PAPER CODE: MB2019101

KAI-OJI NARAHNA RAO UNIVERSITY OF SCIENCES

ARANGAI. TELANGANASTATE- 506002
MBBS FIRST WAR EXAMINATIONS:NOVEMBER. 2023
BIOCHEMISTRY (New Regulation)
PAPER —1
Time: Ilours Max Marks: 100
Note: Answeralt gucsuons
diagramswhenever KNRUHS -2022 I pencillanydart
Colourpencil

Multiple Choice Questions: lox 1-10

Anomenc carbon atom of fructose is in

a) I g carbon atom _b) carbonatom
c) Penultimate carbon atom d) None of the above
2. All the following are unsaturated fatty acids except
-a) Propionicacid b) Linoleicacid
c) Linolcnicacid d) Arachidonicacid
3. During glycogen breakdown, the action of glycogen phosphorylase produces
a) Glucose -6-phosphate •b) Glucose-I-phosphate

c) Fructose- 6-phosphate d) None of the above

4. The key enzyme in the pathway of cholesterolbiosynthesisis
a) HMG COA b) HMGCoA1yase

-c) HMG COA reductase d) Mevalonate kinase

5. Components of the electron transport chain are arranged in order of

. a) Decreasing redox potential b) Increasing redox potential

c) Positive redox potential to negative d) None of the above

redox potential
6. Enzymes act by reducing the
@medi circle
-a) Activation energy b) Heat energy

c) Binding energy d) All of the above

7. Increased levels of lactate dehydrogenase (LDH) can be observed in

a) Myocardial infarction . b) Haemolytic anaemia

c) Lcukaemia •s d) All of the above

 fluid mosau-•model or membrane Includes
a) Cholesterol molecules in the b)
Membrane proteins are fixed
membrane Increase stability of and cannot move
membrane
c) Membranecontatns bimolecular d) Permeabilityof drugs across
leaflet of l'Ptds cell membrane ts dependent on
their solubility in water
9. Mobility of particles during electrophoresis is based on all
the followtng
factors. except
a) Current voltage and ampere Quality of supporting media
c) Ph of buffet medium d) Solubility of particle protein
10. The power house of the cell is
a) Nucleus b) Cell membrane
, c) Mitochondria d) Lysosomes

Essey/Long Answer Questions: 2 x 15=30

41. Whatarc t.ipoproteins.ClassifyLipoproteins.Explainthe transportof TAG (Tri Acyl
glycertdes) in the body. Discuss the clinical significance of LDL and HDL. Add a note on
dyslipidaernias.
$2. What is Glycogen. How is Glycogen broken down in the body. Explain the hormonal
regulation of the pathway. Write about glycogen storage disorders.

ShortAnswerQuestions: @medi circle 7 x 6-42

13. What are the different types of enzyme inhibition. Explatn about competitive inhibition with
two examples of its thetapeutic significance.
J.4. Write about inhibitors and uncouplers of electron transport chain.
Justify Physician role in Health Care System.
J6. Enzyme profile in liver diseases,and write abouttheir clinical significance.
F. Describe the sources. daily requirement and functions of Vitamin C.
Descnbe the regulation of calcium homeostasis.
J'. Define BMR, what is its normal value, and what are all the factors affecting BMR

Very Short Answer Questions: 6 x 3-18

Write about classification of lipids with suitable examples.
Principle and applications of Enzyme Linked Immunosorbent Assay (ELISA).
—22.Antioxidant Vitamins.
.23. Describe about transport systems with examples,
-24. Essential Fatty acids.
'8. Compare and Contrast Kwashiorkor and Marasmus.
 PAPER CODE: MB2019102
KALO.JINARAYANARAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL,TELANGANASTATE- 506002
MBBSFIRST VEAREXAMINATIONS:
NOVEMBER,2023
BIOCHEMISTRY (New Regulation)
PAPER — 11
Time:3 Ilours Max Marks: 100
Note; Answer all questions
Draw diagrams whenevernceessary With Black Ball point pen '11Bpencil "any dark
Colour pencil

MultipleChoiceQuestions: 10 x 1-10
1. Peptidebond is
a) Singlebondin character b) Doublebondin character
c) Partialdoublebond in character d) Triplebond in character
2. Duringurea cycle, the twonitrogenatomsare derivedfrom
a) Ammoniaand Arginine b) AmmoniaandAsparticacid
c) BothfromAmmonia d) Ammoniaand Ornithine
3. The sourcesOfoxalicacidin urineare
a) Ornithineand citrulline b) Oxalosuecinateand formicacid
c) Oxaloacetateand asparticacid d) Ascorbicacidand Glycine
4. Elevatedhomoeysteinelevels are associatedwith a risk of
a) Bronchiectasis b) Nephrotie
c) Coronaryarterydisease d) Diabetesmellitus
5. RegardingDNA structurewhichis not correct.
a) Two strands arc covalently b) Two strands are antiparallel
bonded
c) Strands have polarity. d) Strands are complementaryto
eachother
6. Whicho t n 1i s is not associatedwith hyperuricemia.
a) Multiplemyeloma b) Xanthinuri*'
c) Psoriasis d) Polycythemiavera
7. Sickle cell anaemia occursdue to
a) Silentmutation b) Mis-sensemutation
c) Nonsensemutation d) Frameshiftmutation
8. Whichof the followingrenal functionaltests are used to measure the
GlomemlarFiltrationRate(GFR)
a) Clearancetests. b) Urineconcentrationtests
c) Urine dilutiontests d) Urine acidificationtests
9. Which is an anticancerdrug.
a) Zidovudine b) 6-mercaptopuri»e
c) Allopurinol d) Acyclovir
 10. Okazaki fragments occur on the
a) Leadingstrand b) Lagging strand
c) Double helical DNA strand d) All the above
Essay/ Long Answer Questions: 2 x 15-30
A 15-year-old boy complained of swelling and pain in the distal phalangeal
joints. Blood investigations showed the following results. On diagnosing
the pathology, the physician decided to treat patient with allopurinol.
a. What is your probable diagnosis in the above patient.
b. Write tlle synthesis of Uric Acid.
c. Whatis the normal uric acid level.
d. What are other blood investigations would you suggest.
e. Commenton the serum uric acid level and explain the cause of pain in
joints.
f. Writethe ways for loweringserumuric acid level. 0)
g. What is the biochemical explanation for the treatment given in the
above patient.
. Describe the steps of catabolism of Phenylalanine and Tyrosine. Indicate
the inborn errors of metabolism. What are the Biomedically important
compounds derived from tyrosine. (8+5+2)
ShortAnswerQuestions: 7 x 6=42
Medi Circle
13. Namc the enzymes measured to assess liver functions. Discuss the clinical
significance of Alanine transaminase and Alkaline phosphatase in assessing
liver ['unction.
. Discuss the Watson and Crick model ofDNA. Add a note on different forms
CDNA.
. Write on the classification of Acid-base disorders in the body and also
ention the compensatorymechanismsfor each type.
. ustify the statement "Physician is a lifelong learner".
Describethe formation ofbilirubin. Name the different types of jaundice.
J What are tumour markers. Discuss the clinical utility Ofany three tumour
markers,
Write about structure, classification and functions of immunoglobulins.
Very Short Answer Questions: 6 x 3=18
Orotic aciduria.
List the thyroid function tests. Mention the laboratory findings in a case
of
ypothyroidism.
What is Polymerase Chain Reaction (PCR). Mention two clinical
applications of PCR technique.
23. Importance of cytochrome P450 in detoxification.
What is foetal haemoglobin. How does its structure differ from
adult
haemoglobin and explain how it is useful to the foetus.
. ACTH.
 MB2019103
PAPER CODE:
SCIENCES
KALOJI NARAYANA RAO UNIVERSITY OF HEALTH
WARANGAL, TELANGANA STATE - 506 002
2023
MBBS FIRST YEAR EXAMINATIONS: NOVEMBER,
ANATOMY(New Regulation)
PAPER —1
Time:3 Hours Max Marks: 100
Note: Answerall questions
pencil /any' dark
Draw diagrams wherever necessary with Black Ball point pen 11-1B
Colourpencil

Multiple Choice Questions: lox 1=10

1. Which of the nerve Injury leads to wrist drop?
a) Ulnar b) Radial
c) Median d) Axillary
2. Which layer of scalp is regarded as the dangerous layer
a) Subcutaneouslayer b) Aponeuroticlayer
c) layer of loose areolar d) pericranium
tissue
3. Cartilage seen in intervertebraldisc is Medi Circle
a) Hyaline cartilage b) Elastic cartilage
c) White fibro cartilage d) None of the above
4. The viability of OVUM released after ovulation is
a) 24-28 hrs b) 12 hrs
c) 72-90 hrs d) 6 hrs
5. The space between the right and left vocal folds is called
a) Vestibule b) Rima vestibuli
c) ventricle d) Rima glottidis
6. Lateral wall of cavernous sinus contain all of the following nerves except
a) Oculomotor b) Trochlear
c) Ophthalmic d) Abducent
7. Most of the supero- lateral surface of the cerebral hemisphere is supplied by
a) Anterior cerebral artery b) Middle cerebral artery
c) Posterior cerebral d) None of the above.
artery
8. All the muscles of the tongue are supplied by the hypoglossal nerve except.
a) Palatoglossus b) Styloglossus
c) Hyoglossus d) Genioglossus
9. Taste buds are not present in one of the following
papillae
a) Circumvallate b) Filiform
c) Fungiform d) Foliate
10. Which part of pituitary gland contains herring bodies
a) Pars nervosa b) Pars Intel-media
c) Pars anterior d) Pars distalis

Essay/ Long Answer Questions: 2 x 15=30

11. A child is brought to the hospital with a compliant of bleeding from the nose
after inserting a foreign object into the nose.
a) Name the area which is the commonest site of nasal bleeding.
b) Enumerate the structures in the lateral wall of the nasal cavity.
c) Name the nerve supply and arterial supply to the lateral wall,
( 1 +6+4+4)
d) Applied Anatomy,
12. Describe the brachial artery under the followingheadings.
a) Origin b) Branches c) Relations d) Applied anatomy
(2+5+5+3)

Short Answer Questions: Medi Circle 7 x 6=42

ventricle.
13. Describe the floor of fourth
of face.
14. Discuss briefly the development
sulci and gyri of medial surface of cerebral hemisphere.
15. Draw the different
Explain the boundaries and contents of suboccipital triangle.
16.
Draw a neatly labelled diagram of the microanatomy of retina.
17.
Explain- The Cadaver as our first teacher.
18.
featuresof cerebellum.
19. External and internal
6 x 3=18
Questions:
Very Short Answer
diagram of histology of Hyaline cartilage.
20. Draw a neatly labelled
contents.
21. Cubital fossa-boundaries and
microstructure of palatine tonsil.
22. Draw a neatly labelled diagram of
23. Anatomical basis of wrist drop.
24. Clavi pectoral fascia.
25. Name the nerves related to the posterior border of Sternocleidomastoid
Muscle.
 OF HEAL
KALOJI NARAYANARAO UNIVERSITYSTATE - 506 002
TELANGANA
WARANGAL,
NOVEMBER, 2023
MBBS FIRST YEAR EXAMINATIONS:
ANATOMY (NEW REGULATION)
PAPER - 11 MaxMarks: 100
Time: 3 Hours
Note: Answerall questions Ball point pen /HB pencil 'any dark
Black
Draw diagrams Wherever necessary with
Colour pencil

lox 1=10
Multiple Choice Questions:
are protected by the thoracic
1. All of the following abdominal viscera
cage except
a) Liver b) Spleen
c) Pancreas• d) Stomach
2. All are characteristicfeatures of large intestine except
a) Appendicesepiploicae b) Sacculations
c) Villi. d) Taeniacoli
3.Patellais developed in the tendon of
MeAl Circle
a) Rectus Femoris b) Quadriceps
c) Vastus Medialis d) Vastus Intermedius
4. Name the muscle present on the dorsum of foot
a) Soleus b) Extensor digitorum brevis •
c) Peroneus brevis d) Peroneus tertius
5. Which spinal nerve is affected in Thoracic Inlet Syndrome
a) 7th Cervical b) 8th Cervical
c) 1st Thoracic d) 2nd Thoracic
6. Indentations in the oesophagus are caused by all except
a) Aortic arch b) Left bronchus
c) Left atrium d) Left ventricle
7. Mutation of which chromosome occurs in haemophilia
a) Chromosome 21 b) Chromosome22
c) Chromosome X d) Chromosome Y
8. Aberration of which chromosome is seen in Palau's syndrome
a) 13 b) 14
c) 18 d) 21
9. Skeletal frame work of epiglottisformedby
Hyaline •
a) Elastic cartilage b)
c) White fibro cartilage d) Reticulartissue
 10. Macrophagesin the liver are
a) Hepatocytes b) Ito cells
c) Cholangiocytes d) Kupffercells
Essay/ Long Answer Questions: 2X15=30
11. A 60-year-old female came to gynaecology OPD with history of mass per
vagina and difficulty in micturition. (I+4+3+5+2)
a) Evaluate the probable diagnosis.
b) Discuss the general features of involved organ.
c) Relations d) Supports e) Blood supply
12. Describe the hip joint under the following headings: (2+4+2+3+ +3)
a) Type and articular surfaces b) Capsule and ligaments
c) Relations d) Movements and muscles causing movements
e) Blood supply f) Clinical anatomy
Short Answer Questions:
Medi Circle 7X6=42

13. Describe the external features, relations of thoracic part of Oesophagus.

14. Embryological basis Of anomalies of diaphragm.
15. Describe various sites of portocaval anastomosis.
16. Draw a neatly labelled diagram of histology of adrenal gland and write about its
functional correlatiom
17. Describe the boundaries and contents of superior mediastinum.
18. Enumerate the tributaries of coronary sinus.
19. Ethical considerations of organ donation.

Very Short Answer Questions: 6X3=18

of duodenum.
20. Draw a neatly labelled diagram of histology
21. Derivatives of midgut.
epiphyses.
22. Enumerate various types of
basis and applied aspects of Tendo Achilles.
23. Describe the anatomical
hypothesis.
24. Describe Lyon's
body. Add a note on Perineal tear,
Perineal
25. Describe the
 KALOJI NARA PAPER CODE: MB2019105
VANARAO
UNIVERSITYOF HEALTH SCIENCEs
MBRSWARANGAL
FliCSTYEAR TELANGANASTATE- 506 002 2023
EXAMINATIONS:NOVEMBER,
PHYSIOLOGY (New Regulation)
Time:3 Hours
Note: Answer PAPER
-1
all questions Max Marks:100
Drawdiagrams
Colour Whenever
necessary
ncil With Black Ball point 'HB pencil lany dark
Multiple Choice
Questions:
1. Which statement lox 1-10
a) Most about feedbackcontrolsystemsis incorrect
controlsystems
act by negative of the body b) . Positivefeedbackusuallypromotes
c) Generation feedback
of nerveactions stability in a system
potentials involves positive d) Feed-forward
controlis importantin
feedback regulating muscle activity
2. Gapjunctions
a) Maintaincellular
c) polarity
Havecorresponding
connections d) Help ofpolypeptides
3. pso or the P02
Whichproduces saturationofartcrial haemoglobinis
a) 30 mm Hg
c) 28 mm Hg b) 26 mm Hg •
Central pattern generator: d) 22 mm Hg
a) Pre-Botzinger complex •
c) Nucleus ambigus b) Nucleusof tractussolitarius
5. Whichpart ofthe ECGcorresponds d) Retrofacialis
a) The P wave to ventricular
repolarization?
c) The T wave • b) QRSduration
6. Duration of cardiac cycle at the heart rate d) The U wave
of 100beats/minis
a) 0.8sec b)• 0 6sec
c) I sec d) 0.2scc
7. Renin is secreted by
a) Cells in the macula densa. b) Cells in the proximal
c) Cellsin the distaltubules tubules
Juxtaglomerular
cells
8. Small intestinal motility is increasedby:
a) Gastrin.
9.
c) Glucagon
Trypsin inhibitor:
b)
d) GIPMedi Circle
Secretin

a) Inhibitsthe actionofpancreatic b) Inhibits activation of trypsin in

the pancreas•
enzymes in the lumen of the
duodenum
c) In excess causes acute pancreatitis d) Is producedby enterocytes

10. In which part ofthe cell does the inbomerrorsof metabolismcharacterizedbyaccumulation

Ofsubstratein excess in variousorgancells due to defectivefunctioning
a) Lysosome b) Mitochondria
c) GolgiApparatus d) Nucleus
 Essay/ Long Answer Questions:

11. A 23-year-old male met with a road traffic accident

brought to 30
with restlessness and irritability. On examination, the Em
patient had ergeneydepartment
rapid thread
hypotension, rapid shallow breathing and oliguria. •ypulse,
a) Identify the condition.
b) Define shock and its types.
c) State aboutcardiacoutputin this patient.
d) Discuss in detail about factors regulating cardiac output.
12. A 22-year-old female attending to outpatient department complains
of tirednessand
easy
fatiguability even with mild exertion. On examination, patient's skin and
mucous membranes
appear pale. Patient's peripheralsmear showed decrease in the size of RBC
with increased
central pallor. Lab report shows decreased MCV, decreased MCH and
decreased MCHC.
a) Identify the above condition.
b) Discuss in detailabout stages the ofErythropoiesis
c) Describethe regulationof Erythropoiesis.
d) Add a note on osmoticfragility ofRBC's.
Short Answer Questions:
13. Describe the factors influencing GFR.
Medi Circle 7 x 6=42

14. Name the differentbody fluid compartments. Give the composition

of
extracellular and intracellular fluids. Mention the methods to measure
ECF.
15. Write compositionand explainthe functionsof Pancreaticjuice
16. Write the movements of small intestine.
17. Enumerate the factorsregulating Chemical Respiration
18. Define Asphyxia, types and stages of Asphyxia.
19. Describe professional qualities of a physician.

Very Short Answer Questions: 6X3=18

20. Heart block.
21. Mismatched blood transfusion reaction.
22. Describe the physiological significance of Pulmonary surfactant.
23. Loop ofHenle - filtrationfraction.
24. Cystometrogram.
25. Endocytosis.
 PAPER CODE: MB2019106
RAC) UNIVERs1TY OF HEALTH SCIENCES
KAI-OJI NARAYANA
WARANGAL,
'VELASGANASTATE —506 002
MBBSFIRSTYEAR NOVEMBER,2023
EXAMINAT10Ns:
PHYSIOLOGY (New Regulation)
pApER—11
Max Marks: 100
•rime:3 Hours
Note: Answer questions
Drawdiagramswhenevernecessarywith Blackballpointpen/HB pencil'any dark
Co/our •neil
MultipleChoiceQuestions:
10 x 1=10
1. Contractileunit of muscleis the portionof myofibril
a) A and H band b) Z linebetween:
Two adjacent Z Iines d) A and and A band
I band
2. An example for multi-unit (non syncytial) smoothmuscle is:
a) Stomach b) Uterinemyometrium
Iris d) Ureters
3. The inhibitoryamino acid neurotransmitterS in the CNS are
a) Glutamateand glycine b) Glutamate and aspartate
GABA and glycine d) Aspartateand glycine
4. Whichof the followingis the correctBrodmann'snumberdesignationfor the primary
motorcortex.

5.
Medi Circle
The abilityto detecttwo pointssimultaneouslyappliedto the skin is based on which of the
followingphysiologicmechanisms.
a) Presynapticinhibition b) Lateralinhibition
L) Medial inhibition - bitiou_v
A 45-year-oldwoman reportedwithdiminishedhearing in the right ear for the last years;—
Rinne's test (withoutmasking)is negativeon the right ear and positiveon the left side.
With the Weber'stest, the tone is perceivedas louderin the left ear. Which of the
followingis mostlikely.
a) Conductionlossin the rightear b) Sensorineuralhearinglossin the right ear
Sensorineural hearing loss in the
left ear d) Conductionlossin the left ear
7. Pheochromocytomas predominantly secrete
a) Epinephrine b) Nprepinephrine
pi' Bothepinephrineand
norepinephrine d) Dopamine
8. Not a feature of Sertolicell:
Nourish sperms and control their
a) b)
release Provideblood testis barrier
Secretetestosterone d) Secreteinhibin
9. A 30-year-oldwomanis breastfeeding infantduringsucklingreflex, which Ofthe
followinghormonalresponsesis expected,
Increasedsecretionof antidiuretic Increasedsecretionof ADH from the
a) hormone(ADH) from the b) paraventricular nuclei
supraopticnuclei
Increased secretion of oxytocin
from the paraventricular nuclei Decreasedsecretion of neurophysin
10. The HCG is first measured in the blood
a) 8 to 9 days after ovluation 8 to 9 days alter fertilizationof ovum
d) At 8 weeks of pregnancy
c) At 10-12weeks of pregnancy
Essay/ Long
Answer Questions: 2 x 15=30
Il. A 10-year-old
male reported with historyof excessive thirst, frequent urination and weight
loss for the past
six months and in the past two days he has nausea and vomited on several
occasions. He was
brought with extreme nauseating feeling to the casualty and his breath
emitted fruity
odour. The lab investigationin casualty
mg/dl. pH of 7.23 revealed blood glucose level Of435
(NR—7.35-7.45) and urine tested positive for glucose and acetone

a. Identify the condition. Medi Circle

State the hormonesregulating blood glucose.
c. Describe the regulationof blood glucose.
d. Discuss in detail the Mechanism Of action of insulin. (2-2+5+6)
12. A person aged
60 years with drunken gait attended to outpatient department. On
examination he had Slurred speech, dysmetria and intentional tremor.
a) Identify the condition.
b) Enumerate the other syppp9ms in the above disease.
c) Describe about the functionsof the part damaged in the above condition.
d) Discuss about Feed- Forward inhibitipn.
Short Answer Questions: 7X6-42
Discuss the functions or Hypothalamus. 9
Discuss in detail about Motor End Plate.
Define Aphasia. And list out other types briefly.
p. Writein detailthe actionof Oxytocin.
Impedance matching.
Define Sleep. Write in detail about types of Sleep and waves in stages of Sleep. z,
Describe about molecular basis of Skeletal Muscle Contraction. z_
Very Short Answer Questions:
Structure and function of cornea.
AV. Describe Ovulation and add a note on safe period.
22. Enumerate the theories of ageing and measures to prevent ageing.
Describe Cryptorchidism and ts effectv
—.24' Muscle proteins.
. Describe the rights and responsibilities of Patients.