Weighted Average Cost of Capital
Perpetuity Growth Rate (Inflation) 2.500%
𝐾𝐾 𝐵𝐵+𝐾𝐾 𝐸𝐸 [5.0007%X0.39749]+[15.1775%X0.60251]
𝑊𝑊𝑊𝑊𝑊𝑊𝑊𝑊 = 𝐵𝐵 𝐸𝐸
=
Discussion B+E 1.000
The analyst produced three distinct prospective models of FCFE: 1) [1.98772%] + [9.14461%]
=
Static model varying WACC; 2) Static model varying Revenue 1.000
Growth Rate; and 3) Dynamic multi-iterative Monte Carlo model = 11.13233%
oscillating all variables within a tolerance of 10% coefficient of Market Capitalization Basis; B=Total Debt (adj. with carrying
variability. These models suggest a range of Equity valuation for costs); E = Equity Market Capitalization xxiii
Imunon, Inc. The results page discusses the outcomes of these WACC derives KE from Capital Asset Pricing Model
Equity valuation simulations.
4
The analyst derived these variables as statistical calculations from fifteen years of the proxy reference: Gilead Sciences, Inc. audited financial statements.
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Discussion
The analyst expects the firm will aggressively grow
revenue into the several multiples potentially to
75%-100% Y-oY growth within the next 2-3 years.
Once the firm enters maturity (10+ years), one
expects long-term revenue growth rate of 2.50% -
3.50% (mimicking U.S. long-term inflation +50 to
100 basis points) with some additional upside
potential as new therapeutic properties come
online.
Sensitivity Analysis
The Monte Carlo FCFE DISCOUNTED CASH FLOW PROJECTION is sensitive to particular conditions. Because the
perpetuity
CashFlow dwarfs
estimated cash-flow
in any given annum,
the terminal year
factors typically
assert control over
the Firm and its
weighted Equity
valuation: 1) 2024
SGA; 2) 2034 R&D;
3) 2034 CoGS; 4)
WACC for
simulation; 5) 2034
Tax xxiv Rate and 6)
2024 Revenue.
The Tornado Chart sensitivity analysis of Imunon valuation with these instant variables imputes a heavy
weighting upon the perpetuity model – likely because of the unknowns: Taxation xxv regime and Revenue
potential. This analyst believes that IMNN has excellent upside potential in its pipeline R&D, especially the
PlaCCine and IMMN-01 modalities for vaccine platform and cancer therapeutics respectively.
Imunon, Inc. Closest Competitors:
NAME STAGE FOCUS FOUNDED
Discovery, development, and commercialization of therapeutics
Astria Therapeutics, BioPharmaceutical
ATXS for rare and niche allergic, and immunological diseases in the 2008
Inc. Company
United States
Eterna Therapeutics Synthetic mRNA, ToRNAdo mRNA Delivery, mRNA Gene Editing,
ERNA Preclinical
Inc. and mRNA Cell Reprogramming
Fresh Tracks Prescription therapeutics for the treatment of autoimmune,
FRTX Clinical 2009
Therapeutics, Inc. inflammatory diseases...
BioPharmaceutical Discovers and develops drug candidates and diagnostic solutions
GNFT Genfit S.A. 1999
Company for metabolic and liver-related diseases
Hillstream BioPharma,
HILS Preclinical Immuno-oncology, ferroptosis 2017
Inc.
Development of immunotherapies and vaccines to treat cancer
IMNN Imunon, Inc. Clinical 1982
and infectious diseases
Lisata Therapeutics, Innovative therapies for the treatment of solid tumors and other
LSTA Clinical 2015
Inc. diseases
Moleculin Biotech,
MBRX Clinical Treatment of cancers and viruses 2015
Inc.
Processa
PCSA Clinical Ulcerative and non-ulcerative necrobiosis lipoidica 2011
Pharmaceuticals, Inc.
Quince Therapeutics,
QNCX Preclinical Precision therapeutics for debilitating and rare diseases 2012
Inc.
FINANCIAL INDICES
FINANCIAL INDICES
FINANCIAL INDICES
FINANCIAL INDICES
FINANCIAL INDICES
FINANCIAL INDICES
FINANCIAL INDICES
FINANCIAL INDICES
END NOTES
i
About ThermoDox® (https://investor.celsion.com/news-releases/news-release-details/celsion-corporation-announces-issuance-new-patent-thermodoxr)
Celsion's most advanced program is a heat-mediated drug delivery technology that employs a novel heat-sensitive liposome engineered to address a range of
difficult-to-treat cancers. The first application of this platform is ThermoDox®, a lyso-thermosensitive liposomal doxorubicin (LTLD), whose novel mechanism of
action delivers high concentrations of doxorubicin to a region targeted with the application of localized heat at 40°C, just above body temperature. ThermoDox®
is positioned for use with multiple heating technologies and has the potential to treat of a broad range of cancers including metastatic liver, recurrent chest wall
(RCW) breast cancer and non-muscle invading bladder cancers.
Celsion's LTLD technology leverages two mechanisms of tumor biology to deliver higher concentrations of drug directly to the tumor site. In the first mechanism,
rapidly growing tumors have leaky vasculature, which is permeable to liposomes and enables their accumulation within tumors. Leaky vasculature influences a
number of factors within the tumor, including the access of therapeutic agents to tumor cells. Administered intravenously, ThermoDox® is engineered with a
half-life to allow significant accumulation of liposomes at the tumor site as these liposomes recirculate in the blood stream. In the second mechanism, when an
external heating device heats tumor tissue to a temperature of 40°C or greater, the heat-sensitive liposome rapidly changes structure and the liposomal
membrane selectively dissolves, creating openings that can release a chemotherapeutic agent directly into the tumor and into the surrounding vasculature. Drug
concentration increases as a function of the accumulation of liposomes at the tumor site, but only where the heat is present. This method damages only the
tumor and the area related to tumor invasion, supporting more precise drug targeting.
ii
Celsion 2006 10K, p. 1
iii
Sourced directly from https://www.baltimoresun.com/news/bs-xpm-2006-01-18-0601180097-story.html
iv
Sourced from 8-k https://www.sec.gov/Archives/edgar/data/749647/0000749647-96-000003.txt
v
Sourced from https://www.sec.gov/Archives/edgar/data/749647/0000931731-99-000020.txt
vi
Sourced from https://www.sec.gov/Archives/edgar/data/749647/0000931731-99-000020.txt
vii
Docetaxel is marketed worldwide under the name Taxotere by Sanofi-Aventis.
viii
Celsion 2010 10K
ix
Celsion 2012 10-K
x
Celsion 2012 10-K
xi
Celsion 2014 10-K
xii
TheraPlas™ is a technology platform for the delivery of DNA and messenger RNA (mRNA) therapeutics via synthetic non-viral carriers and is capable of
providing cell transfection for double-stranded DNA plasmids and large therapeutic RNA segments such as mRNA. There are two components of a TheraPlas
system, a plasmid DNA or mRNA payload encoding a therapeutic protein, and a delivery system. The delivery system is designed to protect the DNA/RNA from
degradation and promote trafficking into cells and through intracellular compartments. We designed the delivery system of TheraPlas™ by chemically modifying
the low molecular weight polymer to improve its gene transfer activity without increasing toxicity. We believe that TheraPlas™ is a viable alternative to current
approaches to gene delivery due to several distinguishing characteristics, including enhanced molecular versatility that allows for complex modifications to
improve activity and safety. (2014 10-K)
xiii
Celsion 2014 10-K
xiv
Celsion 2014 10-K
xv
Celsion 2014 10-K
xvi
OECD: Vaccinating the World,
https://www.oecd.org/coronavirus/en/vaccines?fbclid=IwAR0QlkEJ0iGWcTaVPPpkY5jeeK2sTPJQyoSKhkA2BZ_GSmNU8j5dNTQpHFY
xvii
Copied in its entirety from: https://wwwnc.cdc.gov/eid/article/29/2/ac-
2902_article#:~:text=As%20human%20societies%20expand%20in,adapt%20to%20spread%20among%20humans.%E2%80%9D
xviii
During the Trump PotUS Administration, Congress passed the Tax Cuts and Jobs Act (TCJA) in 2018, reducing corporate taxes to a flat 21% across the board.
Because of high U.S. debt and annual deficit expenditure, the analyst believes that this ultra-favorable tax regime is not sustainable. The reader should note that
any change in taxation rates will immediately affect Imunon equity valuation.
xix
The analyst plugged a conservative, arbitrary estimate of 10.00% to accommodate risk and inflation.
xx
RoE conservative estimate of 20.00%
xxi
Stern at NYU provides this 5.80 average BV multiple for the Drugs: Biotechnology sector (Price to Book Ratios (nyu.edu))
xxii
During the Trump PotUS Administration, Congress passed the Tax Cuts and Jobs Act (TCJA) in 2018, reducing corporate taxes to a flat 21% across the board.
Because of high U.S. debt and annual deficit expenditure, the analyst believes that this ultra-favorable tax regime is not sustainable. The reader should note that
any change in taxation rates will immediately affect Imunon equity valuation.
xxiii
See the WACC Worksheet for details of each component. The Monte Carlo Workbook algorithm is hard coded to calculate WACC using various methods:
CAPM, Gordon Dividend Growth Model, RoE model, or combinations. In this instant, the system derived the WACC using market capitalization with the then
share price of $1.250 and with weighted number of shares equivalent to the average of 9,370 Thousands (Yahoo Finance value for shares outstanding) and 9,100
Thousands (the 2022-12-31 adj. value). The coded WACC calculation added the Book Value of all Debt (adj. with carrying costs) (B) to the Equity Capitalization
for total Capitalization. The cost of debt (B) was derived above. The cost of Equity emerged from the CAPM with an estimated β eta of 2.09, 10.000% market
returns, and 5.250% rF according to the stated calculations.
Watermark: Science – IMUNON
Pipeline Progress: ClinicalTrials.gov
xxiv
During the Trump PotUS Administration, Congress passed the Tax Cuts and Jobs Act (TCJA) in 2018, reducing corporate taxes to a flat 21% across the board.
Because of high U.S. debt and annual deficit expenditure, the analyst believes that this ultra-favorable tax regime is not sustainable. The reader should note that
any change in taxation rates will immediately affect Imunon equity valuation.
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During the Trump PotUS Administration, Congress passed the Tax Cuts and Jobs Act (TCJA) in 2018, reducing corporate taxes to a flat 21% across the board.
Because of high U.S. debt and annual deficit expenditure, the analyst believes that this ultra-favorable tax regime is not sustainable. The reader should note that
any change in taxation rates will immediately affect Imunon equity valuation.